{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:07:46Z","timestamp":1785600466552,"version":"3.56.0"},"reference-count":185,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2143826"],"award-info":[{"award-number":["2143826"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is an endogenous signaling molecule that greatly influences several important (patho)physiological processes related to cardiovascular health and disease, including vasodilation, angiogenesis, inflammation, and cellular redox homeostasis. Consequently, H2S supplementation is an emerging area of interest, especially for the treatment of cardiovascular-related diseases. To fully unlock the medicinal properties of hydrogen sulfide, however, the development and refinement of H2S releasing compounds (or donors) are required to augment its bioavailability and to better mimic its natural enzymatic production. Categorizing donors by the biological stimulus that triggers their H2S release, this review highlights the fundamental chemistry and releasing mechanisms of a range of H2S donors that have exhibited promising protective effects in models of myocardial ischemia-reperfusion (MI\/R) injury and cancer chemotherapy-induced cardiotoxicity, specifically. Thus, in addition to serving as important investigative tools that further advance our knowledge and understanding of H2S chemical biology, the compounds highlighted in this review have the potential to serve as vital therapeutic agents for the treatment (or prevention) of various cardiomyopathies.<\/jats:p>","DOI":"10.3390\/antiox12030650","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T05:18:43Z","timestamp":1678079923000},"page":"650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["H2S Donors with Cytoprotective Effects in Models of MI\/R Injury and Chemotherapy-Induced Cardiotoxicity"],"prefix":"10.3390","volume":"12","author":[{"given":"Qiwei","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Wake Forest University, Wake Downtown Campus, 455 Vine Street, Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-8491","authenticated-orcid":false,"suffix":"III","given":"John C.","family":"Lukesh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Wake Forest University, Wake Downtown Campus, 455 Vine Street, Winston-Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A Critical Review of the Literature on Hydrogen Sulfide Toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/25245","article-title":"Smelly Cats","volume":"396","author":"Tomlin","year":"1998","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1289\/ehp.10531","article-title":"Sensory and Cognitive Effects of Acute Exposure to Hydrogen Sulfide","volume":"116","author":"Fiedler","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The Possible Role of Hydrogen Sulfide as an Endogenous Neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"013","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen Sulfide as a Neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/15216540500217875","article-title":"Hydrogen Sulfide as a Vasodilator","volume":"57","author":"Bhatia","year":"2005","journal-title":"IUBMB Life Int. Union Biochem. Mol. Biol. Life"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21903","DOI":"10.1074\/jbc.R110.128363","article-title":"Redox Biochemistry of Hydrogen Sulfide","volume":"285","author":"Kabil","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s Company, Three\u2019s a Crowd: Can H2S Be the Third Endogenous Gaseous Transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/152308603768295249","article-title":"The Gasotransmitter Role of Hydrogen Sulfide","volume":"5","author":"Wang","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.1073\/pnas.1206646109","article-title":"Shared Signaling Pathways among Gasotransmitters","volume":"109","author":"Wang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/bph.13005","article-title":"Pharmacology of the \u2018Gasotransmitters\u2019 NO, CO and H2S: Translational Opportunities","volume":"172","author":"Papapetropoulos","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.freeradbiomed.2009.09.018","article-title":"Making and Working with Hydrogen Sulfide","volume":"47","author":"Hughes","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/tx2005234","article-title":"Small Molecule Signaling Agents: The Integrated Chemistry and Biochemistry of Nitrogen Oxides, Oxides of Carbon, Dioxygen, Hydrogen Sulfide, and Their Derived Species","volume":"25","author":"Fukuto","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7058","article-title":"A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?","volume":"31","author":"Cao","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen Sulfide: Its Production, Release and Functions","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical Biology of H2S Signaling through Persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1089\/ars.2020.8249","article-title":"New Therapeutic Approaches Using Hydrogen Sulfide Donors in Inflammation and Immune Response","volume":"35","author":"Li","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen Sulfide and Inflammation: The Good, the Bad, the Ugly and the Promising","volume":"4","author":"Whiteman","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1159\/000453210","article-title":"H2S Attenuates LPS-Induced Acute Lung Injury by Reducing Oxidative\/Nitrative Stress and Inflammation","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen Sulfide Is an Endogenous Stimulator of Angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Corvino, A., Frecentese, F., Magli, E., Perissutti, E., Santagada, V., Scognamiglio, A., Caliendo, G., Fiorino, F., and Severino, B. (2021). Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10030429"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29871","DOI":"10.1074\/jbc.R400005200","article-title":"Cystathionine \u03b2-Synthase: Structure, Function, Regulation, and Location of Homocystinuria-Causing Mutations","volume":"279","author":"Miles","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/ars.2011.4349","article-title":"Role of Cystathionine \u03b3 -Lyase\/Hydrogen Sulfide Pathway in Cardiovascular Disease: A Novel Therapeutic Strategy?","volume":"17","author":"Pan","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/bph.14446","article-title":"Regulators of the Transsulfuration Pathway: Modulating the Transsulfuration Pathway in Disease","volume":"176","author":"Sbodio","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The Quantitative Significance of the Transsulfuration Enzymes for H2S Production in Murine Tissues","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2337\/db05-1082","article-title":"l-Cysteine Inhibits Insulin Release from the Pancreatic \u03b2-Cell","volume":"55","author":"Kaneko","year":"2006","journal-title":"Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Patel, P., Vatish, M., Heptinstall, J., Wang, R., and Carson, R.J. (2009). The Endogenous Production of Hydrogen Sulphide in Intrauterine Tissues. Reprod. Biol. Endocrinol., 7.","DOI":"10.1186\/1477-7827-7-10"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The Possible Role of Hydrogen Sulfide as an Endogenous Smooth Muscle Relaxant in Synergy with Nitric Oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s004180050286","article-title":"Tissue and Subcellular Distribution of Mercaptopyruvate Sulfurtransferase in the Rat: Confocal Laser Fluorescence and Immunoelectron Microscopic Studies Combined with Biochemical Analysis","volume":"110","author":"Nagahara","year":"1998","journal-title":"Histochem. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1152\/ajpregu.00421.2012","article-title":"Thiosulfate: A Readily Accessible Source of Hydrogen Sulfide in Oxygen Sensing","volume":"305","author":"Olson","year":"2013","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","article-title":"Hydrogen Sulfide Chemical Biology: Pathophysiological Roles and Detection","volume":"35","author":"Kolluru","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zuhra, K., Augsburger, F., Majtan, T., and Szabo, C. (2020). Cystathionine-\u03b2-Synthase: Molecular Regulation and Pharmacological Inhibition. Biomolecules, 10.","DOI":"10.3390\/biom10050697"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1021\/bi300778t","article-title":"Human Sulfide:Quinone Oxidoreductase Catalyzes the First Step in Hydrogen Sulfide Metabolism and Produces a Sulfane Sulfur Metabolite","volume":"51","author":"Jackson","year":"2012","journal-title":"Biochemistry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/bs.mie.2014.11.037","article-title":"Role of Human Sulfide","volume":"Volume 554","author":"Jackson","year":"2015","journal-title":"Methods in Enzymology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/0006-2952(80)90029-5","article-title":"Thiol S-Methyltransferase: Suggested Role in Detoxication of Intestinal Hydrogen Sulfide","volume":"29","author":"Weisiger","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1021\/ja972654m","article-title":"Unusual Rocking Freedom of the Heme in the Hydrogen Sulfide-Binding Hemoglobin from Lucina pectinata","volume":"120","author":"Silfa","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1476-5381.2009.00248.x","article-title":"Detection of Exhaled Hydrogen Sulphide Gas in Rats Exposed to Intravenous Sodium Sulphide","volume":"157","author":"Insko","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/ars.2008.2132","article-title":"A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain","volume":"11","author":"Ishigami","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/0006-2952(80)90346-9","article-title":"Oxidation of Sodium Sulphide by Rat Liver, Lungs and Kidney","volume":"29","author":"Bartholomew","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phrs.2016.08.023","article-title":"S-Sulfhydration of ATP Synthase by Hydrogen Sulfide Stimulates Mitochondrial Bioenergetics","volume":"113","author":"Ju","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Szabo, C. (2021). Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells. Cells, 10.","DOI":"10.3390\/cells10020220"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kimura, H. (2021). Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years. Biomolecules, 11.","DOI":"10.3390\/biom11060896"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-319-18144-8_2","article-title":"Persulfidation (S-Sulfhydration) and H2S","volume":"Volume 230","author":"Moore","year":"2015","journal-title":"Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.bbapap.2014.01.002","article-title":"H2S and Its Role in Redox Signaling","volume":"1844","author":"Kabil","year":"2014","journal-title":"Biochim. Biophys. Acta BBA Proteins Proteomics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/biof.1061","article-title":"H2S: A \u201cDouble Face\u201d Molecule in Health and Disease","volume":"39","author":"Ascenzi","year":"2013","journal-title":"BioFactors"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.tibs.2015.08.007","article-title":"H2S: A Novel Gasotransmitter That Signals by Sulfhydration","volume":"40","author":"Paul","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen Sulfide Mediates the Vasoactivity of Garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12967-017-1206-8","article-title":"Anti-Inflammatory Effects of H2S during Acute Bacterial Infection: A Review","volume":"15","author":"Benedetti","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.niox.2014.11.010","article-title":"H2S-Releasing Drugs: Anti-Inflammatory, Cytoprotective and Chemopreventative Potential","volume":"46","author":"Gemici","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.mie.2014.11.034","article-title":"Anti-Inflammatory and Cytoprotective Properties of Hydrogen Sulfide","volume":"Volume 555","author":"Gemici","year":"2015","journal-title":"Methods in Enzymology"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Paganelli, F., Mottola, G., Fromonot, J., Marlinge, M., Deharo, P., Guieu, R., and Ruf, J. (2021). Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041690"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1139\/cjpp-2015-0193","article-title":"Adenosine Plasma Level Correlates with Homocysteine and Uric Acid Concentrations in Patients with Coronary Artery Disease","volume":"94","author":"Fromonot","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.niox.2010.11.001","article-title":"Cardioprotective Effects of Hydrogen Sulfide","volume":"25","author":"Veres","year":"2011","journal-title":"Nitric Oxide"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/925167","article-title":"The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential","volume":"2015","author":"Shen","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1002\/jcp.29761","article-title":"Protective Mechanisms of Hydrogen Sulfide in Myocardial Ischemia","volume":"235","author":"Chen","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4010395","article-title":"The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease","volume":"2018","author":"Wen","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/cb400090d","article-title":"Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury","volume":"8","author":"Zhao","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ejcts.2008.01.047","article-title":"The Effects of Therapeutic Sulfide on Myocardial Apoptosis in Response to Ischemia\u2013Reperfusion Injury","volume":"33","author":"Sodha","year":"2008","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/FJC.0b013e3181b2b72b","article-title":"Effect of Hydrogen Sulfide in a Porcine Model of Myocardial Ischemia-Reperfusion: Comparison of Different Administration Regimens and Characterization of the Cellular Mechanisms of Protection","volume":"54","author":"Osipov","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.03.044","article-title":"Exogenous Hydrogen Sulfide Postconditioning Protects Isolated Rat Hearts against Ischemia-Reperfusion Injury","volume":"587","author":"Ji","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ahmed, N. (2019). Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection, Elsevier.","DOI":"10.1016\/B978-0-12-818023-5.00004-2"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/hrt.2003.029017","article-title":"The Pathophysiology of Myocardial Ischaemia","volume":"90","author":"Crossman","year":"2004","journal-title":"Heart"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial Ischaemia\u2013Reperfusion Injury and Cardioprotection in Perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"935","DOI":"10.5455\/medscience.2013.02.8082","article-title":"Pathophysiology of Myocardial Ischemia Reperfusion Injury: A Review","volume":"2","author":"Parlakpinar","year":"2013","journal-title":"Med. Sci. Int. Med. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5470457","article-title":"The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases","volume":"2016","author":"Pei","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1111\/jcmm.15279","article-title":"The Role of Mitochondrial Reactive Oxygen Species, NO and H2S in Ischemia\/Reperfusion Injury and Cardioprotection","volume":"24","author":"Andreadou","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00395-005-0569-9","article-title":"Exogenous Hydrogen Sulfide (H2S) Protects against Regional Myocardial Ischemia\u2013Reperfusion Injury: Evidence for a Role of KATP Channels","volume":"101","author":"Johansen","year":"2006","journal-title":"Basic Res. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.shk.0000225722.56681.64","article-title":"The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat","volume":"26","author":"Sivarajah","year":"2006","journal-title":"Shock"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen Sulfide Attenuates Myocardial Ischemia-Reperfusion Injury by Preservation of Mitochondrial Function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","unstructured":"Moore, P.K., and Whiteman, M. (2015). Handbook of Experimental Pharmacology, Springer International Publishing. [1st ed.]."