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NAFLD does not have specific drug therapies, with a healthy lifestyle and weight loss being the main approaches to prevent and treat NAFLD. The aim was to assess the antioxidant and pro-inflammatory state in patients with NAFLD after 12-month-lifestyle intervention depending on the change in adherence to a Mediterranean diet (AMD). Antioxidant and inflammatory biomarkers were measured in 67 adults (aged 40\u201360 years old) diagnosed with NAFLD. Anthropometric parameters and dietary intake were measured by a validated semi-quantitative 143-item food frequency questionnaire. The nutritional intervention improved anthropometric and biochemical parameters after a 12-month follow-up. However, decreases in alanine aminotransferase (ALT) and C reactive protein (CRP) were higher in participants with high AMD, which also showed higher improvement in physical fitness (Chester step test) and intrahepatic fat contents. The intervention reduced plasma levels of malondialdehyde, myeloperoxidase, zonulin, and omentin, and increased resolvin D1 (RvD1), whereas the decrease in leptin, ectodysplasin-A (EDA), cytokeratin-18 (CK-18), interleukin-1ra (IL-1ra) and endotoxin was only significant in participants with higher AMD. The current study showed that a one-year nutritional intervention improved main NAFLD features such as body mass index, IFC, liver enzymes, and prooxidant and proinflammatory status. There was also a decrease in the concentration of plasmatic endotoxin, suggesting an improvement in intestinal permeability. These health benefits were more evident in participants that improved AMD to a greater extent. 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Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41575-019-0144-8","article-title":"Past, present and future perspectives in nonalcoholic fatty liver disease","volume":"16","author":"Sanyal","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Su\u00e1rez, M., Boqu\u00e9, N., del Bas, J.M., Mayneris-Perxachs, J., Arola, L., and Caimari, A. (2017). Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease. Nutrients, 9.","DOI":"10.3390\/nu9101052"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Prikhodko, V.A., Bezborodkina, N.N., and Okovityi, S.V. (2022). Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020274"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.3748\/wjg.v24.i19.2083","article-title":"Mediterranean diet and nonalcoholic fatty liver disease","volume":"24","author":"Anania","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.23736\/S0026-4806.20.07089-5","article-title":"Mediterranean diet and probiotics supplementation to treat non-alcoholic fatty liver disease","volume":"111","author":"Abenavoli","year":"2020","journal-title":"Minerva Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Torres, M.C.P., Aghemo, A., Lleo, A., Bodini, G., Furnari, M., Marabotto, E., Miele, L., and Giannini, E.G. (2019). Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered. Nutrients, 11.","DOI":"10.3390\/nu11122971"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/gerona\/glx227","article-title":"Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms","volume":"73","author":"Tosti","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Nani, A., Murtaza, B., Khan, A.S., Khan, N.A., and Hichami, A. (2021). Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms. Molecules, 26.","DOI":"10.3390\/molecules26040985"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"ref_15","unstructured":"U.S. Department of Health and Human Services (2015). Dietary Guidelines for Americans 2015\u20132020 U.S."},{"key":"ref_16","first-page":"16","article-title":"The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study; a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control","volume":"26","author":"Zulet","year":"2011","journal-title":"Nutr. Hosp."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1017\/S0007114513002778","article-title":"A new dietary strategy for long-term treatment of the metabolic syndrome is compared with the American Heart Association (AHA) guidelines: The MEtabolic Syndrome REduction in NAvarra (RESMENA) project","volume":"111","author":"Abete","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMc1806491","article-title":"Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bouzas, C., del Bibiloni, M., Julibert, A., Ruiz-Canela, M., Salas-Salvad\u00f3, J., Corella, D., Zome\u00f1o, M.D., Romaguera, D., Vioque, J., and Alonso-G\u00f3mez, \u00c1.M. (2020). Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study. Nutrients, 12.","DOI":"10.3390\/nu12072114"},{"key":"ref_20","unstructured":"Clinical Trials.gov (2022, May 18). US National Library of Medicine. Prevention and Reversion of NAFLD in Obese Patients with Metabolic Syndrome by Mediterranean Diet and Physical Activity (FLIPAN), Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04442620."