{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:01:16Z","timestamp":1791511276818,"version":"4.3.4"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["DK 077152"],"award-info":[{"award-number":["DK 077152"]}]},{"name":"National Institutes of Health","award":["#0000005"],"award-info":[{"award-number":["#0000005"]}]},{"name":"National Institutes of Health","award":["PEN04771"],"award-info":[{"award-number":["PEN04771"]}]},{"name":"National Institutes of Health","award":["K01DK123495"],"award-info":[{"award-number":["K01DK123495"]}]},{"name":"Office of Dietary Supplements","award":["DK 077152"],"award-info":[{"award-number":["DK 077152"]}]},{"name":"Office of Dietary Supplements","award":["#0000005"],"award-info":[{"award-number":["#0000005"]}]},{"name":"Office of Dietary Supplements","award":["PEN04771"],"award-info":[{"award-number":["PEN04771"]}]},{"name":"Office of Dietary Supplements","award":["K01DK123495"],"award-info":[{"award-number":["K01DK123495"]}]},{"name":"USDA-NIFA","award":["DK 077152"],"award-info":[{"award-number":["DK 077152"]}]},{"name":"USDA-NIFA","award":["#0000005"],"award-info":[{"award-number":["#0000005"]}]},{"name":"USDA-NIFA","award":["PEN04771"],"award-info":[{"award-number":["PEN04771"]}]},{"name":"USDA-NIFA","award":["K01DK123495"],"award-info":[{"award-number":["K01DK123495"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Selenoprotein W (Selenow) is a ~9 kDa selenoprotein suggested to play a beneficial role in resolving inflammation. However, the underlying mechanisms are poorly understood. SELENOW expression in the human GI tract using ScRNAseq Gut Cell Atlas and Gene Expression Omnibus (GEO) databases revealed its expression in the small intestine and colonic epithelial, endothelial, mesenchymal, and stem cells and correlated with a protective effect in ulcerative colitis patients. Selenow KO mice treated with 4% dextran sodium sulfate (DSS) showed exacerbated acute colitis, with greater weight loss, shorter colons, and increased fecal occult blood compared to the WT counterparts. Selenow KO mice expressed higher colonic Tnf\u03b1, increased Tnf\u03b1+ macrophages in the colonic lamina propria, and exhibited loss in epithelial barrier integrity and decreased zonula occludens 1 (Zo-1) expression following DSS treatment. Expression of epithelial cellular adhesion marker (EpCam), yes-associated protein 1 (Yap1), and epidermal growth factor receptor (Egfr) were decreased along with CD24lo cycling epithelial cells in Selenow KO mice. Colonic lysates and organoids confirmed a crosstalk between Egfr and Yap1 that was regulated by Selenow. Overall, our findings suggest Selenow expression is key for efficient resolution of inflammation in experimental colitis that is mediated through the regulation of Egfr and Yap1.<\/jats:p>","DOI":"10.3390\/antiox12040850","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T03:32:59Z","timestamp":1680492779000},"page":"850","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair"],"prefix":"10.3390","volume":"12","author":[{"given":"Shaneice K.","family":"Nettleford","sequence":"first","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Medicine-Infectious Diseases, University of California, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah P.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN 37232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall M.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Mouse Transgenic Core Facility, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Sandeep","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Molodecky, N.A., Soon, I.S., Rabi, D.M., Ghali, W.A., Ferris, M., Chernoff, G., Benchimol, E.I., Panaccione, R., Ghosh, S., and Barkema, H.W. (2012). Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. 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