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Additionally, cell-, oxygen carrier-free and antioxidants-supplemented solutions could potentially prevent adverse effects (transfusion reactions, inflammation, hemolysis), associated with the use of autologous packed red blood cell (pRBC)-based perfusates. This study compared 6 h NMP of porcine kidneys, using an established pRBC-based perfusate (pRBC, n = 7), with the novel cell- and oxygen carrier-free organ preservation solution Ecosol, containing taurine (Ecosol, n = 7). Despite the enhanced tissue edema and tubular injury in the Ecosol group, related to a suboptimal molecular mass of polyethylene glycol as colloid present in the solution, functional parameters (renal blood flow, intrarenal resistance, urinary flow, pH) and oxygenation (arterial pO2, absence of hypoxia-inducible factor 1-alpha) were similar to the pRBC group. Furthermore, taurine significantly improved the antioxidant capacity in the Ecosol group, reflected in decreased lactate dehydrogenase, urine protein and tubular vacuolization compared to pRBC. This study demonstrates the feasibility of 6 h NMP using a taurine containing, cell- and oxygen carrier-free perfusate, achieving a comparable organ quality to pRBC perfused porcine kidneys.<\/jats:p>","DOI":"10.3390\/antiox12030768","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T06:56:48Z","timestamp":1679381808000},"page":"768","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Taurine as Antioxidant in a Novel Cell- and Oxygen Carrier-Free Perfusate for Normothermic Machine Perfusion of Porcine Kidneys"],"prefix":"10.3390","volume":"12","author":[{"given":"Laura","family":"Zarnitz","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict M.","family":"Doorschodt","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3808-4222","authenticated-orcid":false,"given":"Lisa","family":"Ernst","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisa","family":"Hosseinnejad","sequence":"additional","affiliation":[{"name":"DWI\u2014Leibniz-Institute for Interactive Materials e.V., 52056 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Edgworth","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Fechter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Thei\u00dfen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Djudjaj","sequence":"additional","affiliation":[{"name":"Institute of Pathology & Division of Nephrology, Medical Faculty, RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-4284","authenticated-orcid":false,"given":"Peter","family":"Boor","sequence":"additional","affiliation":[{"name":"Institute of Pathology & Division of Nephrology, Medical Faculty, RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Rossaint","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 H.","family":"Tolba","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bleilevens","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e068769","DOI":"10.1136\/bmj-2021-068769","article-title":"Survival for Waitlisted Kidney Failure Patients Receiving Transplantation versus Remaining on Waiting List: Systematic Review and Meta-Analysis","volume":"376","author":"Chaudhry","year":"2022","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of Mortality in All Patients on Dialysis, Patients on Dialysis Awaiting Transplantation, and Recipients of a First Cadaveric Transplant","volume":"341","author":"Wolfe","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_3","unstructured":"(2023, January 29). Eurotransplant Statistics Report Library. Available online: https:\/\/statistics.eurotransplant.org\/index.php?search_type=&search_organ=kidney&search_region=All+ET&search_period=by+year&search_characteristic=&search_text=."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ki.2015.88","article-title":"Kidney Donation after Circulatory Death (DCD): State of the Art","volume":"88","author":"Summers","year":"2015","journal-title":"Kidney Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/tri.13506","article-title":"Donation after Circulatory Death Today: An Updated Overview of the European Landscape","volume":"33","author":"Lomero","year":"2020","journal-title":"Transpl. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.eclinm.2018.09.007","article-title":"Equivalent Long-Term Transplantation Outcomes for Kidneys Donated after Brain Death and Cardiac Death: Conclusions from a Nationwide Evaluation","volume":"4","author":"Schaapherder","year":"2018","journal-title":"EClinicalMedicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/TP.0000000000003415","article-title":"A Short Period of Normothermic Machine Perfusion May Not Be Able to Predict Primary Nonfunction in Uncontrolled Circulatory Death Kidneys","volume":"105","author":"Hosgood","year":"2021","journal-title":"Transplantation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/bjs.10733","article-title":"Normothermic Machine Perfusion for the Assessment and Transplantation of Declined Human Kidneys from Donation after Circulatory Death Donors","volume":"105","author":"Hosgood","year":"2018","journal-title":"Br. J. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/TP.0000000000003066","article-title":"Normothermic Ex Vivo Kidney Perfusion Improves Early DCD Graft Function Compared with Hypothermic Machine Perfusion and Static Cold Storage","volume":"104","author":"Urbanellis","year":"2020","journal-title":"Transplantation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.29337\/ijsp.165","article-title":"Additional Normothermic Machine Perfusion versus Hypothermic Machine Perfusion in Suboptimal Donor Kidney Transplantation: Protocol of a Randomized, Controlled, Open-Label Trial","volume":"25","author":"Rijkse","year":"2021","journal-title":"Int. J. Surg. Protoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/ajt.12179","article-title":"Renal Transplantation after Ex Vivo Normothermic Perfusion: The First Clinical Study","volume":"13","author":"Hosgood","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"zraa024","DOI":"10.1093\/bjsopen\/zraa024","article-title":"Safety and Feasibility of 2 h of Normothermic Machine Perfusion of Donor Kidneys in the Eurotransplant Senior Program","volume":"5","author":"Rijkse","year":"2021","journal-title":"BJS Open"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"E308","DOI":"10.1111\/aor.13499","article-title":"Dissemination of a Novel Organ Perfusion Technique: Ex Vivo Normothermic Perfusion of Deceased Donor Kidneys","volume":"43","author":"Chandak","year":"2019","journal-title":"Artif. Organs"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pool, M.B.F., Hamelink, T.L., van Goor, H., van den Heuvel, M.C., Leuvenink, H.G.D., and Moers, C. (2021). Prolonged Ex-Vivo Normothermic Kidney Perfusion: The Impact of Perfusate Composition. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0251595"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pool, M.B.F., Hartveld, L., Leuvenink, H.G.D., and Moers, C. (2020). Normothermic Machine Perfusion of Ischaemically Damaged Porcine Kidneys with Autologous, Allogeneic Porcine and Human Red Blood Cells. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0229566"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Edgworth, E., Ernst, L., Czigany, Z., Saritas, T., Zarnitz, L.S., Wiartalla, M., Boor, P., Buhl, E.M., Rossaint, R., and Tolba, R.H. (2022). HBOC-301 in Porcine Kidney Normothermic Machine Perfusion and the Effect of Vitamin C on Methemoglobin Formation. Antioxidants, 11.","DOI":"10.3390\/antiox11071329"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/aor.13403","article-title":"Role of Erythrocytes in Short-Term Rewarming Kidney Perfusion after Cold Storage","volume":"43","author":"Minor","year":"2019","journal-title":"Artif. Organs"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1016\/j.jss.2010.08.033","article-title":"Protective Effect of Lifor Solution in Experimental Renal Ischemia-Reperfusion Injury","volume":"164","author":"Regner","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1016\/j.transproceed.2009.06.228","article-title":"Room Temperature Pulsatile Perfusion of Renal Allografts with Lifor Compared with Hypothermic Machine Pump Solution","volume":"41","author":"Gage","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/ajt.15647","article-title":"First-in-Man Controlled Rewarming and Normothermic Perfusion with Cell-Free Solution of a Kidney Prior to Transplantation","volume":"20","author":"Minor","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13897","DOI":"10.1038\/s41598-019-50101-7","article-title":"Cold Preflush of Porcine Kidney Grafts Prior to Normothermic Machine Perfusion Aggravates Ischemia Reperfusion Injury","volume":"9","author":"Fabry","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bleilevens, C., Doorschodt, B.M., Fechter, T., Grzanna, T., Thei\u00dfen, A., Liehn, E.A., Breuer, T., Tolba, R.H., Rossaint, R., and Stoppe, C. (2019). Influence of Vitamin C on Antioxidant Capacity of In Vitro Perfused Porcine Kidneys. Nutrients, 11.","DOI":"10.3390\/nu11081774"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000366155","article-title":"Determination of the Preferred Conditions for the Isolated Perfusion of Porcine Kidneys","volume":"54","author":"Mancina","year":"2015","journal-title":"Eur. Surg. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.12659\/AOT.892823","article-title":"Improved Preservation of Warm Ischemia-Damaged Porcine Kidneys after Cold Storage in Ecosol, a Novel Preservation Solution","volume":"20","author":"Kalenski","year":"2015","journal-title":"Ann. Transplant."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1111\/ajt.16371","article-title":"Cytokine Absorption during Human Kidney Perfusion Reduces Delayed Graft Function\u2013Associated Inflammatory Gene Signature","volume":"21","author":"Ferdinand","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/08941930390153041","article-title":"Use of Taurine as Antioxidant in Resuscitating Livers from Non-Heart-Beating Donors by Gaseous Oxygen Persufflation","volume":"16","author":"Lauschke","year":"2003","journal-title":"J. Investig. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1432-2277.1995.tb01499.x","article-title":"Effects of Taurine on Liver Preservation in UW Solution with Consecutive Ischemic Rewarming in the Isolated Perfused Rat Liver","volume":"8","author":"Minor","year":"1995","journal-title":"Transpl. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5114\/ceh.2021.104675","article-title":"Taurine Mitigates Bile Duct Obstruction-Associated Cholemic Nephropathy: Effect on Oxidative Stress and Mitochondrial Parameters","volume":"7","author":"Abdoli","year":"2021","journal-title":"Clin. Exp. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Stacchiotti, A., Favero, G., Lavazza, A., Monsalve, M., Rodella, L.F., and Rezzani, R. (2018). Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney. Nutrients, 10.","DOI":"10.3390\/nu10060689"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/ajt.16334","article-title":"Urine Recirculation Prolongs Normothermic Kidney Perfusion via More Optimal Metabolic Homeostasis\u2014A Proteomics Study","volume":"21","author":"Weissenbacher","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.3390\/cimb43030137","article-title":"Repetitive Treatment with Volatile Anesthetics Does Not Affect the In Vivo Plasma Concentration and Composition of Extracellular Vesicles in Rats","volume":"43","author":"Bleilevens","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/ajt.14491","article-title":"Normothermic Ex Vivo Kidney Perfusion for Graft Quality Assessment Prior to Transplantation","volume":"18","author":"Kaths","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/bjs.9894","article-title":"Ex Vivo Normothermic Perfusion for Quality Assessment of Marginal Donor Kidney Transplants","volume":"102","author":"Hosgood","year":"2015","journal-title":"Br. J. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.transproceed.2006.06.117","article-title":"Effects of the Molecular Weight of Peg Molecules (8, 20 and 35 KDA) on Cell Function and Allograft Survival Prolongation in Pancreatic Islets Transplantation","volume":"38","author":"Neuzillet","year":"2006","journal-title":"Transplant. Proc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/S1166-7087(14)70062-4","article-title":"Polyethylene Glycols and Organ Protection against I\/R Injury Poly\u00e9thyl\u00e8ne Glycol et Protection Des L\u00e9sions d\u2019isch\u00e9mie-Reperfusion","volume":"24","author":"Giraud","year":"2014","journal-title":"Progr\u00e8s Urol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-\u03b1 to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated","volume":"292","author":"Hydroxylation","year":"2001","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"22642","DOI":"10.1074\/jbc.272.36.22642","article-title":"Hypoxia-Inducible Factor 1\u03b1 (HIF-1\u03b1) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions. Its Stabilization by Hypoxia Depends on Redox-Induced Changes","volume":"272","author":"Salceda","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_38","first-page":"5447","article-title":"A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1097\/01.ASN.0000017223.49823.2A","article-title":"Expression of Hypoxia-Inducible Factor-1\u03b1 and -2\u03b1 in Hypoxic and Ischemic Rat Kidneys","volume":"13","author":"Rosenberger","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/j.1600-6143.2009.02675.x","article-title":"Early Renal Ischemia-Reperfusion Injury in Humans Is Dominated by IL-6 Release from the Allograft","volume":"9","author":"Lindeman","year":"2009","journal-title":"Am. J. Transplant."