{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:49:41Z","timestamp":1790707781153,"version":"4.1.0"},"reference-count":168,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Long-term neurological complications, persisting in patients who cannot fully recover several months after severe SARS-CoV-2 coronavirus infection, are referred to as neurological sequelae of the long COVID syndrome. Among the numerous clinical post-acute COVID-19 symptoms, neurological and psychiatric manifestations comprise prolonged fatigue, \u201cbrain fog\u201d, memory deficits, headache, ageusia, anosmia, myalgias, cognitive impairments, anxiety, and depression lasting several months. Considering that neurons are highly vulnerable to inflammatory and oxidative stress damages following the overproduction of reactive oxygen species (ROS), neuroinflammation and oxidative stress have been suggested to dominate the pathophysiological mechanisms of the long COVID syndrome. It is emphasized that mitochondrial dysfunction and oxidative stress damages are crucial for the pathogenesis of neurodegenerative disorders. Importantly, antioxidant therapies have the potential to slow down and prevent disease progression. However, many antioxidant compounds display low bioavailability, instability, and transport to targeted tissues, limiting their clinical applications. Various nanocarrier types, e.g., liposomes, cubosomes, solid lipid nanoparticles, micelles, dendrimers, carbon-based nanostructures, nanoceria, and other inorganic nanoparticles, can be employed to enhance antioxidant bioavailability. Here, we highlight the potential of phytochemical antioxidants and other neuroprotective agents (curcumin, quercetin, vitamins C, E and D, melatonin, rosmarinic acid, N-acetylcysteine, and Ginkgo Biloba derivatives) in therapeutic strategies for neuroregeneration. A particular focus is given to the beneficial role of nanoparticle-mediated drug-delivery systems in addressing the challenges of antioxidants for managing and preventing neurological disorders as factors of long COVID sequelae.<\/jats:p>","DOI":"10.3390\/antiox12020393","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T04:59:10Z","timestamp":1675659550000},"page":"393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Potential of Nano-Antioxidants and Nanomedicine for Recovery from Neurological Disorders Linked to Long COVID Syndrome"],"prefix":"10.3390","volume":"12","author":[{"given":"Thelma","family":"Akanchise","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0285-0637","authenticated-orcid":false,"given":"Angelina","family":"Angelova","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2020.06.009","article-title":"Potential Neurological Effects of Severe COVID-19 Infection","volume":"158","author":"Nuzzo","year":"2020","journal-title":"Neurosci. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"204062232210768","DOI":"10.1177\/20406223221076890","article-title":"Neurological Manifestations of Long-COVID Syndrome: A Narrative Review","volume":"13","author":"Stefanou","year":"2022","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e00712","DOI":"10.1016\/j.btre.2022.e00712","article-title":"Perspectives on Nano-Nutraceuticals to Manage Pre and Post COVID-19 Infections","volume":"33","author":"Dubey","year":"2022","journal-title":"Biotechnol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1021\/acschemneuro.0c00725","article-title":"Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV-2 on the CNS in Chronic COVID Syndrome","volume":"11","author":"Baig","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5603\/PJNNS.a2021.0072","article-title":"Neuro-COVID-19: An Insidious Virus in Action","volume":"56","year":"2022","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Satoh, T., Trudler, D., Oh, C.-K., and Lipton, S.A. (2022). Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer\u2019s Disease, Parkinson\u2019s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. Antioxidants, 11.","DOI":"10.3390\/antiox11010124"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neurol.2020.10.001","article-title":"Neurological Manifestations Associated with SARS-CoV-2 and Other Coronaviruses: A Narrative Review for Clinicians","volume":"177","author":"Maury","year":"2021","journal-title":"Rev. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3390\/psychiatryint3020013","article-title":"Neurological and Psychiatric Symptoms of COVID-19: A Narrative Review","volume":"3","author":"Edinoff","year":"2022","journal-title":"Psychiatry Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.2020.12603","article-title":"Persistent Symptoms in Patients After Acute COVID-19","volume":"324","author":"Bernabei","year":"2020","journal-title":"JAMA"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Taquet, M., Dercon, Q., Luciano, S., Geddes, J.R., Husain, M., and Harrison, P.J. (2021). Incidence, Co-Occurrence, and Evolution of Long-COVID Features: A 6-Month Retrospective Cohort Study of 273,618 Survivors of COVID-19. PLoS Med., 18.","DOI":"10.1371\/journal.pmed.1003773"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e161167","DOI":"10.1172\/JCI161167","article-title":"Long COVID Endotheliopathy: Hypothesized Mechanisms and Potential Therapeutic Approaches","volume":"132","author":"Ahamed","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1056\/NEJMp2109285","article-title":"Confronting Our Next National Health Disaster\u2014Long-Haul COVID","volume":"385","author":"Phillips","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s13365-021-00977-x","article-title":"Neuropathies and Neurological Dysfunction Induced by Coronaviruses","volume":"27","author":"Gholami","year":"2021","journal-title":"J. Neurovirol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jamaneurol.2020.2065","article-title":"Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review","volume":"77","author":"Zubair","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12576-020-00743-4","article-title":"Respiratory Pattern and Phrenic and Hypoglossal Nerve Activity during Normoxia and Hypoxia in 6-OHDA-Induced Bilateral Model of Parkinson\u2019s Disease","volume":"70","author":"Andrzejewski","year":"2020","journal-title":"J. Physiol. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/exnr.2002.7891","article-title":"Modeling Parkinson\u2019s Disease in Rats: An Evaluation of 6-OHDA Lesions of the Nigrostriatal Pathway","volume":"175","author":"Deumens","year":"2002","journal-title":"Exp. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Pennisi, M., Lanza, G., Falzone, L., Fisicaro, F., Ferri, R., and Bella, R. (2020). SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms. IJMS, 21.","DOI":"10.3390\/ijms21155475"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2020.03.045","article-title":"Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10571-020-00915-1","article-title":"Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus","volume":"42","author":"Xu","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"899198","DOI":"10.3389\/fphar.2022.899198","article-title":"Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C","volume":"13","author":"Vollbracht","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3389\/fphys.2020.00671","article-title":"Disentangling the Hypothesis of Host Dysosmia and SARS-CoV-2: The Bait Symptom That Hides Neglected Neurophysiological Routes","volume":"11","author":"Briguglio","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Picca, A., Calvani, R., Coelho-Junior, H.J., Landi, F., Bernabei, R., and Marzetti, E. (2020). Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration. Antioxidants, 9.","DOI":"10.3390\/antiox9080647"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/acschemneuro.1c00675","article-title":"Mitochondrial Dysfunction: A Prelude to Neuropathogenesis of SARS-CoV-2","volume":"13","author":"Pliss","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"153331752097676","DOI":"10.1177\/1533317520976761","article-title":"Nanotargeting of Drug(s) for Delaying Dementia: Relevance of COVID-19 Impact on Dementia","volume":"35","year":"2020","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_26","first-page":"4535","article-title":"COVID-19 and Neurodegenerative Diseases","volume":"26","author":"Fu","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"748591","DOI":"10.3389\/fragi.2021.748591","article-title":"Patho-Physiology of Aging and Immune-Senescence: Possible Correlates With Comorbidity and Mortality in Middle-Aged and Old COVID-19 Patients","volume":"2","author":"Farheen","year":"2021","journal-title":"Front. Aging"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"C\u00e1rdenas-Rodr\u00edguez, N., Bandala, C., Vanoye-Carlo, A., Ignacio-Mej\u00eda, I., G\u00f3mez-Manzo, S., Hern\u00e1ndez-Cruz, E.Y., Pedraza-Chaverri, J., Carmona-Aparicio, L., and Hern\u00e1ndez-Ochoa, B. (2021). Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19. Antioxidants, 10.","DOI":"10.3390\/antiox10060971"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1021\/acsomega.8b03101","article-title":"Curcumin- and Fish Oil-Loaded Spongosome and Cubosome Nanoparticles with Neuroprotective Potential against H 2 O 2 -Induced Oxidative Stress in Differentiated Human SH-SY5Y Cells","volume":"4","author":"Rakotoarisoa","year":"2019","journal-title":"ACS Omega"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-2010-101374","article-title":"Neuroprotective and Neurorescue Effects of a Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurcTM) in the Neuronal Cell Culture and Animal Model: Implications for Alzheimer\u2019s Disease","volume":"23","author":"Ray","year":"2011","journal-title":"JAD"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JAD-2012-112141","article-title":"Neuronal Uptake and Neuroprotective Effect of Curcumin-Loaded PLGA Nanoparticles on the Human SK-N-SH Cell Line","volume":"30","author":"Doggui","year":"2012","journal-title":"JAD"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.phrs.2017.08.004","article-title":"Curcumin in Alzheimer\u2019s Disease: Can We Think to New Strategies and Perspectives for This Molecule?","volume":"124","author":"Serafini","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.7150\/ijms.48053","article-title":"COVID-19: Rational Discovery of the Therapeutic Potential of Melatonin as a SARS-CoV-2 Main Protease Inhibitor","volume":"17","author":"Feitosa","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/08830185.2020.1756284","article-title":"Can Melatonin Reduce the Severity of COVID-19 Pandemic?","volume":"39","author":"Shneider","year":"2020","journal-title":"Int. Rev. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14821","DOI":"10.1021\/acssuschemeng.1c04706","article-title":"Composition-Switchable Liquid Crystalline Nanostructures as Green Formulations of Curcumin and Fish Oil","volume":"9","author":"Rakotoarisoa","year":"2021","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11483-016-9432-9","article-title":"Influence of Lipid Phase Composition of Excipient Emulsions on Curcumin Solubility, Stability, and Bioaccessibility","volume":"11","author":"Zou","year":"2016","journal-title":"Food Biophys."