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"27359","DOI":"10.1039\/C8RA03658F","article-title":"Small Molecule Generators of Biologically Reactive Sulfur Species","volume":"8","author":"Bora","year":"2018","journal-title":"RSC Adv."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1039\/C6CS00212A","article-title":"A Practical Guide to Working with H2S at the Interface of Chemistry and Biology","volume":"45","author":"Hartle","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1089\/ars.2019.7841","article-title":"Activatable Small-Molecule Hydrogen Sulfide Donors","volume":"32","author":"Levinn","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A Review of Hydrogen Sulfide (H2S) Donors: Chemistry and Potential Therapeutic Applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1002\/chem.201804895","article-title":"Strategies for the Design of Donors and Precursors of Reactive Sulfur Species","volume":"25","author":"Xu","year":"2019","journal-title":"Chem.-Eur. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a Novel, Water-Soluble Hydrogen Sulfide\u2013Releasing Molecule (GYY4137): New Insights Into the Biology of Hydrogen Sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.mie.2014.11.014","article-title":"GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule","volume":"Volume 554","author":"Rose","year":"2015","journal-title":"Methods in Enzymology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1039\/C5MD00170F","article-title":"Investigating the Generation of Hydrogen Sulfide from the Phosphonamidodithioate Slow-Release Donor GYY4137","volume":"6","author":"Alexander","year":"2015","journal-title":"MedChemComm"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"(2015). GYY4137 Protects against Myocardial Ischemia and Reperfusion Injury by Attenuating Oxidative Stress and Apoptosis in Rats. J. Biomed. Res., 29, 203\u2013213.","DOI":"10.7555\/JBR.28.20140037"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jss.2017.12.030","article-title":"GYY4137 Protects against Myocardial Ischemia\/Reperfusion Injury via Activation of the PHLPP-1\/Akt\/Nrf2 Signaling Pathway in Diabetic Mice","volume":"225","author":"Qiu","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.phrs.2016.06.028","article-title":"Pharmacological Postconditioning against Myocardial Infarction with a Slow-Releasing Hydrogen Sulfide Donor, GYY4137","volume":"111","author":"Karwi","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Robinson, H., and Wray, S. (2012). A New Slow Releasing, H2S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046278"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/cr60234a004","article-title":"The Chemistry of 1,2-Dithiole-3-Thiones","volume":"65","author":"Landis","year":"1965","journal-title":"Chem. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0002-9629(15)40606-8","article-title":"Treatment of Xerostomia with the Bile Secretion-Stimulating Drug Anethole Trithione: A Clinical Trial","volume":"318","author":"Hamada","year":"1999","journal-title":"Am. J. Med. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bmcl.2008.02.007","article-title":"New Sulfurated Derivatives of Valproic Acid with Enhanced Histone Deacetylase Inhibitory Activity","volume":"18","author":"Perrino","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1016\/j.bmc.2010.05.011","article-title":"New Aryldithiolethione Derivatives as Potent Histone Deacetylase Inhibitors","volume":"18","author":"Tazzari","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/bbrc.1996.0026","article-title":"Inhibition of NF-\u039aB Activation in Human T-Cell Lines by Anetholdithiolthione","volume":"218","author":"Sen","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1071\/CH09517","article-title":"Synthesis and Preliminary Pharmacological Evaluation of Aryl Dithiolethiones with Cyclooxygenase-2-Selective Inhibitory Activity and Hydrogen Sulfide-Releasing Properties","volume":"63","author":"Zanatta","year":"2010","journal-title":"Aust. J. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"17244","DOI":"10.3390\/ijms131217244","article-title":"Prodrugs of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), More Than Meets the Eye: A Critical Review","volume":"13","author":"Qandil","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/jm901638j","article-title":"Synthesis and Biological Effects of Hydrogen Sulfide (H2S): Development of H2S-Releasing Drugs as Pharmaceuticals","volume":"53","author":"Caliendo","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1039\/D0NJ04415F","article-title":"A Novel H2S Releasing-Monastrol Hybrid (MADTOH) Inhibits L-Type Calcium Channels","volume":"45","author":"Braga","year":"2021","journal-title":"New J. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/01.CIR.65.6.1114","article-title":"Acute Hemodynamic Effects of Nifedipine in Patients with Ischemic Heart Disease","volume":"65","author":"Majid","year":"1982","journal-title":"Circulation"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.freeradbiomed.2008.11.013","article-title":"Pharmacological Profile of a Novel H2S-Releasing Aspirin","volume":"46","author":"Sparatore","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Huang, Q., Sparatore, A., Del Soldato, P., Wu, L., and Desai, K. (2014). Hydrogen Sulfide Releasing Aspirin, ACS14, Attenuates High Glucose-Induced Increased Methylglyoxal and Oxidative Stress in Cultured Vascular Smooth Muscle Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097315"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejphar.2010.08.039","article-title":"Activity of a New Hydrogen Sulfide-Releasing Aspirin (ACS14) on Pathological Cardiovascular Alterations Induced by Glutathione Depletion in Rats","volume":"648","author":"Rossoni","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phrs.2016.08.019","article-title":"The Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP123 and AP39 Protect against Hyperglycemic Injury in Microvascular Endothelial Cells in Vitro","volume":"113","author":"Torregrossa","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","article-title":"AP39, a Novel Mitochondria-Targeted Hydrogen Sulfide Donor, Stimulates Cellular Bioenergetics, Exerts Cytoprotective Effects and Protects against the Loss of Mitochondrial DNA Integrity in Oxidatively Stressed Endothelial Cells in Vitro","volume":"41","author":"Szczesny","year":"2014","journal-title":"Nitric Oxide"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.niox.2015.05.001","article-title":"Mitochondria-Targeted Hydrogen Sulfide Donor AP39 Improves Neurological Outcomes after Cardiac Arrest in Mice","volume":"49","author":"Ikeda","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/SHK.0000000000000478","article-title":"AP39, a Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo","volume":"45","author":"Ahmad","year":"2016","journal-title":"Shock"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bph.13688","article-title":"AP39, a Mitochondria-Targeting Hydrogen Sulfide (H2S) Donor, Protects against Myocardial Reperfusion Injury Independently of Salvage Kinase Signalling: Cardioprotection with AP39","volume":"174","author":"Karwi","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1021\/jacs.6b01373","article-title":"PH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury","volume":"138","author":"Kang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejmech.2019.05.017","article-title":"Toxicity, Bioactivity, Release of H2S in Vivo and Pharmaco-Kinetics of H2S-Donors with Thiophosphamide Structure","volume":"176","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1021\/acs.jmedchem.5b01033","article-title":"Design, Synthesis, and Cardioprotective Effects of N -Mercapto-Based Hydrogen Sulfide Donors","volume":"58","author":"Zhao","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1039\/C9CC02829C","article-title":"Controllable Thioester-Based Hydrogen Sulfide Slow-Releasing Donors as Cardioprotective Agents","volume":"55","author":"Yao","year":"2019","journal-title":"Chem. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1021\/jacs.9b12180","article-title":"Alkylamine-Substituted Perthiocarbamates: Dual Precursors to Hydropersulfide and Carbonyl Sulfide with Cardioprotective Actions","volume":"142","author":"Khodade","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.phrs.2016.09.006","article-title":"The Novel H2S-Donor 4-Carboxyphenyl Isothiocyanate Promotes Cardioprotective Effects against Ischemia\/Reperfusion Injury through Activation of MitoK ATP Channels and Reduction of Oxidative Stress","volume":"113","author":"Testai","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jare.2020.02.017","article-title":"Structure-Activity Relationships Study of Isothiocyanates for H2S Releasing Properties: 3-Pyridyl-Isothiocyanate as a New Promising Cardioprotective Agent","volume":"27","author":"Citi","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e202210754","DOI":"10.1002\/anie.202210754","article-title":"Intramolecular Thiol- and Selenol-Assisted Delivery of Hydrogen Sulfide","volume":"61","author":"Hu","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1021\/acs.jmedchem.5b01223","article-title":"Synthesis and Pharmacological Evaluation of Novel Adenine\u2013Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents","volume":"59","author":"Lougiakis","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ejcn.2012.178","article-title":"Aged Garlic Extract Reduces Blood Pressure in Hypertensives: A Dose\u2013Response Trial","volume":"67","author":"Ried","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1055\/s-0028-1088299","article-title":"Perspective on Recent Developments on Sulfur-Containing Agents and Hydrogen Sulfide Signaling","volume":"74","author":"Jacob","year":"2008","journal-title":"Planta Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and Therapeutic Potential of Hydrogen Sulfide and Hydrogen Sulfide-Releasing Chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pharmthera.2009.05.005","article-title":"Actions and Interactions of Nitric Oxide, Carbon Monoxide and Hydrogen Sulphide in the Cardiovascular System and in Inflammation\u2014A Tale of Three Gases!","volume":"123","author":"Li","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.phrs.2010.06.002","article-title":"Hydrogen Sulfide and Ischemia\u2013Reperfusion Injury","volume":"62","author":"Nicholson","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"R297","DOI":"10.1152\/ajpregu.00045.2011","article-title":"The Therapeutic Potential of Hydrogen Sulfide: Separating Hype from Hope","volume":"301","author":"Olson","year":"2011","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2012.4612","article-title":"Hydrogen Sulfide in Biochemistry and Medicine","volume":"17","author":"Predmore","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1021\/acs.accounts.9b00315","article-title":"Development and Application of Carbonyl Sulfide-Based Donors for H2S Delivery","volume":"52","author":"Levinn","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1021\/acs.orglett.9b02117","article-title":"Isothiocyanates as H2S Donors Triggered by Cysteine: Reaction Mechanism and Structure and Activity Relationship","volume":"21","author":"Lin","year":"2019","journal-title":"Org. Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.apsb.2018.05.005","article-title":"Human Carboxylesterases: A Comprehensive Review","volume":"8","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/acs.orglett.6b03336","article-title":"Esterase Activated Carbonyl Sulfide\/Hydrogen Sulfide (H2S) Donors","volume":"19","author":"Chauhan","year":"2017","journal-title":"Org. Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/acschembio.1c00805","article-title":"Esterase-Activated Perthiocarbonate Persulfide Donors Provide Insights into Persulfide Persistence and Stability","volume":"17","author":"Fosnacht","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"9999","DOI":"10.1039\/C9OB02273B","article-title":"Esterase-Sensitive Trithiane-Based Hydrogen Sulfide Donors","volume":"17","author":"Shyaka","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/acschembio.7b00279","article-title":"Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS\/H2S Donors","volume":"12","author":"Steiger","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1021\/acs.orglett.8b02611","article-title":"Esterase-Sensitive Glutathione Persulfide Donor","volume":"20","author":"Yuan","year":"2018","journal-title":"Org. Lett."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1002\/anie.201511244","article-title":"Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide","volume":"55","author":"Zheng","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1002\/ange.201704117","article-title":"An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species","volume":"129","author":"Zheng","year":"2017","journal-title":"Angew. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"7396","DOI":"10.1039\/D2CC02267B","article-title":"Enzyme-Responsive Hybrid Prodrug of Nitric Oxide and Hydrogen Sulfide for Heart Failure Therapy","volume":"58","author":"Liu","year":"2022","journal-title":"Chem. Commun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"14858","DOI":"10.1002\/ange.201608052","article-title":"Hydrogen Sulfide Donors Activated by Reactive Oxygen Species","volume":"128","author":"Zhao","year":"2016","journal-title":"Angew. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1002\/anie.201803087","article-title":"A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential","volume":"57","author":"Powell","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1021\/acs.orglett.8b03471","article-title":"A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS)","volume":"20","author":"Bora","year":"2018","journal-title":"Org. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"22238","DOI":"10.1002\/anie.202010530","article-title":"An Innovative Hydrogen Peroxide-Sensing Scaffold and Insight Towards Its Potential as an ROS-Activated Persulfide Donor","volume":"59","author":"Hankins","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"152944","DOI":"10.1016\/j.tetlet.2021.152944","article-title":"Illuminating and Alleviating Cellular Oxidative Stress with an ROS-Activated, H2S-Donating Theranostic","volume":"69","author":"Zhu","year":"2021","journal-title":"Tetrahedron Lett."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ar200126t","article-title":"Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems","volume":"44","author":"Lippert","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/acs.analchem.9b04990","article-title":"Reaction-Based Luminescent Probes for Reactive Sulfur, Oxygen, and Nitrogen Species: Analytical Techniques and Recent Progress","volume":"92","author":"Bezner","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1021\/acs.biomac.9b00628","article-title":"Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System","volume":"20","author":"Ye","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1039\/C9SC02323B","article-title":"Reactive Oxygen Species-Triggered off-on Fluorescence Donor for Imaging Hydrogen Sulfide Delivery in Living Cells","volume":"10","author":"Hu","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/acssensors.9b01093","article-title":"A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Reporting Fluorescence","volume":"5","author":"Zhang","year":"2020","journal-title":"ACS Sens."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bioactmat.2021.07.011","article-title":"A ROS-Responsive, Self-Immolative and Self-Reporting Hydrogen Sulfide Donor with Multiple Biological Activities for the Treatment of Myocardial Infarction","volume":"9","author":"Yao","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1002\/1097-0142(19850615)55:12<2761::AID-CNCR2820551206>3.0.CO;2-P","article-title":"Early and Delayed Clinical Cardiotoxicity of Doxorubicin","volume":"55","author":"Buzdar","year":"1985","journal-title":"Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/cncr.11407","article-title":"Congestive Heart Failure in Patients Treated with Doxorubicin: A Retrospective Analysis of Three Trials","volume":"97","author":"Swain","year":"2003","journal-title":"Cancer"},{"key":"ref_143","first-page":"586","article-title":"Chemotherapy-Induced