{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:46:50Z","timestamp":1790646410648,"version":"4.1.0"},"reference-count":425,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Melrose Personal Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They have received considerable attention as potential therapeutic agents in biomedicine and have been widely used in traditional complimentary medicine for generations. Such complimentary medical herbal formulations are extremely complex mixtures of many pharmacologically active compounds that provide a therapeutic outcome through a network pharmacological effects of considerable complexity. Methods are emerging to determine the active components used in complimentary medicine and their therapeutic targets and to decipher the complexities of how network pharmacology provides such therapeutic effects. The gut microbiome has important roles to play in the generation of bioactive flavonoid metabolites retaining or exceeding the antioxidative and anti-inflammatory properties of the intact flavonoid and, in some cases, new antitumor and antineurodegenerative bioactivities. Certain food items have been identified with high prebiotic profiles suggesting that neutraceutical supplementation may be beneficially employed to preserve a healthy population of bacterial symbiont species and minimize the establishment of harmful pathogenic organisms. Gut health is an important consideration effecting the overall health and wellbeing of linked organ systems. Bioconversion of dietary flavonoid components in the gut generates therapeutic metabolites that can also be transported by the vagus nerve and systemic circulation to brain cell populations to exert a beneficial effect. This is particularly important in a number of neurological disorders (autism, bipolar disorder, AD, PD) characterized by effects on moods, resulting in depression and anxiety, impaired motor function, and long-term cognitive decline. Native flavonoids have many beneficial properties in the alleviation of inflammation in tissues, however, concerns have been raised that therapeutic levels of flavonoids may not be achieved, thus allowing them to display optimal therapeutic effects. Dietary manipulation and vagal stimulation have both yielded beneficial responses in the treatment of autism spectrum disorders, depression, and anxiety, establishing the vagal nerve as a route of communication in the gut-brain axis with established roles in disease intervention. While a number of native flavonoids are beneficial in the treatment of neurological disorders and are known to penetrate the blood\u2013brain barrier, microbiome-generated flavonoid metabolites (e.g., protocatechuic acid, urolithins, \u03b3-valerolactones), which retain the antioxidant and anti-inflammatory potency of the native flavonoid in addition to bioactive properties that promote mitochondrial health and cerebrovascular microcapillary function, should also be considered as potential biotherapeutic agents. Studies are warranted to experimentally examine the efficacy of flavonoid metabolites directly, as they emerge as novel therapeutic options.<\/jats:p>","DOI":"10.3390\/antiox12030663","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T03:29:05Z","timestamp":1678246145000},"page":"663","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-0524","authenticated-orcid":false,"given":"James","family":"Melrose","sequence":"first","affiliation":[{"name":"Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia"},{"name":"Graduate School of Biomedical Engineering, University of NSW, Sydney, NSW 2052, Australia"},{"name":"Sydney Medical School, Northern Campus, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/head.12649","article-title":"Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III","volume":"56","author":"Yuan","year":"2016","journal-title":"Headache"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/head.12647","article-title":"Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part I","volume":"56","author":"Yuan","year":"2016","journal-title":"Headache"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/head.12650","article-title":"Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part II","volume":"56","author":"Yuan","year":"2016","journal-title":"Headache"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0006-3223(99)00308-X","article-title":"Vagus nerve stimulation: A new tool for brain research and therapy","volume":"47","author":"George","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1586\/14737175.7.1.63","article-title":"Vagus nerve stimulation for the treatment of depression and other neuropsychiatric disorders","volume":"7","author":"George","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"727117","DOI":"10.3389\/fpsyt.2021.727117","article-title":"Psychedelics and Other Psychoplastogens for Treating Mental Illness","volume":"12","author":"Vargas","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41386-022-01389-z","article-title":"Towards an understanding of psychedelic-induced neuroplasticity","volume":"48","author":"Calder","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41593-022-01177-4","article-title":"The neural basis of psychedelic action","volume":"25","author":"Kwan","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1179069518800508","DOI":"10.1177\/1179069518800508","article-title":"Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics","volume":"12","author":"Olson","year":"2018","journal-title":"J. Exp. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/revneuro-2018-0080","article-title":"Application of quercetin in neurological disorders: From nutrition to nanomedicine","volume":"30","author":"Amanzadeh","year":"2019","journal-title":"Rev. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.2174\/0929867327666201020151804","article-title":"Chalcones Acting as Inhibitors of Cholinesterases, \u03b2-Secretase and \u03b2- Amyloid Aggregation and other Targets for Alzheimer\u2019s Disease: A Critical Review","volume":"28","author":"Antoniolli","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Banc, R., Rusu, M.E., Filip, L., and Popa, D.S. (2023). The Impact of Ellagitannins and Their Metabolites through Gut Microbiome on the Gut Health and Brain Wellness within the Gut-Brain Axis. Foods, 12.","DOI":"10.3390\/foods12020270"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Calderaro, A., Patan\u00e8, G.T., Tellone, E., Barreca, D., Ficarra, S., Misiti, F., and Lagan\u00e0, G. (2022). The Neuroprotective Potentiality of Flavonoids on Alzheimer\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314835"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1389557519666190617150051","article-title":"The Roles of Flavonols\/Flavonoids in Neurodegeneration and Neuroinflammation","volume":"20","author":"Calis","year":"2020","journal-title":"Mini. Rev. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/ejn.14631","article-title":"Gut microbiota-brain axis in depression: The role of neuroinflammation","volume":"53","author":"Carlessi","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Evans, J., Mendonca, P., and Soliman, K.F.A. (2022). Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases. Nutrients, 14.","DOI":"10.3390\/nu14112228"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13668-018-0226-1","article-title":"Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration","volume":"7","author":"Flanagan","year":"2018","journal-title":"Curr. Nutr. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e2101019","DOI":"10.1002\/mnfr.202101019","article-title":"Urolithins: A Comprehensive Update on their Metabolism, Bioactivity, and Associated Gut Microbiota","volume":"66","author":"Selma","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/BPL-200098","article-title":"Flavonoids as an Intervention for Alzheimer\u2019s Disease: Progress and Hurdles Towards Defining a Mechanism of Action","volume":"6","author":"Hole","year":"2021","journal-title":"Brain Plast."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"136020","DOI":"10.1016\/j.chemosphere.2022.136020","article-title":"Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases","volume":"307","author":"Islam","year":"2022","journal-title":"Chemosphere"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"665031","DOI":"10.3389\/fphar.2021.665031","article-title":"Neuropharmacological Effects of Quercetin: A Literature-Based Review","volume":"12","author":"Islam","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/jmf.2017.4078","article-title":"Beneficial Effects of Flavonoids Against Parkinson\u2019s Disease","volume":"21","author":"Jung","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/biof.1687","article-title":"Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma","volume":"47","author":"Kempuraj","year":"2021","journal-title":"Biofactors"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Khan, A., Ikram, M., Hahm, J.R., and Kim, M.O. (2020). Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders. Antioxidants, 9.","DOI":"10.3390\/antiox9070609"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"111817","DOI":"10.1016\/j.fct.2020.111817","article-title":"Flavonoids targeting NRF2 in neurodegenerative disorders","volume":"146","author":"Khan","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Koklesova, L., Liskova, A., Samec, M., Zhai, K., Al-Ishaq, R.K., Bugos, O., \u0160udomov\u00e1, M., Biringer, K., Pec, M., and Adamkov, M. (2021). Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168649"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"115257","DOI":"10.1016\/j.bcp.2022.115257","article-title":"Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration","volume":"205","author":"Magni","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e11440","DOI":"10.1016\/j.heliyon.2022.e11440","article-title":"Potential therapeutic use of plant flavonoids in AD and PD","volume":"8","author":"Ju","year":"2022","journal-title":"Heliyon"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Nouri, Z., Fakhri, S., El-Senduny, F.F., Sanadgol, N., Abd-ElGhani, G.E., Farzaei, M.H., and Chen, J.T. (2019). On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective. Biomolecules, 9.","DOI":"10.3390\/biom9110690"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8377362","DOI":"10.1155\/2021\/8377362","article-title":"Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina","volume":"2021","author":"Pan","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3389\/fmicb.2017.01521","article-title":"Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid","volume":"8","author":"Selma","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/1440-1681.13691","article-title":"Epigallocatechin gallate for Parkinson\u2019s disease","volume":"49","author":"Sergi","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Winter, A., and Bickford, P.C. (2019). Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease. Antioxidants, 8.","DOI":"10.3390\/antiox8090333"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e13662","DOI":"10.1111\/acel.13662","article-title":"Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis","volume":"21","author":"Olmer","year":"2022","journal-title":"Aging Cell."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.molmed.2021.04.009","article-title":"Impact of the Natural Compound Urolithin A on Health, Disease, and Aging","volume":"27","author":"Andreux","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"101109","DOI":"10.1016\/j.mam.2022.101109","article-title":"Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota","volume":"89","author":"Selma","year":"2023","journal-title":"Mol. Asp. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"j1805","DOI":"10.1136\/bmj.j1805","article-title":"Complementary and integrative medicine in the management of headache","volume":"357","author":"Millstine","year":"2017","journal-title":"BMJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.2147\/NDT.S309065","article-title":"Ameliorative Effect of Parishin C Against Cerebral Ischemia-Induced Brain Tissue Injury by Reducing Oxidative Stress and Inflammatory Responses in Rat Model","volume":"17","author":"Wang","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"583279","DOI":"10.3389\/fphar.2021.583279","article-title":"Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation","volume":"12","author":"Ma","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"827308","DOI":"10.1155\/2015\/827308","article-title":"Neuroprotective Activity of Coptisine from Coptis chinensis (Franch)","volume":"2015","author":"Friedemann","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2174\/1567205019666220805100008","article-title":"Ayurvedic Herbal Therapies: A Review of Treatment and Management of Dementia","volume":"19","author":"Srivastava","year":"2022","journal-title":"Curr. Alzheimer Res."