{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:27:57Z","timestamp":1793381277898,"version":"4.5.0"},"reference-count":134,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Chemerin is a multifaceted adipokine that is involved in multiple biological processes, including inflammation, angiogenesis, adipogenesis, and energy metabolism, as well as oxidative stress. There is a vast body of evidence for a crucial role of chemerin in the development of different cardiovascular diseases. Blood chemerin levels, as well as its placental expression, are elevated in patients with pre-eclampsia (PE) and correlate positively with the severity of the disease. This narrative review summarizes the current knowledge about the potential role of chemerin during PE development, with a particular focus on its involvement in oxidative stress and endothelial dysfunction.<\/jats:p>","DOI":"10.3390\/antiox12040830","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T02:03:53Z","timestamp":1680055433000},"page":"830","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Understanding the Role of Chemerin in the Pathophysiology of Pre-Eclampsia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-1963","authenticated-orcid":false,"given":"Katarzyna","family":"Pankiewicz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, 01-211 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-3550","authenticated-orcid":false,"given":"Tadeusz","family":"Issat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Kasprzaka 17a, 01-211 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/ITT.S73223","article-title":"The Role of Adipokines in Chronic Inflammation","volume":"5","author":"Mancuso","year":"2016","journal-title":"ImmunoTargets Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional Cloning of the Mouse Obese Gene and Its Human Homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/biof.185","article-title":"Adipokines: Biofactors from White Adipose Tissue. A Complex Hub among Inflammation, Metabolism, and Immunity","volume":"37","author":"Conde","year":"2011","journal-title":"BioFactors"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/1523-1747.ep12276660","article-title":"Tazarotene-Induced Gene 2 (TIG2), a Novel Retinoid-Responsive Gene in Skin","volume":"109","author":"Nagpal","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1530\/JOE-18-0174","article-title":"Chemerin: A Multifaceted Adipokine Involved in Metabolic Disorders","volume":"238","author":"Helfer","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Macvanin, M.T., Rizzo, M., Radovanovic, J., Sonmez, A., Paneni, F., and Isenovic, E.R. (2022). Role of Chemerin in Cardiovascular Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112970"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/CS20210989","article-title":"Placental Trophoblast-Specific Overexpression of Chemerin Induces Preeclampsia-like Symptoms","volume":"136","author":"Tan","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.preghy.2018.05.004","article-title":"The Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis & Management Recommendations for International Practice","volume":"13","author":"Brown","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/1471-0528.14384","article-title":"Serious Maternal Complications in Relation to Severe Pre-Eclampsia: A Retrospective Cohort Study of the Impact of Hospital Volume","volume":"124","author":"Ananth","year":"2017","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"i1753","DOI":"10.1136\/bmj.i1753","article-title":"Clinical Risk Factors for Pre-Eclampsia Determined in Early Pregnancy: Systematic Review and Meta-Analysis of Large Cohort Studies","volume":"353","author":"Bartsch","year":"2016","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/bmj.323.7323.1213","article-title":"Long Term Mortality of Mothers and Fathers after Pre-Eclampsia: Population Based Cohort Study","volume":"323","author":"Irgens","year":"2001","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0140-6736(13)60741-2","article-title":"Pre-Eclampsia and the Risk of Kidney Disease","volume":"382","author":"Vikse","year":"2013","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1097\/HJH.0b013e328331b8c6","article-title":"Preeclampsia and Increased Blood Pressure in the Offspring: Meta-Analysis and Critical Review of the Evidence","volume":"27","author":"Ferreira","year":"2009","journal-title":"J. Hypertens."