{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:28:09Z","timestamp":1787502489127,"version":"build-2736575974"},"reference-count":219,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Progetto Fondazione di Sardegna","award":["bando 2022\u20132023"],"award-info":[{"award-number":["bando 2022\u20132023"]}]},{"name":"Progetto Fondazione di Sardegna","award":["FAR2020-Pintus"],"award-info":[{"award-number":["FAR2020-Pintus"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts critical phases of the fetus\u2019s life and correlates to an increased risk of chronic pathological conditions, such as diabetes, obesity, and cardiovascular diseases, in both the mother\u2019s and adult offspring\u2019s life. The dietary intake of naturally occurring antioxidants promotes health benefits and disease prevention. In this regard, maternal dietary intake of polyphenolic antioxidants is linked to a reduced risk of maternal obesity and cardio-metabolic disorders, positively affecting both the fetus and offspring. In this work, we will gather and critically appraise the current literature highlighting the effect\/s of the naturally occurring polyphenol antioxidant resveratrol on oxidative stress, inflammation, and other molecular and physiological phenomena associated with pregnancy and pregnancy conditions, such as gestational diabetes, preeclampsia, and preterm labor. The resveratrol impact on prenatal complications and pregnancy-associated structures, such as the fetus and placenta, will also be discussed. Finally, we will draw conclusions from the current knowledge and provide future perspectives on potentially exploiting resveratrol as a therapeutic tool in pregnancy-associated conditions.<\/jats:p>","DOI":"10.3390\/antiox12020341","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:52:02Z","timestamp":1675219922000},"page":"341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations"],"prefix":"10.3390","volume":"12","author":[{"given":"Iman","family":"Ramli","sequence":"first","affiliation":[{"name":"Departement de Biologie Animale, Universit\u00e9 des Fr\u00e8res Mentouri Constantine 1, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Posadino","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Giordo","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Fenu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Fardoun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, American University of Beirut, Beirut 11-0236, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-0378","authenticated-orcid":false,"given":"Rabah","family":"Iratni","sequence":"additional","affiliation":[{"name":"Department of Biology, United Arab Emirates University, Al-Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-5675","authenticated-orcid":false,"given":"Ali H.","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-6638","authenticated-orcid":false,"given":"Hatem","family":"Zayed","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-7733","authenticated-orcid":false,"given":"Gianfranco","family":"Pintus","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1001\/jamacardio.2021.4391","article-title":"Interventions to Mitigate Risk of Cardiovascular Disease After Adverse Pregnancy Outcomes: A Review","volume":"7","author":"Jowell","year":"2022","journal-title":"JAMA Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e902","DOI":"10.1161\/CIR.0000000000000961","article-title":"Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association","volume":"143","author":"Parikh","year":"2021","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.phrs.2019.04.020","article-title":"Systematic review: Impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications-Are we ready for the clinic?","volume":"144","author":"Darby","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/1570161117666190715121939","article-title":"Herbal medicine for slowing aging and aging-associated conditions: Efficacy, mechanisms and safety","volume":"18","author":"Phu","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13020-022-00651-2","article-title":"Propolis: An update on its chemistry and pharmacological applications","volume":"17","author":"Hossain","year":"2022","journal-title":"Chin. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fphar.2020.00422","article-title":"Herbal medicine for cardiovascular diseases: Efficacy, mechanisms, and safety","volume":"11","author":"Shaito","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2019.04.014","article-title":"Flavonoids in hypertension: A brief review of the underlying mechanisms","volume":"45","author":"Maaliki","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Shaito, A., Posadino, A.M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W.M., Eid, A.H., and Nasrallah, G.K. (2020). Potential adverse effects of resveratrol: A literature review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062084"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Giordo, R., Cossu, A., Porcu, M.C., Cappuccinelli, R., Biosa, G., Sharifi-Rad, J., Pretti, L., Nasrallah, G.K., Pintus, G., and Posadino, A.M. (2022). Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells. Nat. Prod. Res., 1\u20137.","DOI":"10.1080\/14786419.2022.2130304"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115722","DOI":"10.1016\/j.jep.2022.115722","article-title":"Low concentrations of Ambrosia maritima L. phenolic extract protect endothelial cells from oxidative cell death induced by H2O2 and sera from Crohn\u2019s disease patients","volume":"300","author":"Ramli","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Posadino, A.M., Cossu, A., Giordo, R., Piscopo, A., Abdel-Rahman, W.M., Piga, A., and Pintus, G. (2021). Antioxidant properties of olive mill wastewater polyphenolic extracts on human endothelial and vascular smooth muscle cells. Foods, 10.","DOI":"10.3390\/foods10040800"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.tiv.2017.05.005","article-title":"Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells","volume":"42","author":"Posadino","year":"2017","journal-title":"Toxicol. Vitr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Giordo, R., Zinellu, A., Eid, A.H., and Pintus, G. (2021). Therapeutic potential of resveratrol in COVID-19-associated hemostatic disorders. Molecules, 26.","DOI":"10.3390\/molecules26040856"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/fsn3.855","article-title":"Resveratrol: A miraculous natural compound for diseases