},{"key":"ref_44","first-page":"740","article-title":"Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis","volume":"15","author":"Yang","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tjog.2013.04.005","article-title":"The meridian system and mechanism of acupuncture: A comparative review. Part 3: Mechanisms of acupuncture therapies","volume":"52","author":"Chang","year":"2013","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3727\/036012915X14473562232987","article-title":"A New Theory on the Evaluation of Traditional Chinese Acupuncture Mechanisms from the Latest Medical Scientific Point of View","volume":"40","year":"2015","journal-title":"Acupunct. Electrother. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/jme.21.4.239","article-title":"Chinese Confucian culture and the medical ethical tradition","volume":"21","author":"Guo","year":"1995","journal-title":"J. Med. Ethics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2648.2001.01968.x","article-title":"Chinese values, health and nursing","volume":"36","author":"Chen","year":"2001","journal-title":"J. Adv. Nurs."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11684-012-0173-y","article-title":"Individualized medicine, health medicine, and constitutional theory in Chinese medicine","volume":"6","author":"Wang","year":"2012","journal-title":"Front. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S2095-4964(17)60310-8","article-title":"A review on different English versions of an ancient classic of Chinese medicine: Huang Di Nei Jing","volume":"15","author":"Ye","year":"2017","journal-title":"J. Integr. Med."},{"key":"ref_51","first-page":"325985","article-title":"Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis","volume":"71","author":"Fairbrass","year":"2021","journal-title":"Gut"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/MOG.0000000000000779","article-title":"The bi-directional role of the gut-brain axis in inflammatory and other gastrointestinal diseases","volume":"37","author":"Mogilevski","year":"2021","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"736814","DOI":"10.3389\/fnins.2021.736814","article-title":"Dietary Regulation of Gut-Brain Axis in Alzheimer\u2019s Disease: Importance of Microbiota Metabolites","volume":"15","author":"Frausto","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/07853890.2021.1890330","article-title":"The gut-brain axis and Parkinson disease: Clinical and pathogenetic relevance","volume":"53","author":"Menozzi","year":"2021","journal-title":"Ann. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.coph.2021.08.018","article-title":"Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy","volume":"61","author":"Tang","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"108915","DOI":"10.1016\/j.neuropharm.2021.108915","article-title":"Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases","volume":"205","author":"Matsubara","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"775526","DOI":"10.3389\/fimmu.2021.775526","article-title":"The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/MCP.0000000000000853","article-title":"Lung microbiome, gut-lung axis and chronic obstructive pulmonary disease","volume":"28","author":"Gokulan","year":"2021","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","article-title":"A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"102858","DOI":"10.1016\/j.autneu.2021.102858","article-title":"Transcutaneous vagus nerve stimulation (tVNS) as a potential therapeutic application for neurodegenerative disorders\u2014A focus on dysautonomia in Parkinson\u2019s disease","volume":"235","author":"Ko","year":"2021","journal-title":"Auton. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/17434440.2021.1969913","article-title":"Noninvasive vagus nerve stimulation in Parkinson\u2019s disease: Current status and future prospects","volume":"18","author":"Sigurdsson","year":"2021","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neubiorev.2021.04.018","article-title":"Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms","volume":"127","author":"Wang","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"153001","DOI":"10.1016\/j.tox.2021.153001","article-title":"Chronic consumption of food-additives lead to changes via microbiota gut-brain axis","volume":"464","year":"2021","journal-title":"Toxicology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"113887","DOI":"10.1016\/j.expneurol.2021.113887","article-title":"Potential roles of vagus nerve stimulation on traumatic brain injury: Evidence from in vivo and clinical studies","volume":"247","author":"Srihagulang","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/1545968320948065","article-title":"Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-\u03baB\/NLRP3 Signaling Pathway","volume":"34","author":"Tang","year":"2020","journal-title":"Neurorehabil Neural Repair"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12028-015-0203-0","article-title":"Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury","volume":"24","author":"Neren","year":"2016","journal-title":"Neurocrit Care"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/TA.0b013e3182569875","article-title":"Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury","volume":"72","author":"Lopez","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41420-022-00852-6","article-title":"Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via \u03b17 nicotinic acetylcholine receptor","volume":"8","author":"Tang","year":"2022","journal-title":"Cell. Death Discov."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"G175","DOI":"10.1152\/ajpgi.00368.2020","article-title":"Musings on the wanderer: What\u2019s new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism","volume":"320","author":"Pitra","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"G180","DOI":"10.1152\/ajpgi.00413.2002","article-title":"Musings on the wanderer: What\u2019s new in our understanding of vago-vagal reflexes? III. Activity-dependent plasticity in vago-vagal reflexes controlling the stomach","volume":"284","author":"Travagli","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/seiz.1999.0354","article-title":"Vagus nerve stimulation for epilepsy: A review","volume":"9","author":"Binnie","year":"2000","journal-title":"Seizure"},{"key":"ref_73","first-page":"1145","article-title":"Vagus nerve stimulation in refractory epilepsy: SPECT activation study","volume":"41","author":"Vonck","year":"2000","journal-title":"J. Nucl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1176\/appi.ajp.2017.16010034","article-title":"A 5-Year Observational Study of Patients with Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality","volume":"174","author":"Aaronson","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0006-3223(99)00304-2","article-title":"Vagus nerve stimulation (VNS) for treatment-resistant depressions: A multicenter study","volume":"47","author":"Rush","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/4600","article-title":"Enhanced recognition memory following vagus nerve stimulation in human subjects","volume":"2","author":"Clark","year":"1999","journal-title":"Nat. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/j.sempedsurg.2004.10.019","article-title":"Developmental biology of the enteric nervous system: Pathogenesis of Hirschsprung\u2019s disease and other congenital dysmotilities","volume":"13","author":"Gershon","year":"2004","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-med-042320-014032","article-title":"The Gut-Brain Axis","volume":"73","author":"Mayer","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnagi.2019.00284","article-title":"Neuroinflammation and the Gut Microbiota: Possible Alternative Therapeutic Targets to Counteract Alzheimer\u2019s Disease?","volume":"11","author":"Cerovic","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.3748\/wjg.v23.i30.5486","article-title":"Influence of gut microbiota on neuropsychiatric disorders","volume":"23","author":"Cenit","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1038\/s41598-017-13368-2","article-title":"Therapeutic potential of bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer\u2019s disease","volume":"7","author":"Kobayashi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11910-017-0802-6","article-title":"Microbiota-brain-gut axis and neurodegenerative diseases","volume":"17","author":"Quigley","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/bdi.13049","article-title":"Bipolar disorder and the gut microbiome: A systematic review","volume":"23","author":"Sublette","year":"2021","journal-title":"Bipolar Disord."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Beopoulos, A., Gea, M., Fasano, A., and Iris, F. (2021). Autonomic Nervous System Neuroanatomical Alterations Could Provoke and Maintain Gastrointestinal Dysbiosis in Autism Spectrum Disorder (ASD): A Novel Microbiome-Host Interaction Mechanistic Hypothesis. Nutrients, 14.","DOI":"10.3390\/nu14010065"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/1516-4446-2020-0987","article-title":"The role of the microbiota-gut-brain axis in neuropsychiatric disorders","volume":"43","author":"Generoso","year":"2021","journal-title":"Braz. J. Psychiatry"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/14737175.2019.1638763","article-title":"Microbiota-gut brain axis involvement in neuropsychiatric disorders","volume":"19","author":"Iannone","year":"2019","journal-title":"Expert Rev. Neurother."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"698172","DOI":"10.3389\/fncel.2021.698172","article-title":"The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research","volume":"15","author":"Rosshart","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"705859","DOI":"10.3389\/fped.2021.705859","article-title":"Towards Tailored Gut Microbiome-Based and Dietary Interventions for Promoting the Development and Maintenance of a Healthy Brain","volume":"9","author":"Larroya","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Dicks, L., Hurn, D., and Hermanus, D. (2021). Gut Bacteria and Neuropsychiatric Disorders. Microorganisms, 9.","DOI":"10.3390\/microorganisms9122583"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"105640","DOI":"10.1016\/j.psyneuen.2021.105640","article-title":"The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: A systematic review","volume":"137","author":"Barrio","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fphys.2020.00643","article-title":"Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fnins.2019.00877","article-title":"An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation","volume":"13","author":"Caravaca","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"667036","DOI":"10.3389\/fnins.2021.667036","article-title":"Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease","volume":"15","author":"Mastitskaya","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.neuro.20.1.125","article-title":"The role of vesicular transport proteins in synaptic transmission and neural degeneration","volume":"20","author":"Liu","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02740633","article-title":"Vesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function","volume":"15","author":"Varoqui","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1113\/jphysiol.2013.258947","article-title":"Specific amino acids inhibit food intake via the area postrema or vagal afferents","volume":"59","author":"Jordi","year":"2013","journal-title":"J. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.3945\/ajcn.2009.27462W","article-title":"Protein, amino acids, vagus nerve signaling, and the brain","volume":"90","author":"Schwarz","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/acschemneuro.5b00260","article-title":"Pomegranate\u2019s Neuroprotective Effects against Alzheimer\u2019s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites","volume":"7","author":"Yuan","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Ishii, Y., Muta, O., Teshima, T., Hirasima, N., Odaka, M., Fushimi, T., Fujii, Y., and Osakabe, N. (2021). Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation. Nutrients, 13.","DOI":"10.20944\/preprints202109.0268.v1"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Lin, T., Lu, C.W., Hsieh, P.W., Chiu, K.M., Lee, M.Y., and Wang, S.J. (2021). Natural Product Isoliquiritigenin Activates GABAB Receptors to Decrease Voltage-Gate Ca2+ Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals. Biomolecules, 11.","DOI":"10.3390\/biom11101537"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/acschemneuro.0c00684","article-title":"Inhibitory Mechanism of the Isoflavone Derivative Genistein in the Human CaV3.3 Channel","volume":"12","author":"Rangel","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/vms3.318","article-title":"Baicalin prevents the up-regulation of TRPV1 in dorsal root ganglion and attenuates chronic neuropathic pain","volume":"6","author":"Wang","year":"2020","journal-title":"Vet. Med. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13041-019-0428-5","article-title":"Baicalin regulates the dopamine system to control the core symptoms of ADHD","volume":"12","author":"Zhou","year":"2019","journal-title":"Mol. Brain"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/acschemneuro.9b00547","article-title":"The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels","volume":"10","author":"Zhou","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1021\/acschemneuro.8b00493","article-title":"CGRPergic Nerve TRPA1 Channels Contribute to Epigallocatechin Gallate-Induced Neurogenic Vasodilation","volume":"10","author":"Soni","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/WNR.0000000000001138","article-title":"Effects of baicalin on diabetic neuropathic pain involving transient receptor potential vanilloid 1 in the dorsal root ganglia of rats","volume":"29","author":"Li","year":"2018","journal-title":"Neuroreport"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2015.05.035","article-title":"Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus","volume":"762","author":"Chang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1089\/jmf.2014.3219","article-title":"Myricetin inhibits the release of glutamate in rat cerebrocortical nerve terminals","volume":"18","author":"Chang","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Lin, T., Hung, C.F., Weng, J.R., Hsieh, T.Y., and Wang, S.J. (2022). Kaempferol 3-Rhamnoside on Glutamate Release from Rat Cerebrocortical Nerve Terminals Involves P\/Q-Type Ca2+ Channel and Ca2+\/Calmodulin-Dependent Protein Kinase II-Dependent Pathway Suppression. Molecules, 27.","DOI":"10.3390\/molecules27041342"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wang, C., Hsieh, P.W., Kuo, J.R., and Wang, S.J. (2021). Rosmarinic Acid, a Bioactive Phenolic Compound, Inhibits Glutamate Release from Rat Cerebrocortical Synaptosomes through GABAA Receptor Activation. Biomolecules, 11.","DOI":"10.3390\/biom11071029"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/09168451.2018.1444467","article-title":"Flavonoid metabolism: The interaction of metabolites and gut microbiota","volume":"82","author":"Murota","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Suraweera, T., Rupasinghe, H.P.V., Dellaire, G., and Xu, Z. (2020). Regulation of Nrf2\/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?. Antioxidants, 9.","DOI":"10.3390\/antiox9100973"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"100057","DOI":"10.1016\/j.mbplus.2021.100057","article-title":"The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix","volume":"10","author":"Hiebert","year":"2021","journal-title":"Matrix Biol Plus"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Vomund, S., Sch\u00e4fer, A., Parnham, M.J., Br\u00fcne, B., and von Knethen, A. (2017). Nrf2, the Master Regulator of Anti-Oxidative Responses. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122772"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Heurtaux, T., Bouvier, D.S., Benani, A., Helgueta Romero, S., Frauenknecht, K.B.M., Mittelbronn, M., and Sinkkonen, L. (2022). Normal and Pathological NRF2 Signalling in the Central Nervous System. Antioxidants, 11.","DOI":"10.3390\/antiox11081426"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Cores, \u00c1., Piquero, M., Villacampa, M., Le\u00f3n, R., and Men\u00e9ndez, J.C. (2020). NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules, 10.","DOI":"10.3390\/biom10060904"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"147661","DOI":"10.1016\/j.brainres.2021.147661","article-title":"Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2","volume":"1772","author":"Guan","year":"2021","journal-title":"Brain Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3389\/fphar.2020.00662","article-title":"Dihydroquercetin Activates AMPK\/Nrf2\/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice","volume":"11","author":"Lei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Sun, L., Xu, G., Dong, Y., Li, M., Yang, L., and Lu, W. (2020). Quercetin Protects Against Lipopolysaccharide-Induced Intestinal Oxidative Stress in Broiler Chickens through Activation of Nrf2 Pathway. Molecules, 25.","DOI":"10.3390\/molecules25051053"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"111017","DOI":"10.1016\/j.biopha.2020.111017","article-title":"Myricetin: A review of the most recent research","volume":"134","author":"Song","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"13917","DOI":"10.1007\/s11356-021-16711-3","article-title":"Kaempferol prevents cadmium chloride-induced liver damage by upregulating Nrf2 and suppressing NF-\u03baB and keap1","volume":"29","author":"Alshehri","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1080\/13880209.2021.1961823","article-title":"Kaempferol induced GPER upregulation attenuates atherosclerosis via the PI3K\/AKT\/Nrf2 pathway","volume":"59","author":"Feng","year":"2021","journal-title":"Pharm. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1002\/ptr.7033","article-title":"New insights into the role of the Nrf2 signaling pathway in green tea catechin applications","volume":"35","author":"Talebi","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"120019","DOI":"10.1016\/j.lfs.2021.120019","article-title":"Gallocatechin-silver nanoparticle impregnated cotton gauze patches enhance wound healing in diabetic rats by suppressing oxidative stress and inflammation via modulating the Nrf2\/HO-1 and TLR4\/NF-\u03baB pathways","volume":"286","author":"Vendidandala","year":"2021","journal-title":"Life Sci."},{"key":"ref_127","first-page":"9420704","article-title":"Apigenin Protects Mouse Retina against Oxidative Damage by Regulating the Nrf2 Pathway and Autophagy","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1007\/s11033-020-05346-1","article-title":"Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, antiinflammatory, anti-apoptotic, and Nrf2\/HO-1 signaling pathways","volume":"47","author":"Albarakati","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/iub.2066","article-title":"Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2\/ARE\/ HO-1 pathway","volume":"71","author":"Gowthami","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_130","first-page":"1","article-title":"Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells","volume":"51","author":"Kang","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1111\/jcmm.16604","article-title":"Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-\u03baB signalling suppression","volume":"25","author":"Dai","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"118192","DOI":"10.1016\/j.lfs.2020.118192","article-title":"Protective role of wogonin against cadmium induced testicular toxicity: Involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways","volume":"258","author":"Yu","year":"2020","journal-title":"Life Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/FJC.0000000000000989","article-title":"Chrysin Ameliorates Sepsis-Induced Cardiac Dysfunction through Upregulating Nfr2\/Heme Oxygenase 1 Pathway","volume":"77","author":"Xingyue","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1007\/s11010-021-04105-5","article-title":"Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats","volume":"476","author":"Yuvaraj","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"173399","DOI":"10.1016\/j.ejphar.2020.173399","article-title":"Daidzein ameliorates LPSinduced hepatocyte injury by inhibiting inflammation and oxidative stress","volume":"885","author":"Yu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-020-01009-8","article-title":"Involvement of \u03b17nAChR in the Protective Effects of Genistein against \u03b2-Amyloid-Induced Oxidative Stress in Neurons via a PI3K\/Akt\/Nrf2 Pathway-Related Mechanism","volume":"41","author":"Guo","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbrc.2020.04.100","article-title":"Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling","volume":"527","author":"Wang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5603\/FHC.a2021.0006","article-title":"Genistein exerts a cell-protective effect via Nrf2\/HO-1\/ \/PI3K signaling in Ab25-35-induced Alzheimer\u2019s disease models in vitro","volume":"59","author":"Yi","year":"2021","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1800975","DOI":"10.1002\/mnfr.201800975","article-title":"Hesperidin Protects against Intestinal Inflammation by Restoring Intestinal Barrier Function and up-Regulating Treg Cells","volume":"63","author":"Guo","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"19426","DOI":"10.1038\/s41598-020-76156-5","article-title":"Hesperidin ameliorates hypobaric hypoxiainduced retinal impairment through activation of Nrf2\/HO-1 pathway and inhibition of apoptosis","volume":"10","author":"Xin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.biopha.2019.01.030","article-title":"Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2\/are\/glyoxalase 1 pathway","volume":"111","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1039\/D0FO02736G","article-title":"Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K\/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1039\/C9FO02552A","article-title":"The protective effect of hesperetin in osteoarthritis: An in vitro and in vivo study","volume":"11","author":"Lin","year":"2020","journal-title":"Food Funct."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4053276","DOI":"10.1155\/2021\/4053276","article-title":"Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/1028415X.2019.1594554","article-title":"Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptormediated antioxidant defense and attenuates methylglyoxalinduced neurite damage and apoptotic death","volume":"24","author":"Tseng","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3389\/fphar.2017.00868","article-title":"Pelargonidin Modulates Keap1\/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells","volume":"8","author":"Anand","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s10787-021-00799-7","article-title":"Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress","volume":"29","author":"Rahman","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1208\/s12248-019-0355-5","article-title":"Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway","volume":"21","author":"Kuo","year":"2019","journal-title":"AAPS J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1111\/1750-3841.15153","article-title":"Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt\/Nrf2 pathway","volume":"85","author":"Zheng","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"109547","DOI":"10.1016\/j.biopha.2019.109547","article-title":"Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling","volume":"122","author":"Qi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1039\/D0FO03353G","article-title":"Cardamonin protects nucleus pulposus cells against IL-1\u03b2-induced inflammation and catabolism via Nrf2\/NF-\u03baB axis","volume":"12","author":"Xie","year":"2021","journal-title":"Food Funct. J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"111238","DOI":"10.1016\/j.biopha.2021.111238","article-title":"Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice","volume":"137","author":"Chen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4155\/fmc-2021-0241","article-title":"Xanthohumol alleviates T2DM-induced liver steatosis and fibrosis by mediating the NRF2\/RAGE\/NF-\u03baB signaling pathway","volume":"13","author":"Wang","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"7161592","DOI":"10.1155\/2018\/7161592","article-title":"Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2\/HO-1 Pathway","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.3748\/wjg.v10.i13.1854","article-title":"Theory of traditional Chinese medicine and therapeutic method of diseases","volume":"10","author":"Lu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.tips.2005.09.006","article-title":"Therapeutic wisdom in traditional Chinese medicine: A perspective from modern science","volume":"26","author":"Jiang","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"13205","DOI":"10.1021\/acs.jmedchem.0c00626","article-title":"Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)","volume":"63","author":"Choudhry","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"113854","DOI":"10.1016\/j.jep.2021.113854","article-title":"Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification","volume":"271","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"109370","DOI":"10.1016\/j.biopha.2019.109370","article-title":"A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer\u2019s disease","volume":"120","author":"Zeng","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.2147\/DDDT.S315060","article-title":"Network Pharmacology and Experimental Evidence: PI3K\/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug. Des. Devel. Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"112940","DOI":"10.1016\/j.jep.2020.112940","article-title":"Network pharmacology-based strategy to investigate pharmacological mechanisms of Tinospora sinensis for treatment of Alzheimer\u2019s disease","volume":"259","author":"Zhou","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3176483","DOI":"10.1155\/2019\/3176483","article-title":"The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance","volume":"2019","author":"Xu","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"113839","DOI":"10.1016\/j.ejmech.2021.113839","article-title":"Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine","volume":"226","author":"Singh","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1080\/21655979.2021.1996508","article-title":"Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes","volume":"12","author":"Cai","year":"2021","journal-title":"Bioengineered"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2021.09.005","article-title":"Berberine exerts neuroprotective activities against cerebral ischemia\/reperfusion injury through up-regulating PPAR-\u03b3 to suppress NF-\u03baB-mediated pyroptosis","volume":"177","author":"Zhao","year":"2021","journal-title":"Brain Res. Bull."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/np060516h","article-title":"Aurantiomides A-C, quinazoline alkaloids from the sponge-derived fungus Penicillium aurantiogriseum SP0-19","volume":"70","author":"Xin","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1021\/acs.jnatprod.1c00585","article-title":"Total Syntheses and Anti-inflammatory Activities of Syringin and Its Natural Analogues","volume":"84","author":"Dong","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1055\/s-0034-1368614","article-title":"Phillyrin, a natural lignan, attenuates tumor necrosis factor \u03b1-mediated insulin resistance and lipolytic acceleration in 3T3-L1 adipocytes","volume":"80","author":"Kong","year":"2014","journal-title":"Planta Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"956218","DOI":"10.3389\/fnut.2022.956218","article-title":"Phillyrin restores metabolic disorders in mice fed with high-fat diet through inhibition of interleukin-6-mediated basal lipolysis","volume":"9","author":"Fang","year":"2022","journal-title":"Front Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41401-020-0483-6","article-title":"Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients","volume":"41","author":"Su","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_171","first-page":"857","article-title":"Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex","volume":"57","author":"Wang","year":"2002","journal-title":"Pharmazie"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1055\/s-0029-1243121","article-title":"Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site","volume":"66","author":"Hui","year":"2000","journal-title":"Planta Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-2005-873193","article-title":"Anxiolytic-Like Effect of baicalin and its additivity with other anxiolytics","volume":"72","author":"Xu","year":"2006","journal-title":"Planta Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(03)01422-5","article-title":"Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice","volume":"464","author":"Liao","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1078\/0944-7113-00374","article-title":"Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic properties","volume":"10","author":"Awad","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2011.02.038","article-title":"Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice","volume":"221","author":"Duarte","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejphar.2007.07.011","article-title":"Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis","volume":"574","author":"Park","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_178","first-page":"14","article-title":"An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways","volume":"25","author":"Hu","year":"2022","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1016\/j.bmc.2008.04.067","article-title":"Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor","volume":"16","author":"Kichik","year":"2008","journal-title":"Bioorganic Med. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bcp.2019.01.013","article-title":"New tricks of prolyl oligopeptidase inhibitors\u2014A common drug therapy for several neurodegenerative diseases","volume":"161","author":"Svarcbahs","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/138920308783565723","article-title":"Structure, function and biological relevance of prolyl oligopeptidase","volume":"9","author":"Szeltner","year":"2008","journal-title":"Curr. Protein. Pept. Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"S482","DOI":"10.4103\/0973-1296.191464","article-title":"Elucidation of Molecular Mechanism(s) of Cognition Enhancing Activity of Bacomind\u00ae: A Standardized Extract of Bacopa Monnieri","volume":"12","author":"Dethe","year":"2016","journal-title":"Pharmacogn. Mag."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"9634","DOI":"10.1111\/jcmm.16910","article-title":"Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy","volume":"25","author":"Cui","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"110788","DOI":"10.1016\/j.biopha.2020.110788","article-title":"Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells","volume":"131","author":"Rostami","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"10827","DOI":"10.1038\/s41598-017-11302-0","article-title":"New compounds identified through in silico approaches reduce the \u03b1-synuclein expression by inhibiting prolyl oligopeptidase in vitro","volume":"7","author":"Kumar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.euroneuro.2016.02.015","article-title":"Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume","volume":"26","author":"Kulesskaya","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"104820","DOI":"10.1016\/j.phrs.2020.104820","article-title":"Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study","volume":"157","author":"Yang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_188","first-page":"3848084","article-title":"Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential","volume":"2022","author":"Quispe","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Yamada, H., Wakamori SHirokane, T., Ikeuchi, K., and Matsumoto, S. (2018). Structural revisions in natural ellagitannins. Molecules, 23.","DOI":"10.3390\/molecules23081901"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.4103\/1673-5374.335163","article-title":"Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice","volume":"17","author":"Gong","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jnutbio.2009.04.012","article-title":"Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism","volume":"21","author":"Larrosa","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"289","DOI":"10.17306\/J.AFS.2014.3.7","article-title":"The structure, occurrence and biological activity of ellagitannins: A general review","volume":"13","author":"Klewicka","year":"2014","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Alfei, S., Marengo, B., and Zuccari, G. (2020). Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?. Antioxidants, 9.","DOI":"10.3390\/antiox9080707"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.1021\/jf9025794","article-title":"Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay","volume":"57","author":"Bialonska","year":"2009","journal-title":"J. Agric. Food. Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/jf049144d","article-title":"Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: Identification of biomarkers and individual variability","volume":"53","year":"2005","journal-title":"J. Agr. Food. Chem."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"5194508","DOI":"10.1155\/2020\/5194508","article-title":"Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress","volume":"2020","author":"Djedjibegovic","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/mnfr.201100677","article-title":"Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-\u03b1-induced inflammation and associated molecular markers in human aortic endothelial cells","volume":"56","author":"Larrosa","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Toney, A., Albusharif, M., Works, D., Polenz, L., Schlange, S., Chaidez, V., Ramer-Tait, A.E., and Chung, S. (2020). Differential Effects of Whole Red Raspberry Polyphenols and Their Gut Metabolite Urolithin A on Neuroinflammation in BV-2 Microglia. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18010068"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"19963","DOI":"10.1038\/s41598-020-77003-3","article-title":"High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents","volume":"10","author":"Kanjanasirirat","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Jayatunga, D., Hone, E., Khaira, H., Lunelli, T., Singh, H., Guillemin, G.J., Fernando, B., Garg, M.L., Verdile, G., and Martins, R.N. (2021). Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer\u2019s Disease. Nutrients, 13.","DOI":"10.3390\/nu13113744"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"966276","DOI":"10.3389\/fnut.2022.966276","article-title":"Identification of ellagic acid and urolithins as natural inhibitors of A\u03b225-35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking","volume":"9","author":"Li","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1039\/D1FO02534A","article-title":"Urolithin A protects dopaminergic neurons in experimental models of Parkinson\u2019s disease by promoting mitochondrial biogenesis through the SIRT1\/PGC-1\u03b1 signaling pathway","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"108963","DOI":"10.1016\/j.neuropharm.2022.108963","article-title":"Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson\u2019s disease model","volume":"207","author":"Qiu","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/1028415X.2017.1360558","article-title":"Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro","volume":"22","author":"DaSilva","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Kujawska, M., Jourdes, M., Kurpik, M., Szulc, M., Szaefer, H., Chmielarz, P., Kreiner, G., Krajka-Ku\u017aniak, V., Miko\u0142ajczak, P.\u0141., and Teissedre, P.L. (2019). Neuroprotective Effects of Pomegranate Juice against Parkinson\u2019s Disease and Presence of Ellagitannins-Derived Metabolite-Urolithin A-In the Brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010202"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/acs.jafc.7b03285","article-title":"Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-\u03baB Signaling Pathways","volume":"66","author":"Xu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00394-020-02386-y","article-title":"Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions","volume":"60","author":"Bobowska","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Singh, R., Chandrashekharappa, S., Vemula, P.K., Haribabu, B., and Jala, V.R. (2020). Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme. Metabolites, 10.","DOI":"10.3390\/metabo10060258"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.2174\/092986712800672102","article-title":"Protocatechuic acid and human disease prevention: Biological activities and molecular mechanisms","volume":"19","author":"Masella","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"11551","DOI":"10.1021\/jf303712e","article-title":"Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits","volume":"60","author":"Li","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"113285","DOI":"10.1016\/j.expneurol.2020.113285","article-title":"Crosstalk between the mTOR and Nrf2\/ARE signaling pathways as a target in the improvement of long-term potentiation","volume":"328","author":"Gureev","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"173588","DOI":"10.1016\/j.ejphar.2020.173588","article-title":"Phytochemical compounds targeting on Nrf2 for chemoprevention in colorectal cancer","volume":"887","author":"Zhu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/jnr.23986","article-title":"Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease","volume":"95","author":"Pennisi","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","article-title":"The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans","volume":"1","author":"Andreux","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"e2144279","DOI":"10.1001\/jamanetworkopen.2021.44279","article-title":"Effect of Urolithin A Supplementation on Muscle Endurance and and Mitochondrial Health in Older Adults: A Randomized Clinical Trial","volume":"5","author":"Liu","year":"2022","journal-title":"JAMA Netw. Open."