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific Recruitment of Antigen-Presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0014-5793(03)01312-7","article-title":"Characterization of Human Circulating TIG2 as a Ligand for the Orphan Receptor ChemR23","volume":"555","author":"Meder","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/pr.116.013177","article-title":"International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function","volume":"70","author":"Kennedy","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"28175","DOI":"10.1074\/jbc.M700793200","article-title":"Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism","volume":"282","author":"Goralski","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.2337\/db09-0277","article-title":"Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells","volume":"58","author":"Sell","year":"2009","journal-title":"Diabetes"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhao, L., Leung, L.L., and Morser, J. (2022). Chemerin Forms: Their Generation and Activity. Biomedicines, 10.","DOI":"10.3390\/biomedicines10082018"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.exphem.2006.05.003","article-title":"Chemoattractants, Extracellular Proteases, and the Integrated Host Defense Response","volume":"34","author":"Zabel","year":"2006","journal-title":"Exp. Hematol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"De Henau, O., Degroot, G.-N., Imbault, V., Robert, V., De Poorter, C., Mcheik, S., Gal\u00e9s, C., Parmentier, M., and Springael, J.-Y. (2016). Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164179"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molimm.2018.12.016","article-title":"Chemerin-Activated Functions of CMKLR1 Are Regulated by G Protein-Coupled Receptor Kinase 6 (GRK6) and \u03b2-Arrestin 2 in Inflammatory Macrophages","volume":"106","author":"Serafin","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1007\/s00018-021-03894-8","article-title":"Ligand-Binding and -Scavenging of the Chemerin Receptor GPR1","volume":"78","author":"Fischer","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Degroot, G.-N., Lepage, V., Parmentier, M., and Springael, J.-Y. (2022). The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with \u03b2-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking. Cells, 11.","DOI":"10.3390\/cells11061037"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yu, M., Yang, Y., Huang, C., Ge, L., Xue, L., Xiao, Z., Xiao, T., Zhao, H., Ren, P., and Zhang, J.V. (2022). Chemerin: A Functional Adipokine in Reproductive Health and Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081910"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Treeck, O., Buechler, C., and Ortmann, O. (2019). Chemerin and Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153750"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12944-020-01378-5","article-title":"Chemerin Enhances the Adhesion and Migration of Human Endothelial Progenitor Cells and Increases Lipid Accumulation in Mice with Atherosclerosis","volume":"19","author":"Jia","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1689::AID-IMMU1689>3.0.CO;2-I","article-title":"ChemR23, a Putative Chemoattractant Receptor, Is Expressed in Monocyte-Derived Dendritic Cells and Macrophages and Is a Coreceptor for SIV and Some Primary HIV-1 Strains","volume":"28","author":"Samson","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1210\/jc.2010-0042","article-title":"Chemerin, a Novel Adipokine in the Regulation of Angiogenesis","volume":"95","author":"Bozaoglu","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-021-09818-1","article-title":"Chemerin Regulates Normal Angiogenesis and Hypoxia-Driven Neovascularization","volume":"25","author":"Mandi","year":"2022","journal-title":"Angiogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1359\/jbmr.091106","article-title":"Role of Chemerin\/CMKLR1 Signaling in Adipogenesis and Osteoblastogenesis of Bone Marrow Stem Cells","volume":"25","author":"Muruganandan","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0143-4004(91)90339-H","article-title":"Current Topic: Pre-Eclampsia and the Placenta","volume":"12","author":"Redman","year":"1991","journal-title":"Placenta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.placenta.2013.12.008","article-title":"IFPA Senior Award Lecture: Making Sense of Pre-Eclampsia\u2014Two Placental Causes of Preeclampsia?","volume":"35","author":"Redman","year":"2014","journal-title":"Placenta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The Two-Stage Placental Model of Preeclampsia: An Update","volume":"134\u2013135","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1007\/s43032-020-00212-8","article-title":"Regulation of Uterine Spiral Artery Remodeling: A Review","volume":"27","author":"Albrecht","year":"2020","journal-title":"Reprod. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S907","DOI":"10.1016\/j.ajog.2020.09.047","article-title":"Syncytiotrophoblast Stress in Preeclampsia: The Convergence Point for Multiple Pathways","volume":"226","author":"Redman","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Pankiewicz, K., Fija\u0142kowska, A., Issat, T., and Maciejewski, T.M. (2021). Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063132"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S9.e1","DOI":"10.1016\/j.ajog.2015.08.003","article-title":"Preeclampsia, Biomarkers, Syncytiotrophoblast Stress, and Placental Capacity","volume":"213","author":"Redman","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_39","first-page":"S0002937820311960","article-title":"Imbalances in Circulating Angiogenic Factors in the Pathophysiology of Preeclampsia and Related Disorders","volume":"226","author":"Rana","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-Eclampsia Part 1: Current Understanding of Its Pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1095\/biolreprod.113.116186","article-title":"Increasing Maternal Body Mass Index Is Associated with Systemic Inflammation in the Mother and the Activation of Distinct Placental Inflammatory Pathways","volume":"90","author":"Aye","year":"2014","journal-title":"Biol. Reprod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/HYPERTENSIONAHA.116.07099","article-title":"Preconception Cardiovascular Risk Factor Differences Between Gestational Hypertension and Preeclampsia: Cohort Norway Study","volume":"67","author":"Egeland","year":"2016","journal-title":"Hypertension"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0065-2571(85)90049-4","article-title":"Oxidative Stress: Excited Oxygen Species and Enzyme Activity","volume":"23","author":"Cadenas","year":"1985","journal-title":"Adv. Enzym. Regul."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.placenta.2022.12.009","article-title":"Evaluation of Oxidative Stress Markers in Subtypes of Preeclampsia: A Systematic Review and Meta-Analysis","volume":"132","author":"Freire","year":"2023","journal-title":"Placenta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative Stress","volume":"25","author":"Burton","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_46","first-page":"8238727","article-title":"Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia","volume":"2019","author":"Ferreira","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Aouache, R., Biquard, L., Vaiman, D., and Miralles, F. (2018). Oxidative Stress in Preeclampsia and Placental Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051496"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.placenta.2008.11.003","article-title":"Placental Endoplasmic Reticulum Stress and Oxidative Stress in the Pathophysiology of Unexplained Intrauterine Growth Restriction and Early Onset Preeclampsia","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/j.semperi.2014.03.005","article-title":"Pathophysiology of Ischemic Placental Disease","volume":"38","author":"Roberts","year":"2014","journal-title":"Semin. Perinatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1053\/plac.1999.0513","article-title":"Carter, A.M. Placental Oxygen Consumption. Part I: In Vivo Studies\u2014A Review","volume":"21","author":"Carter","year":"2000","journal-title":"Placenta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"165354","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative Stress: Normal Pregnancy versus Preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim. Biophys. Acta Mol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1573402115666190119163942","article-title":"The Role of Oxidative Stress, Adhesion Molecules and Antioxidants in Preeclampsia","volume":"15","author":"Haram","year":"2019","journal-title":"Curr. Hypertens. Rev."},{"key":"ref_53","first-page":"372","article-title":"Endothelial Dysfunction and Preeclampsia: Role of Oxidative Stress","volume":"5","author":"Prada","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tice.2014.08.004","article-title":"Oxidative Stress and Apoptosis in Preeclampsia","volume":"46","author":"Can","year":"2014","journal-title":"Tissue Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fphys.2018.00602","article-title":"Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease","volume":"9","author":"Arribas","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tomimatsu, T., Mimura, K., Matsuzaki, S., Endo, M., Kumasawa, K., and Kimura, T. (2019). Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174246"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/14767050400028816","article-title":"Plasma Soluble Vascular Endothelial Growth Factor Receptor-1 Concentration Is Elevated Prior to the Clinical Diagnosis of Pre-Eclampsia","volume":"17","author":"Chaiworapongsa","year":"2005","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Modzelewski, J., Siarkowska, I., Pajurek-Dudek, J., Feduniw, S., Muzyka-Placzy\u0144ska, K., Baran, A., Kajdy, A., Bednarek-J\u0119drzejek, M., Cymbaluk-P\u0142oska, A., and Kwiatkowska, E. (2023). Atypical Preeclampsia before 20 Weeks of Gestation-A Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043752"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Dymara-Konopka, W., Laskowska, M., Grywalska, E., Hymos, A., B\u0142a\u017cewicz, A., and Leszczy\u0144ska-Gorzelak, B. (2023). Similar Pro- and Antiangiogenic Profiles Close to Delivery in Different Clinical Presentations of Two Pregnancy Syndromes: Preeclampsia and Fetal Growth Restriction. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020972"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/jhh.2017.61","article-title":"Placental Growth Factor and Pre-Eclampsia","volume":"31","author":"Chau","year":"2017","journal-title":"J. Hum. Hypertens."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2147\/IJWH.S368454","article-title":"Perspectives on the Use of Placental Growth Factor (PlGF) in the Prediction and Diagnosis of Pre-Eclampsia: Recent Insights and Future Steps","volume":"15","author":"Creswell","year":"2023","journal-title":"Int. J. Womens Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"a023473","DOI":"10.1101\/cshperspect.a023473","article-title":"Molecular Mechanisms of Preeclampsia","volume":"5","author":"Hod","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3109\/10641955.2013.858745","article-title":"Relationship between Nulliparity and Preeclampsia May Be Explained by Altered Circulating Soluble Fms-like Tyrosine Kinase 1","volume":"33","author":"Bdolah","year":"2014","journal-title":"Hypertens. Pregnancy"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/HYPERTENSIONAHA.112.195065","article-title":"Circulating Angiogenic Factors and Risk of Adverse Maternal and Perinatal Outcomes in Twin Pregnancies with Suspected Preeclampsia","volume":"60","author":"Rana","year":"2012","journal-title":"Hypertension"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Amraoui, F., Spijkers, L., Hassani Lahsinoui, H., Vogt, L., van der Post, J., Peters, S., Afink, G., Ris-Stalpers, C., and van den Born, B.-J. (2014). SFlt-1 Elevates Blood Pressure by Augmenting Endothelin-1-Mediated Vasoconstriction in Mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091897"},{"key":"ref_66","first-page":"2","article-title":"Bevacizumab-Mediated Interference with VEGF Signaling Is Sufficient to Induce a Preeclampsia-like Syndrome in Nonpregnant Women","volume":"5","author":"Cross","year":"2012","journal-title":"Rev. Obstet. Gynecol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1096\/fj.14-252684","article-title":"Ouabain Inhibits Placental SFlt1 Production by Repressing HSP27-Dependent HIF-1\u03b1 Pathway","volume":"28","author":"Rana","year":"2014","journal-title":"FASEB J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.2353\/ajpath.2010.090800","article-title":"Effects of Hypoxia-Inducible Factor-1alpha Overexpression in Pregnant Mice: Possible Implications for Preeclampsia and Intrauterine Growth Restriction","volume":"177","author":"Tal","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/HYPERTENSIONAHA.115.05314","article-title":"Hypoxia-Independent Upregulation of Placental Hypoxia Inducible Factor-1\u03b1 Gene Expression Contributes to the Pathogenesis of Preeclampsia","volume":"65","author":"Iriyama","year":"2015","journal-title":"Hypertension"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/10641955.2016.1259627","article-title":"Relationship between Hypoxia and Downstream Pathogenic Pathways in Preeclampsia","volume":"36","author":"Korkes","year":"2017","journal-title":"Hypertens. Pregnancy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1161\/HYPERTENSIONAHA.108.115006","article-title":"Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-like Tyrosine Kinase-1 and Soluble Endogline in Preeclampsia","volume":"52","author":"Sandrim","year":"2008","journal-title":"Hypertension"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.regpep.2011.03.005","article-title":"Serum Levels of the Adipokine Chemerin Are Increased in Preeclampsia during and 6 Months after Pregnancy","volume":"168","author":"Stepan","year":"2011","journal-title":"Regul. Pept."},{"key":"ref_74","first-page":"121","article-title":"Serum Levels of the Adipokine Chemerin in Preeclampsia","volume":"40","author":"Duan","year":"2011","journal-title":"J. Perinat. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.peptides.2014.10.002","article-title":"The Predictive Value of the First-Trimester Maternal Serum Chemerin Level for Pre-Eclampsia","volume":"62","author":"Xu","year":"2014","journal-title":"Peptides"},{"key":"ref_76","first-page":"195","article-title":"Chemerin Level in Pregnancies Complicated by Preeclampsia and Its Relation with Disease Severity and Neonatal Outcomes","volume":"37","author":"Cetin","year":"2017","journal-title":"J. Obstet. Gynaecol. J. Inst. Obstet. Gynaecol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"154172","DOI":"10.1016\/j.metabol.2020.154172","article-title":"The Role of Serum Adipokine Levels in Preeclampsia: A Systematic Review","volume":"106","author":"Daskalakis","year":"2020","journal-title":"Metabolism"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"473","DOI":"10.12891\/ceog1873.2015","article-title":"Serum Levels of the Adipokines, Free Fatty Acids, and Oxidative Stress Markers in Obese and Non-Obese Preeclamptic Patients","volume":"42","author":"Turgut","year":"2015","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1210\/jc.2012-1102","article-title":"Chemerin Regulates NK Cell Accumulation and Endothelial Cell Morphogenesis in the Decidua during Early Pregnancy","volume":"97","author":"Carlino","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.placenta.2012.02.007","article-title":"Expression and Regulation of Chemerin during Rat Pregnancy","volume":"33","author":"Garces","year":"2012","journal-title":"Placenta"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"112802","DOI":"10.1016\/j.yexcr.2021.112802","article-title":"HOXA9-Induced Chemerin Signals through CMKLR1\/AMPK\/TXNIP\/NLRP3 Pathway to Induce Pyroptosis of Trophoblasts and Aggravate Preeclampsia","volume":"408","author":"Quan","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s11684-017-0577-9","article-title":"Role of Chemerin\/CMKLR1 in the Maintenance of Early Pregnancy","volume":"12","author":"Yang","year":"2018","journal-title":"Front. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"110699","DOI":"10.1016\/j.mce.2019.110699","article-title":"Endovascular Trophoblast and Spiral Artery Remodeling","volume":"503","author":"Sato","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"883636","DOI":"10.3389\/fcell.2022.883636","article-title":"The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10565-021-09636-7","article-title":"Chemerin Promotes the Pathogenesis of Preeclampsia by Activating CMKLR1\/p-Akt\/CEBP\u0251 Axis and Inducing M1 Macrophage Polarization","volume":"38","author":"Ji","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3389\/fimmu.2019.00792","article-title":"Macrophage Polarization in Physiological and Pathological Pregnancy","volume":"10","author":"Yao","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The Role of Inflammation in the Pathology of Preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1189\/jlb.1112603","article-title":"A Leading Role for the Immune System in the Pathophysiology of Preeclampsia","volume":"94","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.placenta.2017.01.127","article-title":"HOXA9 Transcriptionally Regulates the EPHB4 Receptor to Modulate Trophoblast Migration and Invasion","volume":"51","author":"Liu","year":"2017","journal-title":"Placenta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2958.2000.02103.x","article-title":"Salmonella Induces Macrophage Death by Caspase-1-Dependent Necrosis","volume":"38","author":"Brennan","year":"2000","journal-title":"Mol. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbrc.2018.03.142","article-title":"Liraglutide Attenuates NLRP3 Inflammasome-Dependent Pyroptosis via Regulating SIRT1\/NOX4\/ROS Pathway in H9c2 Cells","volume":"499","author":"Chen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1182\/blood-2016-03-705434","article-title":"Maternal Extracellular Vesicles and Platelets Promote Preeclampsia via Inflammasome Activation in Trophoblasts","volume":"128","author":"Kohli","year":"2016","journal-title":"Blood"},{"key":"ref_93","first-page":"119","article-title":"LINC00240\/MiR-155 Axis Regulates Function of Trophoblasts and M2 Macrophage Polarization via Modulating Oxidative Stress-Induced Pyroptosis in Preeclampsia","volume":"28","author":"Wu","year":"2022","journal-title":"Mol. Med. Camb. Mass"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41419-019-2162-4","article-title":"Pyroptosis Is a Critical Inflammatory Pathway in the Placenta from Early Onset Preeclampsia and in Human Trophoblasts Exposed to Hypoxia and Endoplasmic Reticulum Stressors","volume":"10","author":"Cheng","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/CS20130286","article-title":"Chemerin Reduces Vascular Nitric Oxide\/CGMP Signalling in Rat Aorta: A Link to Vascular Dysfunction in Obesity?","volume":"127","author":"Neves","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"E556","DOI":"10.1210\/jc.2011-2937","article-title":"Chemerin as a Mediator between Obesity and Vascular Inflammation in Children","volume":"97","author":"Landgraf","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12967-021-03220-7","article-title":"Role of Chemerin\/ChemR23 Axis as an Emerging Therapeutic Perspective on Obesity-Related Vascular Dysfunction","volume":"20","author":"Xie","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Szpakowicz, A., Szpakowicz, M., Lapinska, M., Paniczko, M., Lawicki, S., Raczkowski, A., Kondraciuk, M., Sawicka, E., Chlabicz, M., and