{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:27:33Z","timestamp":1769009253410,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cornell High Energy Synchrotron Source (CHESS)","award":["DMR-1332208"],"award-info":[{"award-number":["DMR-1332208"]}]},{"name":"Cornell High Energy Synchrotron Source (CHESS)","award":["DMR-1829070"],"award-info":[{"award-number":["DMR-1829070"]}]},{"name":"Center for High Energy X-ray Sciences (CHEXS)","award":["DMR-1332208"],"award-info":[{"award-number":["DMR-1332208"]}]},{"name":"Center for High Energy X-ray Sciences (CHEXS)","award":["DMR-1829070"],"award-info":[{"award-number":["DMR-1829070"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and\/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis.<\/jats:p>","DOI":"10.3390\/antiox12040846","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T03:32:59Z","timestamp":1680492779000},"page":"846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver"],"prefix":"10.3390","volume":"12","author":[{"given":"Marko Z.","family":"Vatamaniuk","sequence":"first","affiliation":[{"name":"Animal Science Department, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Cornell High Energy Synchrotron Source (CHESS), Cornell University, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Animal Science Department, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-0684","authenticated-orcid":false,"given":"Xin Gen","family":"Lei","sequence":"additional","affiliation":[{"name":"Animal Science Department, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1021\/cr900223a","article-title":"In situ imaging of metals in cells and tissues","volume":"109","author":"McRae","year":"2009","journal-title":"Chem. 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