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"100633","DOI":"10.1016\/j.xcrm.2022.100633","article-title":"Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults","volume":"3","author":"Singh","year":"2022","journal-title":"Cell. Rep. Med."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Cium\u0103rnean, L., Milaciu, M.V., Runcan, O., Vesa, \u0218.C., R\u0103chi\u0219an, A.L., Negrean, V., Pern\u00e9, M.G., Donca, V.I., Alexescu, T.G., and Para, I. (2020). The Effects of Flavonoids in Cardiovascular Diseases. Molecules, 25.","DOI":"10.3390\/molecules25184320"},{"key":"ref_219","first-page":"378","article-title":"Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients","volume":"26","year":"2007","journal-title":"Int. Angiol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"2073S","DOI":"10.1093\/jn\/130.8.2073S","article-title":"Dietary intake and bioavailability of polyphenols","volume":"130","author":"Scalbert","year":"2000","journal-title":"J. Nutr."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mnfr.201500761","article-title":"Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats","volume":"60","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vph.2018.08.008","article-title":"Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo","volume":"111","author":"Migkos","year":"2018","journal-title":"Vascul. Pharmacol."},{"key":"ref_224","first-page":"345","article-title":"Green tea catechins: Defensive role in cardiovascular disorders","volume":"11","author":"Bhardwaj","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"622640","DOI":"10.3389\/fnins.2021.622640","article-title":"Integrated Multi-Omic Analyses of the Genomic Modifications by Gut Microbiome-Derived Metabolites of Epicatechin, 5-(4\u2019-Hydroxyphenyl)-\u03b3-Valerolactone, in TNFalpha-Stimulated Primary Human Brain Microvascular Endothelial Cells","volume":"15","author":"Nuthikattu","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"104603","DOI":"10.1016\/j.jprot.2022.104603","article-title":"Structurally related (-)-epicatechin metabolites and gut microbiota derived metabolites exert genomic modifications via VEGF signaling pathways in brain microvascular endothelial cells under lipotoxic conditions: Integrated multi-omic study","volume":"263","author":"Nuthikattu","year":"2022","journal-title":"J. Proteomics"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2011.04.032","article-title":"Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties","volume":"51","author":"Lotito","year":"2011","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/acs.chemrev.7b00698","article-title":"Redox signaling by reactive electrophiles and oxidants","volume":"118","author":"Parvez","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.fct.2007.10.006","article-title":"Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG","volume":"46","author":"Na","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"910785","DOI":"10.3389\/fnut.2022.910785","article-title":"Intra- and Inter-individual Differences in the Human Intestinal Microbial Conversion of (-)-Epicatechin and Bioactivity of Its Major Colonic Metabolite 5-(3\u2019,4\u2019-Dihydroxy-Phenyl)-\u03b3-Valerolactone in Regulating Nrf2-Mediated Gene Expression","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/10715760802506349","article-title":"Singlet oxygen quenching by anthocyanin\u2019s flavylium cations","volume":"42","author":"Mercadante","year":"2008","journal-title":"Free. Radic. Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3390\/ijms160921555","article-title":"Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells--A Review","volume":"16","author":"Kamiloglu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"6038996","DOI":"10.1155\/2022\/6038996","article-title":"Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer\u2019s Disease","volume":"2022","author":"Minocha","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"27","DOI":"10.31083\/j.fbe1404027","article-title":"Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline","volume":"14","author":"Melrose","year":"2022","journal-title":"Front. Biosci. Elite"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Speisky, H., Shahidi, F., Costa de Camargo, A., and Fuentes, J. (2022). Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties. Antioxidants, 11.","DOI":"10.3390\/antiox11010133"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"952943","DOI":"10.1155\/2014\/952943","article-title":"A review on protocatechuic Acid and its pharmacological potential","volume":"2014","author":"Kakkar","year":"2014","journal-title":"ISRN Pharmacol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/1028415X.2017.1354543","article-title":"Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans","volume":"22","author":"Krzysztoforska","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2963540","DOI":"10.1155\/2020\/2963540","article-title":"Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia","volume":"2020","author":"He","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s11064-011-0493-3","article-title":"Hesperidin, a flavone glycoside, as mediator of neuronal survival","volume":"36","author":"Nones","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ejmech.2016.03.057","article-title":"Multi-target screening mines hesperidin as a multi-potent inhibitor: Implication in Alzheimer\u2019s disease therapeutics","volume":"121","author":"Chakraborty","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijbiomac.2021.02.073","article-title":"Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer\u2019s disease therapeutics","volume":"176","author":"Chakraborty","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10571-014-0098-x","article-title":"Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer\u2019s disease","volume":"34","author":"Wang","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Hajialyani, M., Hosein Farzaei, M., Echeverr\u00eda, J., Nabavi, S.M., Uriarte, E., and Sobarzo-S\u00e1nchez, E. (2019). Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence. Molecules, 24.","DOI":"10.3390\/molecules24030648"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1007\/s11064-018-2589-5","article-title":"Neohesperidin Prevents A\u03b225-35-Induced Apoptosis in Primary Cultured Hippocampal Neurons by Blocking the S-Nitrosylation of Protein-Disulphide Isomerase","volume":"43","author":"Wang","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12272-015-0662-z","article-title":"Hesperidin attenuates learning and memory deficits in APP\/PS1 mice through activation of Akt\/Nrf2 signaling and inhibition of RAGE\/NF-\u03baB signaling","volume":"41","author":"Hong","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/1871524914666140826111930","article-title":"Plant secondary metabolites- potent inhibitors of monoamine oxidase isoforms","volume":"14","author":"Mathew","year":"2014","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1021\/acs.jafc.5b06043","article-title":"Kaempferol as Selective Human MAO-A Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies","volume":"64","author":"Gidaro","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1021\/acs.jafc.0c04502","article-title":"Luteolin, a Potent Human Monoamine Oxidase-A Inhibitor and Dopamine D4 and Vasopressin V1A Receptor Antagonist","volume":"68","author":"Park","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"100740","DOI":"10.1016\/j.xcrm.2022.100740","article-title":"A genetically modified minipig model for Alzheimer\u2019s disease with SORL1 haploinsufficiency","volume":"3","author":"Andersen","year":"2022","journal-title":"Cell. Rep. Med."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41593-018-0236-8","article-title":"Animal models of neurodegenerative diseases","volume":"21","author":"Dawson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1012422","DOI":"10.3389\/fnana.2022.1012422","article-title":"Neuroprotective effect of naringin against cerebellar changes in Alzheimer\u2019s disease through modulation of autophagy, oxidative stress and tau expression: An experimental study","volume":"16","author":"Hassan","year":"2022","journal-title":"Front. Neuroanat."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/path.4654","article-title":"Genetically modified pig models for neurodegenerative disorders","volume":"238","author":"Holm","year":"2016","journal-title":"J. Pathol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.addr.2007.08.013","article-title":"Transgenic animal models of neurodegenerative diseases and their application to treatment development","volume":"59","author":"Rockenstein","year":"2007","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s13238-022-00912-8","article-title":"New pathogenic insights from large animal models of neurodegenerative diseases","volume":"13","author":"Yin","year":"2022","journal-title":"Protein Cell."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13578-021-00729-8","article-title":"Genetically modified large animal models for investigating neurodegenerative diseases","volume":"11","author":"Yang","year":"2021","journal-title":"Cell. Biosci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3945\/jn.109.109785","article-title":"Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice","volume":"139","author":"Lee","year":"2009","journal-title":"J. Nutr."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainres.2008.02.107","article-title":"Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice","volume":"1214","author":"Arendash","year":"2008","journal-title":"Brain Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s12263-009-0137-2","article-title":"The impact of flavonoids on spatial memory in rodents: From behaviour to underlying hippocampal mechanisms","volume":"4","author":"Rendeiro","year":"2009","journal-title":"Genes. Nutr."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jsfa.6473","article-title":"Effect of flavonoids on learning, memory and neurocognitive performance: Relevance and potential implications for Alzheimer\u2019s disease pathophysiology","volume":"94","author":"Vauzour","year":"2014","journal-title":"J. Sci. Food Agric."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"623753","DOI":"10.1155\/2012\/623753","article-title":"Anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder","volume":"2012","author":"Zhang","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3233\/JAD-210735","article-title":"Flavonoids with Potential Anti-Amyloidogenic Effects as Therapeutic Drugs for Treating Alzheimer\u2019s Disease","volume":"84","author":"Wang","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phymed.2018.03.057","article-title":"Flavonoids as Th1\/Th2 cytokines immunomodulators: A systematic review of studies on animal models","volume":"44","author":"Gandhi","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/WNR.0000000000000803","article-title":"(-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer\u2019s disease","volume":"28","author":"Guo","year":"2017","journal-title":"Neuroreport"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.2147\/DDDT.S289473","article-title":"Epigallocatechin-3-Gallate Provides Protection Against Alzheimer\u2019s Disease-Induced Learning and Memory Impairments in Rats","volume":"15","author":"Nan","year":"2021","journal-title":"Drug. Des. Devel. Ther."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"153316","DOI":"10.1016\/j.phymed.2020.153316","article-title":"The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer\u2019s disease animal model: A systematic review","volume":"79","author":"Zhang","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Zhang, X., Chen, J.Y., Ouyang, D., and Lu, J.H. (2020). Quercetin in Animal Models of Alzheimer\u2019s Disease: A Systematic Review of Preclinical Studies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020493"},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Fakhri, S., Abdian, S., Zarneshan, S.N., Akkol, E.K., Farzaei, M.H., and Sobarzo-S\u00e1nchez, E. (2021). Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212570"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbi.2019.04.016","article-title":"The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials","volume":"307","author":"Lorzadeh","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"651441","DOI":"10.3389\/fnut.2021.651441","article-title":"Effects of Flavonoid Supplementation on Common Eye Disorders: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"8","author":"Davinelli","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ptr.6046","article-title":"Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial","volume":"32","author":"Homayouni","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10151-015-1302-9","article-title":"Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: A prospective, randomized, triple-blind, controlled trial","volume":"19","author":"Giannini","year":"2015","journal-title":"Tech. Coloproctol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1039\/D0FO03456H","article-title":"8 weeks of 2S-Hesperidin supplementation improves muscle mass and reduces fat in amateur competitive cyclists: Randomized controlled trial","volume":"12","author":"Alcaraz","year":"2021","journal-title":"Food Funct."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12970-020-00399-w","article-title":"The effect of citrus flavonoid extract supplementation on anaerobic capacity in moderately trained athletes: A randomized controlled trial","volume":"18","author":"Stevens","year":"2021","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1111\/jocd.14063","article-title":"The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial","volume":"20","author":"Sheen","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1871524922666220404164405","article-title":"Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective Agent","volume":"22","author":"Joshi","year":"2022","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.gim.2022.06.011","article-title":"Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study)","volume":"24","author":"Langohr","year":"2022","journal-title":"Genet. Med."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1001\/jamadermatol.2022.1736","article-title":"Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial","volume":"158","author":"Zhao","year":"2022","journal-title":"JAMA Dermatol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1111\/ajd.13612","article-title":"Topical epigallocatechin-3-gallate in the treatment of vitiligo","volume":"62","author":"Hu","year":"2021","journal-title":"Australas. J. Dermatol."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Ud-Din, S., Wilgus, T.A., McGeorge, D.D., and Bayat, A. (2021). Pre-Emptive Priming of Human Skin Improves Cutaneous Scarring and Is Superior to Immediate and Delayed Topical Anti-Scarring Treatment Post-Wounding: A Double-Blind Randomised Placebo-Controlled Clinical Trial. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13040510"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.jid.2019.01.030","article-title":"A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin","volume":"139","author":"Foden","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Din, U., Sian, T.S., Deane, C.S., Smith, K., Gates, A., Lund, J.N., Williams, J.P., Rueda, R., Pereira, S.L., and Atherton, P.J. (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13.","DOI":"10.3390\/nu13113895"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1038\/s41598-021-98612-6","article-title":"The combined effect of green tea and \u03b1-glucosyl hesperidin in preventing obesity: A randomized placebo-controlled clinical trial","volume":"11","author":"Yoshitomi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1515\/jcim-2020-0090","article-title":"Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: A clinical trial","volume":"18","author":"Bazyar","year":"2020","journal-title":"J. Complement. Integr. Med."},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"de Morais Junior, A., Schincaglia, R.M., Passarelli, M., Pimentel, G.D., and Mota, J.F. (2020). Acute Epigallocatechin-3-Gallate Supplementation Alters Postprandial Lipids after a Fast-Food Meal in Healthy Young Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Nutrients, 12.","DOI":"10.3390\/nu12092533"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.clnu.2019.02.028","article-title":"A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome","volume":"39","author":"Xicota","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1021\/jf001491+","article-title":"Metabolic fate of (-)-[4-(3)H]epigallocatechin gallate in rats after oral administration","volume":"49","author":"Kohri","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1039\/C8NP00062J","article-title":"Phenyl-gamma-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: Synthesis, analysis, bioavailability, and bioactivity","volume":"36","author":"Mena","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41591-018-0297-y","article-title":"Blood\u2013brain barrier breakdown is an early biomarker of human cognitive dysfunction","volume":"25","author":"Nation","year":"2019","journal-title":"Nat. Med."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1021\/jf903375s","article-title":"Metabolism of (-)-epigallocatechin gallate by rat intestinal flora","volume":"58","author":"Takagaki","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1021\/jf900458e","article-title":"Degradation and metabolism of catechin, epigallocatechin-3-gallate (EGCG), and related compounds by the intestinal microbiota in the pig cecum model","volume":"57","author":"Humpf","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2125.2012.04378.x","article-title":"The neuroprotective effects of cocoa flavanol and its influence on cognitive performance","volume":"75","author":"Nehlig","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3233\/JAD-132231","article-title":"Cocoa extracts reduce oligomerization of amyloid-beta: Implications for cognitive improvement in Alzheimer\u2019s disease","volume":"41","author":"Wang","year":"2014","journal-title":"J. Alzheimers. Dis."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.neubiorev.2013.06.013","article-title":"Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior","volume":"37","author":"Sokolov","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jagp.2022.10.002","article-title":"A Randomised Placebo-Controlled Study of Purified Anthocyanins on Cognition in Individuals at Increased Risk for Dementia","volume":"31","author":"Aarsland","year":"2023","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3389\/fneur.2020.00916","article-title":"Effects of Purified Anthocyanins in People at Risk for Dementia: Study Protocol for a Phase II Randomized Controlled Trial","volume":"11","author":"Khalifa","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/ptr.7659","article-title":"Dietary intake of anthocyanins improves arterial stiffness, but not endothelial function, in volunteers with excess weight: A randomized clinical trial","volume":"37","author":"Arisi","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nutres.2022.04.003","article-title":"Anthocyanin intake is associated with improved memory in older adults with mild cognitive impairment","volume":"104","author":"Kent","year":"2022","journal-title":"Nutr. Res."},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Krikorian, R., Skelton, M.R., Summer, S.S., Shidler, M.D., and Sullivan, P.G. (2022). Blueberry Supplementation in Midlife for Dementia Risk Reduction. Nutrients, 14.","DOI":"10.3390\/nu14081619"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"102273","DOI":"10.1016\/j.redox.2022.102273","article-title":"A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects","volume":"51","author":"Cremonini","year":"2022","journal-title":"Redox Biol."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Emamat, H., Zahedmehr, A., Asadian, S., and Nasrollahzadeh, J. (2022). The effect of barberry (Berberis integerrima) on lipid profile and systemic inflammation in subjects with cardiovascular risk factors: A randomized controlled trial. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03539-8"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"103533","DOI":"10.1016\/j.ebiom.2021.103533","article-title":"Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial","volume":"70","author":"Tian","year":"2021","journal-title":"EBioMedicine"},{"key":"ref_302","doi-asserted-by":"crossref","unstructured":"Ahles, S., Joris, P.J., and Plat, J. (2021). Effects of Berry Anthocyanins on Cognitive Performance, Vascular Function and Cardiometabolic Risk Markers: A Systematic Review of Randomized Placebo-Controlled Intervention Studies in Humans. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126482"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1080\/1028415X.2021.1880312","article-title":"The effects of polyphenols-rich tropical fruit juice on cognitive function and metabolomics profile\u2014A randomized controlled trial in middle-aged women","volume":"25","author":"Rosli","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.numecd.2020.11.024","article-title":"Food anthocyanins decrease concentrations of TNF-\u03b1 in older adults with mild cognitive impairment: A randomized, controlled, double blind clinical trial","volume":"31","author":"Fitzgerald","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.clnu.2020.09.041","article-title":"Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial","volume":"40","author":"Chang","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_306","first-page":"8700","article-title":"Effect of quercetin glycosides on cognitive functions and cerebral blood flow: A randomized, double-blind, and placebo-controlled study","volume":"26","author":"Nakamura","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_307","first-page":"22","article-title":"Senolytic Therapy to Modulate the Progression of Alzheimer\u2019s Disease (SToMP-AD): A Pilot Clinical Trial","volume":"9","author":"Gonzales","year":"2022","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"917867","DOI":"10.3389\/fnins.2022.917867","article-title":"Neuroprotective Drug Discovery From Phytochemicals and Metabolites for CNS Viral Infection: A Systems Biology Approach With Clinical and Imaging Validation","volume":"16","author":"Bhattacharjee","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"912217","DOI":"10.3389\/fnut.2022.912217","article-title":"Effects of Quercetin Glycoside Supplementation Combined With Low-Intensity Resistance Training on Muscle Quantity and Stiffness: A Randomized, Controlled Trial","volume":"9","author":"Otsuka","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"745959","DOI":"10.3389\/fendo.2021.745959","article-title":"Quercetin Modulates IGF-I and IGF-II Levels After Eccentric Exercise-Induced Muscle-Damage: A Placebo-Controlled Study","volume":"12","author":"Ceci","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"110101","DOI":"10.1016\/j.foodres.2020.110101","article-title":"Epicatechin and quercetin exhibit in vitro antioxidant effect, improve biochemical parameters related to metabolic syndrome, and decrease cellular genotoxicity in humans","volume":"142","author":"Porras","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.2174\/1381612825666190513095352","article-title":"The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials","volume":"25","author":"Tamtaji","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1080\/10408398.2019.1604491","article-title":"The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials","volume":"60","author":"Tabrizi","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/09637486.2019.1627515","article-title":"Impact of quercetin on systemic levels of inflammation: A meta-analysis of randomised controlled human trials","volume":"71","author":"Ou","year":"2020","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1002\/ptr.7194","article-title":"Targeting interleukin-\u03b2 by plant-derived natural products: Implications for the treatment of atherosclerotic cardiovascular disease","volume":"35","author":"Tasbandi","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"105599","DOI":"10.1016\/j.phrs.2021.105599","article-title":"Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis","volume":"168","author":"Duan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"6627355","DOI":"10.1155\/2021\/6627355","article-title":"Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies","volume":"2021","author":"Zhou","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/ptr.6955","article-title":"Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial","volume":"35","author":"Dehghani","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"e13644","DOI":"10.1111\/aji.13644","article-title":"Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial","volume":"89","author":"Vaez","year":"2022","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1002\/ptr.7464","article-title":"Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review","volume":"36","author":"Neto","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"174615","DOI":"10.1016\/j.ejphar.2021.174615","article-title":"The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial","volume":"914","author":"Shohan","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1039\/D0FO00565G","article-title":"Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer","volume":"11","author":"Henning","year":"2020","journal-title":"Food Funct."