{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:39:35Z","timestamp":1790005175689,"version":"4.0.1"},"reference-count":89,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education AcRF Tier 1","doi-asserted-by":"publisher","award":["NUHSRO\/2017\/055\/T1"],"award-info":[{"award-number":["NUHSRO\/2017\/055\/T1"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education AcRF Tier 1","doi-asserted-by":"publisher","award":["HLCA20Jan-0057"],"award-info":[{"award-number":["HLCA20Jan-0057"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education AcRF Tier 1","doi-asserted-by":"publisher","award":["NMRC\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC\/1264\/2010\/082\/12"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education AcRF Tier 1","doi-asserted-by":"publisher","award":["NMRC-IRG\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC-IRG\/1264\/2010\/082\/12"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education AcRF Tier 1","doi-asserted-by":"publisher","award":["NMRC\/OFTIRG\/0081\/2018"],"award-info":[{"award-number":["NMRC\/OFTIRG\/0081\/2018"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Tan Chin Tuan Centennial Foundation, the Ministry of Health\u2014National Academy of Medicine Healthy Longevity Catalyst Award","doi-asserted-by":"publisher","award":["NUHSRO\/2017\/055\/T1"],"award-info":[{"award-number":["NUHSRO\/2017\/055\/T1"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Tan Chin Tuan Centennial Foundation, the Ministry of Health\u2014National Academy of Medicine Healthy Longevity Catalyst Award","doi-asserted-by":"publisher","award":["HLCA20Jan-0057"],"award-info":[{"award-number":["HLCA20Jan-0057"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Tan Chin Tuan Centennial Foundation, the Ministry of Health\u2014National Academy of Medicine Healthy Longevity Catalyst Award","doi-asserted-by":"publisher","award":["NMRC\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC\/1264\/2010\/082\/12"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Tan Chin Tuan Centennial Foundation, the Ministry of Health\u2014National Academy of Medicine Healthy Longevity Catalyst Award","doi-asserted-by":"publisher","award":["NMRC-IRG\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC-IRG\/1264\/2010\/082\/12"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Tan Chin Tuan Centennial Foundation, the Ministry of Health\u2014National Academy of Medicine Healthy Longevity Catalyst Award","doi-asserted-by":"publisher","award":["NMRC\/OFTIRG\/0081\/2018"],"award-info":[{"award-number":["NMRC\/OFTIRG\/0081\/2018"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Medical Research Council","award":["NUHSRO\/2017\/055\/T1"],"award-info":[{"award-number":["NUHSRO\/2017\/055\/T1"]}]},{"name":"National Medical Research Council","award":["HLCA20Jan-0057"],"award-info":[{"award-number":["HLCA20Jan-0057"]}]},{"name":"National Medical Research Council","award":["NMRC\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC\/1264\/2010\/082\/12"]}]},{"name":"National Medical Research Council","award":["NMRC-IRG\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC-IRG\/1264\/2010\/082\/12"]}]},{"name":"National Medical Research Council","award":["NMRC\/OFTIRG\/0081\/2018"],"award-info":[{"award-number":["NMRC\/OFTIRG\/0081\/2018"]}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NUHSRO\/2017\/055\/T1"],"award-info":[{"award-number":["NUHSRO\/2017\/055\/T1"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["HLCA20Jan-0057"],"award-info":[{"award-number":["HLCA20Jan-0057"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC\/1264\/2010\/082\/12"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC-IRG\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC-IRG\/1264\/2010\/082\/12"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/OFTIRG\/0081\/2018"],"award-info":[{"award-number":["NMRC\/OFTIRG\/0081\/2018"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ESR\/TENG GL PhD","award":["NUHSRO\/2017\/055\/T1"],"award-info":[{"award-number":["NUHSRO\/2017\/055\/T1"]}]},{"name":"ESR\/TENG GL PhD","award":["HLCA20Jan-0057"],"award-info":[{"award-number":["HLCA20Jan-0057"]}]},{"name":"ESR\/TENG GL PhD","award":["NMRC\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC\/1264\/2010\/082\/12"]}]},{"name":"ESR\/TENG GL PhD","award":["NMRC-IRG\/1264\/2010\/082\/12"],"award-info":[{"award-number":["NMRC-IRG\/1264\/2010\/082\/12"]}]},{"name":"ESR\/TENG GL PhD","award":["NMRC\/OFTIRG\/0081\/2018"],"award-info":[{"award-number":["NMRC\/OFTIRG\/0081\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background: Anthracyclines such as doxorubicin remain a primary treatment for hematological malignancies and breast cancers. However, cardiotoxicity induced by anthracyclines, possibly leading to heart failure, severely limits their application. The pathological mechanisms of anthracycline-induced cardiac injury are believed to involve iron-overload-mediated formation of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation. The dietary thione, ergothioneine (ET), is avidly absorbed and accumulated in tissues, including the heart. Amongst other cytoprotective properties, ET was shown to scavenge ROS, decrease proinflammatory mediators, and chelate metal cations, including Fe2+, preventing them from partaking in redox activities, and may protect against mitochondrial damage and dysfunction. Plasma ET levels are also strongly correlated to a decreased risk of cardiovascular events in humans, suggesting a cardioprotective role. This evidence highlights ET\u2019s potential to counteract anthracycline cardiotoxicity. Methods and Findings: We investigated whether ET supplementation can protect against cardiac dysfunction in mice models of doxorubicin-induced cardiotoxicity and revealed that it had significant protective effects. Moreover, ET administration in a mouse breast cancer model did not exacerbate the growth of the tumor or interfere with the chemotherapeutic efficacy of doxorubicin. Conclusion: These results suggest that ET could be a viable co-therapy to alleviate the cardiotoxic effects of anthracyclines in the treatment of cancers.