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.apsb.2021.02.013","article-title":"Recent Advances in Drug Delivery Applications of Cubosomes, Hexosomes, and Solid Lipid Nanoparticles","volume":"11","author":"Yaghmur","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhai, J., Fan, B., Thang, S.H., and Drummond, C.J. (2021). Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles. Molecules, 26.","DOI":"10.3390\/molecules26123648"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.smaim.2022.03.001","article-title":"Liquid Crystalline Lipid Nanoparticles for Combined Delivery of Curcumin, Fish Oil and BDNF: In Vitro Neuroprotective Potential in a Cellular Model of Tunicamycin-Induced Endoplasmic Reticulum Stress","volume":"3","author":"Rakotoarisoa","year":"2022","journal-title":"Smart Mater. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.2147\/IJN.S33838","article-title":"Nanotechnology-Based Approaches in Anticancer Research","volume":"7","author":"Kamal","year":"2012","journal-title":"IJN"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"573095","DOI":"10.3389\/fneur.2020.573095","article-title":"The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in Human and Mouse Brain","volume":"11","author":"Chen","year":"2021","journal-title":"Font. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10571-020-00947-7","article-title":"SARS-CoV-2 Infectivity and Neurological Targets in the Brain","volume":"42","author":"Lukiw","year":"2022","journal-title":"Cell Mol Neurobiol"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00259-021-05215-4","article-title":"18F-FDG Brain PET Hypometabolism in Patients with Long COVID","volume":"48","author":"Guedj","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10286-021-00798-2","article-title":"Long-COVID Postural Tachycardia Syndrome: An American Autonomic Society Statement","volume":"31","author":"Raj","year":"2021","journal-title":"Clin. Auton. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jaccas.2021.01.009","article-title":"Long-Haul Post\u2013COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome","volume":"3","author":"Johansson","year":"2021","journal-title":"JACC Case Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"m810","DOI":"10.1136\/bmj.m810","article-title":"Preventing a COVID-19 Pandemic","volume":"368","author":"Watkins","year":"2020","journal-title":"BMJ"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.mib.2004.06.007","article-title":"Molecular Biology of Severe Acute Respiratory Syndrome Coronavirus","volume":"7","author":"Ziebuhr","year":"2004","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s10096-020-04138-6","article-title":"COVID-19: Angiotensin-Converting Enzyme 2 (ACE2) Expression and Tissue Susceptibility to SARS-CoV-2 Infection","volume":"40","author":"Beyerstedt","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.2174\/1381612811319170013","article-title":"Angiotensin (1-7) and Other Angiotensin Peptides","volume":"19","author":"Ohishi","year":"2013","journal-title":"CPD"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s10875-006-9046-y","article-title":"Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients","volume":"26","author":"Shao","year":"2006","journal-title":"J. Clin. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The Gut-Brain Axis: Is Intestinal Inflammation a Silent Driver of Parkinson\u2019s Disease Pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"NPJ Park. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Panzarini, E., Mariano, S., Tacconi, S., Carata, E., Tata, A.M., and Dini, L. (2020). Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders. Nanomaterials, 11.","DOI":"10.3390\/nano11010002"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral Curcumin for Alzheimer\u2019s Disease: Tolerability and Efficacy in a 24-Week Randomized, Double Blind, Placebo-Controlled Study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimers Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/17474124.2018.1399794","article-title":"The Biological Challenges and Pharmacological Opportunities of Orally Administered Nanomedicine Delivery","volume":"12","author":"Moss","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"17154","DOI":"10.3390\/molecules191117154","article-title":"Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability Is the Problem, What Is the Solution?","volume":"19","author":"Smoliga","year":"2014","journal-title":"Molecules"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"012001","DOI":"10.1088\/2632-959X\/ab8075","article-title":"Organic and Inorganic Nanoparticle Vaccines for Prevention of Infectious Diseases","volume":"1","author":"Poon","year":"2020","journal-title":"Nano Express"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16647","DOI":"10.1021\/la302721n","article-title":"Earliest Stage of the Tetrahedral Nanochannel Formation in Cubosome Particles from Unilamellar Nanovesicles","volume":"28","author":"Angelov","year":"2012","journal-title":"Langmuir"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"587997","DOI":"10.3389\/fmolb.2020.587997","article-title":"Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects","volume":"7","author":"Muraca","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.addr.2008.03.008","article-title":"Micelles and Nanoparticles for Ultrasonic Drug and Gene Delivery","volume":"60","author":"Husseini","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, A., Carreir\u00f3, F., Oliveira, A.M., Neves, A., Pires, B., Venkatesh, D.N., Durazzo, A., Lucarini, M., Eder, P., and Silva, A.M. (2020). Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology. Molecules, 25.","DOI":"10.3390\/molecules25163731"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00339-4","article-title":"Biodegradable Polymeric Nanoparticles as Drug Delivery Devices","volume":"70","author":"Soppimath","year":"2001","journal-title":"J. Control. Release"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2217\/nnm-2019-0443","article-title":"Current Advances in the Development of Novel Polymeric Nanoparticles for the Treatment of Neurodegenerative Diseases","volume":"15","author":"Cano","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mattod.2015.07.004","article-title":"Inorganic Nanoparticles for Biomedicine: Where Materials Scientists Meet Medical Research","volume":"19","year":"2016","journal-title":"Mater. Today"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"702445","DOI":"10.3389\/fphar.2021.702445","article-title":"The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Rakotoarisoa, M., and Angelova, A. (2018). Amphiphilic Nanocarrier Systems for Curcumin Delivery in Neurodegenerative Disorders. Medicines, 5.","DOI":"10.3390\/medicines5040126"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"111578","DOI":"10.1016\/j.biopha.2021.111578","article-title":"Will Curcumin Nanosystems Be the next Promising Antiviral Alternatives in COVID-19 Treatment Trials?","volume":"139","author":"Dourado","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"107088","DOI":"10.1016\/j.intimp.2020.107088","article-title":"Nano-Curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in COVID-19 Patients","volume":"89","author":"Valizadeh","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jphotobiol.2018.11.008","article-title":"A Novel Synthesis of Selenium Nanoparticles Encapsulated PLGA Nanospheres with Curcumin Molecules for the Inhibition of Amyloid \u03b2 Aggregation in Alzheimer\u2019s Disease","volume":"190","author":"Huo","year":"2019","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/ptr.6054","article-title":"Turmeric (Curcuma Longa) and Its Major Constituent (Curcumin) as Nontoxic and Safe Substances: Review","volume":"32","author":"Soleimani","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/ptr.6738","article-title":"Potential Effects of Curcumin in the Treatment of COVID -19 Infection","volume":"34","author":"Zahedipour","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2006.12.028","article-title":"Neuroprotective Effect of Curcumin on Focal Cerebral Ischemic Rats by Preventing Blood\u2013Brain Barrier Damage","volume":"561","author":"Jiang","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Farooqui, A.A. (2019). Curcumin for Neurological and Psychiatric Disorders, Elsevier.","DOI":"10.1016\/B978-0-12-815461-8.00003-7"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2016.03.010","article-title":"Analysis of Anti-Depressant Potential of Curcumin against Depression Induced Male Albino Wistar Rats","volume":"1642","author":"Chang","year":"2016","journal-title":"Brain Res."},{"key":"ref_74","first-page":"e17829","article-title":"Turmeric as a Possible Treatment for COVID-19-Induced Anosmia and Ageusia","volume":"13","author":"Chabot","year":"2021","journal-title":"Cureus"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.colsurfb.2014.11.034","article-title":"Mesenchymal Stromal Cells Loading Curcumin-INVITE-Micelles: A Drug Delivery System for Neurodegenerative Diseases","volume":"125","author":"Tripodo","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/10717544.2018.1461955","article-title":"Curcumin-Loaded PLGA-PEG Nanoparticles Conjugated with B6 Peptide for Potential Use in Alzheimer\u2019s Disease","volume":"25","author":"Fan","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jconrel.2010.11.014","article-title":"Comparison of Five Different Targeting Ligands to Enhance Accumulation of Liposomes into the Brain","volume":"150","author":"Mastrobattista","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1016\/j.biomaterials.2012.06.063","article-title":"Delivery of Gold Nanoparticles to the Brain by Conjugation with a Peptide That Recognizes the Transferrin Receptor","volume":"33","author":"Prades","year":"2012","journal-title":"Biomaterials"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1128\/JVI.74.23.11359-11366.2000","article-title":"Recombinant Human Adenovirus: Targeting to the Human Transferrin Receptor Improves Gene Transfer to Brain Microcapillary Endothelium","volume":"74","author":"Xia","year":"2000","journal-title":"J. Virol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e2957","DOI":"10.1002\/jgm.2957","article-title":"Systemic Tumor-Targeted Sodium Iodide Symporter (NIS) Gene Therapy of Hepatocellular Carcinoma Mediated by B6 Peptide Polyplexes","volume":"19","author":"Urnauer","year":"2017","journal-title":"J. Gene Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.actbio.2015.06.035","article-title":"Sialic Acid (SA)-Modified Selenium Nanoparticles Coated with a High Blood\u2013Brain Barrier Permeability Peptide-B6 Peptide for Potential Use in Alzheimer\u2019s Disease","volume":"25","author":"Yin","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/9949453","article-title":"N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)","volume":"2021","author":"Schwalfenberg","year":"2021","journal-title":"J. Nutr. Metab."