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Additionally, epigenetic changes have been described as playing a pivotal role in SLE. This work aims to assess the effects of oleacein (OLA), one of the main extra virgin olive oil secoiridoids, when used to supplement the diet of a murine pristane-induced SLE model. In the study, 12-week-old female BALB\/c mice were injected with pristane and fed with an OLA-enriched diet (0.01 % (w\/w)) for 24 weeks. The presence of immune complexes was evaluated by immunohistochemistry and immunofluorescence. Endothelial dysfunction was studied in thoracic aortas. Signaling pathways and oxidative-inflammatory-related mediators were evaluated by Western blotting. Moreover, we studied epigenetic changes such as DNA methyltransferase (DNMT-1) and micro(mi)RNAs expression in renal tissue. Nutritional treatment with OLA reduced the deposition of immune complexes, ameliorating kidney damage. These protective effects could be related to the modulation of mitogen-activated protein kinases, the Janus kinase\/signal transducer and transcription activator of transcription, nuclear factor kappa, nuclear-factor-erythroid-2-related factor 2, inflammasome signaling pathways, and the regulation of miRNAs (miRNA-126, miRNA-146a, miRNA-24-3p, and miRNA-123) and DNMT-1 expression. Moreover, the OLA-enriched diet normalized endothelial nitric oxide synthase and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-1 overexpression. These preliminary results suggest that an OLA-supplemented diet could constitute a new alternative nutraceutical therapy in the management of SLE, supporting this compound as a novel epigenetic modulator of the immunoinflammatory response.<\/jats:p>","DOI":"10.3390\/antiox12061303","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T01:37:38Z","timestamp":1687225058000},"page":"1303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb\/C Pristane-Induced Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Roc\u00edo","family":"Mu\u00f1oz-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain"},{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9210-2404","authenticated-orcid":false,"given":"Marina","family":"S\u00e1nchez-Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain"},{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-2720","authenticated-orcid":false,"given":"Manuel","family":"Alcarranza","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain"},{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-4251","authenticated-orcid":false,"given":"Mar\u00eda Victoria","family":"Vazqu\u00e9z-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Normal and Pathological Cytology and Histology, Faculty of Medicine, Universidad de Sevilla, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-1698","authenticated-orcid":false,"given":"Mar\u00eda Alvarez","family":"de Sotomayor","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-1622","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-6356","authenticated-orcid":false,"given":"Mar\u00eda C.","family":"de Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Unidad de Epigen\u00e9tica, Grupo de Investigaci\u00f3n en Reumatolog\u00eda (GIR), Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario, de A Coru\u00f1a (CHUAC), Sergas, 15006 A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6625-3818","authenticated-orcid":false,"given":"Catalina","family":"Alarc\u00f3n-de-la-Lastra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain"},{"name":"Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102861","DOI":"10.1016\/j.jaut.2022.102861","article-title":"Autoantibodies in Systemic Lupus Erythematosus: From Immunopathology to Therapeutic Target","volume":"132","author":"Lou","year":"2022","journal-title":"J. Autoimmun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/08916934.2019.1693545","article-title":"Th1, Th2, and Th17 Cytokines in Systemic Lupus Erythematosus","volume":"53","author":"Yusoff","year":"2020","journal-title":"Autoimmunity"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Alunno, A., Padjen, I., Fanouriakis, A., and Boumpas, D.T. (2019). Pathogenic and Therapeutic Relevance of JAK\/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent. Cells, 8.","DOI":"10.3390\/cells8080898"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Barati, M.T., and Caster, D.J. (2022). The Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus. Metabolites, 12.","DOI":"10.3390\/metabo12020151"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2018.07.009","article-title":"Icariin Alleviates Murine Lupus Nephritis via Inhibiting NF-\u039aB Activation Pathway and NLRP3 Inflammasome","volume":"208","author":"Su","year":"2018","journal-title":"Life Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Richter, P., Cardoneanu, A., Burlui, A.M., Macovei, L.A., Bratoiu, I., Buliga-Finis, O.N., and Rezus, E. (2022). Why Do We Need JAK Inhibitors in Systemic Lupus Erythematosus?