{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:07:58Z","timestamp":1792166878503,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds pour la Chirurgie Cardiaque, Belgium"},{"name":"Medtronic, BeLux, Research Grant, Belgium"},{"name":"Aneurysmal Pathology Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Background: Thoracic aortic dissection (TAD) is a life-threatening condition which usually occurs on an aneurysmal aortic wall. Although increasing data have shown that inflammation and oxidative stress play an important role in the patho-physiology of dissection, systemic oxidative stress status (OSS) has not been clearly determined in patients suffering from TAD. Methods: A cohort of 115 patients presenting type A or B TAD were admitted to our center from 2013 to 2017. Out of this cohort, 46 patients were included in a study on dissected aorta (LIege study on DIssected Aorta: LIDIA). In 18 out of the 46 patients, systemic OSS parameters were evaluated after TAD diagnosis by determination of eight different antioxidants, four trace elements, two markers of oxidative lipid damage and two inflammatory markers. Results: The 18 TAD patients included 10 men and 8 women (median age: 62 years; interquartile range: 55\u201368) diagnosed with type A (N = 8) or B (N = 10) TAD. Low plasma levels of vitamin C, \u03b2-carotene, \u03b3-tocopherol, thiol proteins, paraoxonase and selenium were observed in these 18 patients. By contrast, the concentration of copper and total hydroperoxides, copper\/zinc ratio, as well as inflammatory markers, were higher than the reference intervals. No difference was observed in oxidative stress biomarker concentrations between type A and B TAD patients. Conclusions: This pilot study, limited to 18 TAD patients, revealed a heightened systemic OSS, determined at 15.5 days (median) after the initial diagnosis, in those TAD patients without complications (malperfusion syndrome and aneurysm formation). Larger studies on biological fluids are needed to better characterize the oxidative stress and interpret its consequence in TAD disease.<\/jats:p>","DOI":"10.3390\/antiox12051106","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:52:41Z","timestamp":1684288361000},"page":"1106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Jo\u00ebl","family":"Pincemail","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"},{"name":"Department of Medical Chemistry, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Tchana-Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Courtois","sequence":"additional","affiliation":[{"name":"CHC Montlegia, Onco-Hematology, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-5299","authenticated-orcid":false,"given":"Lucia","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Cheramy-Bien","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobine","family":"Munten","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicos","family":"Labropoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Stony Brook University Hospital, Stony Brook, NY 11794-8191, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Olivier","family":"Defraigne","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0291-934X","authenticated-orcid":false,"given":"Natzi","family":"Sakalihasan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Liege, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2214\/ajr.177.1.1770207","article-title":"Aortic Dissection: CT Features That Distinguish True Lumen from False Lumen","volume":"177","author":"LePage","year":"2001","journal-title":"Am. J. Roentgenol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1038\/nrdp.2016.53","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1161\/CIRCULATIONAHA.112.000483","article-title":"Population-Based Study of Incidence and Outcome of Acute Aortic Dissection and Premorbid Risk Factor Control: 10-Year Results From the Oxford Vascular Study","volume":"127","author":"Howard","year":"2013","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jss.2013.06.007","article-title":"Molecular Mechanisms of Thoracic Aortic Dissection","volume":"184","author":"Wu","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.12945\/j.aorta.2013.13-044","article-title":"Inflammatory Cell Infiltrates in Acute and Chronic Thoracic Aortic Dissection","volume":"1","author":"Wu","year":"2013","journal-title":"Aorta"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","article-title":"Cellular Mechanisms of Aortic Aneurysm Formation","volume":"124","author":"Quintana","year":"2019","journal-title":"Circ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/ehjci\/jeu283","article-title":"(Tissue PET) Vascular Metabolic Imaging and Peripheral Plasma Biomarkers in the Evolution of Chronic Aortic Dissections","volume":"16","author":"Sakalihasan","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1179\/1351000212Y.0000000012","article-title":"On the Potential Increase of the Oxidative Stress Status in Patients with Abdominal Aortic Aneurysm","volume":"17","author":"Pincemail","year":"2012","journal-title":"Redox Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/cvr\/cvt205","article-title":"Oxidative Stress Modulates Vascular Smooth Muscle Cell Phenotype via CTGF in Thoracic Aortic Aneurysm","volume":"100","author":"Branchetti","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pisano, C., Benedetto, U., Ruvolo, G., and Balisteri, C.R. (2022). Oxidative stress in the pathogenesis of aorta diseases as source of potential biomarkers and therapeutic targets, with a particular focus