<\/jats:p>","DOI":"10.3390\/antiox12020320","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T06:06:13Z","timestamp":1675058773000},"page":"320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Protection against Doxorubicin-Induced Cardiotoxicity by Ergothioneine"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9817-468X","authenticated-orcid":false,"given":"Irwin K.","family":"Cheah","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore"},{"name":"Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, #05-01, Singapore 117456, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M. Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore"},{"name":"Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, #05-01, Singapore 117456, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 08-01, Singapore 117599, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma","family":"Sachaphibulkij","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"},{"name":"Life Science Institute, Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore 117456, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-4025","authenticated-orcid":false,"given":"Suet Yen","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 08-01, Singapore 117599, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina H. K.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"},{"name":"Life Science Institute, Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore 117456, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-6082","authenticated-orcid":false,"given":"Jiong-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 08-01, Singapore 117599, Singapore"},{"name":"Department of Physiology and Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"},{"name":"Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-7123","authenticated-orcid":false,"given":"Barry","family":"Halliwell","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore"},{"name":"Life Science Institute, Neurobiology Programme, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, #05-01, Singapore 117456, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11936-014-0315-4","article-title":"Anthracycline-induced cardiotoxicity: A review of pathophysiology, diagnosis, and treatment","volume":"16","author":"Raj","year":"2014","journal-title":"Curr. Treat Options Cardiovasc. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/cncr.11407","article-title":"Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials","volume":"97","author":"Swain","year":"2003","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/S0021-9258(17)35747-2","article-title":"Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical","volume":"261","author":"Doroshow","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10741-020-10063-9","article-title":"Oxidative stress and inflammation: Determinants of anthracycline cardiotoxicity and possible therapeutic targets","volume":"26","author":"Fabiani","year":"2021","journal-title":"Heart Fail Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"811406","DOI":"10.3389\/fphar.2022.811406","article-title":"Understanding Anthracycline Cardiotoxicity from Mitochondrial Aspect","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e132747","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/bbrc.1996.5898","article-title":"Effect of concentration on the cytotoxic mechanism of doxorubicin--apoptosis and oxidative DNA damage","volume":"230","author":"Muller","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2736(80)90145-5","article-title":"Evidence of a specific complex between adriamycin and negatively-charged phospholipids","volume":"597","author":"Goormaghtigh","year":"1980","journal-title":"Biochim. Et Biophys. Acta (BBA)-Biomembr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2202169","DOI":"10.1002\/adma.202202169","article-title":"Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Halliwell, B., and Gutteridge, J.M. (2015). Free Radicals in Biology and Medicine, Clarendon Press. [5th ed.].","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"H795","DOI":"10.1152\/ajpheart.00253.2017","article-title":"Vitamin C mitigates oxidative\/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy","volume":"313","author":"Akolkar","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1742-7843.2005.pto_166.x","article-title":"Activity of d,l-alpha-tocopherol (vitamin E) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice","volume":"97","author":"Bjelogrlic","year":"2005","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/0960327112467043","article-title":"N-acetylcysteine prevents doxorubucin-induced cardiotoxicity in rats","volume":"32","author":"Arica","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00280-013-2260-4","article-title":"The role of antioxidants in the era of cardio-oncology","volume":"72","author":"Vincent","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100259","DOI":"10.1016\/j.phanu.2021.100259","article-title":"Can