{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:49:17Z","timestamp":1790304557221,"version":"4.1.0"},"reference-count":67,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID Chile: Beca Doctorado Nacional","award":["21170812"],"award-info":[{"award-number":["21170812"]}]},{"name":"ANID Chile: Beca Doctorado Nacional","award":["1191276"],"award-info":[{"award-number":["1191276"]}]},{"name":"ANID Chile: Beca Doctorado Nacional","award":["EQM 170023"],"award-info":[{"award-number":["EQM 170023"]}]},{"name":"ANID Chile: Beca Doctorado Nacional","award":["ACE210012"],"award-info":[{"award-number":["ACE210012"]}]},{"name":"FONDECYT","award":["21170812"],"award-info":[{"award-number":["21170812"]}]},{"name":"FONDECYT","award":["1191276"],"award-info":[{"award-number":["1191276"]}]},{"name":"FONDECYT","award":["EQM 170023"],"award-info":[{"award-number":["EQM 170023"]}]},{"name":"FONDECYT","award":["ACE210012"],"award-info":[{"award-number":["ACE210012"]}]},{"name":"FONDEQUIP","award":["21170812"],"award-info":[{"award-number":["21170812"]}]},{"name":"FONDEQUIP","award":["1191276"],"award-info":[{"award-number":["1191276"]}]},{"name":"FONDEQUIP","award":["EQM 170023"],"award-info":[{"award-number":["EQM 170023"]}]},{"name":"FONDEQUIP","award":["ACE210012"],"award-info":[{"award-number":["ACE210012"]}]},{"name":"CENTROS BASALES","award":["21170812"],"award-info":[{"award-number":["21170812"]}]},{"name":"CENTROS BASALES","award":["1191276"],"award-info":[{"award-number":["1191276"]}]},{"name":"CENTROS BASALES","award":["EQM 170023"],"award-info":[{"award-number":["EQM 170023"]}]},{"name":"CENTROS BASALES","award":["ACE210012"],"award-info":[{"award-number":["ACE210012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Polyphenols are bioactive substances that participate in the prevention of chronic illnesses. High content has been described in Berberis microphylla G. Forst (calafate), a wild berry extensively distributed in Chilean\u2013Argentine Patagonia. We evaluated its beneficial effect through the study of mouse plasma metabolome changes after chronic consumption of this fruit. Characterized calafate extract was administered in water, for four months, to a group of mice fed with a high-fat diet and compared with a control diet. Metabolome changes were studied using UHPLC-DAD-QTOF-based untargeted metabolomics. The study was complemented by the analysis of protein biomarkers determined using Luminex technology, and quantification of OH radicals by electron paramagnetic resonance spectroscopy. Thirteen features were identified with a maximum annotation level-A, revealing an increase in succinic acid, activation of tricarboxylic acid and reduction of carnitine accumulation. Changes in plasma biomarkers were related to inflammation and cardiovascular disease, with changes in thrombomodulin (\u221224%), adiponectin (+68%), sE-selectin (\u221234%), sICAM-1 (\u221224%) and proMMP-9 (\u221231%) levels. The production of OH radicals in plasma was reduced after calafate intake (\u221217%), especially for the group fed with a high-fat diet. These changes could be associated with protection against atherosclerosis due to calafate consumption, which is discussed from a holistic and integrative point of view.<\/jats:p>","DOI":"10.3390\/antiox12020304","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T05:57:23Z","timestamp":1675058243000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Berberis microphylla G. Forst Intake Reduces the Cardiovascular Disease Plasmatic Markers Associated with a High-Fat Diet in a Mice Model"],"prefix":"10.3390","volume":"12","author":[{"given":"Lia","family":"Olivares-Caro","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lisis Instrumental, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Nova-Baza","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lisis Instrumental, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Radojkovic","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-474X","authenticated-orcid":false,"given":"Luis","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lisis Instrumental, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duran","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6962-7632","authenticated-orcid":false,"given":"Daniela","family":"Mennickent","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lisis Instrumental, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-4399","authenticated-orcid":false,"given":"Victoria","family":"Melin","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Mec\u00e1nica, Facultad de Ingenier\u00eda, Universidad de Tarapac\u00e1, Avda. General Vel\u00e1squez 1775, Arica 1000007, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-5918","authenticated-orcid":false,"given":"David","family":"Contreras","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica e Inorg\u00e1nica, Facultad de Ciencias Qu\u00edmicas, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-2040","authenticated-orcid":false,"given":"Andy J.","family":"Perez","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lisis Instrumental, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-1610","authenticated-orcid":false,"given":"Claudia","family":"Mardones","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lisis Instrumental, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Unidad de Desarrollo Tecnol\u00f3gico, Universidad de Concepci\u00f3n, Coronel 4191996, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"ref_1","first-page":"30","article-title":"Obesity development in a miniature Yucatan pig model: A multi-compartmental metabolomics study on cloned and normal pigs fed restricted or ad libitum high-energy diets","volume":"18","author":"Curtasu","year":"2019","journal-title":"J. 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