{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:25:30Z","timestamp":1780082730542,"version":"3.54.0"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["NRF-2019M3A9I3080265"],"award-info":[{"award-number":["NRF-2019M3A9I3080265"]}]},{"name":"National Research Foundation of Korea","award":["NRF-2019M3A9I3080266"],"award-info":[{"award-number":["NRF-2019M3A9I3080266"]}]},{"name":"National Research Foundation of Korea","award":["NRF-2022R1A2C1003088"],"award-info":[{"award-number":["NRF-2022R1A2C1003088"]}]},{"name":"Ministry of Science, ICT, and Future Planning","award":["NRF-2019M3A9I3080265"],"award-info":[{"award-number":["NRF-2019M3A9I3080265"]}]},{"name":"Ministry of Science, ICT, and Future Planning","award":["NRF-2019M3A9I3080266"],"award-info":[{"award-number":["NRF-2019M3A9I3080266"]}]},{"name":"Ministry of Science, ICT, and Future Planning","award":["NRF-2022R1A2C1003088"],"award-info":[{"award-number":["NRF-2022R1A2C1003088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Nymphoides peltata has been widely used pharmacologically in traditional Chinese medicine to treat heat strangury and polyuria. The aim of this study was to isolate the bioactive components from N. peltata and evaluate their potential use as antioxidant and anti-wrinkle agents. Phytochemical investigation of the methanolic extract of N. peltata roots led to the isolation of 15 compounds (1\u201315), which were structurally determined as \u03b1-spinasterol (1), 3-O-\u03b2-D-glucopyranosyl-oleanolic acid 28-O-\u03b2-D-glucuronopyranoside (2), 4-hydroxybenzoic acid (3), protocatechuic acid (4), vanillic acid (5), p-coumaric acid (6), caffeic acid (7), ferulic acid (8), neochlorogenic acid (neo-CQA) (9), chlorogenic acid (CQA) (10), cryptochlorogenic acid (crypto-CQA) (11), isochlorogenic acid B (3,4-DCQA) (12), isochlorogenic acid A (3,5-DCQA) (13), isochlorogenic acid C (4,5-DCQA) (14), and 3,4,5-tri-O-caffeoylquinic acid (TCQA) (15). Of these 15 compounds, compound 2 was a new oleanane saponin, the chemical structure of which was characterized by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data and high-resolution electrospray ionization mass spectrometry (HRESIMS), as well as chemical reaction. Biological evaluation of the isolated compounds revealed that 3,4,5-tri-O-caffeoylquinic acid (TCQA) significantly improved Nrf2 levels in an Nrf2\u2013ARE reporter HaCaT cell screening assay. TCQA was found to potently inhibit the Nrf2\/HO-1 pathway and to possess strong anti-wrinkle activity by modulating the MAPK\/NF-\u03baB\/AP-1 signaling pathway and thus inhibiting MMP-1 synthesis in HaCaT cells exposed to UVB. Our results suggest that TCQA isolated from N. peltata might be useful for developing effective antioxidant and anti-wrinkle agents.<\/jats:p>","DOI":"10.3390\/antiox12101899","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:32:24Z","timestamp":1698057144000},"page":"1899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anti-Wrinkling Effect of 3,4,5-tri-O-caffeoylquinic Acid from the Roots of Nymphoides peltata through MAPK\/AP-1, NF-\u03baB, and Nrf2 Signaling in UVB-Irradiated HaCaT Cells"],"prefix":"10.3390","volume":"12","author":[{"given":"Tae-Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No-June","family":"Park","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea"},{"name":"Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom-Geun","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bum Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Ji","family":"Keem","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4563-5255","authenticated-orcid":false,"given":"Taek-Hwan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-9138","authenticated-orcid":false,"given":"Ki Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea"},{"name":"Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hye","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2147\/DDDT.S326332","article-title":"Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action","volume":"16","author":"Sekar","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.molmed.2021.12.003","article-title":"Skin Senescence: Mechanisms and Impact on Whole-Body Aging","volume":"28","author":"Franco","year":"2022","journal-title":"Trends Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/php.13561","article-title":"Photoprotective Effect of Artemisia sieversiana Ehrhart Essential Oil Against UVB-induced Photoaging in