treatment","volume":"6","author":"Koushki","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Posadino, A.M., Giordo, R., Cossu, A., Nasrallah, G.K., Shaito, A., Abou-Saleh, H., Eid, A.H., and Pintus, G. (2019). Flavin oxidase-induced ROS generation modulates PKC biphasic effect of resveratrol on endothelial cell survival. Biomolecules, 9.","DOI":"10.3390\/biom9060209"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"894305","DOI":"10.3389\/fcell.2022.894305","article-title":"Disease-associated regulation of non-coding RNAs by resveratrol: Molecular insights and therapeutic applications","volume":"10","author":"Giordo","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Giordo, R., Nasrallah, G.K., Posadino, A.M., Galimi, F., Capobianco, G., Eid, A.H., and Pintus, G. (2021). Resveratrol-elicited pkc inhibition counteracts nox-mediated endothelial to mesenchymal transition in human retinal endothelial cells exposed to high glucose. Antioxidants, 10.","DOI":"10.3390\/antiox10020224"},{"key":"ref_18","unstructured":"Shaito, A., Al-Mansoob, M., Ahmad, S.M., Haider, M.Z., Eid, A.H., Posadino, A.M., Pintus, G., and Giordo, R. (2022). Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: Molecular insights and potential therapeutic applications. Curr. Neuropharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1113\/JP273478","article-title":"Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring","volume":"595","author":"Zou","year":"2017","journal-title":"J. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S2040174422000332","article-title":"The effect of resveratrol in cardio-metabolic disorders during pregnancy and offspring outcomes: A review","volume":"14","author":"Lacerda","year":"2022","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200900437","article-title":"Resveratrol bioavailability and toxicity in humans","volume":"54","author":"Cottart","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/1535370212473704","article-title":"Diabetic complications in pregnancy: Is resveratrol a solution?","volume":"238","author":"Singh","year":"2013","journal-title":"Exp. Biol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/EC-17-0130","article-title":"Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia","volume":"6","author":"Ding","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1677\/joe.1.06535","article-title":"Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats","volume":"189","author":"Christoffel","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/sj.bjc.6601568","article-title":"Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3, 4, 5, 4\u2032-tetramethoxystilbene","volume":"90","author":"Sale","year":"2004","journal-title":"Br. J. Cancer"},{"key":"ref_26","first-page":"67","article-title":"Plasma, urine and tissue levels of trans-and cis-resveratrol (3, 4\u2032, 5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats","volume":"18","author":"Bertelli","year":"1996","journal-title":"Int. J. Tissue React."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/S0024-3205(03)00096-1","article-title":"Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration","volume":"72","author":"Vitrac","year":"2003","journal-title":"Life Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.placenta.2012.01.012","article-title":"Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia","volume":"33","author":"Bourque","year":"2012","journal-title":"Placenta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","article-title":"The pharmacology of resveratrol in animals and humans","volume":"1852","author":"Park","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/mnfr.200500010","article-title":"Metabolism and bioavailability of trans-resveratrol","volume":"49","author":"Wenzel","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.2010.05842.x","article-title":"Bioavailability of resveratrol","volume":"1215","author":"Walle","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/mnfr.200500003","article-title":"Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats","volume":"49","author":"Wenzel","year":"2005","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41120-022-00058-1","article-title":"Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM)","volume":"8","author":"Kemper","year":"2022","journal-title":"AAPS Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1158\/1940-6207.CAPR-11-0148","article-title":"Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases\u2014Safety, pharmacokinetics, and pharmacodynamics","volume":"4","author":"Howells","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2337\/db12-0975","article-title":"High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition","volume":"62","author":"Poulsen","year":"2013","journal-title":"Diabetes"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and \u03b2-catenin signalling: Diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/03602532.2012.700715","article-title":"Drug interaction potential of resveratrol","volume":"44","author":"Detampel","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Garza, S.L., Laveriano-Santos, E.P., Marhuenda-Mu\u00f1oz, M., Storniolo, C.E., Tresserra-Rimbau, A., Vallverd\u00fa-Queralt, A., and Lamuela-Ravent\u00f3s, R.M. (2018). Health effects of resveratrol: Results from human intervention trials. Nutrients, 10.","DOI":"10.3390\/nu10121892"},{"key":"ref_39","first-page":"2466","article-title":"Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates","volume":"28","author":"Roberts","year":"2014","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1177\/0960327110383625","article-title":"Resveratrol commonly displays hormesis: Occurrence and biomedical significance","volume":"29","author":"Calabrese","year":"2010","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.fct.2009.03.010","article-title":"Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets","volume":"47","author":"Rocha","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3109\/14767058.2011.599081","article-title":"The effect of resveratrol on blood pressure in a rat model of preeclampsia","volume":"25","author":"Moraloglu","year":"2012","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e13109","DOI":"10.14814\/phy2.13109","article-title":"Postnatal resveratrol supplementation improves cardiovascular function in male and female intrauterine growth restricted offspring","volume":"5","author":"Shah","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_44","first-page":"e240","article-title":"Can trans resveratrol plus d-chiro-inositol and myo-inositol improve maternal metabolic profile in overweight pregnant patients?","volume":"168","author":"Malvasi","year":"2017","journal-title":"Clin. Ter."