{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:53:07Z","timestamp":1770144787389,"version":"3.49.0"},"reference-count":194,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The extracellular milieu is a rich source of different stimuli and stressors. Some of them depend on the chemical\u2013physical features of the matrix, while others may come from the \u2018outer\u2019 environment, as in the case of mechanical loading applied on the bones. In addition to these forces, a plethora of chemical signals drives cell physiology and fate, possibly leading to dysfunctions when the homeostasis is disrupted. This variety of stimuli triggers different responses among the tissues: bones represent a particular milieu in which a fragile balance between mechanical and metabolic demands should be tuned and maintained by the concerted activity of cell biomolecules located at the interface between external and internal environments. Plasma membrane ion channels can be viewed as multifunctional protein machines that act as rapid and selective dual-nature hubs, sensors, and transducers. Here we focus on some multisensory ion channels (belonging to Piezo, TRP, ASIC\/EnaC, P2XR, Connexin, and Pannexin families) actually or potentially playing a significant role in bone adaptation to three main stressors, mechanical forces, oxidative stress, and acidosis, through their effects on bone cells including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. Ion channel-mediated bone remodeling occurs in physiological processes, aging, and human diseases such as osteoporosis, cancer, and traumatic events.<\/jats:p>","DOI":"10.3390\/antiox12030689","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:09:56Z","timestamp":1678687796000},"page":"689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Martina","family":"Perin","sequence":"first","affiliation":[{"name":"Department of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Chinig\u00f2","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-8389","authenticated-orcid":false,"given":"Tullio","family":"Genova","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5800-0749","authenticated-orcid":false,"given":"Federico","family":"Mussano","sequence":"additional","affiliation":[{"name":"C.I.R. Dental School, Department of Surgical Sciences, University of Torino, Via Nizza 230, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-4446","authenticated-orcid":false,"given":"Luca","family":"Munaron","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and System Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15226\/2374-6904\/5\/2\/00171","article-title":"Physical Activity, Bone Remodelling and Bone Metabolism Markers","volume":"5","author":"Sahrir","year":"2018","journal-title":"J. Exerc. 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