Cardiovascular Toxicity: Beyond Anthracyclines","volume":"80","author":"Ai","year":"2014","journal-title":"Minerva Anestesiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1002\/pbc.24597","article-title":"Cardiotoxicity in Childhood Cancer Survivors: A Problem with Long-Term Consequences in Need of Early Detection and Prevention: Cardiotoxicity in Childhood Cancer Survivors","volume":"60","author":"Lipshultz","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"2016 ESC Position Paper on Cancer Treatments and Cardiovascular Toxicity Developed under the Auspices of the ESC Committee for Practice Guidelines: The Task Force for Cancer Treatments and Cardiovascular Toxicity of the European Society of Cardiology (ESC)","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1586\/14779072.2015.1032940","article-title":"Cardio-Oncology Part I: Chemotherapy and Cardiovascular Toxicity","volume":"13","author":"Sharma","year":"2015","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-2952(98)00307-4","article-title":"A Critical Evaluation of the Mechanisms of Action Proposed for the Antitumor Effects of the Anthracycline Antibiotics Adriamycin and Daunorubicin","volume":"57","author":"Gewirtz","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/S0021-9258(17)35747-2","article-title":"Redox Cycling of Anthracyclines by Cardiac Mitochondria. II. Formation of Superoxide Anion, Hydrogen Peroxide, and Hydroxyl Radical","volume":"261","author":"Doroshow","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/CIRCRESAHA.119.314681","article-title":"Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy","volume":"126","author":"Wallace","year":"2020","journal-title":"Circ. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.fct.2010.04.007","article-title":"New Advances in Molecular Mechanisms and the Prevention of Adriamycin Toxicity by Antioxidant Nutrients","volume":"48","author":"Quiles","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1172\/JCI109642","article-title":"Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites","volume":"65","author":"Doroshow","year":"1980","journal-title":"J. Clin. Investig."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.yjmcc.2012.03.006","article-title":"Doxorubicin-Induced Cardiomyopathy: From Molecular Mechanisms to Therapeutic Strategies","volume":"52","author":"Octavia","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.31788\/RJC.2020.1325603","article-title":"Anti-Cancer Drug Doxorubicin Induced Cardiotoxicity: Understanding The Mechanisms Involved In Ros Generation Resulting In Mitochondrial Dysfunction","volume":"13","author":"Upadhayay","year":"2020","journal-title":"Rasayan J. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"111708","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-Induced Cardiotoxicity: An Update on the Molecular Mechanism and Novel Therapeutic Strategies for Effective Management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fphar.2018.00032","article-title":"Protective Mechanism of Hydrogen Sulfide against Chemotherapy-Induced Cardiotoxicity","volume":"9","author":"Du","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1253\/circj.CJ-08-0636","article-title":"Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy","volume":"73","author":"Su","year":"2009","journal-title":"Circ. J."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3892\/ijmm.2013.1246","article-title":"Hydrogen Sulfide Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibition of the P38 MAPK Pathway in H9c2 Cells","volume":"31","author":"Guo","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11010-011-1194-6","article-title":"Hydrogen Sulfide Protects H9c2 Cells against Doxorubicin-Induced Cardiotoxicity through Inhibition of Endoplasmic Reticulum Stress","volume":"363","author":"Wang","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.3892\/mmr.2015.4234","article-title":"Hydrogen Sulfide Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Reactive Oxygen Species-Activated Extracellular Signal-Regulated Kinase 1\/2 in H9c2 Cardiac Myocytes","volume":"12","author":"Liu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"118630","DOI":"10.1016\/j.lfs.2020.118630","article-title":"Nephroprotective Effect of Exogenous Hydrogen Sulfide Donor against Cyclophosphamide-Induced Toxicity Is Mediated by Nrf2\/HO-1\/NF-\u039aB Signaling Pathway","volume":"264","author":"Waz","year":"2021","journal-title":"Life Sci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1007\/s11356-019-07266-5","article-title":"Assessment of the Effect of Sodium Hydrogen Sulfide (Hydrogen Sulfide Donor) on Cisplatin-Induced Testicular Toxicity in Rats","volume":"27","author":"Azarbarz","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1021\/acs.jmedchem.6b00184","article-title":"H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance","volume":"59","author":"Chegaev","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/5289","article-title":"Cancer Multidrug Resistance","volume":"17","author":"Persidis","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10637-018-0590-0","article-title":"New NO- and H2S-Releasing Doxorubicins as Targeted Therapy against Chemoresistance in Castration-Resistant Prostate Cancer: In Vitro and in Vivo Evaluations","volume":"36","author":"Bigagli","year":"2018","journal-title":"Invest. New