},{"key":"ref_45","first-page":"504","article-title":"Developmental Origins of Cardiometabolic Diseases: Role of the Maternal Diet","volume":"7","author":"Fernandes","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.3389\/fmicb.2019.02229","article-title":"Effects of Quercetin and Resveratrol on in vitro Properties Related to the Functionality of Potentially Probiotic Lactobacillus Strains","volume":"10","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Badran, A., Nasser, S.A., Mesmar, J., El-Yazbi, A.F., Bitto, A., Fardoun, M.M., Baydoun, E., and Eid, A.H. (2020). Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228764"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31083\/j.fbl2703105","article-title":"Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases","volume":"27","author":"Shaito","year":"2022","journal-title":"Front. Biosci.-Landmark"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3109\/14767058.2011.600796","article-title":"Implications of maternal systemic oxidative stress in normal pregnancy and in pregnancy complicated by preeclampsia","volume":"25","author":"Mihu","year":"2012","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"525218","DOI":"10.1155\/2015\/525218","article-title":"Effects of Dietary Supplementation of Oregano Essential Oil to Sows on Oxidative Stress Status, Lactation Feed Intake of Sows, and Piglet Performance","volume":"2015","author":"Tan","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10565-014-9285-2","article-title":"Oxidative stress in pregnancy and fertility pathologies","volume":"30","author":"Pereira","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"ref_52","first-page":"372","article-title":"Endothelial dysfunction and preeclampsia: Role of oxidative stress","volume":"5","author":"Prada","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1113\/JP271543","article-title":"Resveratrol partially prevents oxidative stress and metabolic dysfunction in pregnant rats fed a low protein diet and their offspring","volume":"594","author":"Vega","year":"2016","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/mnfr.201000457","article-title":"Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam","volume":"55","author":"Singh","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"457","DOI":"10.17843\/rpmesp.2015.323.1674","article-title":"Capacidad antiteratog\u00e9nica del resveratrol en diabetes inducida por estreptozotocina en ratas","volume":"32","year":"2015","journal-title":"Rev. Peru. Med. Exp. Salud P\u00fablica"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7966","DOI":"10.1002\/jcp.30468","article-title":"Oxidative stress in oocyte aging and female reproduction","volume":"236","author":"Wang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"021","DOI":"10.1055\/s-0040-1721377","article-title":"The role of oocyte quality in explaining \u201cunexplained\u201d infertility","volume":"38","author":"Homer","year":"2020","journal-title":"Semin. Reprod. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e12651","DOI":"10.1111\/aji.12651","article-title":"Mitochondrial dysfunction and ovarian aging","volume":"77","author":"Wang","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.18632\/aging.101494","article-title":"Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo","volume":"10","author":"Liang","year":"2018","journal-title":"Aging"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1262\/jrd.2013-102","article-title":"Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes","volume":"60","author":"Takeo","year":"2014","journal-title":"J. Reprod. Dev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.fertnstert.2018.01.020","article-title":"Resveratrol improves in vitro maturation of oocytes in aged mice and humans","volume":"109","author":"Liu","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.18632\/aging.102768","article-title":"Effects of resveratrol, granulocyte-macrophage colony-stimulating factor or dichloroacetic acid in the culture media on embryonic development and pregnancy rates in aged mice","volume":"12","author":"Yoon","year":"2020","journal-title":"Aging"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/humrep\/des437","article-title":"Resveratrol protects against age-associated infertility in mice","volume":"28","author":"Liu","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1093\/humrep\/dew203","article-title":"Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation","volume":"31","author":"Igarashi","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/2096-2924.210693","article-title":"Mitochondrial Dysfunction and Age-related Oocyte Quality","volume":"1","author":"Li","year":"2017","journal-title":"Reprod. Dev. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"BSR20171741","DOI":"10.1042\/BSR20171741","article-title":"Maternal resveratrol consumption and its programming effects on metabolic health in offspring mechanisms and potential implications","volume":"38","author":"Zheng","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00264-013-2037-8","article-title":"High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells","volume":"37","author":"Park","year":"2013","journal-title":"Int. Orthop."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9179270","DOI":"10.1155\/2018\/9179270","article-title":"Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice","volume":"2018","author":"Sebori","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: Mechanisms, pathophysiological roles, and analysis","volume":"393","author":"Ding","year":"2012","journal-title":"Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/jam.14747","article-title":"Resveratrol promotes mammary cell proliferation and antioxidation capacity during pregnancy and lactation in mice","volume":"130","author":"Zha","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5581570","DOI":"10.1155\/2021\/5581570","article-title":"The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus)","volume":"2021","author":"Phoswa","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/hr.2010.264","article-title":"The role of oxidative stress in the pathophysiology of hypertension","volume":"34","author":"Rodrigo","year":"2011","journal-title":"Hypertens. Res."