Mice","volume":"98","author":"Zhou","year":"2022","journal-title":"Photochem. Photobiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e13580","DOI":"10.1016\/j.heliyon.2023.e13580","article-title":"Molecular Basis of Skin Photoaging and Therapeutic Interventions by Plant-Derived Natural Product Ingredients: A Comprehensive Review","volume":"9","author":"Tanveer","year":"2023","journal-title":"Heliyon"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2022.05.016","article-title":"Protective Actions of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) and Downstream Pathways against Environmental Stressors","volume":"187","author":"Frenis","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sharma, V., Kaur, A., and Singh, T.G. (2020). Counteracting Role of Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Alzheimer\u2019s Disease. Biomed. Pharmacother., 129.","DOI":"10.1016\/j.biopha.2020.110373"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kasai, S., Shimizu, S., Tatara, Y., Mimura, J., and Itoh, K. (2020). Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology. Biomolecules, 10.","DOI":"10.3390\/biom10020320"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2009.08.018","article-title":"A Systems Biology Perspective on Nrf2-Mediated Antioxidant Response","volume":"244","author":"Zhang","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115935","DOI":"10.1016\/j.jep.2022.115935","article-title":"ErZhiFormula Prevents UV-Induced Skin Photoaging by Nrf2\/HO-1\/NQO1 Signaling: An in Vitro and in Vivo Studies","volume":"309","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbrc.2010.04.117","article-title":"Simvastatin Lowers Reactive Oxygen Species Level by Nrf2 Activation via PI3K\/Akt Pathway","volume":"396","author":"Chartoumpekis","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Papaccio, F., D\u2019Arino, A., Caputo, S., and Bellei, B. (2022). Focus on the Contribution of Oxidative Stress in Skin Aging. Antioxidants, 11.","DOI":"10.3390\/antiox11061121"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/exd.12536","article-title":"Compound K Inhibits MMP-1 Expression through Suppression of c-Src-Dependent ERK Activation in TNF-\u03b1-Stimulated Dermal Fibroblast","volume":"23","author":"Lee","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kirindage, K.G.I.S., Jayasinghe, A.M.K., Han, E.-J., Jee, Y., Kim, H.-J., Do, S.G., Fernando, I.P.S., and Ahn, G. (2022). Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-\u03b1\/IFN-\u03b3-Stimulated Human Dermal Fibroblasts Via Regulating Nrf2\/HO-1 and NF-\u03baB\/MAPK Pathways. Antioxidants, 11.","DOI":"10.3390\/antiox11081429"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0006-2952(02)01153-X","article-title":"Oxidative Stress, Transcription Factors and Chromatin Remodelling in Lung Inflammation","volume":"64","author":"Rahman","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/14756366.2016.1161620","article-title":"Matrix Metalloproteinases (MMPs), the Main Extracellular Matrix (ECM) Enzymes in Collagen Degradation, as a Target for Anticancer Drugs","volume":"31","author":"Matejczyk","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1467-2494.2004.00241.x","article-title":"Ultraviolet Radiation and Skin Aging: Roles of Reactive Oxygen Species, Inflammation and Protease Activation, and Strategies for Prevention of Inflammation-Induced Matrix Degradation\u2014A Review","volume":"27","author":"Pillai","year":"2005","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.2002.tb04602.x","article-title":"Ultraviolet-B Irradiation and Matrix Metalloproteinases","volume":"973","author":"Brenneisen","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.mad.2005.06.003","article-title":"Augmentation of UV-Induced Skin Wrinkling by Infrared Irradiation in Hairless Mice","volume":"126","author":"Kim","year":"2005","journal-title":"Mech. Ageing Dev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Oh, J.H., Joo, Y.H., Karadeniz, F., Ko, J., and Kong, C.-S. (2020). Syringaresinol Inhibits UVA-Induced MMP-1 Expression by Suppression of MAPK\/AP-1 Signaling in HaCaT Keratinocytes and Human Dermal Fibroblasts. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113981"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.mad.2006.09.007","article-title":"Regulation of Type I Procollagen and MMP-1 Expression after Single or Repeated Exposure to Infrared Radiation in Human Skin","volume":"127","author":"Kim","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111160","DOI":"10.1016\/j.mad.2019.111160","article-title":"NF-\u03baB Signaling in Skin Aging","volume":"184","author":"Wang","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s10787-021-00827-6","article-title":"Protective Effect of (+)\u2013Catechin against Lipopolysaccharide-Induced Inflammatory Response in RAW 264.7 Cells through Downregulation of NF-\u03baB and P38 MAPK","volume":"29","author":"Sunil","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijbiomac.2020.10.232","article-title":"Fucoidan Isolated from Hizikia fusiforme Suppresses Ultraviolet B-Induced Photodamage by down-Regulating the Expressions of Matrix Metalloproteinases and pro-Inflammatory Cytokines via Inhibiting NF-\u03baB, AP-1, and MAPK Signaling Pathways","volume":"166","author":"Wang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"114575","DOI":"10.1016\/j.jep.2021.114575","article-title":"Embelia laeta Aqueous Extract Suppresses Acute Inflammation via Decreasing COX-2\/iNOS Expression and Inhibiting NF-\u03baB Pathway","volume":"281","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10522-017-9715-7","article-title":"Plant Extracts and Natural Compounds Used against UVB-Induced Photoaging","volume":"18","author":"Cavinato","year":"2017","journal-title":"Biogerontology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.phymed.2011.10.003","article-title":"Bioactive Compounds from Natural Resources against Skin Aging","volume":"19","author":"Mukherjee","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"njb02545","DOI":"10.1111\/njb.02545","article-title":"Phylogenetics and Seed Morphology of African Nymphoides (Menyanthaceae)","volume":"38","author":"Tippery","year":"2020","journal-title":"Nord. J. Bot."},{"key":"ref_28","unstructured":"Lee, B.Y., Nam, G.H., Lee, J.Y., Park, C.H., Lim, C.E., Kim, M.H., Lee, S.J., Roh, T.K., Lim, J.A., and Han, J.E. (2011). National List of Species of Korea (Vascular Plants)."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.biocon.2009.05.012","article-title":"Toward the Restoration of a Sustainable Population of a Threatened Aquatic Plant, Nymphoides peltata: Integrated Genetic\/Demographic Studies and Practices","volume":"142","author":"Nishihiro","year":"2009","journal-title":"Biol. Conserv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/np010323o","article-title":"A Neutrophil Multitarget Functional Bioassay to Detect Anti-Inflammatory Natural Products","volume":"65","author":"Johansson","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kim, T.-Y., Park, N.-J., Jegal, H., Paik, J.-H., Choi, S., Kim, S.-N., and Yang, M.H. (2023). Nymphoides peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice. Antioxidants, 12.","DOI":"10.3390\/antiox12040873"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lee, D., Kim, J.-Y., Kwon, H.C., Kwon, J., Jang, D.S., and Kang, K.S. (2022). Dual Beneficial Effects of \u03b1-Spinasterol Isolated from Aster Pseudoglehnii on Glucose Uptake in Skeletal Muscle Cells and Glucose-Stimulated Insulin Secretion in Pancreatic \u03b2-Cells. Plants, 11.","DOI":"10.3390\/plants11050658"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.5423\/PPJ.OA.08.2020.0162","article-title":"Inhibitory Activity of Sedum Middendorffianum-Derived 4-Hydroxybenzoic Acid and Vanillic Acid on the Type III Secretion System of Pseudomonas Syringae Pv. Tomato DC3000","volume":"36","author":"Kang","year":"2020","journal-title":"Plant Pathol. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1590\/S0102-695X2010005000027","article-title":"Validated High-Performance Liquid Chromatographic Method for the Standardisation of Ptychopetalum olacoides Benth., Olacaceae, Commercial Extracts","volume":"20","author":"Colombo","year":"2010","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"201386","DOI":"10.1155\/2015\/201386","article-title":"Isolation, Characterization, and RP-HPLC Estimation of p-Coumaric Acid from Methanolic Extract of Durva Grass (Cynodon dactylon Linn.) (Pers.)","volume":"2015","author":"Karthikeyan","year":"2015","journal-title":"Int. J. Anal. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1749-8546-6-25","article-title":"Neuroprotective and Anti-Oxidant Effects of Caffeic Acid Isolated from Erigeron annuus Leaf","volume":"6","author":"Jeong","year":"2011","journal-title":"Chin. Med."