{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:55:58Z","timestamp":1791197758568,"version":"4.1.0"},"reference-count":147,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NSERC","award":["#RGPIN-2019-06738"],"award-info":[{"award-number":["#RGPIN-2019-06738"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene is upregulated in a number of pathologies, including Alzheimer\u2019s disease, Parkinson\u2019s disease, cancer, and hypothyroidism. Upregulation of ApoD is linked to decreased oxidative stress and inflammation in several models, including humans, mice, Drosophila melanogaster and plants. Studies suggest that the mechanism through which ApoD modulates oxidative stress and regulate inflammation is via its capacity to bind arachidonic acid (ARA). This polyunsaturated omega-6 fatty acid can be metabolised to generate large variety of pro-inflammatory mediators. ApoD serves as a sequester, blocking and\/or altering arachidonic metabolism. In recent studies of diet-induced obesity, ApoD has been shown to modulate lipid mediators derived from ARA, but also from eicosapentaenoic acid and docosahexaenoic acid in an anti-inflammatory way. High levels of ApoD have also been linked to better metabolic health and inflammatory state in the round ligament of morbidly obese women. Since ApoD expression is upregulated in numerous diseases, it might serve as a therapeutic agent against pathologies aggravated by OS and inflammation such as many obesity comorbidities. This review will present the most recent findings underlying the central role of ApoD in the modulation of both OS and inflammation.<\/jats:p>","DOI":"10.3390\/antiox12051027","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:02:31Z","timestamp":1682942551000},"page":"1027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Apolipoprotein D in Oxidative Stress and Inflammation"],"prefix":"10.3390","volume":"12","author":[{"given":"Guillaume","family":"Fyfe-Desmarais","sequence":"first","affiliation":[{"name":"Laboratory of Metabolism of Lipids, Centre d\u2019Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois (CERMO-FC), Department of Biological Sciences, University of Quebec in Montreal (UQAM), 141 Av. du Pr\u00e9sident-Kennedy, Montreal, QC H2X 1Y4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9derik","family":"Desmarais","sequence":"additional","affiliation":[{"name":"Department of Medecine, Faculty of Medecine, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, 1050 Av. de la M\u00e9decine, Qu\u00e9bec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Rassart","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism of Lipids, Centre d\u2019Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois (CERMO-FC), Department of Biological Sciences, University of Quebec in Montreal (UQAM), 141 Av. du Pr\u00e9sident-Kennedy, Montreal, QC H2X 1Y4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Mounier","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism of Lipids, Centre d\u2019Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois (CERMO-FC), Department of Biological Sciences, University of Quebec in Montreal (UQAM), 141 Av. du Pr\u00e9sident-Kennedy, Montreal, QC H2X 1Y4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/bioinformatics\/btp073","article-title":"Meta-analysis of age-related gene expression profiles identifies common signatures of aging","volume":"25","author":"Curado","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11357-009-9117-0","article-title":"Apolipoprotein D synthesis progressively increases in frontal cortex during human lifespan","volume":"32","author":"Navarro","year":"2010","journal-title":"Age"},{"key":"ref_3","first-page":"361","article-title":"Apolipoprotein D expression in substantia nigra of Parkinson disease","volume":"21","author":"Ordonez","year":"2006","journal-title":"Histol. Histopathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jnr.1054","article-title":"Altered apolipoprotein D expression in the brain of patients with Alzheimer disease","volume":"64","author":"Belloir","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s12192-013-0428-9","article-title":"Overexpression of Hsp27 ameliorates symptoms of Alzheimer\u2019s disease in APP\/PS1 mice","volume":"18","author":"Szegedi","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-5793(91)81244-3","article-title":"Apolipoprotein D transcription occurs specifically in nonproliferating quiescent and senescent fibroblast cultures","volume":"290","author":"Provost","year":"1991","journal-title":"FEBS Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.bbamcr.2007.03.007","article-title":"Modulation of apolipoprotein D expression and translocation under specific stress conditions","volume":"1773","author":"Levros","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1474-9726.2008.00395.x","article-title":"Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress","volume":"7","author":"Ganfornina","year":"2008","journal-title":"Aging Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00384-012-1616-2","article-title":"Expression and potential role of apolipoprotein D on the death-survival balance of human colorectal cancer cells under oxidative stress conditions","volume":"28","author":"Gutierrez","year":"2013","journal-title":"Int. J. Colorectal. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/JAD-130215","article-title":"Oxidative stress induces apolipoprotein D overexpression in hippocampus during aging and Alzheimer\u2019s disease","volume":"36","author":"Martinez","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/aesa\/saw035","article-title":"Molecular Identification and Expression Patterns of Apolipoprotein D from Bombyx mori (Lepidoptera: Bombycidae) in Response to Oxidative Stress and Bacterial Challenge","volume":"109","author":"Chen","year":"2016","journal-title":"Ann. Entomol. Soc. Am."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/andr.12250","article-title":"Differential expression of apolipoprotein D in male reproductive system of rats by high-fat diet","volume":"4","author":"Lim","year":"2016","journal-title":"Andrology"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Diez-Hermano, S., Mejias, A., Sanchez, D., Gutierrez, G., and Ganfornina, M.D. (2020). Control of the neuroprotective Lipocalin Apolipoprotein D expression by alternative promoter regions and differentially expressed mRNA 5\u2019 UTR variants. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0234857"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1074\/jbc.M105057200","article-title":"Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter","volume":"277","author":"Seguin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_15","first-page":"310","article-title":"Expression and prognostic significance of apolipoprotein D in breast cancer","volume":"144","author":"Vizoso","year":"1994","journal-title":"Am. J. Pathol."},{"key":"ref_16","first-page":"1833","article-title":"Invasion-specific genes in malignancy: Serial analysis of gene expression comparisons of primary and passaged cancers","volume":"61","author":"Ryu","year":"2001","journal-title":"Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jso.10245","article-title":"Apolipoprotein D expression in cutaneous malignant melanoma","volume":"83","author":"Miranda","year":"2003","journal-title":"J. Surg. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/01.pas.0000126857.86186.4c","article-title":"Apo D in soft tissue tumors: A novel marker for dermatofibrosarcoma protuberans","volume":"28","author":"West","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12944-022-01713-y","article-title":"The prognostic value of arachidonic acid metabolism in breast cancer by integrated bioinformatics","volume":"21","author":"Li","year":"2022","journal-title":"Lipids Health Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/02841860802620613","article-title":"Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer\u2013possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients","volume":"48","author":"Soiland","year":"2009","journal-title":"Acta Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1007\/s11064-019-02859-5","article-title":"Hippocampal Up-Regulation of Apolipoprotein D in a Rat Model of Maternal Hypo- and Hyperthyroidism: Implication of Oxidative Stress","volume":"44","author":"Salami","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1523\/JNEUROSCI.2644-08.2008","article-title":"Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice","volume":"28","author":"Jacomy","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-5793(95)00484-Q","article-title":"Arachidonic acid binds to apolipoprotein D: Implications for the protein\u2019s function","volume":"366","author":"Cabral","year":"1995","journal-title":"FEBS Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1111\/febs.12394","article-title":"Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: Functional implications for cell differentiation","volume":"280","author":"Ruiz","year":"2013","journal-title":"FEBS J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/protein\/10.6.621","article-title":"Probing the structure of the ligand binding cavity of lipocalins by fluorescence spectroscopy","volume":"10","author":"Patel","year":"1997","journal-title":"Protein Eng."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.bbrc.2017.11.044","article-title":"Secreted glycoprotein BmApoD1 plays a critical role in anti-oxidation and anti-apoptosis in Bombyx mori","volume":"495","author":"Zhou","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/bi00648a010","article-title":"Studies on the isolation and partial characterization of apolipoprotein D and lipoprotein D of human plasma","volume":"15","author":"McConathy","year":"1976","journal-title":"Biochemistry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0022-2275(20)41336-7","article-title":"Characterization of disulfide-linked heterodimers containing apolipoprotein D in human plasma lipoproteins","volume":"33","author":"Via","year":"1992","journal-title":"J. Lipid Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1016\/S0021-9258(19)43566-7","article-title":"A specific progesterone-binding component of human breast cyst fluid","volume":"248","author":"Pearlman","year":"1973","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0039-128X(88)90135-3","article-title":"Binding properties of progesterone-binding Cyst protein, PBCP","volume":"52","author":"Lea","year":"1988","journal-title":"Steroids"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"BSR20201423","DOI":"10.1042\/BSR20201423","article-title":"Small angle X-ray scattering analysis of ligand-bound forms of tetrameric apolipoprotein-D","volume":"41","author":"Kielkopf","year":"2021","journal-title":"Biosci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/1099-1352(200101\/02)14:1<79::AID-JMR521>3.0.CO;2-4","article-title":"Bacterially produced apolipoprotein D binds progesterone and arachidonic acid, but not bilirubin or E-3M2H","volume":"14","author":"Vogt","year":"2001","journal-title":"J. Mol. Recognit."