},{"key":"ref_73","first-page":"24","article-title":"TEMPORARY REMOVAL: The hypertensive disorders of pregnancy: ISSHP classification, diagnosis and management recommendations for international practice 2018","volume":"72","author":"Magee","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/10408363.2017.1422109","article-title":"Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring","volume":"55","author":"Agarwal","year":"2018","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1111\/j.1749-6632.2009.04952.x","article-title":"The Role of Sirtuins in the Control of Metabolic Homeostasis","volume":"1173","author":"Yu","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phrs.2009.12.006","article-title":"Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation","volume":"62","author":"Yu","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"111998","DOI":"10.18632\/oncotarget.22960","article-title":"A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: Beneficial effects of resveratrol","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative stress","volume":"25","author":"Burton","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_79","first-page":"137","article-title":"Preeclampsia: An update","volume":"65","author":"Lambert","year":"2014","journal-title":"Acta Anaesthesiol. Belg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"100638","DOI":"10.1016\/j.blre.2019.100638","article-title":"Thrombocytopenia in pregnancy: Diagnosis and approach to management","volume":"40","author":"Pishko","year":"2020","journal-title":"Blood Rev."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Silvestro, S., Calcaterra, V., Pelizzo, G., Bramanti, P., and Mazzon, E. (2020). Prenatal Hypoxia and Placental Oxidative Stress: Insights from Animal Models to Clinical Evidences. Antioxidants, 9.","DOI":"10.3390\/antiox9050414"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Hu, X.-Q., and Zhang, L. (2021). Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications. Antioxidants, 10.","DOI":"10.3390\/antiox10030405"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.2337\/db11-0374","article-title":"Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted","volume":"60","author":"Dolinsky","year":"2011","journal-title":"Diabetes"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"c72","DOI":"10.1159\/000101801","article-title":"Pre-Eclampsia: Clinical Manifestations and Molecular Mechanisms","volume":"106","author":"Baumwell","year":"2007","journal-title":"Nephron Clin. Pract."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/j.ackd.2013.02.005","article-title":"Preeclampsia: An Obstetrician\u2019s Perspective","volume":"20","author":"Rosser","year":"2013","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"586578","DOI":"10.1155\/2012\/586578","article-title":"Preeclampsia 2012","volume":"2012","author":"Eiland","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fphys.2014.00516","article-title":"Oxidative stress in preeclampsia and the role of free fetal hemoglobin","volume":"5","author":"Hansson","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Murthi, P., and Vaillancourt, C. (2018). Preeclampsia: Methods and Protocols, Springer.","DOI":"10.1007\/978-1-4939-7498-6"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0301-2115(03)00368-3","article-title":"Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsia","volume":"113","author":"Benian","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/01.ogx.0000193879.79268.59","article-title":"The Role of Placental Oxidative Stress and Lipid Peroxidation in Preeclampsia","volume":"60","author":"Gupta","year":"2005","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"105725","DOI":"10.1016\/j.phrs.2021.105725","article-title":"Resveratrol and endothelial function: A literature review","volume":"170","author":"Parsamanesh","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_93","first-page":"117","article-title":"Nrf2\/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: Implications for atherosclerosis and preeclampsia","volume":"59","author":"Mann","year":"2007","journal-title":"Acta Physiol. Sin.-Chin. Ed."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.preghy.2021.01.001","article-title":"Resveratrol and grape juice: Effects on redox status and nitric oxide production of endothelial cells in in vitro preeclampsia model","volume":"23","author":"Sandrim","year":"2021","journal-title":"Pregnancy Hypertens."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Poudel, R., Stanley, J.L., Rueda-Clausen, C.F., Andersson, I.J., Sibley, C.P., Davidge, S.T., and Baker, P.N. (2013). Effects of Resveratrol in Pregnancy Using Murine Models with Reduced Blood Supply to the Uterus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064401"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"110659","DOI":"10.1016\/j.biopha.2020.110659","article-title":"SIRT1-dependent effects of resveratrol and grape juice in an in vitro model of preeclampsia","volume":"131","author":"Cinegaglia","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1471-0528.1986.tb07830.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants","volume":"93","author":"Khong","year":"1986","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1471-0528.1987.tb02302.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small-for-gestational-age infants","volume":"94","author":"Labarrere","year":"1987","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrc1075","article-title":"Tumour-cell invasion and migration: Diversity and escape mechanisms","volume":"3","author":"Friedl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e429","DOI":"10.1038\/emm.2017.239","article-title":"Effects of microRNA-135a on the epithelial\u2013mesenchymal transition, migration and invasion of bladder cancer cells by targeting GSK3\u03b2 through the Wnt\/\u03b2-catenin signaling pathway","volume":"50","author":"Mao","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","article-title":"Cadherins in the human placenta\u2014Epithelial\u2013mesenchymal transition (EMT) and placental development","volume":"31","author":"Kokkinos","year":"2010","journal-title":"Placenta"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1111\/jcmm.14175","article-title":"Resveratrol promotes trophoblast invasion in pre-eclampsia by inducing epithelial-mesenchymal transition","volume":"23","author":"Zou","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"993","DOI":"10.7150\/ijms.73012","article-title":"SIRT1: A Novel Protective Molecule in Pre-eclampsia","volume":"19","author":"Liu","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1172\/JCI70431","article-title":"Preeclampsia: A link between trophoblast dysregulation and an antiangiogenic