{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:29:23Z","timestamp":1791142163650,"version":"4.1.0"},"reference-count":173,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Support of research and development capacities aimed at the digital transformation of clinical and laboratory procedures in the provision of health care, European Regional Development Fund","award":["ITMS: 313011BWX3"],"award-info":[{"award-number":["ITMS: 313011BWX3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress (OS) has an important role in female reproduction, whether it is ovulation, endometrium decidualization, menstruation, oocyte fertilization, or development andimplantation of an embryo in the uterus. The menstrual cycle is regulated by the physiological concentration of reactive forms of oxygen and nitrogen as redox signal molecules, which trigger and regulate the length of individual phases of the menstrual cycle. It has been suggested that the decline in female fertility is modulated by pathological OS. The pathological excess of OS compared to antioxidants triggers many disorders of female reproduction which could lead to gynecological diseases and to infertility. Therefore, antioxidants are crucial for proper female reproductive function. They play a part in the metabolism of oocytes; in endometrium maturation via the activation of antioxidant signaling pathways Nrf2 and NF-\u03baB; and in the hormonal regulation of vascular action. Antioxidants can directly scavenge radicals and act as a cofactor of highly valuable enzymes of cell differentiation and development, or enhance the activity of antioxidant enzymes. Compensation for low levels of antioxidants through their supplementation can improve fertility. This review considers the role of selected vitamins, flavonoids, peptides, and trace elements with antioxidant effects in female reproduction mechanisms.<\/jats:p>","DOI":"10.3390\/antiox12040907","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T03:49:17Z","timestamp":1681271357000},"page":"907","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["The Importance of Natural Antioxidants in Female Reproduction"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-7950","authenticated-orcid":false,"given":"Janka","family":"Va\u0161kov\u00e1","sequence":"first","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Klepcov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"},{"name":"Medirex, a.s., Holubyho 35, 902 01 Pezinok, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"\u0160pakov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-232X","authenticated-orcid":false,"given":"Peter","family":"Urdz\u00edk","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-4153","authenticated-orcid":false,"given":"Jana","family":"\u0160tofilov\u00e1","sequence":"additional","affiliation":[{"name":"Center for Clinical and Preclinical Research MEDIPARK, Department of Experimental Medicine, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Bertkov\u00e1","sequence":"additional","affiliation":[{"name":"Center for Clinical and Preclinical Research MEDIPARK, Department of Experimental Medicine, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"K\u013eoc","sequence":"additional","affiliation":[{"name":"Medirex, a.s., Holubyho 35, 902 01 Pezinok, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Rabajdov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7827-11-66","article-title":"Lifestyle Factors and Reproductive Health: Taking Control of Your Fertility","volume":"11","author":"Sharma","year":"2013","journal-title":"Reprod. 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