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"G356","DOI":"10.1152\/ajpgi.2000.279.2.G356","article-title":"Role of apolipoprotein D in the transport of bilirubin in plasma","volume":"279","author":"Goessling","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1073\/pnas.93.13.6626","article-title":"A human axillary odorant is carried by apolipoprotein D","volume":"93","author":"Zeng","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1042\/BJ20111166","article-title":"Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: Implications for lipid antioxidant activity and Alzheimer\u2019s disease","volume":"442","author":"Bhatia","year":"2012","journal-title":"Biochem. J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Oakley, A.J., Bhatia, S., Ecroyd, H., and Garner, B. (2012). Molecular dynamics analysis of apolipoprotein-D-lipid hydroperoxide interactions: Mechanism for selective oxidation of Met-93. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034057"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-2275(20)38304-8","article-title":"Protein polymorphism of a human plasma apolipoprotein D antigenic epitope","volume":"30","author":"Camato","year":"1989","journal-title":"J. Lipid Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.schres.2004.05.007","article-title":"Association of plasma apolipoproteins D with RBC membrane arachidonic acid levels in schizophrenia","volume":"72","author":"Yao","year":"2005","journal-title":"Schizophr. Res."},{"key":"ref_39","first-page":"3751516","article-title":"Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson\u2019s Disease: A Cross-Sectional Study","volume":"2018","author":"Waldner","year":"2018","journal-title":"Park. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00011-022-01679-8","article-title":"Apolipoprotein D modulates lipid mediators and osteopontin in an anti-inflammatory direction","volume":"72","author":"Kurano","year":"2023","journal-title":"Inflamm. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0014-5793(73)80453-3","article-title":"Isolation and partial characterization of apolipoprotein D: A new protein moiety of the human plasma lipoprotein system","volume":"37","author":"McConathy","year":"1973","journal-title":"FEBS Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"718983","DOI":"10.3389\/fphys.2021.718983","article-title":"An Evolutionary Perspective of the Lipocalin Protein Family","volume":"12","author":"Ganfornina","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"17805","DOI":"10.1016\/S0021-9258(18)38235-8","article-title":"Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein AI","volume":"265","author":"Boyles","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0022-2275(20)42739-7","article-title":"Cellular localization of apolipoprotein D and lecithin: Cholesterol acyltransferase mRNA in rhesus monkey tissues by in situ hybridization","volume":"31","author":"Smith","year":"1990","journal-title":"J. Lipid Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0022-2275(20)41899-1","article-title":"Localization of the major sites of rabbit apolipoprotein D gene transcription by in situ hybridization","volume":"32","author":"Provost","year":"1991","journal-title":"J. Lipid Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"23097","DOI":"10.1074\/jbc.270.39.23097","article-title":"Stationary phase expression of a novel Escherichia coli outer membrane lipoprotein and its relationship with mammalian apolipoprotein D. Implications for the origin of lipocalins","volume":"270","author":"Bishop","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0169-328X(95)00008-G","article-title":"Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D","volume":"30","author":"Seguin","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(02)02606-6","article-title":"Molecular and structural analyses of a novel temperature stress-induced lipocalin from wheat and Arabidopsis","volume":"517","author":"Breton","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_49","first-page":"349","article-title":"Characterization of two novel lipocalins expressed in the Drosophila embryonic nervous system","volume":"44","author":"Sanchez","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/S0022-2275(20)42112-1","article-title":"Identification, characterization, and tissue distribution of apolipoprotein D in the rat","volume":"31","author":"Boyles","year":"1990","journal-title":"J. Lipid Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0378-1119(96)00099-6","article-title":"The murine gene encoding apolipoprotein D exhibits a unique expression pattern as compared to other species","volume":"171","author":"Cofer","year":"1996","journal-title":"Gene"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0167-4781(93)90292-L","article-title":"Structure of the human apolipoprotein D gene promoter region","volume":"1172","author":"Lambert","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbamcr.2010.04.011","article-title":"Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: Implication of PARP-1, APEX-1 and ERK1\/2 catalytic activities","volume":"1803","author":"Levros","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Hull-Thompson, J., Muffat, J., Sanchez, D., Walker, D.W., Benzer, S., Ganfornina, M.D., and Jasper, H. (2009). Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000460"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/glia.21200","article-title":"Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems","volume":"59","author":"Ganfornina","year":"2011","journal-title":"Glia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s12035-013-8456-0","article-title":"Binding and repressive activities of apolipoprotein E3 and E4 isoforms on the human ApoD promoter","volume":"48","author":"Levros","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16077","DOI":"10.1074\/jbc.M115.644302","article-title":"Apolipoprotein D internalization is a basigin-dependent mechanism","volume":"290","author":"Najyb","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Desmarais, F., Herve, V., Bergeron, K.F., Ravaut, G., Perrotte, M., Fyfe-Desmarais, G., Rassart, E., Ramassamy, C., and Mounier, C. (2021). Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084118"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Li, H., Ruberu, K., Karl, T., and Garner, B. (2016). Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148238"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Pascua-Maestro, R., Diez-Hermano, S., Lillo, C., Ganfornina, M.D., and Sanchez, D. (2017). Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1006603"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/glia.23274","article-title":"M yelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal","volume":"66","author":"Lillo","year":"2018","journal-title":"Glia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1007\/s12035-022-02829-z","article-title":"The Neuroprotective Lipocalin Apolipoprotein D Stably Interacts with Specific Subtypes of Detergent-Resistant Membrane Domains in a Basigin-Independent Manner","volume":"59","author":"Sanchez","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.acthis.2015.04.003","article-title":"Apolipoprotein D subcellular distribution pattern in neuronal cells during oxidative stress","volume":"117","author":"Navarro","year":"2015","journal-title":"Acta Histochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105046","DOI":"10.1016\/j.nbd.2020.105046","article-title":"Apolipoprotein D-mediated preservation of lysosomal function promotes cell survival and delays motor impairment in Niemann-Pick type A disease","volume":"144","author":"Ledesma","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_65","unstructured":"Desmarais, F., Bergeron, K.-F., Ntambi, J.M., Rassart, E., and Mounier, C. (2020). Lipid Signaling and Metabolism, Elsevier."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/1570161043476465","article-title":"Biological nitration of arachidonic acid","volume":"2","author":"Balazy","year":"2004","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jare.2018.03.005","article-title":"Synopsis of arachidonic acid metabolism: A review","volume":"11","author":"Hanna","year":"2018","journal-title":"J. Adv. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3109\/10715762.2010.498477","article-title":"Chemistry and biochemistry of lipid peroxidation products","volume":"44","author":"Gueraud","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_69","first-page":"2233906","article-title":"Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases","volume":"2022","author":"Li","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.plefa.2003.08.014","article-title":"Apolipoprotein D modulates arachidonic acid signaling in cultured cells: Implications for psychiatric disorders","volume":"69","author":"Thomas","year":"2003","journal-title":"Prostaglandins Leukot Essent Fat. Acids"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2009.03.038","article-title":"Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury","volume":"455","author":"He","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_72","first-page":"374","article-title":"Schwann cell-derived Apolipoprotein D controls the dynamics of post-injury myelin recognition and degradation","volume":"8","author":"Ganfornina","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1007\/s12035-016-9920-4","article-title":"Apolipoprotein D Overexpression Protects Against Kainate-Induced Neurotoxicity in Mice","volume":"54","author":"Najyb","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bbalip.2019.01.001","article-title":"Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis","volume":"1864","author":"Desmarais","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.abb.2015.11.017","article-title":"Oxidative stress and antioxidants: Distress or eustress?","volume":"595","author":"Niki","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative Stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Hajam, Y.A., Rani, R., Ganie, S.Y., Sheikh, T.A., Javaid, D., Qadri, S.S., Pramodh, S., Alsulimani, A., Alkhanani, M.F., and Harakeh, S. (2022). Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives. Cells, 11.","DOI":"10.3390\/cells11030552"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"44557","DOI":"10.1074\/jbc.M111.279208","article-title":"SOD1 (copper\/zinc superoxide dismutase) deficiency drives amyloid beta protein oligomerization and memory loss in mouse model of Alzheimer disease","volume":"286","author":"Murakami","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-2006-9209","article-title":"Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer\u2019s disease","volume":"9","author":"Wands","year":"2006","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Arroyave-Ospina, J.C., Wu, Z., Geng, Y., and Moshage, H. (2021). Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy. Antioxidants, 10.","DOI":"10.3390\/antiox10020174"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/ars.2014.5849","article-title":"The thioredoxin superfamily in oxidative protein folding","volume":"21","author":"Lu","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 fatty acids and inflammatory processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"144874","DOI":"10.1016\/j.gene.2020.144874","article-title":"Apolipoprotein d","volume":"756","author":"Rassart","year":"2020","journal-title":"Gene"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"738991","DOI":"10.3389\/fphys.2021.738991","article-title":"The lipocalin apolipoprotein D functional portrait: A systematic review","volume":"12","author":"Sanchez","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/br.2016.630","article-title":"Role of oxidative stress in Alzheimer\u2019s disease","volume":"4","author":"Huang","year":"2016","journal-title":"Biomed. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1046\/j.1471-4159.1998.71041643.x","article-title":"Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer\u2019s patients","volume":"71","author":"Terrisse","year":"1998","journal-title":"J. Neurochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/01616412.2000.11740678","article-title":"Apolipoprotein D in the aging brain and in Alzheimer\u2019s dementia","volume":"22","author":"Kalman","year":"2000","journal-title":"Neurol. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3233\/JAD-122278","article-title":"Increased apolipoprotein D dimer formation in Alzheimer\u2019s disease hippocampus is associated with lipid conjugated diene levels","volume":"35","author":"Bhatia","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/hipo.20571","article-title":"Temporal patterns of lipoperoxidation and antioxidant enzymes are modified in the hippocampus of vitamin A-deficient rats","volume":"19","author":"Fonzo","year":"2009","journal-title":"Hippocampus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbadis.2011.10.011","article-title":"Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer\u2019s disease: Implications to mitochondria-targeted antioxidant therapeutics","volume":"1822","author":"Reddy","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/elps.11501401175","article-title":"Disulfide linked dimers of apolipoprotein D in urine","volume":"14","author":"Pownall","year":"1993","journal-title":"Electrophoresis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"12451","DOI":"10.1021\/bi00207a011","article-title":"Structure of human apolipoprotein D: Locations of the intermolecular and intramolecular disulfide links","volume":"33","author":"Yang","year":"1994","journal-title":"Biochemistry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1046\/j.1471-4159.1999.0731660.x","article-title":"Decrease in peptide methionine sulfoxide reductase in Alzheimer\u2019s disease brain","volume":"73","author":"Gabbita","year":"1999","journal-title":"J. Neurochem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Collins, A.E., Saleh, T.M., and Kalisch, B.E. (2022). Naturally Occurring Antioxidant Therapy in Alzheimer\u2019s Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11020213"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1477-7827-7-92","article-title":"Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain","volume":"7","author":"Forest","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1210\/endo-126-6-3223","article-title":"Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: A new marker of steroid action in breast cancer","volume":"126","author":"Simard","year":"1990","journal-title":"Endocrinology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.placenta.2009.11.002","article-title":"Increase in placental apolipoprotein D as an adaptation to human gestational diabetes","volume":"31","author":"Navarro","year":"2010","journal-title":"Placenta"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1464-5491.1994.tb00252.x","article-title":"Apolipoprotein D gene polymorphism: A new genetic marker for type 2 diabetic subjects in Nauru and south India","volume":"11","author":"Baker","year":"1994","journal-title":"Diabet. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0026-0495(81)90027-5","article-title":"Plasma apolipoprotein concentrations in familial apolipoprotein AI and A-II deficiency (Tangier disease)","volume":"30","author":"Alaupovic","year":"1981","journal-title":"Metabolism"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.neurobiolaging.2015.02.010","article-title":"Apolipoprotein D modulates amyloid pathology in APP\/PS1 Alzheimer\u2019s disease mice","volume":"36","author":"Li","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/1071576021000049890","article-title":"Amyloid \u03b2-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer\u2019s disease brain. A review","volume":"36","year":"2002","journal-title":"Free Radic. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12640-011-9283-6","article-title":"Amyloid-\u03b2 production: Major link between oxidative stress and BACE1","volume":"22","author":"Tamagno","year":"2012","journal-title":"Neurotox. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00702-004-0255-3","article-title":"Oxidative stress potentiates BACE1 gene expression and Abeta generation","volume":"112","author":"Tong","year":"2005","journal-title":"J. Neural. Transm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1471-4159.2011.07266.x","article-title":"Apolipoprotein D alters the early transcriptional response to oxidative stress in the adult cerebellum","volume":"117","author":"Sanchez","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.pharmthera.2009.11.004","article-title":"Transcriptional responses to oxidative stress: Pathological and toxicological implications","volume":"125","author":"Ma","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1073\/pnas.1315986110","article-title":"Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease","volume":"110","author":"Tsukamoto","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.cub.2006.03.024","article-title":"Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila","volume":"16","author":"Sanchez","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cub.2006.01.057","article-title":"Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan","volume":"16","author":"Walker","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1096\/fj.13-240556","article-title":"Ligand binding-dependent functions of the lipocalin NLaz: An in vivo study in Drosophila","volume":"28","author":"Ruiz","year":"2014","journal-title":"FASEB J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1073\/pnas.0800896105","article-title":"Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila","volume":"105","author":"Muffat","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1093\/hmg\/ddq183","article-title":"Altered lipid metabolism in a Drosophila model of Friedreich\u2019s ataxia","volume":"19","author":"Navarro","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.exger.2011.02.014","article-title":"Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz","volume":"46","author":"Ruiz","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Jia, F.J., Han, Z., Ma, J.H., Jiang, S.Q., Zhao, X.M., Ruan, H., Xie, W.D., and Li, X. (2020). Involvement of Reactive Oxygen Species in the Hepatorenal Toxicity of Actinomycin V In Vitro and In Vivo. Mar. Drugs, 18.","DOI":"10.3390\/md18080428"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Charron, J.B., Ouellet, F., Houde, M., and Sarhan, F. (2008). The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress. BMC Plant Biol., 8.","DOI":"10.1186\/1471-2229-8-86"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.plaphy.2020.11.009","article-title":"Ectopic expression of human apolipoprotein D in Arabidopsis plants lacking chloroplastic lipocalin partially rescues sensitivity to drought and oxidative stress","volume":"158","author":"Henri","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0006-8993(97)01552-7","article-title":"A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions","volume":"788","author":"Sandhya","year":"1998","journal-title":"Brain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3940(00)01409-9","article-title":"Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats","volume":"291","author":"Klamt","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cellsig.2007.11.014","article-title":"Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice","volume":"20","author":"Shin","year":"2008","journal-title":"Cell Signal."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"101380","DOI":"10.1016\/j.redox.2019.101380","article-title":"7-Ketocholesterol in disease and aging","volume":"29","author":"Anderson","year":"2020","journal-title":"Redox Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(98)00639-9","article-title":"Pattern of apolipoprotein D immunoreactivity in human brain","volume":"254","author":"Navarro","year":"1998","journal-title":"Neurosci. Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3389\/fncel.2018.00526","article-title":"Extracellular vesicles secreted by astroglial cells transport apolipoprotein D to neurons and mediate neuronal survival upon oxidative stress","volume":"12","author":"Lillo","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1158\/0008-5472.CAN-14-2260","article-title":"Genetic disruption of lactate\/H+ symporters (MCTs) and their subunit CD147\/BASIGIN sensitizes glycolytic tumor cells to phenformin","volume":"75","author":"Marchiq","year":"2015","journal-title":"Cancer Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1471-4159.1998.70010242.x","article-title":"Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D","volume":"70","author":"Suresh","year":"1998","journal-title":"J. Neurochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.4103\/1673-5374.358614","article-title":"Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration","volume":"18","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exger.2015.04.003","article-title":"Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex","volume":"67","author":"Sanchez","year":"2015","journal-title":"Exp. Gerontol."