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"\u0160alamon, \u0160., Kramar, B., Marolt, T.P., Polj\u0161ak, B., and Milisav, I. (2019). Medical and Dietary Uses of N-Acetylcysteine. Antioxidants, 8.","DOI":"10.3390\/antiox8050111"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2147\/copd.2006.1.4.425","article-title":"Role of N-Acetylcysteine in the Management of COPD","volume":"1","author":"Sadowska","year":"2006","journal-title":"Int. J. COPD"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1734-1140(10)70250-4","article-title":"N-Acetylcysteine Inhibits IL-8 and MMP-9 Release and ICAM-1 Expression by Bronchoalveolar Cells from Interstitial Lung Disease Patients","volume":"62","author":"Sobiecka","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular Mechanisms of N -Acetylcysteine Actions","volume":"60","author":"Zafarullah","year":"2003","journal-title":"Cell. Mol. Life Sci. (CMLS)"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/brb3.208","article-title":"N-acetylcysteine (NAC) in Neurological Disorders: Mechanisms of Action and Therapeutic Opportunities","volume":"4","author":"Harrigan","year":"2014","journal-title":"Brain Behav."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/nan.12103","article-title":"N-Acetyl-L-Cysteine Protects against Cadmium-Induced Neuronal Apoptosis by Inhibiting ROS-Dependent Activation of Akt\/MTOR Pathway in Mouse Brain: NAC Prevents Cd Neurotoxicity via Targeting ROS-MTOR Signalling","volume":"40","author":"Chen","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_89","first-page":"450","article-title":"Chronic Fatigue Syndrome: Oxidative Stress and Dietary Modifications","volume":"6","author":"Logan","year":"2001","journal-title":"Altern. Med. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Bonilla, H., Quach, T., Tiwari, A., Bonilla, A., Miglis, M., Yang, P., Eggert, L., Sharifi, H., Horomanski, A., and Subramanian, A. (2022). Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) Is Common in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC): Results from a Post-COVID-19 Multidisciplinary Clinic. medRxiv, prepint.","DOI":"10.1101\/2022.08.03.22278363"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/btm2.10094","article-title":"Scalable Synthesis and Validation of PAMAM Dendrimer- N -Acetyl Cysteine Conjugate for Potential Translation","volume":"3","author":"Sharma","year":"2018","journal-title":"Bioeng. Transl. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"130ra46","DOI":"10.1126\/scitranslmed.3003162","article-title":"Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model","volume":"4","author":"Kannan","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/bab.2156","article-title":"Advances in Biochemistry and the Biotechnological Production of Taxifolin and Its Derivatives","volume":"69","author":"Thuan","year":"2022","journal-title":"Biotech. Appl. Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11373-005-9031-0","article-title":"Taxifolin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats through Its Anti-Oxidative Effect and Modulation of NF-Kappa B Activation","volume":"13","author":"Wang","year":"2006","journal-title":"J. Biomed. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Park, S.Y., Kim, H.Y., Park, H.J., Shin, H.K., Hong, K.W., and Kim, C.D. (2016). Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of \u03b2-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2\/P-STAT3\/NF-\u039aB\/BACE1 Signaling Pathways. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168286"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"112066","DOI":"10.1016\/j.phytochem.2019.112066","article-title":"An Insight into the Health-Promoting Effects of Taxifolin (Dihydroquercetin)","volume":"166","author":"Sunil","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Varlamova, E.G., Khabatova, V.V., Gudkov, S.V., Plotnikov, E.Y., and Turovsky, E.A. (2022). Cytoprotective Properties of a New Nanocomplex of Selenium with Taxifolin in the Cells of the Cerebral Cortex Exposed to Ischemia\/Reoxygenation. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14112477"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Berlansky, S., Sallinger, M., Grabmayr, H., Humer, C., Bernhard, A., Fahrner, M., and Frischauf, I. (2022). Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies. Cells, 11.","DOI":"10.3390\/cells11020253"},{"key":"ref_99","first-page":"E34","article-title":"Antioxidants and COVID-19","volume":"62","author":"Balansky","year":"2021","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Khaerunnisa, S., Kurniawan, H., Awaluddin, R., Suhartati, S., and Soetjipto, S. (2020). Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study. Med. Pharmacol., preprint.","DOI":"10.20944\/preprints202003.0226.v1"},{"key":"ref_101","first-page":"000189","article-title":"In-Silico Identification of Potent Inhibitors of COVID-19 Main Protease (Mpro) from Natural Products","volume":"5","author":"Sekiou","year":"2020","journal-title":"IJBP"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Utomo, R.Y., Ikawati, M., and Meiyanto, E. (2020). Revealing the Potency of Citrus and Galangal Constituents to Halt SARS-CoV-2 Infection. Med. Pharmacol., preprint.","DOI":"10.20944\/preprints202003.0214.v1"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6307457","DOI":"10.1155\/2020\/6307457","article-title":"Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study","volume":"2020","author":"Tallei","year":"2020","journal-title":"Scientifica"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"105452","DOI":"10.1016\/j.compbiomed.2022.105452","article-title":"Multidimensional in Silico Strategy for Identification of Natural Polyphenols-Based SARS-CoV-2 Main Protease (Mpro) Inhibitors to Unveil a Hope against COVID-19","volume":"145","author":"Adem","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1021\/acsabm.9b00518","article-title":"Quercetin Encapsulated Polymer Nanoparticle for Inhibiting Intracellular Polyglutamine Aggregation","volume":"2","author":"Debnath","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Kopa\u0144ska, M., Batoryna, M., Bartman, P., Szczygielski, J., and Bana\u015b-Z\u0105bczyk, A. (2022). Disorders of the Cholinergic System in COVID-19 Era\u2014A Review of the Latest Research. IJMS, 23.","DOI":"10.3390\/ijms23020672"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbr.2010.09.027","article-title":"Quercetin and Rutin Prevent Scopolamine-Induced Memory Impairment in Zebrafish","volume":"217","author":"Richetti","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bfopcu.2016.10.004","article-title":"Quercetin Nanoparticles Attenuates Scopolamine Induced Spatial Memory Deficits and Pathological Damages in Rats","volume":"55","author":"Palle","year":"2017","journal-title":"Bull. Fac. Pharmacy Cairo Univ."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2019.03.010","article-title":"Dual-Drug Loaded Nanoparticles of Epigallocatechin-3-Gallate (EGCG)\/Ascorbic Acid Enhance Therapeutic Efficacy of EGCG in a APPswe\/PS1dE9 Alzheimer\u2019s Disease Mice Model","volume":"301","author":"Cano","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"9764","DOI":"10.1021\/acs.jafc.1c00569","article-title":"PLGA-PEG Nanoparticles Facilitate In Vivo Anti-Alzheimer\u2019s Effects of Fucoxanthin, a Marine Carotenoid Derived from Edible Brown Algae","volume":"69","author":"Yang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol Regulates Neuro-Inflammation and Induces Adaptive Immunity in Alzheimer\u2019s Disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1021\/acsnano.8b01994","article-title":"Simultaneous Blood\u2013Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles","volume":"12","author":"Bao","year":"2018","journal-title":"ACS Nano"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"14144","DOI":"10.1021\/ja9051087","article-title":"PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry","volume":"131","author":"Karakoti","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1002-0721(14)60486-5","article-title":"Recent Advances of Cerium Oxide Nanoparticles in Synthesis, Luminescence and Biomedical Studies: A Review","volume":"33","author":"He","year":"2015","journal-title":"J. Rare Earths"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e1444","DOI":"10.1002\/wnan.1444","article-title":"Cerium Oxide Nanoparticles in Neuroprotection and Considerations for Efficacy and Safety","volume":"9","author":"Rzigalinski","year":"2017","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1016\/j.freeradbiomed.2012.10.540","article-title":"Real-Time Monitoring of Superoxide Accumulation and Antioxidant Activity in a Brain Slice Model Using an Electrochemical Cytochrome c Biosensor","volume":"53","author":"Ganesana","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.freeradbiomed.2011.06.006","article-title":"Neuroprotective Mechanisms of Cerium Oxide Nanoparticles in a Mouse Hippocampal Brain Slice Model of Ischemia","volume":"51","author":"Estevez","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"11552","DOI":"10.1021\/acsnano.9b05075","article-title":"Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma","volume":"13","author":"Yan","year":"2019","journal-title":"ACS Nano"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1021\/acsnano.5b08045","article-title":"Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer\u2019s Disease","volume":"10","author":"Kwon","year":"2016","journal-title":"ACS Nano"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"11039","DOI":"10.1002\/anie.201203780","article-title":"Ceria Nanoparticles That Can Protect against Ischemic Stroke","volume":"51","author":"Kim","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fncel.2020.00021","article-title":"Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer\u2019s Disease","volume":"14","author":"Luo","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/adma.201503893","article-title":"Dietary Iron Oxide Nanoparticles Delay Aging and Ameliorate Neurodegeneration in Drosophila","volume":"28","author":"Zhang","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1477-3155-11-32","article-title":"Age-Dependent Effects of Microglial Inhibition in Vivo on Alzheimer\u2019s Disease Neuropathology Using Bioactive-Conjugated Iron Oxide Nanoparticles","volume":"11","author":"Glat","year":"2013","journal-title":"J. Nanobiotechnol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.msec.2015.10.026","article-title":"Effect of PEGylated Superparamagnetic Iron Oxide Nanoparticles (SPIONs) under Magnetic Field on Amyloid Beta Fibrillation Process","volume":"59","author":"Mirsadeghi","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2147\/IJN.S191878","article-title":"Superparamagnetic Iron Oxide Nanoparticles