Kozuch, M. (2021). Serum Chemerin Concentration Is Associated with Proinflammatory Status in Chronic Coronary Syndrome. Biomolecules, 11.","DOI":"10.3390\/biom11081149"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"16678","DOI":"10.18632\/oncotarget.24659","article-title":"Chemerin Induces Endothelial Cell Inflammation: Activation of Nuclear Factor-Kappa Beta and Monocyte-Endothelial Adhesion","volume":"9","author":"Dimitriadis","year":"2018","journal-title":"Oncotarget"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Socha, M.W., Malinowski, B., Puk, O., Wart\u0119ga, M., Stankiewicz, M., Kazdepka-Ziemi\u0144ska, A., and Wici\u0144ski, M. (2021). The Role of NF-\u039aB in Uterine Spiral Arteries Remodeling, Insight into the Cornerstone of Preeclampsia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020704"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.bbrc.2009.12.150","article-title":"Identification of Chemerin Receptor (ChemR23) in Human Endothelial Cells: Chemerin-Induced Endothelial Angiogenesis","volume":"391","author":"Kaur","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"55684","DOI":"10.18632\/oncotarget.18264","article-title":"The P38 Pathway, a Major Pleiotropic Cascade That Transduces Stress and Metastatic Signals in Endothelial Cells","volume":"8","author":"Corre","year":"2017","journal-title":"Oncotarget"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e13962","DOI":"10.14814\/phy2.13962","article-title":"Chemerin Promotes Angiogenesis In Vivo","volume":"6","author":"Nakamura","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Palei, A.C., Cruz, J.D.O., Chaguri, J.L., Pera\u00e7oli, J.C., Rom\u00e3o-Veiga, M., Ribeiro-Vasques, V.R., Cavalli, R.C., Nunes, P.R., Luizon, M.R., and Sandrim, V.C. (2022). Circulating Levels of Tissue Inhibitor of Metalloproteinase 3, a Protein with Inhibitory Effects on Angiogenesis, Are Increased in Pre-Eclampsia. Int. J. Gynaecol. Obstet. Off. Organ Int. Fed. Gynaecol. Obstet.","DOI":"10.1002\/ijgo.14552"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-Eclampsia: Pathophysiology and Clinical Implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11010-021-04294-z","article-title":"The Role of Endoglin and Its Soluble Form in Pathogenesis of Preeclampsia","volume":"477","author":"Petousis","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e32741","DOI":"10.1097\/MD.0000000000032741","article-title":"Identification and Validation of an Angiogenesis-Related Signature Associated with Preeclampsia by Bioinformatic Analysis","volume":"102","author":"Ma","year":"2023","journal-title":"Medicine"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Chua, S.-K., Shyu, K.-G., Lin, Y.-F., Lo, H.-M., Wang, B.-W., Chang, H., and Lien, L.-M. (2016). Tumor Necrosis Factor-Alpha and the ERK Pathway Drive Chemerin Expression in Response to Hypoxia in Cultured Human Coronary Artery Endothelial Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165613"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/ATVBAHA.113.301476","article-title":"Chemerin Connects Fat to Arterial Contraction","volume":"33","author":"Watts","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"H498","DOI":"10.1152\/ajpheart.00998.2015","article-title":"The Adipokine Chemerin Amplifies Electrical Field-Stimulated Contraction in the Isolated Rat Superior Mesenteric Artery","volume":"311","author":"Darios","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12944-023-01777-4","article-title":"Adipokine Chemerin Overexpression in Trophoblasts Leads to Dyslipidemia in Pregnant Mice: Implications for Preeclampsia","volume":"22","author":"Tan","year":"2023","journal-title":"Lipids Health Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/HJH.0000000000000588","article-title":"Elevating Circulation Chemerin Level Is Associated with Endothelial Dysfunction and Early Atherosclerotic Changes in Essential Hypertensive Patients","volume":"33","author":"Gu","year":"2015","journal-title":"J. Hypertens."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Joo, E.H., Kim, Y.R., Kim, N., Jung, J.E., Han, S.H., and Cho, H.Y. (2021). Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810122"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2012.11.011","article-title":"Oxidative Stress Mediates Chemerin-Induced Autophagy in Endothelial Cells","volume":"55","author":"Shen","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbrc.2019.01.125","article-title":"Involvement of Obesity-Associated Upregulation of Chemerin\/Chemokine-like Receptor 1 in Oxidative Stress and Apoptosis in Ovaries and Granulosa Cells","volume":"510","author":"Yao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tjog.2021.05.019","article-title":"The Significance of Blood and Salivary Oxidative Stress Markers and Chemerin in Gestational Diabetes Mellitus","volume":"60","author":"Bulut","year":"2021","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/jcmm.12282","article-title":"Association of Chemerin with Oxidative Stress, Inflammation and Classical Adipokines in Non-Diabetic Obese Patients","volume":"18","author":"Seres","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Neves, K.B., Montezano, A.C., Alves-Lopes, R., Bruder-Nascimento, T., Costa, R.M., Costa, R.S., Touyz, R.M., and Tostes, R.C. (2018). Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082454"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12020-014-0286-y","article-title":"Chemerin Plays a Protective Role by Regulating Human Umbilical Vein Endothelial Cell-Induced Nitric Oxide Signaling in Preeclampsia","volume":"48","author":"Wang","year":"2015","journal-title":"Endocrine"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/uog.20126","article-title":"Metabolic Syndrome and Pre-Eclampsia","volume":"54","author":"Hooijschuur","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCULATIONAHA.113.003664","article-title":"Cardiovascular Implications in Preeclampsia: An Overview","volume":"130","author":"Melchiorre","year":"2014","journal-title":"Circulation"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.vph.2016.11.009","article-title":"Chemerin-Induced Arterial Contraction Is Gi- and Calcium-Dependent","volume":"88","author":"Ferland","year":"2017","journal-title":"Vascul. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"116580","DOI":"10.1016\/j.lfs.2019.116580","article-title":"Chemerin Influences Endothelin- and Serotonin-Induced Pulmonary Artery Vasoconstriction in Rats","volume":"231","author":"Hanthazi","year":"2019","journal-title":"Life Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1113\/JP277643","article-title":"Uterine Perivascular Adipose Tissue Is a Novel Mediator of Uterine Artery Blood Flow and Reactivity in Rat Pregnancy","volume":"597","author":"Osikoya","year":"2019","journal-title":"J. Physiol."},{"key":"ref_125","first-page":"1327","article-title":"Chemerin Stimulates Aortic Smooth Muscle Cell Proliferation and Migration via Activation of Autophagy in VSMCs of Metabolic Hypertension Rats","volume":"11","author":"Wen","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"H1017","DOI":"10.1152\/ajpheart.00820.2014","article-title":"Chemerin Promotes the Proliferation and Migration of Vascular Smooth Muscle and Increases Mouse Blood Pressure","volume":"309","author":"Kunimoto","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"767705","DOI":"10.3389\/fphar.2022.767705","article-title":"Chemerin Regulates the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via the ERK1\/2 Signaling Pathway","volume":"13","author":"Peng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/ars.2009.2875","article-title":"Oxidative Stress and Vascular Smooth Muscle Cell Growth: A Mechanistic Linkage by Cyclophilin A","volume":"12","author":"Satoh","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1152\/advan.00114.2010","article-title":"Neural Control of the Circulation","volume":"35","author":"Thomas","year":"2011","journal-title":"Adv. Physiol. Educ."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"bqad041","DOI":"10.1210\/endocr\/bqad041","article-title":"Circulating Chemerin Is Elevated in Women with Preeclampsia","volume":"164","author":"Bartho","year":"2023","journal-title":"Endocrinology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e003497","DOI":"10.1161\/CIRCOUTCOMES.116.003497","article-title":"Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis","volume":"10","author":"Wu","year":"2017","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/1471-0528.12191","article-title":"Risk of Cardiovascular Disease after Pre-Eclampsia and the Effect of Lifestyle Interventions: A Literature-Based Study","volume":"120","author":"Berks","year":"2013","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5114\/pm.2019.85785","article-title":"Non-Obstetric Complications in Preeclampsia","volume":"18","author":"Pankiewicz","year":"2019","journal-title":"Prz. Menopauzalny Menopause Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e027930","DOI":"10.1161\/JAHA.122.027930","article-title":"Third-Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study","volume":"12","author":"Chen","year":"2023","journal-title":"J. Am. Heart Assoc."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/4\/830\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:05:35Z","timestamp":1760123135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/4\/830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":134,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["antiox12040830"],"URL":"https:\/\/doi.org\/10.3390\/antiox12040830","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,29]]}}}