{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:13:03Z","timestamp":1773213183072,"version":"3.50.1"},"reference-count":82,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Agencia Estatal de Investigaci\u00f3n","award":["PID2019-108695RB-C32\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2019-108695RB-C32\/AEI\/10.13039\/501100011033"]}]},{"name":"Spanish Agencia Estatal de Investigaci\u00f3n","award":["PRE2020-092891"],"award-info":[{"award-number":["PRE2020-092891"]}]},{"name":"Spanish Government","award":["PID2019-108695RB-C32\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2019-108695RB-C32\/AEI\/10.13039\/501100011033"]}]},{"name":"Spanish Government","award":["PRE2020-092891"],"award-info":[{"award-number":["PRE2020-092891"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>An adequate intestinal environment before weaning may contribute to diarrhea predisposition and piglet development. This study evaluates how the dietary supplementation of vitamin E (VE) (100 mg\/kg), hydroxytyrosol (HXT) (1.5 mg\/kg) or the combined administration (VE + HXT) given to Iberian sows from gestation affects the piglet\u2019s faecal characteristics, short chain fatty acids (SCFAs), fatty acid profile or intestinal morphology as indicators of gut health; and quantify the contribution of the oxidative status and colostrum\/milk composition to the piglet\u2019s SCFAs content and intestinal health. Dietary VE increased isobutyric acid (iC4), butyric acid (C4), isovaleric acid (iC5), and \u2211SCFAs, whereas HXT increased iC4 and tended to decrease \u2211SCFAs of faeces. Piglets from HXT-supplemented sows also tended to have higher faecal C20:4n-6\/C20:2 ratio C22:6 proportion and showed lower occludin gene expression in the duodenum. The combination of both antioxidants had a positive effect on iC4 and iC5 levels. Correlation analyses and regression equations indicate that faecal SCFAs were related to oxidative status (mainly plasma VE) and colostrum and milk composition (mainly C20:2, C20:3, C20:4 n-6). This study would confirm the superiority of VE over HXT supplementation to improve intestinal homeostasis, gut health, and, consequently piglet growth.<\/jats:p>","DOI":"10.3390\/antiox12091761","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:57:56Z","timestamp":1694685476000},"page":"1761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning"],"prefix":"10.3390","volume":"12","author":[{"given":"Hernan D.","family":"Laviano","sequence":"first","affiliation":[{"name":"Departamento Producci\u00f3n Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s\/n., 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Instituto Regional de Investigaci\u00f3n y Desarrollo Agroalimentario y Forestal de Castilla-La Mancha (IRIAF), 13700 Tomelloso, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0124-3632","authenticated-orcid":false,"given":"Rosa","family":"Escudero","sequence":"additional","affiliation":[{"name":"Departamento Producci\u00f3n Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s\/n., 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Departamento de Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, INIA, CSIC, Ctra Coru\u00f1a km 7.5, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Garc\u00eda-Casco","sequence":"additional","affiliation":[{"name":"Departamento de Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, INIA, CSIC, Ctra Coru\u00f1a km 7.5, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-6977","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, INIA, CSIC, Ctra Coru\u00f1a km 7.5, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7496-9680","authenticated-orcid":false,"given":"Ana","family":"Heras-Molina","sequence":"additional","affiliation":[{"name":"Departamento Producci\u00f3n Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s\/n., 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-8057","authenticated-orcid":false,"given":"Clemente","family":"L\u00f3pez-Bote","sequence":"additional","affiliation":[{"name":"Departamento Producci\u00f3n Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s\/n., 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-4475","authenticated-orcid":false,"given":"Antonio","family":"Gonz\u00e1lez-Bulnes","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n y Sanidad Animal, Facultad de Veterinaria, Universidad Cardenal Herrera\u2014CEU, CEU Universities, C\/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"\u00d3vilo","sequence":"additional","affiliation":[{"name":"Departamento de Mejora Gen\u00e9tica Animal, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, INIA, CSIC, Ctra Coru\u00f1a km 7.5, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-9225","authenticated-orcid":false,"given":"Ana I.","family":"Rey","sequence":"additional","affiliation":[{"name":"Departamento Producci\u00f3n Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s\/n., 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-6226(97)00057-2","article-title":"Factors influencing the structure and function of the small intestine in the weaned pig: A review","volume":"51","author":"Pluske","year":"1997","journal-title":"Livest. Prod. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Riaz Rajoka, M.S., Thirumdas, R., Mehwish, H.M., Umair, M., Khurshid, M., Hayat, H.F., Phimolsiripol, Y., Pallar\u00e9s, N., Mart\u00ed-Quijal, F.J., and Barba, F.J. (2021). Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health. 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