{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:45:17Z","timestamp":1790261117529,"version":"4.1.0"},"reference-count":81,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Selva Rivas-Arancibia","award":["PAPIIT-DGAPA IN221521"],"award-info":[{"award-number":["PAPIIT-DGAPA IN221521"]}]},{"name":"Selva Rivas-Arancibia","award":["CVU 385286"],"award-info":[{"award-number":["CVU 385286"]}]},{"name":"CONAHCyT postdoctoral fellowship","award":["PAPIIT-DGAPA IN221521"],"award-info":[{"award-number":["PAPIIT-DGAPA IN221521"]}]},{"name":"CONAHCyT postdoctoral fellowship","award":["CVU 385286"],"award-info":[{"award-number":["CVU 385286"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Repeated exposure to environmental ozone causes a chronic state of oxidative stress. This state is present in chronic degenerative diseases and induces a loss of control of the inflammatory response. Redox system dysfunction and failures in control of inflammatory responses are involved in a vicious circle that maintains and increases the degenerative process. The intestine also responds to secondary reactive species formed by exposure to ozone doses, generating noxious stimuli that increase degenerative damage. This review aims to elucidate how environmental pollution, mainly by ozone, induces a state of chronic oxidative stress with the loss of regulation of the inflammatory response, both in the intestine and in the brain, where the functionality of both structures is altered and plays a determining role in some neurodegenerative and chronic degenerative diseases. For this purpose, we searched for information on sites such as the Cochrane Library Database, PubMed, Scopus, and Medscape. Reviewing the data published, we can conclude that environmental pollutants are a severe health problem. Ozone pollution has different pathways of action, both molecular and systemic, and participates in neurodegenerative diseases such as Parkinson\u2019s and Alzheimer\u2019s disease as well in bowel diseases as Inflammatory Bowel Disease, Crohn\u2019s Disease, and Irritable Bowel Syndrome.<\/jats:p>","DOI":"10.3390\/antiox12071323","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T01:54:56Z","timestamp":1687485296000},"page":"1323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ozone Environmental Pollution: Relationship between the Intestine and Neurodegenerative Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-1416","authenticated-orcid":false,"given":"Selva","family":"Rivas-Arancibia","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Miranda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Hern\u00e1ndez-Orozco","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlen","family":"Vald\u00e9s-Fuentes","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De la Rosa-Sierra","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization, Regional Office for Europe (2010). WHO Guidelines for Indoor Air Quality: Selected Pollutants, World Health Organization, Regional Office for Europe."},{"key":"ref_2","unstructured":"Centers for Disease Control and Prevention (2023, March 04). Climate Change Decreases the Quality of the Air We Breathe, Available online: https:\/\/www.cdc.gov\/climateandhealth\/pubs\/air-quality-final_508.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"105876","DOI":"10.1016\/j.envint.2020.105876","article-title":"Short-term exposure to particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis","volume":"142","author":"Orellano","year":"2020","journal-title":"Environ. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.procs.2020.04.221","article-title":"Forecasting air pollution particulate matter (PM2.5) using machine learning regression models","volume":"171","author":"Harishkumar","year":"2020","journal-title":"Procedia Comput. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/WAD.0b013e318209e63a","article-title":"Association study of the GAB2 gene with the risk of Alzheimer disease in the chinese population","volume":"25","author":"Wang","year":"2011","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_6","unstructured":"Organizaci\u00f3n Mundial de la Salud (2002). Convenio Marco de la OMS Para el Control del Tabaco Ginebra, WHO."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.1021\/ja2009554","article-title":"Allostery in a disordered protein: Oxidative modifications to \u03b1-synuclein act distally to regulate membrane binding","volume":"133","author":"Sevcsik","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00401-010-0788-5","article-title":"Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington\u2019s disease mice","volume":"121","author":"Lee","year":"2011","journal-title":"Acta Neuropathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/brain\/awr074","article-title":"Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis","volume":"134","author":"Beers","year":"2011","journal-title":"Brain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.freeradbiomed.2011.04.014","article-title":"Translational research involving oxidative stress and diseases of aging","volume":"51","author":"Floyd","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/eji.201948322","article-title":"The microbiota and immune-mediated diseases: Opportunities for therapeutic intervention","volume":"50","author":"Fitzgibbon","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"ref_12","unstructured":"Barrett, K.E. (2013). Ganong Fisiolog\u00eda M\u00e9dica (24a), McGraw Hill."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/wsbm.19","article-title":"Gastrointestinal system","volume":"2","author":"Cheng","year":"2010","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/00075197-200211000-00012","article-title":"Intestinal barrier function","volume":"5","author":"Baumgart","year":"2002","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fmicb.2020.00301","article-title":"The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/MOG.0000000000000139","article-title":"The gut microbiome in health and in disease","volume":"31","author":"Shreiner","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/eji.201646721","article-title":"Contributions of the intestinal microbiome in lung immunity","volume":"48","author":"McAleer","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3389\/fimmu.2020.02144","article-title":"Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease","volume":"11","author":"Raftery","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.freeradbiomed.2019.12.044","article-title":"Impact of air pollution on intestinal redox lipidome and microbiome","volume":"151","author":"Feng","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.pharep.2014.04.005","article-title":"Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases","volume":"66","author":"Sobczak","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.med.2022.02.010","article-title":"Interacciones entre microbiota y hu\u00e9sped","volume":"13","author":"Pascual","year":"2022","journal-title":"Med.