{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:18:24Z","timestamp":1791908304646,"version":"4.3.4"},"reference-count":226,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Ministry of Education, Science, Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","award":["APVV-15_0075"],"award-info":[{"award-number":["APVV-15_0075"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Ministry of Education, Science, Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","award":["VEGA 1\/0131\/22"],"award-info":[{"award-number":["VEGA 1\/0131\/22"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Ministry of Education, Science, Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","award":["APVV-18-0084"],"award-info":[{"award-number":["APVV-18-0084"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Ministry of Education, Science, Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","award":["APVV-22-0342"],"award-info":[{"award-number":["APVV-22-0342"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Ministry of Education, Science, Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","award":["VEGA 1\/0093\/22"],"award-info":[{"award-number":["VEGA 1\/0093\/22"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the therapeutic protocols of cystic fibrosis. NAC is also administered as an antidote in acetaminophen (paracetamol) overdosing. Thanks to its wide antioxidative and anti-inflammatory effects, NAC may also be of benefit in other chronic inflammatory and fibrotizing respiratory diseases, such as chronic obstructive pulmonary disease, bronchial asthma, idiopathic lung fibrosis, or lung silicosis. In addition, NAC exerts low toxicity and rare adverse effects even in combination with other treatments, and it is cheap and easily accessible. This article brings a review of information on the mechanisms of inflammation and oxidative stress in selected chronic respiratory diseases and discusses the use of NAC in these disorders.<\/jats:p>","DOI":"10.3390\/antiox12091713","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:14:50Z","timestamp":1693793690000},"page":"1713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Advances in the Use of N-Acetylcysteine in Chronic Respiratory Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-6360","authenticated-orcid":false,"given":"Daniela","family":"Mokra","sequence":"first","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, SK-03601 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-5569","authenticated-orcid":false,"given":"Juraj","family":"Mokry","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, SK-03601 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana","family":"Barosova","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, SK-03601 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Hanusrichterova","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, SK-03601 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","article-title":"N-Acetylcysteine as an antioxidant and disulphide breaking agent: The reasons why","volume":"52","author":"Aldini","year":"2018","journal-title":"Free Radic. 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