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1136\/bjsm.2003.005389","article-title":"Reliability and validity of measures taken during the Chester step test to predict aerobic power and to prescribe aerobic exercise","volume":"38","author":"Buckley","year":"2004","journal-title":"Br. J. Sports Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.mric.2010.08.013","article-title":"Quantification of liver fat with magnetic resonance imaging","volume":"18","author":"Reeder","year":"2010","journal-title":"Magn. Reson. Imaging Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in Vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzym. Anal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kubiliene, L., Laugaliene, V., Pavilonis, A., Maruska, A., Majiene, D., Barcauskaite, K., Kubilius, R., Kasparaviciene, G., and Savickas, A. (2015). Alternative preparation of propolis extracts: Comparison of their composition and biological activities. BMC Complement. Altern. Med., 15.","DOI":"10.1186\/s12906-015-0677-5"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2337\/dc18-0836","article-title":"Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial","volume":"42","author":"Basora","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cmet.2018.01.005","article-title":"An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans","volume":"27","author":"Mardinoglu","year":"2018","journal-title":"Cell Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1210\/jc.2016-2353","article-title":"Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD","volume":"101","author":"Cuthbertson","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1113\/jphysiol.2011.225011","article-title":"Regulation and limitations to fatty acid oxidation during exercise","volume":"590","author":"Jeppesen","year":"2012","journal-title":"J. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.recesp.2014.09.018","article-title":"Greater Adherence to a Mediterranean Dietary Pattern Is Associated With Improved Plasma Lipid Profile: The Aragon Health Workers Study Cohort","volume":"68","author":"Oliva","year":"2015","journal-title":"Rev. Espa\u00f1ola Cardiol. English Ed."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3748\/wjg.v25.i4.509","article-title":"Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease","volume":"25","author":"Biolato","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.3748\/wjg.v23.i17.3150","article-title":"Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease","volume":"23","author":"Gelli","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.nutres.2016.02.009","article-title":"Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: A meta-analysis","volume":"36","author":"Neale","year":"2016","journal-title":"Nutr. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5152\/tjg.2016.16106","article-title":"Role of oxidative stress and insulin resistance in disease severity of non-alcoholic fatty liver disease","volume":"27","author":"Canbakan","year":"2016","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1080\/10715762.2019.1635691","article-title":"Oxidative stress biomarkers in the serum and plasma of patients with non-alcoholic fatty liver disease (NAFLD). Can plasma AGE be a marker of NAFLD? Oxidative stress biomarkers in NAFLD patients","volume":"53","author":"Maciejczyk","year":"2019","journal-title":"Free Radic. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/10715762.2013.837577","article-title":"Involvement of free radicals and oxidative stress in NAFLD\/NASH","volume":"47","author":"Sumida","year":"2013","journal-title":"Free Radic. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sim\u00f5es, I.C.M., Amorim, R., Teixeira, J., Karkucinska-wieckowska, A., Carvalho, A., Pereira, S.P., Sim\u00f5es, R.F., Szymanska, S., D\u0105browski, M., and Janikiewicz, J. (2021). The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136848"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/9780470531792.ch3","article-title":"Biochemical actions of plant phenolics compounds: Thermodynamic and kinetic aspects","volume":"3","author":"Fraga","year":"2009","journal-title":"Plant Phenolics Hum. Health Biochem. Nutr. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s11033-018-4279-4","article-title":"Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects","volume":"45","author":"Ali","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Monserrat-Mesquida, M., Quetglas-Llabr\u00e9s, M., Bouzas, C., Montemayor, S., Mascar\u00f3, C.M., Casares, M., Llompart, I., Ugarriza, L., Mart\u00ednez, J.A., and Tur, J.A. (2022). Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11081440"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1123\/pes.25.1.12","article-title":"Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens","volume":"25","author":"Many","year":"2013","journal-title":"Pediatr. Exerc. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1758-5996-4-37","article-title":"Omentin as a novel biomarker of metabolic risk factors","volume":"4","author":"Shibata","year":"2012","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.clnesp.2020.06.014","article-title":"The association between serum omentin level and bodyweight: A systematic review and meta-analysis of observational studies","volume":"39","author":"Arab","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/00365521.2010.516452","article-title":"Serum levels of omentin, chemerin and adipsin in patients with biopsy-proven nonalcoholic fatty liver disease","volume":"46","author":"Yilmaz","year":"2011","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Moreno-Navarrete, J.M., Sabater, M., Ortega, F., Ricart, W., and Fern\u00e1ndez-Real, J.M. (2012). Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037160"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/apm.12696","article-title":"Evaluation of circulating zonulin as a potential marker in the pathogenesis of nonalcoholic fatty liver disease","volume":"125","author":"Hendy","year":"2017","journal-title":"APMIS"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.numecd.2012.02.007","article-title":"Gut--liver axis: The impact of gut microbiota on non alcoholic fatty liver disease","volume":"22","author":"Compare","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.2174\/1381612811319290011","article-title":"Gut-liver Axis and Microbiota in NAFLD: Insight Pathophysiology for Novel Therapeutic Target","volume":"19","author":"Miele","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.jhep.2006.02.011","article-title":"Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2","volume":"44","author":"Haukeland","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3674390","DOI":"10.1155\/2017\/3674390","article-title":"Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development","volume":"2017","author":"Casas","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"837","DOI":"10.5604\/16652681.1171767","article-title":"Correlation between serum cytokeratin-18 and the progression or regression of non-alcoholic fatty liver disease","volume":"14","author":"Kawanaka","year":"2015","journal-title":"Ann. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9252536","DOI":"10.1155\/2018\/9252536","article-title":"Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease","volume":"2018","author":"Kosasih","year":"2018","journal-title":"Int. J. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3177\/jnsv.56.271","article-title":"Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD)","volume":"56","author":"Tabuchi","year":"2010","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.dsx.2019.01.005","article-title":"Effect of diet-induced weight loss on cytokeratin-18 levels in overweight and obese patients with liver fibrosis","volume":"13","author":"Safarian","year":"2019","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1467-789X.2006.00270.x","article-title":"The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review","volume":"8","author":"Klok","year":"2007","journal-title":"Obes. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3390\/medicina58050641","article-title":"Chronic Inflammation-A Link between Nonalcoholic Fatty Liver Disease (NAFLD) and Dysfunctional Adipose Tissue","volume":"58","author":"Chen","year":"2022","journal-title":"Medicina"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4291\/wjgp.v8.i2.11","article-title":"Nonalcoholic fatty liver disease: Diagnostic biomarkers","volume":"8","author":"Hadizadeh","year":"2017","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"106634","DOI":"10.1016\/j.prostaglandins.2022.106634","article-title":"The role of Resolvin D1 in liver diseases","volume":"160","author":"Yang","year":"2022","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cca.2019.09.009","article-title":"Circulating ectodysplasin A is a potential biomarker for nonalcoholic fatty liver disease","volume":"499","author":"Yang","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/nm.4420","article-title":"Bruning. A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle","volume":"23","author":"Gabel","year":"2017","journal-title":"Nat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"642432","DOI":"10.3389\/fendo.2021.642432","article-title":"Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes","volume":"12","author":"Bayliss","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/jn\/138.8.1452","article-title":"Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake","volume":"138","author":"Thuy","year":"2008","journal-title":"J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e03263-19","DOI":"10.1128\/mBio.03263-19","article-title":"Endotoxin producers overgrowing in human gut microbiota as the causative agents for nonalcoholic fatty liver disease","volume":"11","author":"Fei","year":"2020","journal-title":"MBio"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Calabrese, F.M., Disciglio, V., Franco, I., Sorino, P., Bonfiglio, C., Bianco, A., Campanella, A., Lippolis, T., Pesole, P.L., and Polignano, M. (2022). A low glycemic index Mediterranean diet combined with aerobic physical activity rearranges the gut microbiota signature in NAFLD patients. Nutrients, 14.","DOI":"10.3390\/nu14091773"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"594150","DOI":"10.3389\/fimmu.2020.594150","article-title":"Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions","volume":"11","author":"Mohammad","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Nier, A., Huber, Y., Labenz, C., Michel, M., Bergheim, I., and Schattenberg, J.M. (2020). Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD). 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