on ascending aorta aneurysms. Antioxidants, 11.","DOI":"10.3390\/antiox11020182"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1089\/ars.2006.8.1865","article-title":"Redefining Oxidative Stress","volume":"8","author":"Jones","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13510002.2021.1899473","article-title":"Oxidative Stress in Genetically Triggered Thoracic Aortic Aneurysm: Role in Pathogenesis and Therapeutic Opportunities","volume":"26","author":"Portelli","year":"2021","journal-title":"Redox Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pisano, C., Ruvolo, G., and Balisteri, C.R. (2022). Oxidative stress inside the pathogenesis of ascending aorta aneurysms: A clearer vision for identtifying promising biomarkers and therapeutic targets. Antioxidants, 11.","DOI":"10.3390\/antiox11020182"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Flieger, J., Flieger, W., Baj, J., and Maciejewski, R. (2021). Antioxidants: Classification, natural Sources, activity\/Capacity measurements, and usefulness for the synthesis of nanoparticles. Materials, 14.","DOI":"10.3390\/ma14154135"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"760694","DOI":"10.1155\/2014\/760694","article-title":"Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies","volume":"2014","author":"Soto","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.jtcvs.2017.05.065","article-title":"Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve","volume":"154","author":"Billaud","year":"2017","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.athoracsur.2016.10.039","article-title":"Bicuspid aortic valve morphotype correlates with regional antioxidant gene expression profiles in the proximal ascending aorta","volume":"104","author":"Philippi","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5392454","DOI":"10.1155\/2020\/5392454","article-title":"Oxidant\/antioxidant profile in the thoracic aneurysm of patients with the Loeys-Dietz syndrome","volume":"2020","author":"Soto","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rysz, J., Gluba-Brzozka, A., Rokicki, R., and Franczyk, B. (2021). Oxidative stress-related susceptibility to aneurysm in Marfan\u2019s syndrome. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091171"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtcvs.2007.11.017","article-title":"A Proteomic Study of the Aortic Media in Human Thoracic Aortic Dissection: Implication for Oxidative Stress","volume":"136","author":"Liao","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijcard.2010.04.077","article-title":"Evidence of oxidative stress in plasma of patients with Marfan syndrome","volume":"145","author":"Fiorillo","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"ref_22","first-page":"719","article-title":"Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms","volume":"6","author":"Irace","year":"2021","journal-title":"J. Am. Coll. Cardiol. Basic Transl. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Pincemail, J., Cavalier, E., Charlier, C., Cheramy\u2013Bien, J.-P., Brevers, E., Courtois, A., Fadeur, M., Meziane, S., Goff, C.L., and Misset, B. (2021). Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study. Antioxidants, 10.","DOI":"10.3390\/antiox10020257"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pincemail, J., Rousseau, A.-F., Kaux, J.-F., Cheramy-Bien, J.-P., Bruy\u00e8re, C., Prick, J., Stern, D., Kaci, M.-M., De Noordhout, B.M., and Albert, A. (2023). Determination of Redox Status in surviving COVID-19 patients during their recovery in a rehabilitation facility. Potential use of the electrochemical PAOT\u00ae technology. A Pilot Study. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051308"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"201843","DOI":"10.1155\/2015\/201843","article-title":"Heterogeneity of systemic oxidative stress profiles in COPD: A potential role of gender","volume":"2015","author":"Maury","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.freeradbiomed.2012.06.041","article-title":"Functional Muscle Impairment in Facioscapulohumeral Muscular Dystrophy Is Correlated with Oxidative Stress and Mitochondrial Dysfunction","volume":"53","author":"Turki","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2008.11.001","article-title":"Paraoxonase 1 (PON1) Status and Substrate Hydrolysis","volume":"235","author":"Richter","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_28","unstructured":"Pincemail, J., Le Goff, C., Charlier, C., Gillion, P., Cheramy-Bien, J.-P., Van Honacker, E., Chapelle, J.-P., and Defraigne, J.-O. (2010). Evaluation biologique du stress oxydant. Application en routine clinique. Nutr. Endocrinol., 16\u201331."},{"key":"ref_29","unstructured":"Pincemail, J., Christelbach, S., Gillain, S., Ricour, C., Dardenne, N., Cheramy-Bien, J.-P., Defraigne, J.-O., and Petermans, J. (2015, January 24\u201326). Oxidative stress or not in healty older subjects. Proceedings of the OCC Meeting 2015, Poster P61, Valencia, Spain."},{"key":"ref_30","unstructured":"Siegel, S., and Castellan, N.J. (2003). Nonparametric Statistics for the Behavioral Sciences, McGraw-Hill. [2nd ed.]."},{"key":"ref_31","unstructured":"Spiegel, M.R., and Lindstrom, D.P. (2000). Schaum\u2019s Easy Outlines: Statistics: Based on Schaum\u2019s Outline of Theory and Problems of Statistics, McGraw-Hill."