state","volume":"123","author":"Romero","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: Pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14767050701830480","article-title":"A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate","volume":"21","author":"Romero","year":"2008","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1038\/s41598-017-01993-w","article-title":"Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction\u2014Implications as a preeclampsia treatment","volume":"7","author":"Hannan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"20570","DOI":"10.3390\/molecules191220570","article-title":"Resveratrol Inhibits Trophoblast Apoptosis through Oxidative Stress in Preeclampsia-Model Rats","volume":"19","author":"Zou","year":"2014","journal-title":"Molecules"},{"key":"ref_110","first-page":"968","article-title":"Effects of comorbid gestational diabetes mellitus and depression on glucose metabolism during pregnancy and neonatal morphological outcome","volume":"54","author":"Jiao","year":"2020","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/scd.2014.0349","article-title":"Umbilical Cord Mesenchymal Stromal Cells Affected by Gestational Diabetes Mellitus Display Premature Aging and Mitochondrial Dysfunction","volume":"24","author":"Kim","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Choi, D.-J., Yoon, C.-H., Lee, H., Ahn, S.-Y., Oh, K.J., Park, H.-Y., Lee, H.Y., Cho, M.C., Chung, I.-M., and Shin, M.-S. (2016). The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus on the Occurrence of Gestational Hypertensive Disease and Diabetes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167528"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"16435","DOI":"10.1038\/s41598-021-95903-w","article-title":"Metabolic signatures in the conversion from gestational diabetes mellitus to postpartum abnormal glucose metabolism: A pilot study in Asian women","volume":"11","author":"Wang","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Su, M., Zhao, W., Xu, S., and Weng, J. (2022). Resveratrol in Treating Diabetes and Its Cardiovascular Complications: A Review of Its Mechanisms of Action. Antioxidants, 11.","DOI":"10.3390\/antiox11061085"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/mnfr.201200067","article-title":"Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db\/db mice","volume":"56","author":"Do","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_116","first-page":"2956795","article-title":"The Effect of Resveratrol on Blood Glucose and Blood Lipids in Rats with Gestational Diabetes Mellitus","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/10717544.2020.1775722","article-title":"Biological investigations on therapeutic effect of chitosan encapsulated nano resveratrol against gestational diabetes mellitus rats induced by streptozotocin","volume":"27","author":"Du","year":"2020","journal-title":"Drug Deliv."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1113\/JP278082","article-title":"Maternal resveratrol administration protects against gestational diabetes-induced glucose intolerance and islet dysfunction in the rat offspring","volume":"597","author":"Brawerman","year":"2019","journal-title":"J. Physiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jnutbio.2018.02.007","article-title":"Resveratrol improves glucose uptake in insulin-resistant adipocytes via Sirt1","volume":"55","author":"Chen","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.febslet.2009.12.006","article-title":"Structural requirements of anthocyanins in relation to inhibition of endothelial injury induced by oxidized low-density lipoprotein and correlation with radical scavenging activity","volume":"584","author":"Yi","year":"2010","journal-title":"Febs. Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2147\/DMSO.S240956","article-title":"Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice","volume":"13","author":"Shu","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/2211536606666170811151503","article-title":"Environment and Neurodegenerative Diseases: An Update on miRNA Role","volume":"6","author":"Ferrante","year":"2017","journal-title":"MicroRNA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.critrevonc.2015.10.003","article-title":"Exploring miRNA based approaches in cancer diagnostics and therapeutics","volume":"98","author":"Mishra","year":"2016","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/1568009617666170630142725","article-title":"MicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy","volume":"18","author":"Tiwari","year":"2018","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"683594","DOI":"10.3389\/fcell.2021.683594","article-title":"EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: Potential link with oxidative stress","volume":"9","author":"Giordo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Wehbe, N., Nasser, S.A., Pintus, G., Badran, A., Eid, A.H., and Baydoun, E. (2019). MicroRNAs in cardiac hypertrophy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194714"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1210\/jc.2017-01909","article-title":"Altered Expression of miR-181a-5p and miR-23a-3p Is Associated With Obesity and TNF\u03b1-Induced Insulin Resistance","volume":"103","author":"Vendrell","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molimm.2021.06.011","article-title":"Resveratrol ameliorates the glucose uptake and lipid metabolism in gestational diabetes mellitus mice and insulin-resistant adipocytes via miR-23a-3p\/NOV axis","volume":"137","author":"Zheng","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pop.2015.09.003","article-title":"Obesity in Special Populations: Pregnancy","volume":"43","author":"Downs","year":"2016","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/s41430-021-00905-6","article-title":"Overweight and obesity in pregnancy: Their impact on epigenetics","volume":"75","author":"Reichetzeder","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.11124\/JBIES-20-00442","article-title":"Women\u2019s experiences of living with obesity during pregnancy, birthing, and postpartum: A qualitative systematic review protocol","volume":"19","author":"Macdonald","year":"2021","journal-title":"JBI Evid. Synth."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez, D., Mu\u00f1oz, Y., Ortiz, M., Maliqueo, M., Chouinard-Watkins, R., and Valenzuela, R. (2021). Impact of Maternal Obesity on the Metabolism and Bioavailability of Polyunsaturated Fatty Acids during Pregnancy and Breastfeeding. Nutrients, 13.","DOI":"10.3390\/nu13010019"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ogc.2015.01.008","article-title":"Pregnancy Risks Associated with Obesity","volume":"42","author":"Mission","year":"2015","journal-title":"Obstet. Gynecol. Clin. North Am."