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911788"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jnutbio.2015.09.017","article-title":"Dietary Extra Virgin Olive Oil Attenuates Kidney Injury in Pristane-Induced SLE Model via Activation of HO-1\/Nrf-2 Antioxidant Pathway and Suppression of JAK\/STAT, NF-\u039aB and MAPK Activation","volume":"27","author":"Rosillo","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.4049\/jimmunol.1201195","article-title":"Self Double-Stranded (Ds)DNA Induces IL-1\u03b2 Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti\u2013DsDNA Antibodies","volume":"190","author":"Shin","year":"2013","journal-title":"J. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112140","DOI":"10.1016\/j.foodres.2022.112140","article-title":"Oleocanthal Supplemented Diet Improves Renal Damage and Endothelial Dysfunction in Pristane-Induced Systemic Lupus Erythematosus in Mice","volume":"163","author":"Montoya","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1039\/D0FO00235F","article-title":"Dietary Oleuropein and Its Acyl Derivative Ameliorate Inflammatory Response in Peritoneal Macrophages from Pristane-Induced SLE Mice: Via Canonical and Noncanonical NLRP3 Inflammasomes Pathway","volume":"11","author":"Montoya","year":"2020","journal-title":"Food Funct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/rheumatology\/keaa210","article-title":"Beneficial Effect of Mediterranean Diet on Disease Activity and Cardiovascular Risk in Systemic Lupus Erythematosus Patients: A Cross-Sectional Study","volume":"60","year":"2021","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/1871530317666171114114321","article-title":"Anti-Inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases?","volume":"18","author":"Santangelo","year":"2017","journal-title":"Endocr. Metab. Immune Disord. Drug. Targets"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108229","DOI":"10.1016\/j.jnutbio.2019.108229","article-title":"Dietary Oleuropein and Its New Acyl-Derivate Attenuate Murine Lupus Nephritis through HO-1\/Nrf2 Activation and Suppressing JAK\/STAT, NF-\u039aB, MAPK and NLRP3 Inflammasome Signaling Pathways","volume":"74","author":"Castejon","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jff.2016.12.001","article-title":"Dietary Hydroxytyrosol and Hydroxytyrosyl Acetate Supplementation Prevent Pristane-Induced Systemic Lupus Erythematous in Mice","volume":"29","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1007\/s10067-020-05493-7","article-title":"Lupus Animal Models and Neuropsychiatric Implications","volume":"40","author":"Karnopp","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1039\/D0FO00089B","article-title":"Oleacein Inhibits STAT3, Activates the Apoptotic Machinery, and Exerts Anti-Metastatic Effects in the SH-SY5Y Human Neuroblastoma Cells","volume":"11","author":"Cirmi","year":"2020","journal-title":"Food Funct."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fendo.2018.00116","article-title":"Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice","volume":"9","author":"Lombardo","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cirmi, S., Maugeri, A., Russo, C., Musumeci, L., Navarra, M., and Lombardo, G.E. (2022). Oleacein Attenuates Lipopolysaccharide-Induced Inflammation in THP-1-Derived Macrophages by the Inhibition of TLR4\/MyD88\/NF-\u03baB Pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031206"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Costa, V., Costa, M., Videira, R.A., Andrade, P.B., and Paiva-Martins, F. (2022). Anti-Inflammatory Activity of Olive Oil Polyphenols\u2014The Role of Oleacein and Its Metabolites. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112990"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Garc\u00eda, R., S\u00e1nchez-Hidalgo, M., Montoya, T., Alcarranza, M., Ortega-Vidal, J., Altarejos, J., and Alarc\u00f3n-de-la-Lastra, C. (2022). Effects of Oleacein, a New Epinutraceutical Bioproduct from Extra Virgin Olive Oil, in LPS-Activated Murine Immune Cells. Pharmaceuticals, 15.","DOI":"10.3390\/ph15111338"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez-Miranda, B., Gallardo, I., Melliou, E., Cabero, I., \u00c1lvarez, Y., Magiatis, P., Hern\u00e1ndez, M., and Nieto, M.L. (2020). Oleacein Attenuates the Pathogenesis of Experimental Autoimmune Encephalomyelitis through Both Antioxidant and Anti-Inflammatory Effects. Antioxidants, 9.","DOI":"10.3390\/antiox9111161"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13148-019-0632-2","article-title":"The Emerging Role of Epigenetics in Human Autoimmune Disorders","volume":"11","author":"Mazzone","year":"2019","journal-title":"Clin. Epigenet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S0954422421000287","article-title":"Epigenetic Linkage of Systemic Lupus Erythematosus and Nutrition","volume":"36","author":"Montoya","year":"2021","journal-title":"Nutr. Res. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Carpi, S., Scoditti, E., Massaro, M., Polini, B., Manera, C., Digiacomo, M., Salsano, J.E., Poli, G., Tuccinardi, T., and Doccini, S. (2019). The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and Mirna Expression in Adipocytes by Attenuating Nf-\u039ab Activation. Nutrients, 11.","DOI":"10.3390\/nu11122855"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"574317","DOI":"10.3389\/fphar.2020.574317","article-title":"MiRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells","volume":"11","author":"Carpi","year":"2020","journal-title":"Front. Pharm."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Juli, G., Oliverio, M., Bellizzi, D., Cantafio, M.E.G., Grillone, K., Passarino, G., Colica, C., Nardi, M., Rossi, M., and Procopio, A. (2019). Anti-Tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers, 11.","DOI":"10.3390\/cancers11070990"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1021\/np401010x","article-title":"One-Step Semisynthesis of Oleacein and the Determination as a 5-Lipoxygenase Inhibitor","volume":"77","author":"Vougogiannopoulou","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1084\/jem.180.6.2341","article-title":"Induction of Lupus-Associated Autoantibodies in BALB\/c Mice by Intraperitoneal Injection of Pristane","volume":"180","author":"Satoh","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"du Sert, N.P., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., and Dirnagl, U. (2020). The Arrive Guidelines 2.0: Updated Guidelines for Reporting Animal Research. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000410"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yabuki, A., Sawa, M., Kohyama, M., Hamamoto, T., and Yamato, O. (2017). Paraffin Immunofluorescence for Detection of Immune Complexes in Renal Biopsies: An Efficient Salvage Technique for Diagnosis of Glomerulonephritis in Dogs. BMC Vet. Res., 13.","DOI":"10.1186\/s12917-017-1287-x"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jff.2015.03.008","article-title":"Phenolic Content of Extra Virgin Olive Oil Is Essential to Restore Endothelial Dysfunction but Not to Prevent Vascular Inflammation in Atherosclerotic Lesions of Apo E Deficient Mice","volume":"15","author":"Claro","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"46704","DOI":"10.1038\/srep46704","article-title":"MiR-146b Is down-Regulated during the Chondrogenic Differentiation of Human Bone Marrow Derived Skeletal Stem Cells and up-Regulated in Osteoarthritis","volume":"7","author":"Budd","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, X., Liu, J., Zhao, Y., Xu, N., Lv, E., Ci, C., and Li, X. (2022). 1,25-Dihydroxyvitamin D3 Ameliorates Lupus Nephritis through Inhibiting the NF-\u039aB and MAPK Signalling Pathways in MRL\/Lpr Mice. BMC Nephrol., 23.","DOI":"10.1186\/s12882-022-02870-z"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e14734","DOI":"10.14814\/phy2.14734","article-title":"Hypertension and Endothelial Dysfunction in the Pristane Model of Systemic Lupus Erythematosus","volume":"9","author":"McClung","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fphar.2020.00929","article-title":"Coptisine Alleviates Pristane-Induced Lupus-Like Disease and Associated Kidney and Cardiovascular Complications in Mice","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Pharm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102438","DOI":"10.1016\/j.jaut.2020.102438","article-title":"Clinical Significance of MiRNAs in Autoimmunity","volume":"109","author":"Zhang","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3389\/fimmu.2019.01525","article-title":"The Role of Epigenetics in Autoimmune\/Inflammatory Disease","volume":"10","author":"Surace","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_40","first-page":"313","article-title":"Systemic Lupus Erythematosus","volume":"18","author":"Rao","year":"2016","journal-title":"Indian J. Pract. Pediatr."