{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:12:29Z","timestamp":1785805949722,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002848","name":"National Agency for Research and Development, ANID, Chile","doi-asserted-by":"publisher","award":["ACT210097"],"award-info":[{"award-number":["ACT210097"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"National Agency for Research and Development, ANID, Chile","doi-asserted-by":"publisher","award":["FONDECYT #11201322"],"award-info":[{"award-number":["FONDECYT #11201322"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"National Agency for Research and Development, ANID, Chile","doi-asserted-by":"publisher","award":["FONDECYT #1181168"],"award-info":[{"award-number":["FONDECYT #1181168"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"National Agency for Research and Development, ANID, Chile","doi-asserted-by":"publisher","award":["PAI77170001"],"award-info":[{"award-number":["PAI77170001"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The influence of an inflammatory microenvironment on tumorigenesis has been widely accepted. Systemic conditions that favor the onset of an inflammatory landscape predispose the progression of breast cancer. Under obesity conditions, the endocrine function of adipose tissue is one of the main determinants of the production of local and systemic inflammatory mediators. Although these mediators can stimulate tumorigenesis and recruit inflammatory cells, as macrophages, the mechanism involved remains poorly understood. In the present work, we describe that the TNF\u03b1 treatment of mammary preadipocytes from human normal patients blocks adipose differentiation and promotes the generation of pro-inflammatory soluble factors. The latter stimulate the mobilization of THP-1 monocytes and MCF-7 epithelial cancer cells in an MCP1\/CCL2- and mitochondrial-ROS-dependent manner. Together, these results reaffirm the contribution of an inflammatory microenvironment and mtROS in the progression of breast cancer.<\/jats:p>","DOI":"10.3390\/antiox12040813","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:31:21Z","timestamp":1679891481000},"page":"813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["TNF-Alpha Promotes an Inflammatory Mammary Microenvironment That Favors Macrophage and Epithelial Migration in a CCL2- and Mitochondrial-ROS-Dependent Manner"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6099-0311","authenticated-orcid":false,"given":"Mar\u00eda Jes\u00fas","family":"Vera","sequence":"first","affiliation":[{"name":"Molecular and Cell Biology Laboratory, INTA, University of Chile, Santiago 7830490, Chile"},{"name":"MIBI: Interdisciplinary Group on Mitochondrial Targeting and Bioenergetics, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Guajardo","sequence":"additional","affiliation":[{"name":"MIBI: Interdisciplinary Group on Mitochondrial Targeting and Bioenergetics, Santiago 8380453, Chile"},{"name":"Metabolic Plasticity and Bioenergetics Laboratory, Program of Clinical and Molecular Pharmacology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile"},{"name":"Network for Snake Venom Research and Drug Discovery, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-4399","authenticated-orcid":false,"given":"Felix A.","family":"Urra","sequence":"additional","affiliation":[{"name":"MIBI: Interdisciplinary Group on Mitochondrial Targeting and Bioenergetics, Santiago 8380453, Chile"},{"name":"Metabolic Plasticity and Bioenergetics Laboratory, Program of Clinical and Molecular Pharmacology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380453, Chile"},{"name":"Network for Snake Venom Research and Drug Discovery, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-9014","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Tobar","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology Laboratory, INTA, University of Chile, Santiago 7830490, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Molecular and Cell Biology Laboratory, INTA, University of Chile, Santiago 7830490, Chile"},{"name":"MIBI: Interdisciplinary Group on Mitochondrial Targeting and Bioenergetics, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40169-018-0205-6","article-title":"Cytokines, breast cancer stem cells (BCSCs) and chemoresistance","volume":"7","author":"Chen","year":"2018","journal-title":"Clin. 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