antioxidant vitamins avoid the cardiotoxicity of doxorubicin in treating breast cancer?","volume":"16","author":"Cavalcanti","year":"2021","journal-title":"PharmaNutrition"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1200\/JCO.19.01203","article-title":"Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients with Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)","volume":"38","author":"Ambrosone","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jnci\/djn148","article-title":"Should Supplemental Antioxidant Administration Be Avoided During Chemotherapy and Radiation Therapy?","volume":"100","author":"Lawenda","year":"2008","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zou, Z.V., Le Gal, K., El Zowalaty, A.E., Pehlivanoglu, L.E., Garellick, V., Gul, N., Ibrahim, M., Bergh, P., Henricsson, M., and Wiel, C. (2021). Antioxidants Promote Intestinal Tumor Progression in Mice. Antioxidants, 10.","DOI":"10.3390\/antiox10020241"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"221ra15","DOI":"10.1126\/scitranslmed.3007653","article-title":"Antioxidants accelerate lung cancer progression in mice","volume":"6","author":"Sayin","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e127647","DOI":"10.1172\/jci.insight.127647","article-title":"The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice","volume":"4","author":"Breau","year":"2019","journal-title":"JCI Insight"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF01976756","article-title":"The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes","volume":"40","author":"Buss","year":"1993","journal-title":"Agents Actions"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"djv357","DOI":"10.1093\/jnci\/djv357","article-title":"Cardioprotection and Second Malignant Neoplasms Associated with Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis","volume":"108","author":"Shaikh","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.bbadis.2011.09.017","article-title":"Ergothioneine; antioxidant potential, physiological function and role in disease","volume":"1822","author":"Cheah","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101868","DOI":"10.1016\/j.redox.2021.101868","article-title":"Ergothioneine, recent developments","volume":"42","author":"Cheah","year":"2021","journal-title":"Redox Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0083-6729(08)60271-X","article-title":"Ergothioneine","volume":"17","author":"Melville","year":"1959","journal-title":"Vitam. Horm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1002\/1873-3468.13123","article-title":"Ergothioneine\u2014A diet-derived antioxidant with therapeutic potential","volume":"592","author":"Halliwell","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/s41598-018-20021-z","article-title":"Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues","volume":"8","author":"Tang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2019.02.122","article-title":"Specificity of the ergothioneine transporter natively expressed in HeLa cells","volume":"513","author":"Tucker","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/1873-3468.14269","article-title":"The ergothioneine transporter (ETT): Substrates and locations, an inventory","volume":"596","author":"Grundemann","year":"2022","journal-title":"FEBS Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0003-9861(91)90158-F","article-title":"The antioxidant action of ergothioneine","volume":"288","author":"Akanmu","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s12017-020-08620-4","article-title":"Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury","volume":"23","author":"Koh","year":"2021","journal-title":"Neuromolecular Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1248\/cpb.22.654","article-title":"Metal-complexes of ergothioneine","volume":"22","author":"Motohash","year":"1974","journal-title":"Chem. Pharm. Bull."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/tx100214t","article-title":"Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex","volume":"24","author":"Zhu","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/cdd.2009.163","article-title":"The unusual amino acid L-ergothioneine is a physiologic cytoprotectant","volume":"17","author":"Paul","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1161\/HYPERTENSIONAHA.119.13929","article-title":"L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model","volume":"75","author":"Williamson","year":"2020","journal-title":"Hypertension"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/heartjnl-2019-315485","article-title":"Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease","volume":"106","author":"Smith","year":"2020","journal-title":"Heart"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/1871525719666210809122541","article-title":"Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats","volume":"20","author":"Dare","year":"2022","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"key":"ref_39","first-page":"4697","article-title":"Ergothioneine prevents endothelial dysfunction induced by mercury chloride","volume":"15","author":"Arun","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1124\/jpet.114.214049","article-title":"Uptake and protective effects of ergothioneine in human endothelial cells","volume":"350","author":"Li","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jcrc.2008.03.021","article-title":"Ergothioneine prevents acute lung injury in mesenteric ischemia and reperfusion injury in rats","volume":"23","author":"Sakrak","year":"2008","journal-title":"J. Crit. Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jss.2004.06.016","article-title":"Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70","volume":"122","author":"Bedirli","year":"2004","journal-title":"J. Surg Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jss.2007.04.020","article-title":"Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury","volume":"144","author":"Sakrak","year":"2008","journal-title":"J. Surg Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1089\/jmf.2009.0194","article-title":"The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease","volume":"13","author":"Martin","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0003-9861(90)90410-Z","article-title":"The reduction of ferryl myoglobin by ergothioneine: A novel function for ergothioneine","volume":"281","author":"Arduini","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/CIRCHEARTFAILURE.114.001151","article-title":"Metabolomic analysis of pressure-overloaded and infarcted mouse hearts","volume":"7","author":"Sansbury","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2015.12.124","article-title":"Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis","volume":"470","author":"Halliwell","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/10715762.2015.1099642","article-title":"Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence?","volume":"50","author":"Cheah","year":"2016","journal-title":"Free Radic. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"9193","DOI":"10.1038\/s41598-017-09451-3","article-title":"Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function and Reduces Fibrosis in Sustained Pressure Overload","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/cvr\/cvz057","article-title":"Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction","volume":"115","author":"Chong","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_51","first-page":"135","article-title":"New non-invasive index for combined systolic and diastolic ventricular function","volume":"26","author":"Tei","year":"1995","journal-title":"J. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1525-1594.2004.47350.x","article-title":"Echocardiographic assessment of global ventricular function using the myocardial performance index in rats with hypertrophy","volume":"28","author":"Salemi","year":"2004","journal-title":"Artif. Organs"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/ars.2016.6778","article-title":"Administration of pure ergothioneine to healthy human subjects; Uptake, metabolism and effects on biomarkers of oxidative damage and inflammation","volume":"26","author":"Cheah","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/annonc\/mdw604","article-title":"Causes of death among cancer patients","volume":"28","author":"Zaorsky","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/jnci\/djh253","article-title":"Probabilities of death from breast cancer and other causes among female breast cancer patients","volume":"96","author":"Schairer","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_57","first-page":"59","article-title":"Chemotherapy-induced Cardiotoxicity","volume":"8","author":"Florescu","year":"2013","journal-title":"Maedica (Bucur)"},{"key":"ref_58","first-page":"72","article-title":"Epidemiology of anthracycline cardiotoxicity in children and adults","volume":"25","author":"Grenier","year":"1998","journal-title":"Semin. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12012-007-0013-5","article-title":"Anthracycline cardiotoxicity in breast cancer patients: Synergism with trastuzumab and taxanes","volume":"7","author":"Gianni","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Halliwell, B., Tang, R., and Cheah, I. (2023). Diet-Derived Antioxidants: The Special Case of Ergothioneine. Annu. Rev. Food Sci. Technol., 14.","DOI":"10.1146\/annurev-food-060822-122236"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s11095-010-0076-z","article-title":"Gene knockout and metabolome analysis of carnitine\/organic cation transporter OCTN1","volume":"27","author":"Kato","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2015.02.026","article-title":"Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels","volume":"83","author":"Pfeiffer","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3109\/10715762.2013.848354","article-title":"Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage","volume":"47","author":"Cheah","year":"2013","journal-title":"Free Radic. Res."},{"key":"ref_64","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: A simple and reproducible measure of cardiac function\u2014A study in normals and dilated cardiomyopathy","volume":"26","author":"Tei","year":"1995","journal-title":"J. Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"624057","DOI":"10.3389\/fonc.2021.624057","article-title":"Cardiac Surveillance for Early Detection of Late Subclinical Cardiac Dysfunction in Childhood Cancer Survivors after Anthracycline Therapy","volume":"11","author":"Sofia","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/01.CIR.0000142049.14227.AD","article-title":"Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice","volume":"110","author":"Dawson","year":"2004","journal-title":"Circulation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.7150\/thno.63354","article-title":"Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis","volume":"11","author":"Chong","year":"2021","journal-title":"Theranostics"},{"key":"ref_68","first-page":"17","article-title":"L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts","volume":"56","author":"Obayashi","year":"2005","journal-title":"J. Cosmet. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/bbrc.1997.6109","article-title":"Antioxidant action of ergothioneine: Assessment of its ability to scavenge peroxynitrite","volume":"231","author":"Aruoma","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0278-6915(99)00090-3","article-title":"Intracellular antioxidants: From chemical to biochemical mechanisms","volume":"37","author":"Chaudiere","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.clnu.2005.10.005","article-title":"Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine","volume":"25","author":"Colognato","year":"2006","journal-title":"Clin. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0278-6915(99)00098-8","article-title":"Protection against oxidative damage and cell death by the natural antioxidant ergothioneine","volume":"37","author":"Aruoma","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"ref_73","first-page":"3339","article-title":"Ergothioneine produces relaxation in isolated rat aorta by inactivating superoxide anion","volume":"18","author":"Gokce","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2017.03.009","article-title":"Ergothioneine products derived by superoxide oxidation in endothelial cells exposed to high-glucose","volume":"108","author":"Servillo","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2014.11.017","article-title":"An uncommon redox behavior sheds light on the cellular antioxidant properties of ergothioneine","volume":"79","author":"Servillo","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/bbb\/zbab006","article-title":"A proposed antioxidation mechanism of ergothioneine based on the chemically derived oxidation product hercynine and further decomposition products","volume":"85","author":"Ando","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1021\/bi00537a001","article-title":"Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex","volume":"21","author":"Myers","year":"1982","journal-title":"Biochemistry"},{"key":"ref_78","first-page":"245","article-title":"Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: Studies in rat heart cells in culture","volume":"122","author":"Hershko","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.jacc.2007.02.060","article-title":"Potentiation of Doxorubicin cardiotoxicity by iron loading in a rodent model","volume":"49","author":"Panjrath","year":"2007","journal-title":"J. Am. Coll Cardiol"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/03630269.2010.484766","article-title":"Iron chelation for amelioration of liver ischemia-reperfusion injury","volume":"34","author":"Arkadopoulos","year":"2010","journal-title":"Hemoglobin"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1248\/bpb.b19-00434","article-title":"Involvement of gamma-Glutamyl Transpeptidase in Ischemia\/Reperfusion-Induced Cardiac Dysfunction in Isolated Rat Hearts","volume":"42","author":"Koyama","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/01.ATV.0000251993.20372.40","article-title":"Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: The Framingham Heart Study","volume":"27","author":"Lee","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cca.2017.11.026","article-title":"Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease","volume":"476","author":"Ndrepepa","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"119572","DOI":"10.1016\/j.lfs.2021.119572","article-title":"Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-kappaB, and apoptotic signaling and inhibiting gamma-glutamyl transpeptidase","volume":"278","author":"Salama","year":"2021","journal-title":"Life Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"14603","DOI":"10.1074\/jbc.RA119.009304","article-title":"Sulfur-containing histidine compounds inhibit gamma-glutamyl transpeptidase activity in human cancer cells","volume":"294","author":"Brancaccio","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2015.05.026","article-title":"Dermato-protective properties of ergothioneine through induction of Nrf2\/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes","volume":"86","author":"Hseu","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/1873-3468.14310","article-title":"Diet-derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3\/MLKL pathway","volume":"596","author":"Martino","year":"2022","journal-title":"FEBS Lett."},{"key":"ref_88","first-page":"4629","article-title":"Safety of synthetic l-ergothioneine (Ergoneine\u00ae) as a novel food pursuant to Regulation (EC) No 258\/97","volume":"14","author":"Turck","year":"2016","journal-title":"EFSA J."},{"key":"ref_89","first-page":"5060","article-title":"Statement on the safety of synthetic l-ergothioneine as a novel food\u2014Supplementary dietary exposure and safety assessment for infants and young children, pregnant and breastfeeding women","volume":"15","author":"Turck","year":"2017","journal-title":"EFSA J."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/2\/320\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:19:57Z","timestamp":1760120397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/2\/320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":89,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["antiox12020320"],"URL":"https:\/\/doi.org\/10.3390\/antiox12020320","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.12.21.521347","asserted-by":"object"}]},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]}}}