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Gonz\u00e1lez, G.L., Vargas-Hern\u00e1ndez, L., Reyes-Castro, L.A., Ib\u00e1\u00f1ez, C.A., Bautista, C.J., Lomas-Soria, C., Itani, N., Estrada-Gutierrez, G., Espejel-Nu\u00f1ez, A., and Flores-Pliego, A. (2022). Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress. Antioxidants, 11.","DOI":"10.3390\/antiox11101871"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1801385","DOI":"10.1002\/mnfr.201801385","article-title":"Resveratrol Treatment Ameliorates Leptin Resistance and Adiposity Programed by the Combined Effect of Maternal and Post-Weaning High-Fat Diet","volume":"63","author":"Yu","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"108260","DOI":"10.1016\/j.jnutbio.2019.108260","article-title":"Resveratrol treatment improves the altered metabolism and related dysbiosis of gut programed by prenatal high-fat diet and postnatal high-fat diet exposure","volume":"75","author":"Huang","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1210\/en.2017-00610","article-title":"Resveratrol Intake During Pregnancy and Lactation Modulates the Early Metabolic Effects of Maternal Nutrition Differently in Male and Female Offspring","volume":"159","author":"Ros","year":"2017","journal-title":"Endocrinology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/jpn.13064","article-title":"Effects of dietary resveratrol supplementation during gestation and lactation of sows on milk composition of sows and fat metabolism of sucking piglets","volume":"103","author":"Sun","year":"2019","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/hepr.13198","article-title":"Resveratrol regulates the silent information regulator 1\u2013nuclear factor-\u03baB signaling pathway in intrahepatic cholestasis of pregnancy","volume":"48","author":"Liao","year":"2018","journal-title":"Hepatol. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1139\/cjpp-2015-0454","article-title":"Resveratrol reduces matrix metalloproteinases and alleviates intrahepatic cholestasis of pregnancy in rats","volume":"94","author":"Chen","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.beem.2010.05.006","article-title":"Disturbances in lipid metabolism in diabetic pregnancy\u2014Are these the cause of the problem?","volume":"24","author":"Herrera","year":"2010","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbrc.2007.12.140","article-title":"Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters","volume":"367","author":"Cho","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1365-2125.2007.02905.x","article-title":"Risk of congenital anomalies in pregnant users of statin drugs","volume":"64","author":"Ofori","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-015-0114-0","article-title":"Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK","volume":"13","author":"Yao","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_145","first-page":"81","article-title":"The epidemiology of non-alcoholic fatty liver disease","volume":"37","author":"Bellentani","year":"2017","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"ref_146","first-page":"2640","article-title":"Heritable IUGR and adult metabolic syndrome are reversible and associated with alterations in the metabolome following dietary supplementation of 1-carbon intermediates","volume":"29","author":"Seferovic","year":"2015","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.taap.2013.11.009","article-title":"Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats","volume":"274","author":"Shen","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2131\/jts.46.413","article-title":"Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring","volume":"46","author":"Shen","year":"2021","journal-title":"J. Toxicol. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jnutbio.2019.04.002","article-title":"Resveratrol prevents combined prenatal N(G)-nitro-L-arginine-methyl ester (L-NAME) treatment plus postnatal high-fat diet induced programmed hypertension in adult rat offspring: Interplay between nutrient-sensing signals, oxidative stress and gut microbiota","volume":"70","author":"Chen","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1017\/S204017441300010X","article-title":"Developmental programming of cardiovascular disease by prenatal hypoxia","volume":"4","author":"Giussani","year":"2013","journal-title":"J. Dev. Orig. Health Dis"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000353633","article-title":"Long-term follow-up of intrauterine growth restriction: Cardiovascular disorders","volume":"36","author":"Demicheva","year":"2014","journal-title":"Fetal Diagn. Ther."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/bmj.311.6998.171","article-title":"Fetal origins of coronary heart disease","volume":"311","author":"Barker","year":"1995","journal-title":"BMJ"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/uog.12314","article-title":"Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow","volume":"41","author":"Bjarnegard","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_155","first-page":"1401","article-title":"Insulin resistance early in adulthood in subjects born with intrauterine growth retardation","volume":"85","author":"Jaquet","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cvr\/cvn341","article-title":"Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood","volume":"81","author":"Morton","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.109.153239","article-title":"Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: Role of protein kinase C epsilon","volume":"330","author":"Xue","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1113\/JP271133","article-title":"Effect of resveratrol on metabolic and cardiovascular function in male and female adult offspring exposed to prenatal hypoxia and a high-fat diet","volume":"594","author":"Shah","year":"2016","journal-title":"J. Physiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1515\/jbcpp-2013-0011","article-title":"Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons","volume":"25","author":"Madhyastha","year":"2014","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.pbb.2012.09.012","article-title":"Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na+, K+-ATPase