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"e000392","DOI":"10.1136\/bmjresp-2018-000392","article-title":"Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease","volume":"7","author":"Han","year":"2020","journal-title":"BMJ Open. Respir. Res."},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Peng, X., Li, S., Zhang, N., Wang, Y., and Wei, H. (2014). Isolation and identification of quercetin degrading bacteria from human fecal microbes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090531"},{"key":"ref_325","first-page":"58","article-title":"In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites","volume":"15","author":"Peng","year":"2014","journal-title":"Food Nutr. Res."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.freeradbiomed.2009.07.031","article-title":"In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites","volume":"47","author":"Jaganath","year":"2009","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1039\/C4FO00418C","article-title":"Cytotoxicity comparison of quercetin and its metabolites from in vitro fermentation of several gut bacteria","volume":"5","author":"Zhang","year":"2014","journal-title":"Food Funct."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1024\/0300-9831.73.2.79","article-title":"Transformation of flavonoids by intestinal microorganisms","volume":"73","author":"Blaut","year":"2003","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"e23165","DOI":"10.1002\/jbt.23165","article-title":"Neuroprotective effect of quercetin against rotenone-induced neuroinflammation and alterations in mice behavior","volume":"36","author":"Jain","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_330","doi-asserted-by":"crossref","unstructured":"Madiha, S., Batool, Z., Tabassum, S., Liaquat, L., Sadir, S., Shahzad, S., Naqvi, F., Saleem, S., Yousuf, S., and Nawaz, A. (2021). Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258928"},{"key":"ref_331","doi-asserted-by":"crossref","unstructured":"Paula, P., Angelica Maria, S.G., Luis, C.H., and Gloria Patricia, C.G. (2019). Preventive Effect of Quercetin in a Triple Transgenic Alzheimer\u2019s Disease Mice Model. Molecules, 24.","DOI":"10.3390\/molecules24122287"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1517\/14740330903026944","article-title":"The multiple faces of quercetin in neuroprotection","volume":"8","author":"Ossola","year":"2009","journal-title":"Expert Opin. Drug. Saf."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"105109","DOI":"10.1016\/j.phrs.2020.105109","article-title":"New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily","volume":"161","author":"Song","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_334","first-page":"1","article-title":"Dietary proanthocyanidins on gastrointestinal health and the interactions with gut microbiota","volume":"3","author":"Chen","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/mnfr.201400243","article-title":"Microbial catabolism of procyanidins by human gut microbiota","volume":"58","author":"Ou","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"108999","DOI":"10.1016\/j.biopha.2019.108999","article-title":"Proanthocyanidins: A comprehensive review","volume":"116","author":"Rauf","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"e2100380","DOI":"10.1002\/mnfr.202100380","article-title":"Flavan-3-ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid-beta (1-42) Levels","volume":"65","author":"Cecarini","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"e1900890","DOI":"10.1002\/mnfr.201900890","article-title":"Flavonoid-Derived Human Phenyl-\u03b3-Valerolactone Metabolites Selectively Detoxify Amyloid-\u03b2 Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer\u2019s Disease","volume":"64","author":"Ruotolo","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1039\/D2FO00080F","article-title":"Daily consumption of cranberry improves endothelial function in healthy adults: A double blind randomized controlled trial","volume":"13","author":"Heiss","year":"2022","journal-title":"Food Funct."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1039\/c0fo00132e","article-title":"Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites","volume":"1","author":"Monagas","year":"2010","journal-title":"Food Funct."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1515\/DMDI.2000.17.1-4.291","article-title":"Bioavailability of flavonoids and potential bioactive forms in vivo","volume":"17","author":"Spencer","year":"2000","journal-title":"Drug. Metabol. Drug. Interact."},{"key":"ref_342","doi-asserted-by":"crossref","unstructured":"Angelino, D., Carregosa, D., Domenech-Coca, C., Savi, M., Figueira, I., Brindani, N., Jang, S., Lakshman, S., Molokin, A., and Urban, J.F. (2019). 5-(Hydroxyphenyl)-\u03b3-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models. Nutrients, 11.","DOI":"10.3390\/nu11112678"},{"key":"ref_343","doi-asserted-by":"crossref","unstructured":"Di Meo, F., Valentino, A., Petillo, O., Peluso, G., Filosa, S., and Crispi, S. (2020). Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072564"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408347.2022.2105641","article-title":"Bioactive Flavonoids: A Comprehensive Review on Pharmacokinetics and Analytical Aspects","volume":"5","author":"Billowria","year":"2022","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_345","doi-asserted-by":"crossref","unstructured":"Chen, B., Zhang, W., Lin, C., and Zhang, L. (2022). A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911569"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"e14189","DOI":"10.1111\/jfbc.14189","article-title":"Epigallocatechin gallate: Phytochemistry, bioavailability, utilization challenges, and strategies","volume":"46","author":"Mehmood","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_347","doi-asserted-by":"crossref","unstructured":"Rapisarda, P., Amenta, M., Ballistreri, G., Fabroni, S., and Timpanaro, N. (2022). Distribution, Antioxidant Capacity, Bioavailability and Biological Properties of Anthocyanin Pigments in Blood Oranges and Other Citrus Species. Molecules, 27.","DOI":"10.3390\/molecules27248675"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"ref_349","doi-asserted-by":"crossref","unstructured":"Wdowiak, K., Walkowiak, J., Pietrzak, R., Bazan-Wo\u017aniak, A., and Cielecka-Piontek, J. (2022). Bioavailability of Hesperidin and Its Aglycone Hesperetin-Compounds Found in Citrus Fruits as a Parameter Conditioning the Pro-Health Potential (Neuroprotective and Antidiabetic Activity)-Mini-Review. Nutrients, 14.","DOI":"10.3390\/nu14132647"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10787-021-00895-8","article-title":"Therapeutic benefits of flavonoids against neuroinflammation: A systematic review","volume":"30","author":"Joghee","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"3255S","DOI":"10.1093\/jn\/133.10.3255S","article-title":"Metabolism of tea flavonoids in the gastrointestinal tract","volume":"133","author":"Spencer","year":"2003","journal-title":"J. Nutr."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/nu5093367","article-title":"Flavonoid bioavailability and attempts for bioavailability enhancement","volume":"5","author":"Thilakarathna","year":"2013","journal-title":"Nutrients"},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"134596","DOI":"10.1016\/j.foodchem.2022.134596","article-title":"Health benefits of proanthocyanidins linking with gastrointestinal modulation: An updated review","volume":"404","author":"Zhang","year":"2023","journal-title":"Food Chem."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"956378","DOI":"10.3389\/fmicb.2022.956378","article-title":"Potential roles of gut microbes in biotransformation of natural products: An overview","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s11357-022-00708-y","article-title":"Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer\u2019s disease","volume":"45","author":"Nguyen","year":"2023","journal-title":"Geroscience"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"147","DOI":"10.15586\/aei.v50i6.743","article-title":"Urolithin A induces protective autophagy to alleviate inflammation, oxidative stress, and endoplasmic reticulum stress in pediatric pneumonia","volume":"50","author":"Cao","year":"2022","journal-title":"Allergol. Immunopathol."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"917266","DOI":"10.3389\/fphar.2022.917266","article-title":"Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived from Ellagitannins","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_358","doi-asserted-by":"crossref","unstructured":"Al Khalaf, A., Abdulrahman, A.O., Kaleem, M., Nur, S.M., Asseri, A.H., Choudhry, H., and Khan, M.I. (2021). Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats. Nutrients, 13.","DOI":"10.3390\/nu13113885"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41430-021-00950-1","article-title":"Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population","volume":"76","author":"Singh","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"001435","DOI":"10.1099\/jmm.0.001435","article-title":"The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis","volume":"70","author":"Hasani","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jff.2017.03.045","article-title":"Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies","volume":"33","author":"Zhou","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.1039\/D0FO01649G","article-title":"Metabolism of different dietary phenolic compounds by the urolithin-producing human-gut bacteria Gordonibacter urolithinfaciens and Ellagibacter isourolithinifaciens","volume":"11","author":"Frutos","year":"2020","journal-title":"Food Funct."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10286020.2022.2045965","article-title":"The potential biological effects of quercetin based on pharmacokinetics and multi-targeted mechanism in vivo","volume":"24","author":"Keranmu","year":"2022","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1080\/21655979.2021.1969194","article-title":"Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis","volume":"12","author":"Lan","year":"2021","journal-title":"Bioengineered"},{"key":"ref_366","doi-asserted-by":"crossref","unstructured":"Sankaranarayanan, R., Sekhon, P.K., Ambat, A., Nelson, J., Jose, D., Bhat, G.J., and Scaria, J. (2021). Screening of Human Gut Bacterial Culture Collection Identifies Species That Biotransform Quercetin into Metabolites with Anticancer Properties. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137045"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"1006434","DOI":"10.3389\/fimmu.2022.1006434","article-title":"Beneficial effects of natural flavonoids on neuroinflammation","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_368","doi-asserted-by":"crossref","unstructured":"Payne, A., Nahashon, S., Taka, E., Adinew, G.M., and Soliman, K.F.A. (2022). Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age. Biomolecules, 12.","DOI":"10.3390\/biom12030371"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41586-020-2288-7","article-title":"C9orf72 suppresses systemic and neural inflammation induced by gut bacteria","volume":"582","author":"Burberry","year":"2020","journal-title":"Nature"},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"796288","DOI":"10.3389\/fimmu.2022.796288","article-title":"Gut Microbiota Interact with the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging","volume":"13","author":"Mou","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_371","doi-asserted-by":"crossref","unstructured":"Shabbir, U., Tyagi, A., Elahi, F., Aloo, S.O., and Oh, D.H. (2021). The Potential Role of Polyphenols in Oxidative Stress and Inflammation Induced by Gut Microbiota in Alzheimer\u2019s Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10091370"},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"16273","DOI":"10.1021\/acs.jafc.2c06585","article-title":"Biodegradation of Punicalagin into Ellagic Acid by Selected Probiotic Bacteria: A Study of the Underlying Mechanisms by MS-Based Proteomics","volume":"70","author":"Caballero","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"6940953","DOI":"10.1155\/2020\/6940953","article-title":"Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances","volume":"2020","author":"Yin","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_374","doi-asserted-by":"crossref","unstructured":"Zou, W., Deng, L., Wu, H., Liu, Z., Lu, W., and He, Y. (2022). Untargeted Metabolomics Profiling Reveals Beneficial Changes in Milk of Sows Supplemented with Fermented Compound Chinese Medicine Feed Additive. Animals, 12.","DOI":"10.3390\/ani12202879"},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"106303","DOI":"10.1016\/j.ejps.2022.106303","article-title":"Kaempferol suppression of acute colitis is regulated by the efflux transporters BCRP and MRP2","volume":"179","author":"Liu","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"973282","DOI":"10.3389\/fcimb.2022.973282","article-title":"Metabolomics and proteomics analyses revealed mechanistic insights on the antimicrobial activity of epigallocatechin gallate against Streptococcus suis","volume":"12","author":"Gao","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"e14210","DOI":"10.1111\/jfbc.14210","article-title":"Kaempferol inhibits the growth of Helicobacter pylori in a manner distinct from antibiotics","volume":"46","author":"Yang","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.2174\/0929867329666220209103538","article-title":"A State-of-the-art Review and Prospective Therapeutic Applications of Prenyl Flavonoids as Chemosensitizers against Antifungal Multidrug Resistance in Candida albicans","volume":"29","author":"Santi","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"ref_379","doi-asserted-by":"crossref","unstructured":"Waditzer, M., and Bucar, F. (2021). Flavonoids as Inhibitors of Bacterial Efflux Pumps. Molecules, 26.","DOI":"10.3390\/molecules26226904"},{"key":"ref_380","doi-asserted-by":"crossref","unstructured":"Palko-\u0141abuz, A., B\u0142aszczyk, M., \u015aroda-Pomianek, K., and Weso\u0142owska, O. (2021). Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter. Molecules, 26.","DOI":"10.3390\/molecules26154637"},{"key":"ref_381","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., and Restani, P. (2021). Polyphenols and Human Health: The Role of Bioavailability. Nutrients, 13.","DOI":"10.3390\/nu13010273"},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/nyas.13350","article-title":"Structure, bioactivity, and synthesis of methylated flavonoids","volume":"1398","author":"Wen","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3109\/03602532.2014.978080","article-title":"Bioavailability of anthocyanins","volume":"46","author":"Fang","year":"2014","journal-title":"Drug. Metab. Rev."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1080\/10408398.2021.1917508","article-title":"Absorption, metabolism and bioavailability of flavonoids: A review","volume":"62","author":"Chen","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1039\/D0FO03403G","article-title":"The biological fate and bioefficacy of citrus flavonoids: Bioavailability, biotransformation, and delivery systems","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct."},{"key":"ref_386","first-page":"643","article-title":"Pharmacological activities of protocatechuic acid","volume":"72","author":"Khan","year":"2015","journal-title":"Acta Pol. Pharm."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"593902","DOI":"10.1155\/2015\/593902","article-title":"Pharmacological properties of protocatechuic Acid and its potential roles as complementary medicine","volume":"2015","author":"Semaming","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/19390211.2017.1406426","article-title":"Phenolic Constituents and Inhibitory Effects of Hibiscus sabdariffa L. (Sorrel) Calyx on Cholinergic, Monoaminergic, and Purinergic Enzyme Activities","volume":"15","author":"Oboh","year":"2018","journal-title":"J. Diet. Suppl."},{"key":"ref_389","doi-asserted-by":"crossref","unstructured":"Haskell-Ramsay, C., Schmitt, J., and Actis-Goretta, L. (2018). The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow. Nutrients, 10.","DOI":"10.3390\/nu10080986"},{"key":"ref_390","doi-asserted-by":"crossref","unstructured":"Kazem, Y., Mahmoud, M.H., Essa, H.A., Azmy, O., Kandeel, W.A., Al-Moghazy, M., El-Attar, I., Hasheesh, A., and Mehanna, N.S. (2021). Role of Bifidobacterium spp. intake in improving depressive mood and well-being and its link to kynurenine blood level: An interventional study. J. Complement. Integr. Med.","DOI":"10.1515\/jcim-2021-0351"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jnr.24476","article-title":"The role of inflammation and the gut microbiome in depression and anxiety","volume":"97","author":"Peirce","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.tiv.2008.11.008","article-title":"Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells","volume":"23","author":"Guan","year":"2009","journal-title":"Toxicol In Vitro"},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-161141","article-title":"The Gut Microbiota and Alzheimer\u2019s Disease","volume":"58","author":"Jiang","year":"2017","journal-title":"J. Alzheimers. Dis."},{"key":"ref_394","doi-asserted-by":"crossref","unstructured":"Kang, J., and Zivkovic, A.M. (2021). The Potential Utility of Prebiotics to Modulate Alzheimer\u2019s Disease: A Review of the Evidence. Microorganisms, 9.","DOI":"10.3390\/microorganisms9112310"},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"111473","DOI":"10.1016\/j.nut.2021.111473","article-title":"Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer\u2019s disease","volume":"93","author":"Li","year":"2022","journal-title":"Nutrition"},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1007\/s12035-020-02073-3","article-title":"Gut Microbiota and Dysbiosis in Alzheimer\u2019s Disease: Implications for Pathogenesis and Treatment","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_397","doi-asserted-by":"crossref","unstructured":"Megur, A., Baltriukien\u0117, D., Bukelskien\u0117, V., and Burokas, A. (2020). The Microbiota-Gut-Brain Axis and Alzheimer\u2019s Disease: Neuroinflammation Is to Blame?. Nutrients, 13.","DOI":"10.3390\/nu13010037"},{"key":"ref_398","doi-asserted-by":"crossref","unstructured":"Shabbir, U., Arshad, M.S., Sameen, A., and Oh, D.H. (2021). Crosstalk between Gut and Brain in Alzheimer\u2019s Disease: The Role of Gut Microbiota Modulation Strategies. Nutrients, 13.","DOI":"10.3390\/nu13020690"},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s12035-018-1188-4","article-title":"The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer\u2019s Disease-a Critical Review","volume":"56","author":"Sochocka","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fnins.2019.00369","article-title":"Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson\u2019s Disease","volume":"13","author":"Fitzgerald","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"106113","DOI":"10.1016\/j.biocel.2021.106113","article-title":"Environmental neurotoxicants and inflammasome activation in Parkinson\u2019s disease\u2014A focus on the gut-brain axis","volume":"142","author":"Johnson","year":"2022","journal-title":"Int J Biochem Cell Biol."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2021.11.017","article-title":"Gut microbiome in Parkinson\u2019s disease: New insights from meta-analysis","volume":"94","author":"Toh","year":"2021","journal-title":"Park. Relat. Disord."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1016\/j.cell.2021.10.015","article-title":"Autism-related dietary preferences mediate autism-gut microbiome associations","volume":"184","author":"Yap","year":"2021","journal-title":"Cell."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"001469","DOI":"10.1099\/jmm.0.001469","article-title":"Treating autism spectrum disorder by intervening with gut microbiota","volume":"70","author":"Tu","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"ref_405","doi-asserted-by":"crossref","unstructured":"Chernikova, M., Flores, G.D., Kilroy, E., Labus, J.S., Mayer, E.A., and Aziz-Zadeh, L. (2021). The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder. Nutrients, 13.","DOI":"10.3390\/nu13124497"},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"650624","DOI":"10.3389\/fped.2021.650624","article-title":"A Ketogenic Diet and the Treatment of Autism Spectrum Disorder","volume":"9","author":"Li","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpsychires.2016.12.007","article-title":"The gut microbiome composition associates with bipolar disorder and illness severity","volume":"87","author":"Evans","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000504496","article-title":"The Gut Microbiome in Bipolar Disorder and Pharmacotherapy Management","volume":"79","author":"Flowers","year":"2020","journal-title":"Neuropsychobiology"},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0029665117002026","article-title":"Nutritional psychiatry: The present state of the evidence","volume":"76","author":"Marx","year":"2017","journal-title":"Proc. Nutr. Soc."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/0706743719874168","article-title":"The Gut Microbiome and Mental Health: What Should We Tell Our Patients? Le microbiote Intestinal et la Sant\u00e9 Mentale: Que Devrions-Nous dire \u00e0 nos Patients?","volume":"64","author":"Butler","year":"2019","journal-title":"Can. J. Psychiatry"},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2021.11.023","article-title":"Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial","volume":"100","author":"Tian","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"101943","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression\u2014A systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin Psychol Rev."},{"key":"ref_413","doi-asserted-by":"crossref","unstructured":"Del Toro-Barbosa, M., Hurtado-Romero, A., Garcia-Amezquita, L.E., and Garc\u00eda-Cayuela, T. (2020). Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products. Nutrients, 12.","DOI":"10.3390\/nu12123896"},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ebiom.2019.05.024","article-title":"The gut microbiome and epilepsy","volume":"44","author":"Dahlin","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"9373060","DOI":"10.1155\/2019\/8373060","article-title":"Crosstalk between the Ketogenic Diet and Epilepsy: From the Perspective of Gut Microbiota","volume":"2019","author":"Fan","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"742449","DOI":"10.3389\/fimmu.2021.742449","article-title":"Microbiota-Gut-Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics","volume":"12","author":"Ding","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1007\/s10072-021-05603-6","article-title":"Influence of the gut microbiome on inflammatory and immune response after stroke","volume":"42","author":"Huang","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/cns.13736","article-title":"Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke","volume":"28","author":"Huang","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref_419","doi-asserted-by":"crossref","unstructured":"Pluta, R., Januszewski, S., and Czuczwar, S.J. (2021). The Role of Gut Microbiota in an Ischemic Stroke. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020915"},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bcp.2017.03.021","article-title":"Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function","volume":"139","author":"Terao","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000516398","article-title":"Role of the Gut Microbiota in Stroke Pathogenesis and Potential Therapeutic Implications","volume":"77","author":"Yamashiro","year":"2021","journal-title":"Ann. Nutr. Metab."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"854249","DOI":"10.3389\/fphar.2022.854249","article-title":"Neuroprotective Effects of Quercetin on Ischemic Stroke: A Literature Review","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/elps.201300568","article-title":"Beneficial mycorrhizal symbionts affecting the production of health-promoting phytochemicals","volume":"35","author":"Sbrana","year":"2014","journal-title":"Electrophoresis"},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiome shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_425","doi-asserted-by":"crossref","unstructured":"Li, D., Sun, T., Tong, Y., Le, J., Yao, Q., Tao, J., Liu, H., Jiao, W., Mei, Y., and Chen, J. (2023). Gut-microbiome-expressed 3\u03b2-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females. Cell Metab.","DOI":"10.1016\/j.cmet.2023.02.017"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/663\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:50:06Z","timestamp":1760122206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,7]]},"references-count":425,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["antiox12030663"],"URL":"https:\/\/doi.org\/10.3390\/antiox12030663","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,7]]}}}