Combined with NGF and Quercetin Promote Neuronal Branching Morphogenesis of PC12 Cells","volume":"14","author":"Katebi","year":"2019","journal-title":"IJN"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1039\/C7NR06976F","article-title":"Dextran-Coated Iron Oxide Nanoparticle-Improved Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Parkinson\u2019s Disease","volume":"10","author":"Chung","year":"2018","journal-title":"Nanoscale"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ijbiomac.2019.02.156","article-title":"Nanoparticle Formulations in the Diagnosis and Therapy of Alzheimer\u2019s Disease","volume":"130","author":"Gupta","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"112575","DOI":"10.1016\/j.msec.2021.112575","article-title":"Cytocompatible Manganese Dioxide-Based Hydrogel Nanoreactors for MRI Imaging","volume":"134","author":"Lopes","year":"2022","journal-title":"Biomater. Adv."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.mssp.2017.08.020","article-title":"Green Synthesis of Nanocrystalline Manganese (II, III) Oxide","volume":"71","author":"Prasad","year":"2017","journal-title":"Mater. Sci. Semicond. Process."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jphotobiol.2018.10.022","article-title":"Green Synthesis of Manganese Nanoparticles: Applications and Future Perspective\u2013A Review","volume":"189","author":"Hoseinpour","year":"2018","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1800086","DOI":"10.1002\/adbi.201800086","article-title":"Scavenging Nanoreactors That Modulate Inflammation","volume":"2","author":"Pereira","year":"2018","journal-title":"Adv. Biosys."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"119467","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese Dioxide Nanoparticles Protect Cartilage from Inflammation-Induced Oxidative Stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1007\/s12274-018-2092-y","article-title":"Scavenging of Reactive Oxygen and Nitrogen Species with Nanomaterials","volume":"11","author":"Ferreira","year":"2018","journal-title":"Nano Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bbagen.2013.10.001","article-title":"Synthesizing and Staining Manganese Oxide Nanoparticles for Cytotoxicity and Cellular Uptake Investigation","volume":"1840","author":"Omid","year":"2014","journal-title":"Biochim. Et Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.2147\/IJN.S225594","article-title":"Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain","volume":"14","author":"Kuthati","year":"2019","journal-title":"IJN"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1039\/C8NR09397K","article-title":"A Manganese Oxide Nanozyme Prevents the Oxidative Damage of Biomolecules without Affecting the Endogenous Antioxidant System","volume":"11","author":"Singh","year":"2019","journal-title":"Nanoscale"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1039\/C7SC05476A","article-title":"ROS Scavenging Mn3O4 Nanozymes for in Vivo Anti-Inflammation","volume":"9","author":"Yao","year":"2018","journal-title":"Chem. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.actbio.2017.07.006","article-title":"Manganese Oxide Particles as Cytoprotective, Oxygen Generating Agents","volume":"59","author":"Tootoonchi","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1753-4887.2006.tb00198.x","article-title":"Bioavailability of Selenium from Foods","volume":"64","author":"Finley","year":"2006","journal-title":"Nutr. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Avery, J., and Hoffmann, P. (2018). Selenium, Selenoproteins, and Immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Mal\u2019tseva, V.N., Goltyaev, M.V., Turovsky, E.A., and Varlamova, E.G. (2022). Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19. IJMS, 23.","DOI":"10.3390\/ijms23042360"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Guillin, O., Vindry, C., Ohlmann, T., and Chavatte, L. (2019). Selenium, Selenoproteins and Viral Infection. Nutrients, 11.","DOI":"10.3390\/nu11092101"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"111053","DOI":"10.1016\/j.nut.2020.111053","article-title":"An Exploratory Study of Selenium Status in Healthy Individuals and in Patients with COVID-19 in a South Indian Population: The Case for Adequate Selenium Status","volume":"82","author":"Majeed","year":"2021","journal-title":"Nutrition"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Moghaddam, A., Heller, R., Sun, Q., Seelig, J., Cherkezov, A., Seibert, L., Hackler, J., Seemann, P., Diegmann, J., and Pilz, M. (2020). Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients, 12.","DOI":"10.20944\/preprints202007.0113.v1"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Lee, S.-C., Lee, N.-H., Patel, K.D., Jun, S.-K., Park, J.-H., Knowles, J.C., Kim, H.-W., Lee, H.-H., and Lee, J.