activity","volume":"103","author":"Sahu","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2346","article-title":"Advances in autism genetics: On the threshold of a new neurobiology","volume":"9","author":"Abrahams","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.mehy.2015.09.001","article-title":"An epigenetic basis for autism spectrum disorder risk and oral contraceptive use","volume":"85","author":"Strifert","year":"2015","journal-title":"Med. Hypotheses"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13229-017-0159-3","article-title":"Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERbeta suppression in the amygdala","volume":"8","author":"Zou","year":"2017","journal-title":"Mol. Autism"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1210\/en.2015-1775","article-title":"Exposure to the Synthetic Progestin, 17alpha-Hydroxyprogesterone Caproate During Development Impairs Cognitive Flexibility in Adulthood","volume":"157","author":"Willing","year":"2016","journal-title":"Endocrinology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1471-4159.2010.07038.x","article-title":"Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-beta","volume":"115","author":"Aguirre","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13229-018-0225-5","article-title":"Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERbeta activation","volume":"9","author":"Xie","year":"2018","journal-title":"Mol. Autism"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40104-018-0248-y","article-title":"Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1","volume":"9","author":"Meng","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"S6.e1","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/aji.12454","article-title":"Oxidative Stress: Placenta Function and Dysfunction","volume":"76","author":"Wu","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mce.2013.09.011","article-title":"Activation of inflammasomes in adipose tissue of women with gestational diabetes","volume":"382","author":"Lappas","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s13105-015-0435-7","article-title":"Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women","volume":"71","author":"Liong","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1677\/joe.1.06227","article-title":"Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies","volume":"186","author":"Lappas","year":"2005","journal-title":"J. Endocrinol."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Tran, H.T., Liong, S., Lim, R., Barker, G., and Lappas, M. (2017). Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173373"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Bonnefont-Rousselot, D. (2016). Resveratrol and Cardiovascular Diseases. Nutrients, 8.","DOI":"10.3390\/nu8050250"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tvjl.2006.06.005","article-title":"Oxidants and antioxidants in disease: Oxidative stress in farm animals","volume":"173","author":"Lykkesfeldt","year":"2007","journal-title":"Vet. J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/bdr2.1962","article-title":"Resveratrol ameliorates toxic effects of cadmium on placental development in mouse placenta and human trophoblast cells","volume":"113","author":"Wang","year":"2021","journal-title":"Birth Defects Res."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Lizarraga, D., and Garcia-Gasca, A. (2021). The Placenta as a Target of Epigenetic Alterations in Women with Gestational Diabetes Mellitus and Potential Implications for the Offspring. Epigenomes, 5.","DOI":"10.3390\/epigenomes5020013"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2174\/1389202920666191030092225","article-title":"Maternal obesity, maternal overnutrition and fetal programming: Effects of epigenetic mechanisms on the development of metabolic disorders","volume":"20","author":"Kabaran","year":"2019","journal-title":"Curr. Genom."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"253.e10","DOI":"10.1016\/j.ajog.2011.11.010","article-title":"Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta","volume":"206","author":"Cudmore","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"nzaa166","DOI":"10.1093\/cdn\/nzaa166","article-title":"Exploring the role of maternal nutritional epigenetics in congenital heart disease","volume":"4","author":"Joshi","year":"2020","journal-title":"Curr. Dev. Nutr."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Samuel, T.M., Sakwinska, O., Makinen, K., Burdge, G.C., Godfrey, K.M., and Silva-Zolezzi, I. (2019). Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction. Nutrients, 11.","DOI":"10.3390\/nu11081811"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/molehr\/gax036","article-title":"Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth","volume":"23","author":"Bariani","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.siny.2006.05.001","article-title":"Inflammation in preterm and term labour and delivery","volume":"11","author":"Romero","year":"2006","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2010.00911.x","article-title":"Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour","volume":"161","author":"Cella","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/j.1476-5381.2012.02239.x","article-title":"Role of TNF-\u03b1 in the mechanisms responsible for preterm delivery induced by Stx2 in rats","volume":"168","author":"Burdet","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jpi.12108","article-title":"Melatonin prevents experimental preterm labor and increases offspring survival","volume":"56","author":"Sordelli","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1477-7827-3-33","article-title":"mRNA expression and localization of bNOS, eNOS and iNOS in human cervix at preterm and term labour","volume":"3","author":"Maul","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"699951","DOI":"10.3389\/fendo.2021.699951","article-title":"Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review","volume":"12","author":"Kozakiewicz","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Carta, G., Poddighe, L., Serra, M.P., Boi, M., Melis, T., Lisai, S., Murru, E., Muredda, L., Collu, M., and Banni, S. (2018). Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020426"},{"key":"ref_191","first-page":"6","article-title":"Pregnancy & perinatal transmission update","volume":"89","author":"Denison","year":"1998","journal-title":"WORLD"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gag001","article-title":"Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term","volume":"9","author":"Osman","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/molehr\/6.4.375","article-title":"Human cervical ripening, an inflammatory process mediated by cytokines","volume":"6","author":"Ekman","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1095\/biolreprod66.2.445","article-title":"Immunolocalization of Proinflammatory Cytokines in Myometrium, Cervix, and Fetal Membranes During Human Parturition at Term1","volume":"66","author":"Young","year":"2002","journal-title":"Biol. Reprod."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1521-6934(03)00069-5","article-title":"The role of prostaglandins in the initiation of parturition","volume":"17","author":"Olson","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/jcem.87.3.8320","article-title":"Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Human Placenta and Fetal Membranes in Relation to Preterm and Term Labor","volume":"87","author":"Xu","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1177\/1933719115589413","article-title":"Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation","volume":"22","author":"Furuya","year":"2015","journal-title":"Reprod. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1080\/14767058.2017.1311310","article-title":"Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro","volume":"31","author":"Yang","year":"2018","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1258\/shorts.2012.012048","article-title":"The fetal origins of adult disease: A narrative review of the epidemiological literature","volume":"3","author":"Skogen","year":"2012","journal-title":"JRSM Short Rep."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/bdra.20119","article-title":"The fetal basis of adult disease: Role of environmental exposures\u2014Introduction","volume":"73","author":"Heindel","year":"2005","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00204-003-0538-8","article-title":"Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on maternal immune response during pregnancy","volume":"78","author":"Camacho","year":"2004","journal-title":"Arch. Toxicol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/jcb.20656","article-title":"Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis","volume":"96","author":"Marlowe","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/mnfr.201000206","article-title":"Resveratrol (3,5,4\u2032-trihydroxystilbene) protects pregnant mother and fetus from the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"55","author":"Singh","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1124\/mol.111.071126","article-title":"Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders","volume":"80","author":"Kumar","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1113\/JP278110","article-title":"Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth","volume":"597","author":"Darby","year":"2019","journal-title":"J. Physiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1113\/EP089237","article-title":"Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep","volume":"106","author":"Aujla","year":"2021","journal-title":"Exp. Physiol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s11033-021-06977-8","article-title":"Revisiting fetal hemoglobin inducers in beta-hemoglobinopathies: A review of natural products, conventional and combinatorial therapies","volume":"49","author":"Mukherjee","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_209","first-page":"974","article-title":"Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and beta-thalassemia patients","volume":"29","author":"Fibach","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bcmd.2015.11.007","article-title":"The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin","volume":"58","author":"Theodorou","year":"2016","journal-title":"Blood Cell Mol. Dis."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"103948","DOI":"10.1016\/j.bioorg.2020.103948","article-title":"Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers","volume":"100","author":"Bosquesi","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2174\/1874091X01307010044","article-title":"Different redox response elicited by naturally occurring antioxidants in human endothelial cells","volume":"7","author":"Giordo","year":"2013","journal-title":"Open Biochem. J."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/toxsci\/kfp301","article-title":"Akt downregulation by flavin oxidase\u2014Induced ROS generation mediates dose-dependent endothelial cell damage elicited by natural antioxidants","volume":"114","author":"Pasciu","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.fct.2015.01.017","article-title":"Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death","volume":"78","author":"Posadino","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Salehi, B., Mishra, A.P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., Fokou, P.V.T., Martins, N., and Sharifi-Rad, J. (2018). Resveratrol: A double-edged sword in health benefits. Biomedicines, 6.","DOI":"10.3390\/biomedicines6030091"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1600522","DOI":"10.1002\/mnfr.201600522","article-title":"Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester","volume":"61","author":"Savchuk","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"3149223","DOI":"10.1155\/2021\/3149223","article-title":"Nanoderived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases","volume":"2021","author":"Quispe","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1556-276X-6-260","article-title":"Novel docetaxel-loaded nanoparticles based on poly (lactide-co-caprolactone) and poly (lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: Formulation, characterization, and cytotoxicity studies","volume":"6","author":"Sanna","year":"2011","journal-title":"Nanoscale Res. Lett."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/jm1013715","article-title":"Targeted biocompatible nanoparticles for the delivery of (\u2212)-epigallocatechin 3-gallate to prostate cancer cells","volume":"54","author":"Sanna","year":"2011","journal-title":"J. Med. Chem."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/2\/341\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:19:52Z","timestamp":1760120392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/2\/341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":219,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["antiox12020341"],"URL":"https:\/\/doi.org\/10.3390\/antiox12020341","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}