},{"key":"ref_32","first-page":"84","article-title":"Optimum Plasma Levels of Antioxidant Micronutrients. Ten years of antioxidant hypothesis on arteriosclerosis","volume":"51","author":"Gey","year":"1994","journal-title":"Bibl. Nutr. Dieta"},{"key":"ref_33","first-page":"4128152","article-title":"Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans","volume":"2019","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.3390\/nu5082860","article-title":"Regulation of Vitamin C Homeostasis during Deficiency","volume":"5","author":"Lindblad","year":"2013","journal-title":"Nutrients"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.freeradbiomed.2013.05.050","article-title":"The Thiol Pool in Human Plasma: The Central Contribution of Albumin to Redox Processes","volume":"65","author":"Turell","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/ars.2010.3774","article-title":"The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis","volume":"16","author":"She","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"20997","DOI":"10.3390\/ijms151120997","article-title":"Exploring the Role of Paraoxonases in the Pathogenesis of Coronary Artery Disease: A Systematic Review","volume":"15","author":"Sancho","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hill, A., Borgs, C., Fitzner, C., and Stoppe, C. (2019). Perioperative vitamin C and E levels in cardiac surgery patients and their clinical significance. Nutrients, 11.","DOI":"10.3390\/nu11092157"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.nut.2013.10.026","article-title":"Massive and long-fasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation","volume":"30","author":"Rodemeister","year":"2014","journal-title":"Nutrition"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hill, A., Clasen, K.C., Wendt, S., Majoros, A.G., Stoppe, C., Ad-hikari, N.K.J., Heyland, D.K., and Benstoem, C. (2019). Effects of Vitamin C On Organ Function In Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. Nutrients, 11.","DOI":"10.3390\/nu11092103"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0300-483X(03)00159-8","article-title":"Copper Toxicity, Oxidative Stress, and Antioxidant Nutrients","volume":"189","author":"Gaetke","year":"2003","journal-title":"Toxicology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9156285","DOI":"10.1155\/2018\/9156285","article-title":"Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems","volume":"2018","author":"Lee","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.clinbiochem.2010.12.017","article-title":"Cu\/Zn Ratios Are Associated with Nutritional Status, Oxidative Stress, Inflammation, and Immune Abnormalities in Patients on Peritoneal Dialysis","volume":"44","author":"Guo","year":"2011","journal-title":"Clin. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.7150\/ijms.5291","article-title":"Effects of Zinc Supplementation on Plasma Copper\/Zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients","volume":"10","author":"Guo","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ajcn\/84.4.762","article-title":"Selenium and Coronary Heart Disease: A Meta-Analysis","volume":"84","author":"Guallar","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ito, F., Sono, Y., and Ito, T. (2019). Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation. Antioxidants, 8.","DOI":"10.3390\/antiox8030072"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-0041-1736589","article-title":"Statins for Patients Undergoing Thoracic Aortic Aneurysm Repair Surgery: What to Do?","volume":"9","author":"Klein","year":"2021","journal-title":"Aorta"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7850659","DOI":"10.1155\/2022\/7850659","article-title":"The Effects of Statin Therapy on Oxidized LDL and Its Antibodies: A Systematic Review and Meta-Analysis","volume":"2022","author":"Jamialahmadi","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cca.2017.10.033","article-title":"Increased Levels of Interleukin-22 in Thoracic Aorta and Plasma from Patients with Acute Thoracic Aortic Dissection","volume":"486","author":"Ye","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7092151","DOI":"10.1155\/2019\/7092151","article-title":"Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease","volume":"2019","author":"Steven","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_52","first-page":"BC01","article-title":"Correlation of Paraoxonase Status with Disease Activity Score and Systemic Inflammation in Rheumatoid Arthritic Patients","volume":"10","author":"Saxena","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4940673","DOI":"10.1155\/2020\/4940673","article-title":"Association between serum vitamin C and the blood pressure: A systematic review and meta-analysis of observational studies","volume":"2020","author":"Ran","year":"2020","journal-title":"Cardiovasc. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1464-5491.1994.tb00375.x","article-title":"Low plasma ascorbate levels in patients with type 2 diabetes mellitus consuming adequate dietary vitamin C","volume":"11","author":"Sinclair","year":"1994","journal-title":"Diabetes Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0002-8223(95)00220-0","article-title":"Plasma and dietary vitamin C and E levels in tobacco chewers, smokers and non-smokers","volume":"6","author":"Giraud","year":"1995","journal-title":"J. Am. Diet. Assoc."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/5\/1106\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:36:19Z","timestamp":1760124979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/5\/1106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["antiox12051106"],"URL":"https:\/\/doi.org\/10.3390\/antiox12051106","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}