-H. (2021). A Study on Myogenesis by Regulation of Reactive Oxygen Species and Cytotoxic Activity by Selenium Nanoparticles. Antioxidants, 10.","DOI":"10.3390\/antiox10111727"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1007\/s00216-022-04285-z","article-title":"Neuroprotective Activity of Selenium Nanoparticles against the Effect of Amino Acid Enantiomers in Alzheimer\u2019s Disease","volume":"414","author":"Madrid","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jiph.2016.02.006","article-title":"Oral Administration of Synthetic Selenium Nanoparticles Induced Robust Th1 Cytokine Pattern after HBs Antigen Vaccination in Mouse Model","volume":"10","author":"Mahdavi","year":"2017","journal-title":"J. Infect. Public Health"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2012.06.060","article-title":"Strong neuroprotection with a novel platinum nanoparticle against ischemic stroke- and tissue plasminogen activator-related brain damages in mice","volume":"221","author":"Takamiya","year":"2012","journal-title":"Neuroscience"},{"key":"ref_150","first-page":"1870","article-title":"Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury","volume":"13","author":"Mu","year":"2019","journal-title":"ACS Nano"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbrc.2006.01.129","article-title":"Cerium and Yttrium Oxide Nanoparticles Are Neuroprotective","volume":"342","author":"Schubert","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.2147\/IJN.S83777","article-title":"Carbon Nanotubes and Graphene as Emerging Candidates in Neuroregeneration and Neurodrug Delivery","volume":"ume 10","author":"Jaganathan","year":"2015","journal-title":"IJN"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1134\/S0006350910050027","article-title":"Fluorescence Analysis of the Action of Soluble Derivatives of Fullerene C60 on Amyloid Fibrils of the Brain Peptide A\u03b2(1\u201342)","volume":"55","author":"Bobylev","year":"2010","journal-title":"Biophysics"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"11744","DOI":"10.1039\/C4NR03275F","article-title":"Antioxidant Chemistry of Graphene-Based Materials and Its Role in Oxidation Protection Technology","volume":"6","author":"Qiu","year":"2014","journal-title":"Nanoscale"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biomaterials.2015.12.009","article-title":"Tissue Plasminogen Activator Followed by Antioxidant-Loaded Nanoparticle Delivery Promotes Activation\/Mobilization of Progenitor Cells in Infarcted Rat Brain","volume":"81","author":"Petro","year":"2016","journal-title":"Biomaterials"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jconrel.2019.12.001","article-title":"Nanoparticles with Antioxidant Enzymes Protect Injured Spinal Cord from Neuronal Cell Apoptosis by Attenuating Mitochondrial Dysfunction","volume":"317","author":"Andrabi","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/0269881114552744","article-title":"Investigation of the Effects of Solid Lipid Curcumin on Cognition and Mood in a Healthy Older Population","volume":"29","author":"Cox","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2019.09.032","article-title":"Curcumin-Loaded Nanocapsules Reverses the Depressant-Like Behavior and Oxidative Stress Induced by \u03b2-Amyloid in Mice","volume":"423","author":"Fidelis","year":"2019","journal-title":"Neuroscience"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1166\/jnn.2021.18668","article-title":"Influence of Nanoparticle-Loaded Edaravone on Postoperative Effects in Patients with Cerebral Hemorrhage","volume":"21","author":"Dang","year":"2021","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"107494","DOI":"10.1016\/j.intimp.2021.107494","article-title":"Nanoparticles of Resveratrol Attenuates Oxidative Stress and Inflammation after Ischemic Stroke in Rats","volume":"94","author":"Ashafaq","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"110534","DOI":"10.1016\/j.mehy.2021.110534","article-title":"Can Bilirubin Nanomedicine Become a Hope for the Management of COVID-19?","volume":"149","author":"Khurana","year":"2021","journal-title":"Med. Hypotheses"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.expneurol.2015.08.008","article-title":"Combination Therapy with Lenalidomide and Nanoceria Ameliorates CNS Autoimmunity","volume":"273","author":"Eitan","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"12","DOI":"10.33263\/LIANBS121.012","article-title":"Cerium Oxide (CeO2) Nanoparticles Could Have Protective Effect Against COVID-19","volume":"12","author":"Ulker","year":"2022","journal-title":"Lett. Appl. NanoBioScience"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1089\/neu.2016.4644","article-title":"Cerium Oxide Nanoparticles Improve Outcome after In Vitro and In Vivo Mild Traumatic Brain Injury","volume":"37","author":"Bailey","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nano.2011.05.010","article-title":"Cross-Linked Antioxidant Nanozymes for Improved Delivery to CNS","volume":"8","author":"Klyachko","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jconrel.2012.07.044","article-title":"Well-Defined Cross-Linked Antioxidant Nanozymes for Treatment of Ischemic Brain Injury","volume":"162","author":"Manickam","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e903","DOI":"10.1038\/cddis.2013.362","article-title":"Nanoparticle-Mediated Catalase Delivery Protects Human Neurons from Oxidative Stress","volume":"4","author":"Singhal","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s12010-008-8232-1","article-title":"Superoxide Dismutase-Loaded PLGA Nanoparticles Protect Cultured Human Neurons Under Oxidative Stress","volume":"151","author":"Reddy","year":"2008","journal-title":"Appl. Biochem. Biotechnol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/2\/393\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:25:34Z","timestamp":1760120734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/2\/393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":168,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["antiox12020393"],"URL":"https:\/\/doi.org\/10.3390\/antiox12020393","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]}}}