-Programa De Form. M\u00e9dica Contin. Acreditado"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11371","DOI":"10.3748\/wjg.v21.i40.11371","article-title":"Role of environmental pollution in irritable bowel syndrome","volume":"21","author":"Marynowski","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"143718","DOI":"10.1016\/j.scitotenv.2020.143718","article-title":"Review article: Epidemiological and animal evidence for the role of air pollution in intestinal diseases","volume":"757","author":"Vignal","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_25","first-page":"686","article-title":"The intestinal barrier function and its involvement in digestive disease","volume":"107","author":"Vicario","year":"2015","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1097\/MIB.0b013e3182a85709","article-title":"Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4+ T cells and defective suppressive function of circulating Foxp3+ regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory bowel disease patients","volume":"19","author":"Ueno","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.3346\/jkms.2018.33.e336","article-title":"Mucosal Immunity Related to FOXP3(+) Regulatory T Cells, Th17 Cells and Cytokines in Pediatric Inflammatory Bowel Disease","volume":"33","author":"Cho","year":"2018","journal-title":"J. Korean Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/ecco-jcc\/jjz176","article-title":"Deletion of IL-6 Exacerbates Colitis and Induces Systemic Inflammation in IL-10-Deficient Mice","volume":"14","author":"Ye","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8813558","DOI":"10.1155\/2020\/8813558","article-title":"The Function and Role of the Th17\/Treg Cell Balance in Inflammatory Bowel Disease","volume":"2020","author":"Yan","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.3748\/wjg.v21.i19.5823","article-title":"Contribution of the IL-17\/IL-23 axis to the pathogenesis of inflammatory bowel disease","volume":"21","author":"Cozma","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature07416","article-title":"A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells","volume":"456","author":"Cadwell","year":"2008","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","article-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","volume":"134","author":"Kaser","year":"2008","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.3748\/wjg.v27.i43.7402","article-title":"Antimicrobial peptides and the gut microbiome in inflammatory bowel disease","volume":"27","author":"Gubatan","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.bbrc.2012.03.068","article-title":"TNF\u03b1 and IL-1\u03b2 are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS","volume":"420","author":"Zheng","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/01902140290092029","article-title":"Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses","volume":"28","author":"Johnston","year":"2002","journal-title":"Exp. Lung Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1164\/rccm.201809-1733OC","article-title":"Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes","volume":"200","author":"Mendy","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1007\/s12264-021-00730-8","article-title":"The Relationship Between the Gut Microbiome and Neurodegenerative Diseases","volume":"37","author":"Zhu","year":"2021","journal-title":"Neurosci. Bull."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/alz.12341","article-title":"Acute systemic inflammation exacerbates neuroinflammation in Alzheimer\u2019s disease: IL-1\u03b2 drives amplified responses in primed astrocytes and neuronal network dysfunction","volume":"17","author":"Hennessy","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1111\/jcmm.15439","article-title":"New mechanism of nerve injury in Alzheimer\u2019s disease: \u03b2-amyloid-induced neuronal pyroptosis","volume":"24","author":"Han","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuroscience.2016.06.007","article-title":"Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharide","volume":"331","author":"Gardner","year":"2016","journal-title":"Neuroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"30891","DOI":"10.1038\/srep30891","article-title":"Exposure to bacterial endotoxin generates a distinct strain of \u03b1-synuclein fibril","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"796867","DOI":"10.3389\/fimmu.2021.796867","article-title":"The Impact of Systemic Inflammation on Alzheimer\u2019s Disease Pathology","volume":"12","author":"Xie","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/cmi.2017.151","article-title":"Vaccine-induced autoimmunity: The role of molecular mimicry and immune crossreaction","volume":"15","author":"Segal","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1073\/pnas.0908005106","article-title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","volume":"106","author":"Luk","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10732","DOI":"10.1073\/pnas.1321785111","article-title":"Intramuscular injection of \u03b1-synuclein induces CNS \u03b1-synuclein pathology and a rapid-onset motor phenotype in transgenic mice","volume":"111","author":"Sacino","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","first-page":"2","article-title":"Pathogenic microbial amyloids: Their function and the host response","volume":"1","author":"Garcia","year":"2013","journal-title":"OA Microbiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.str.2011.05.015","article-title":"Atomic resolution insights into curli fiber biogenesis","volume":"19","author":"Taylor","year":"2011","journal-title":"Structure"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fcimb.2015.00033","article-title":"New insight into the molecular control of bacterial functional amyloids","volume":"5","author":"Taylor","year":"2015","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Miraglia, F., and Colla, E. (2019). Microbiome, Parkinson\u2019s Disease and Molecular Mimicry. Cells, 8.","DOI":"10.3390\/cells8030222"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.toxlet.2010.05.020","article-title":"Oxidative