Drugs"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"106969","DOI":"10.1016\/j.vph.2022.106969","article-title":"Sdox, a H2S Releasing Anthracycline, with a Safer Profile than Doxorubicin toward Vasculature","volume":"143","author":"Durante","year":"2022","journal-title":"Vascul. Pharmacol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2019.04.029","article-title":"Hyaluronated Liposomes Containing H2S-Releasing Doxorubicin Are Effective against P-Glycoprotein-Positive\/Doxorubicin-Resistant Osteosarcoma Cells and Xenografts","volume":"456","author":"Gazzano","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"102338","DOI":"10.1016\/j.redox.2022.102338","article-title":"Mitigation of Doxorubicin-Induced Cardiotoxicity with an H2O2-Activated, H2S-Donating Hybrid Prodrug","volume":"53","author":"Hu","year":"2022","journal-title":"Redox Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive Oxygen Species in Cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejmech.2016.03.063","article-title":"10-Boronic Acid Substituted Camptothecin as Prodrug of SN-38","volume":"116","author":"Wang","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"19278","DOI":"10.1021\/ja2073824","article-title":"Hydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs","volume":"133","author":"Kuang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/acsmedchemlett.8b00539","article-title":"Enhanced Tumor Selectivity of 5-Fluorouracil Using a Reactive Oxygen Species-Activated Prodrug Approach","volume":"10","author":"Ai","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"103158","DOI":"10.1016\/j.bioorg.2019.103158","article-title":"Arylboronate Prodrugs of Doxorubicin as Promising Chemotherapy for Pancreatic Cancer","volume":"91","author":"Skarbek","year":"2019","journal-title":"Bioorganic Chem."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Mirzaei, S., Zarrabi, A., Hashemi, F., Zabolian, A., Saleki, H., Azami, N., Hamzehlou, S., Farahani, M.V., Hushmandi, K., and Ashrafizadeh, M. (2021). Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery. Antioxidants, 10.","DOI":"10.3390\/antiox10030349"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s12012-020-09581-7","article-title":"Disruption of the Keap1\/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo","volume":"20","author":"Nordgren","year":"2020","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Alzahrani, A.M., Rajendran, P., Veeraraghavan, V.P., and Hanieh, H. (2021). Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K\/AKT Pathways. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063269"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"107533","DOI":"10.1016\/j.intimp.2021.107533","article-title":"Pinocembrin Inhibited Cardiomyocyte Pyroptosis against Doxorubicin-Induced Cardiac Dysfunction via Regulating Nrf2\/Sirt3 Signaling Pathway","volume":"95","author":"Gu","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yjmcc.2005.10.003","article-title":"Endogenous Hydrogen Sulfide Contributes to the Cardioprotection by Metabolic Inhibition Preconditioning in the Rat Ventricular Myocytes","volume":"40","author":"Pan","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"R443","DOI":"10.1152\/ajpregu.00088.2013","article-title":"Akt\/ENOS Signaling and PLN S-Sulfhydration Are Involved in H2S-Dependent Cardiac Effects in Frog and Rat","volume":"305","author":"Mazza","year":"2013","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00424-007-0321-4","article-title":"Cardioprotection Induced by Hydrogen Sulfide Preconditioning Involves Activation of ERK and PI3K\/Akt Pathways","volume":"455","author":"Hu","year":"2007","journal-title":"Pfl\u00fcg. Arch.\u2014Eur. J. Physiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3892\/ijmm.2016.2563","article-title":"Hydrogen Sulfide Protects H9c2 Cardiac Cells against Doxorubicin-Induced Cytotoxicity through the PI3K\/Akt\/FoxO3a Pathway","volume":"37","author":"Liu","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1159\/000356602","article-title":"Exogenous Hydrogen Sulfide Protects against Doxorubicin-Induced Inflammation and Cytotoxicity by Inhibiting P38MAPK\/NF&#954;B Pathway in H9c2 Cardiac Cells","volume":"32","author":"Guo","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3892\/ijmm.2014.2007","article-title":"Exogenous H2S Protects H9c2 Cardiac Cells against High Glucose-Induced Injury and Inflammation by Inhibiting the Activation of the NF-\u039aB and IL-1\u03b2 Pathways","volume":"35","author":"Xu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/biof.1763","article-title":"The Cardioprotective Effects of Hydrogen Sulfide by Targeting Endoplasmic Reticulum Stress and the Nrf2 Signaling Pathway: A Review","volume":"47","author":"Yarmohammadi","year":"2021","journal-title":"BioFactors"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3892\/mmr.2021.12515","article-title":"Cardioprotective Effects of Hydrogen Sulfide in Attenuating Myocardial Ischemia-reperfusion Injury (Review)","volume":"24","author":"Wu","year":"2021","journal-title":"Mol. Med. Rep."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/650\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:23Z","timestamp":1760122103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,5]]},"references-count":185,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["antiox12030650"],"URL":"https:\/\/doi.org\/10.3390\/antiox12030650","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,5]]}}}