},{"key":"ref_126","unstructured":"Schrodinger, LLC (The PyMOL Molecular Graphics System, 2015). The PyMOL Molecular Graphics System, version 1.8."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s11033-010-0301-1","article-title":"Antioxidant activities of recombinant amphioxus (Branchiostoma belcheri) apolipoprotein D","volume":"38","author":"Zhang","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cellbi.2006.09.011","article-title":"Characterization and expression of amphioxus ApoD gene encoding an archetype of vertebrate ApoD proteins","volume":"31","author":"Wang","year":"2007","journal-title":"Cell Biol. Int."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","article-title":"The crucial roles of inflammatory mediators in inflammation: A review","volume":"11","author":"Abdulkhaleq","year":"2018","journal-title":"Vet. World"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1471-4159.2005.03508.x","article-title":"Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue","volume":"96","author":"Rickhag","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.jcbfm.9600552","article-title":"Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke: Influence of enriched environment","volume":"28","author":"Rickhag","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0169-328X(99)00123-0","article-title":"Modulation of apolipoprotein D and apolipoprotein E expression in rat hippocampus after entorhinal cortex lesion","volume":"70","author":"Terrisse","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1046\/j.1471-4159.1999.0731615.x","article-title":"Increased expression of apolipoprotein D following experimental traumatic brain injury","volume":"73","author":"Franz","year":"1999","journal-title":"J. Neurochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0306-4522(96)00608-2","article-title":"Differential expression of apolipoprotein D and apolipoprotein E in the kainic acid-lesioned rat hippocampus","volume":"79","author":"Ong","year":"1997","journal-title":"Neuroscience"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/glia.21010","article-title":"ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury","volume":"58","author":"Ganfornina","year":"2010","journal-title":"Glia"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-015-0009-8","article-title":"Lazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy","volume":"10","author":"Acebes","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_137","first-page":"17","article-title":"Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses","volume":"17","author":"Bendito","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"ref_138","first-page":"511","article-title":"Inflammatory biomarkers: The link between obesity and associated pathologies","volume":"22","author":"Zulet","year":"2007","journal-title":"Nutr. Hosp."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1471-0528.2006.01004.x","article-title":"Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue","volume":"113","author":"Cancello","year":"2006","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1017\/S0029665112000092","article-title":"Obesity, inflammation and the immune system","volume":"71","author":"Marcos","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12020-018-1621-5","article-title":"High ApoD protein level in the round ligament fat depot of severely obese women is associated with an improved inflammatory profile","volume":"61","author":"Desmarais","year":"2018","journal-title":"Endocrine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.1152\/ajpendo.90725.2008","article-title":"Human apolipoprotein D overexpression in transgenic mice induces insulin resistance and alters lipid metabolism","volume":"296","author":"Fournier","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Labrie, M., Lalonde, S., Najyb, O., Thiery, M., Daneault, C., Des Rosiers, C., Rassart, E., and Mounier, C. (2015). Apolipoprotein D transgenic mice develop hepatic steatosis through activation of PPAR\u03b3 and fatty acid uptake. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130230"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","article-title":"The importance of the ratio of omega-6\/omega-3 essential fatty acids","volume":"56","author":"Simopoulos","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fimmu.2016.00160","article-title":"Resolution of inflammation: What controls its onset?","volume":"7","author":"Sugimoto","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.21037\/atm-20-7008","article-title":"Apolipoprotein M promotes the anti-inflammatory effect of high-density lipoprotein by binding to scavenger receptor BI","volume":"8","author":"Yao","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/MOL.0000000000000142","article-title":"Apolipoprotein M in lipid metabolism and cardiometabolic diseases","volume":"26","author":"Borup","year":"2015","journal-title":"Curr. Opin. Lipidol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/5\/1027\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:26:15Z","timestamp":1760124375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/5\/1027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":147,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["antiox12051027"],"URL":"https:\/\/doi.org\/10.3390\/antiox12051027","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]}}}