},{"key":"ref_41","first-page":"715","article-title":"One Year in Review 2019: Systemic Lupus Erythematosus","volume":"37","author":"Zucchi","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1017\/S0954422417000026","article-title":"An Update on Diet and Nutritional Factors in Systemic Lupus Erythematosus Management","volume":"30","year":"2017","journal-title":"Nutr. Res. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108389","DOI":"10.1016\/j.clim.2020.108389","article-title":"An Update on Genetic Susceptibility in Lupus Nephritis","volume":"215","author":"Song","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"151871","DOI":"10.1016\/j.imbio.2019.11.006","article-title":"Oxidative Stress and Immune Complexes: Pathogenic Mechanisms in Pristane Induced Murine Model of Lupus","volume":"225","author":"Pannu","year":"2020","journal-title":"Immunobiology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/intimm\/dxz021","article-title":"Molecular Mechanisms Underlying Prostaglandin E2-Exacerbated Inflammation and Immune Diseases","volume":"31","author":"Tsuge","year":"2019","journal-title":"Int. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1159\/000491904","article-title":"Activation of Cyclooxygenase-2 by ATF4 during Endoplasmic Reticulum Stress Regulates Kidney Podocyte Autophagy Induced by Lupus Nephritis","volume":"48","author":"Jin","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Pan, L., Yang, S., Wang, J., Xu, M., Wang, S., and Yi, H. (2020). Inducible Nitric Oxide Synthase and Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis. BMC Immunol., 21.","DOI":"10.1186\/s12865-020-0335-7"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00394-011-0269-1","article-title":"Procyanidin B2 Induces Nrf2 Translocation and Glutathione S-Transferase P1 Expression via ERKs and P38-MAPK Pathways and Protect Human Colonic Cells against Oxidative Stress","volume":"51","author":"Ramos","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref_49","first-page":"139","article-title":"Nrf2 Suppresses Lupus Nephritis through Inhibition of Oxidative Injury and the NF-\u039aB-Mediated Inflammatory Response","volume":"176","author":"Jiang","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1046\/j.1523-1755.2001.00939.x","article-title":"Nrf2-Deficient Female Mice Develop Lupus-like Autoimmune Nephritis","volume":"60","author":"Yoh","year":"2001","journal-title":"Kidney Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.phymed.2013.05.002","article-title":"Oleuropein and Oleacein May Restore Biological Functions of Endothelial Progenitor Cells Impaired by Angiotensin II via Activation of Nrf2\/Heme Oxygenase-1 Pathway","volume":"20","author":"Parzonko","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12515","DOI":"10.1096\/fj.201802805RR","article-title":"Activation of ROS\/MAPKs\/NF-\u039aB\/NLRP3 and Inhibition of Efferocytosis in Osteoclast-Mediated Diabetic Osteoporosis","volume":"33","author":"An","year":"2019","journal-title":"FASEB J."},{"key":"ref_53","first-page":"139","article-title":"Redox-Sensitive Nrf2 and MAPK Signaling Pathways Contribute to Trichloroethene-Mediated Autoimmune Disease Progression","volume":"176","author":"Banerjee","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kim, M., Morales, L.D., Jang, I.S., Cho, Y.Y., and Kim, D.J. (2018). Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092708"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"102390","DOI":"10.1016\/j.autrev.2019.102390","article-title":"JAK Inhibitors for the Treatment of Autoimmune and Inflammatory Diseases","volume":"18","author":"Jamilloux","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"103276","DOI":"10.1016\/j.autrev.2023.103276","article-title":"JAK Inhibitors and Autoimmune Rheumatic Diseases","volume":"22","author":"Benucci","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/art.39818","article-title":"Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction","volume":"69","author":"Furumoto","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB Pathway for the Therapy of Diseases: Mechanism and Clinical Study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in Cancer Inflammation and Immunity: A Leading Role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.intimp.2013.05.027","article-title":"Bay11-7082 Attenuates Murine Lupus Nephritis via Inhibiting NLRP3 Inflammasome and NF-\u039aB Activation","volume":"17","author":"Zhao","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jphs.2018.05.012","article-title":"Lentivirus-Mediated Knockdown of Fc\u03b3RI (CD64) Attenuated Lupus Nephritis via Inhibition of NF-\u039aB Regulating NLRP3 Inflammasome Activation in MRL\/Lpr Mice","volume":"137","author":"Zhang","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"621300","DOI":"10.3389\/fphar.2021.621300","article-title":"Role of NLRP3 Inflammasome in Lupus Nephritis and Therapeutic Targeting by Phytochemicals","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharm."},{"key":"ref_63","first-page":"776","article-title":"This Article Is Protected by Copyright. All Rights 1 Reserved","volume":"50","author":"Whitworth","year":"2006","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41421-020-0167-x","article-title":"Inflammasome Activation and Regulation: Toward a Better Understanding of Complex Mechanisms","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell. Discov."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2174\/1570161118666191227101636","article-title":"Cardiovascular Disease in Systemic Lupus Erythematosus: Recent Data on Epidemiology, Risk Factors and Prevention","volume":"18","author":"Kostopoulou","year":"2019","journal-title":"Curr. Vasc. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"110542","DOI":"10.1016\/j.biopha.2020.110542","article-title":"Role of the NLRP3 Inflammasome in Autoimmune Diseases","volume":"130","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1089\/ars.2014.6158","article-title":"Central Role of ENOS in the Maintenance of Endothelial Homeostasis","volume":"22","author":"Heiss","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/HYPERTENSIONAHA.114.03587","article-title":"Chronic Hydroxychloroquine Improves Endothelial Dysfunction and Protects Kidney in a Mouse Model of Systemic Lupus Erythematosus","volume":"64","author":"Romero","year":"2014","journal-title":"Hypertension"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/HYPERTENSIONAHA.116.08655","article-title":"Activation of Peroxisome Proliferator Activator Receptor \u03b2\/\u03b4 Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus","volume":"69","author":"Romero","year":"2017","journal-title":"Hypertension"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Meza, C.A., La Favor, J.D., Kim, D.H., and Hickner, R.C. (2019). Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153775"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"99","DOI":"10.15171\/apb.2016.015","article-title":"Alteration in Inflammation-Related MiR-146a Expression in NF-KB Signaling Pathway in Diabetic Rat Hippocampus","volume":"6","author":"Habibi","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.12659\/MSM.900667","article-title":"Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis","volume":"23","author":"Zhu","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_73","first-page":"7024","article-title":"MiR-146a Relieves Kidney Injury in Mice with Systemic Lupus Erythematosus through Regulating NF-\u039aB Pathway","volume":"23","author":"Fu","year":"2019","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The MicroRNA MiR-23b Suppresses IL-17-Associated Autoimmune Inflammation by Targeting TAB2, TAB3 and IKK-\u03b1","volume":"18","author":"Zhu","year":"2012","journal-title":"Nat. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2147\/JIR.S347293","article-title":"MicroRNA MiR-24-3p Mediates the Negative Regulation of Lipopolysaccharide-Induced Endometrial Inflammatory Response by Targeting TNF Receptor-Associated Factor 6 (TRAF6)","volume":"15","author":"Oladejo","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000495161","article-title":"MicroRNA-24-3p Attenuates Myocardial Ischemia\/Reperfusion Injury by Suppressing RIPK1 Expression in Mice","volume":"51","author":"Tan","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_77","first-page":"3838","article-title":"Micro RNA-126 Expression and i Ts Me Ch Anism of Action in Pati En Ts Withsy Ste Mic Lu Pus Erythematosu","volume":"19","author":"Liu","year":"2015","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clim.2018.02.002","article-title":"Mechanistic Aspects of Epigenetic Dysregulation in SLE","volume":"196","author":"Hedrich","year":"2018","journal-title":"Clin. Immunol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/6\/1303\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:56:30Z","timestamp":1760126190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/6\/1303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,19]]},"references-count":78,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["antiox12061303"],"URL":"https:\/\/doi.org\/10.3390\/antiox12061303","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,19]]}}}