stress, progressive damage in the substantia nigra and plasma dopamine oxidation, in rats chronically exposed to ozone","volume":"197","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tins.2003.08.009","article-title":"Neuromelanin of the substantia nigra: A neuronal black hole with protective and toxic characteristics","volume":"26","author":"Zecca","year":"2003","journal-title":"Trends Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.09.012","article-title":"Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson\u2019s disease","volume":"155","author":"Zucca","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"ref_55","first-page":"65","article-title":"Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat","volume":"7","author":"Maldonado","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","article-title":"Gastric alpha-synuclein immunoreactive inclusions in Meissner\u2019s and Auerbach\u2019s plexuses in cases staged for Parkinson\u2019s disease-related brain pathology","volume":"396","author":"Braak","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1474-4422(03)00307-7","article-title":"Gastrointestinal dysfunction in Parkinson\u2019s disease","volume":"2","author":"Pfeiffer","year":"2003","journal-title":"Lancet Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nrneurol.2014.252","article-title":"Axial disability and deep brain stimulation in patients with Parkinson disease","volume":"11","author":"Fasano","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S323","DOI":"10.3233\/JPD-191707","article-title":"The Intestinal Barrier in Parkinson\u2019s Disease: Current State of Knowledge","volume":"9","author":"Derkinderen","year":"2019","journal-title":"J. Parkinsons Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1126\/science.280.5361.275","article-title":"Generation of intestinal T cells from progenitors residing in gut cryptopatches","volume":"280","author":"Saito","year":"1998","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/19490976.2019.1629235","article-title":"Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner","volume":"11","author":"Stephens","year":"2020","journal-title":"Gut Microbes."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfp252","article-title":"Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats","volume":"113","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"653334","DOI":"10.3389\/fnagi.2021.653334","article-title":"Role of Neuron and Glia in Alzheimer\u2019s Disease and Associated Vascular Dysfunction","volume":"13","author":"Bandyopadhyay","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"fcac243","DOI":"10.1093\/braincomms\/fcac243","article-title":"Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide","volume":"4","author":"Crepin","year":"2022","journal-title":"Brain Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/(SICI)1097-4547(19970901)49:5<617::AID-JNR12>3.0.CO;2-S","article-title":"Ultrastructural localization of GLUT 1 and GLUT 3 glucose transporters in rat brain","volume":"49","author":"Leino","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JAD-170857","article-title":"Ozone Atmospheric Pollution and Alzheimer\u2019s Disease: From Epidemiological Facts to Molecular Mechanisms","volume":"62","author":"Croze","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-4274(02)00169-8","article-title":"Biomarkers of oxidative stress after controlled human exposure to ozone","volume":"134","author":"Corradi","year":"2002","journal-title":"Toxicol. Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/enrs.1997.3784","article-title":"Effects of ozone exposure in rats on memory and levels of brain and pulmonary superoxide dismutase","volume":"76","year":"1998","journal-title":"Environ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Nery-Flores, S.D., Ram\u00edrez-Herrera, M.A., Mendoza-Maga\u00f1a, M.L., Romero-Prado, M.M.J., Ram\u00edrez-V\u00e1zquez, J.J., Ba\u00f1uelos-Pineda, J., Espinoza-Guti\u00e9rrez, H.A., Ram\u00edrez-Mendoza, A.A., and Tostado, M.C. (2019). Dietary Curcumin Prevented Astrocytosis, Microgliosis, and Apoptosis Caused by Acute and Chronic Exposure to Ozone. Molecules, 24.","DOI":"10.3390\/molecules24152839"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuroscience.2015.07.011","article-title":"Oxidative stress caused by ozone exposure induces \u03b2-amyloid 1-42 overproduction and mitochondrial accumulation by activating the amyloidogenic pathway","volume":"304","year":"2015","journal-title":"Neuroscience"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2174\/156720511796391908","article-title":"Nutritional approaches to modulate oxidative stress in Alzheimer\u2019s disease","volume":"8","author":"Pocernich","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"112166","DOI":"10.1016\/j.yexcr.2020.112166","article-title":"LRP1 knockdown aggravates A\u03b2(1-42)-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4\/NF-\u03baB\/MAPKs signaling pathways","volume":"394","author":"He","year":"2020","journal-title":"Exp. Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neurobiolaging.2013.09.035","article-title":"Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer\u2019s disease","volume":"35","author":"Kamphuis","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.lfs.2006.06.048","article-title":"Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia","volume":"79","author":"Jung","year":"2006","journal-title":"Life Sci."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Reichert, C.O., Levy, D., and Bydlowski, S.P. (2020). Paraoxonase Role in Human Neurodegenerative Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10010011"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1210\/jc.2004-0486","article-title":"Paraoxonase activity in high-density lipoproteins: A comparison between healthy and obese females","volume":"90","author":"Ferretti","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"G1252","DOI":"10.1152\/ajpgi.00369.2007","article-title":"Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats","volume":"293","author":"Levy","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41423-022-00902-0","article-title":"Redox regulation of the immune response","volume":"19","author":"Morris","year":"2022","journal-title":"Cell Mol. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Remigante, A., and Morabito, R. (2022). Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases. Int. J. Mol. 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