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/00007890-199310000-00010","article-title":"Serum and Urine IL-6 and TNF-\u03b1 in Renal Transplant Recipients with Graft Dysfunction","volume":"56","author":"Newstead","year":"1993","journal-title":"Transplantation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/hep.510300215","article-title":"Ischemia Impairs Liver Regeneration after Major Tissue Loss in Rodents: Protective Effects of Interleukin-6","volume":"30","author":"Selzner","year":"1999","journal-title":"Hepatology"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"de Beule, J., Keppens, D., Korf, H., and Jochmans, I. (2022). Differential Cytokine Levels during Normothermic Kidney Perfusion with Whole Blood- or Red Blood Cell-Based Perfusates\u2014Results of a Scoping Review and Experimental Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11226618"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1152\/ajprenal.00474.2009","article-title":"Reactive Oxygen Species Generated by Renal Ischemia and Reperfusion Trigger Protection against Subsequent Renal Ischemia and Reperfusion Injury in Mice","volume":"298","author":"Kim","year":"2010","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jeong, B.Y., Lee, H.Y., Park, C.G., Kang, J., Yu, S.L., Choi, D.R., Han, S.Y., Park, M.H., Cho, S., and Lee, S.Y. (2018). Oxidative Stress Caused by Activation of NADPH Oxidase 4 Promotes Contrast-Induced Acute Kidney Injury. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191034"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1038\/s41598-022-12431-x","article-title":"Mapping Microbiome-Redox Spectrum and Evaluating Microbial-Redox Index in Chronic Gastritis","volume":"12","author":"Panigrahi","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1186\/1757-7241-17-57","article-title":"Injury Severity and Serum Amyloid A Correlate with Plasma Oxidation-Reduction Potential in Multi-Trauma Patients: A Retrospective Analysis","volume":"17","author":"Rael","year":"2009","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jong, C.J., Ito, T., Prentice, H., Wu, J.Y., and Schaffer, S.W. (2017). Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis. Nutrients, 9.","DOI":"10.3390\/nu9080795"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1749-8090-6-31","article-title":"Is There Any Cardioprotective Role of Taurine during Cold Ischemic Period Following Global Myocardial Ischemia?","volume":"6","author":"Sahin","year":"2011","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-009-0101-x","article-title":"The Importance of Myocardial Amino Acids during Ischemia and Reperfusion in Dilated Left Ventricle of Patients with Degenerative Mitral Valve Disease","volume":"330","author":"Venturini","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/10715769800300221","article-title":"Oxidative Stress to Rat Lens In Vitro: Protection by Taurine","volume":"29","author":"Devamanoharan","year":"1998","journal-title":"Free Radic. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00726-012-1378-8","article-title":"Effect of Taurine on Ischemia-Reperfusion Injury","volume":"46","author":"Schaffer","year":"2014","journal-title":"Amino Acids"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1423-0127-17-S1-S4","article-title":"Taurine and the Renal System","volume":"17","author":"Chesney","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s00726-012-1314-y","article-title":"The Role of Taurine in Renal Disorders","volume":"43","author":"Han","year":"2012","journal-title":"Amino Acids"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jss.2009.01.002","article-title":"Protective Effect of Reduced Glutathione and Venous Systemic Oxygen Persufflation on Rat Steatotic Graft following Liver Transplantation","volume":"158","author":"Ye","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Gorelik, Y., Bloch-Isenberg, N., Hashoul, S., Heyman, S.N., and Khamaisi, M. (2022). Hyperglycemia on Admission Predicts Acute Kidney Failure and Renal Functional Recovery among Inpatients. J. Clin. Med., 11.","DOI":"10.3390\/jcm11010054"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14","DOI":"10.31083\/j.fbs1402014","article-title":"Anti-Oxidative Therapy in Diabetic Nephropathy","volume":"14","author":"Hernandez","year":"2022","journal-title":"Front. Biosci. Sch. Ed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41420-019-0142-1","article-title":"The Prodomain of Caspase-3 Regulates Its Own Removal and Caspase Activation","volume":"5","author":"Ponder","year":"2019","journal-title":"Cell Death Discov."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Jong, C.J., Sandal, P., and Schaffer, S.W. (2021). The Role of Taurine in Mitochondria Health: More than Just an Antioxidant. Molecules, 26.","DOI":"10.3390\/molecules26164913"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/768\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:43Z","timestamp":1760122783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/3\/768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["antiox12030768"],"URL":"https:\/\/doi.org\/10.3390\/antiox12030768","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,21]]}}}