},{"key":"ref_37","first-page":"599","article-title":"Isolation, Characterization and Hypolipidemic Activity of Ferulic Acid in High-Fat-Diet-Induced Hyperlipidemia in Laboratory Rats","volume":"15","author":"Jain","year":"2016","journal-title":"EXCLI J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0974-8490.122921","article-title":"Caffeoylquinic Acids in Leaves of Selected Apocynaceae Species: Their Isolation and Content","volume":"6","author":"Wong","year":"2014","journal-title":"Pharmacogn. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jchromb.2007.09.016","article-title":"Purification and Identification of Antiviral Components from Laggera pterodonta by High-Speed Counter-Current Chromatography","volume":"859","author":"Shi","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1021\/jf020120l","article-title":"Identification and Characterization of Foliar Polyphenolic Composition in Sweetpotato (Ipomoea batatas L.) Genotypes","volume":"50","author":"Islam","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1590\/S0074-02762003000500022","article-title":"Saponins from Swartzia langsdorffii: Biological Activities","volume":"98","author":"Magalhaes","year":"2003","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1248\/cpb.38.375","article-title":"Saponins from Bran of Quinoa, Chenopodium quinoa WILLD. II","volume":"38","author":"Mizui","year":"1990","journal-title":"Chem. Pharm. Bull."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1055\/a-2061-7129","article-title":"Ferulic Acid: Signaling Pathways in Aging","volume":"73","author":"Neopane","year":"2023","journal-title":"Drug Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/jcb.23065","article-title":"PI3K and ERK\/Nrf2 Pathways Are Involved in Oleanolic Acid-Induced Heme Oxygenase-1 Expression in Rat Vascular Smooth Muscle Cells","volume":"112","author":"Feng","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ha, J.W., and Boo, Y.C. (2021). Siegesbeckiae Herba Extract and Chlorogenic Acid Ameliorate the Death of HaCaT Keratinocytes Exposed to Airborne Particulate Matter by Mitigating Oxidative Stress. Antioxidants, 10.","DOI":"10.3390\/antiox10111762"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/exd.12137","article-title":"Curcumin Inhibits UVB-Induced Matrix Metalloproteinase-1\/3 Expression by Suppressing the MAPK-P38\/JNK Pathways in Human Dermal Fibroblasts","volume":"22","author":"Hwang","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1039\/c8pp00174j","article-title":"Icariin and Icaritin Recover UVB-Induced Photoaging by Stimulating Nrf2\/ARE and Reducing AP-1 and NF-\u03baB Signaling Pathways: A Comparative Study on UVB-Irradiated Human Keratinocytes","volume":"17","author":"Hwang","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Khan, Z., Chowdhury, N., Sharmin, S., and Sohrab, M.H. (2018). Medicinal Values of Aquatic Plant Genus Nymphoides Grown in Asia: A Review. Asian Pac. J. Trop. Biomed., 8.","DOI":"10.4103\/2221-1691.225615"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nakai, K., and Tsuruta, D. (2021). What Are Reactive Oxygen Species, Free Radicals, and Oxidative Stress in Skin Diseases?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910799"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.taap.2018.09.038","article-title":"Roles of the KEAP1-NRF2 System in Mammalian Skin Exposed to UV Radiation","volume":"360","author":"Ikehata","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-020-00491-x","article-title":"Regulation of Inflammation by the Antioxidant Haem Oxygenase 1","volume":"21","author":"Campbell","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e9897442","DOI":"10.1155\/2022\/9897442","article-title":"Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition","volume":"2022","author":"Xie","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wang, S.-H., Chen, Y.-S., Lai, K.-H., Lu, C.-K., Chang, H.-S., Wu, H.-C., Yen, F.-L., Chen, L.-Y., Lee, J.-C., and Yen, C.-H. (2022). Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte. Antioxidants, 11.","DOI":"10.3390\/antiox11091755"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1080\/15384101.2023.2215084","article-title":"Ultraviolet B Radiation Induces Oxidative Stress and Apoptosis in Human Lens Epithelium Cells by Activating NF-\u03baB Signaling to down-Regulate Sodium Vitamin C Transporter 2 (SVCT2) Expression","volume":"22","author":"Guo","year":"2023","journal-title":"Cell Cycle"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.exger.2008.12.005","article-title":"Atypical Pathways of NF-\u03baB Activation and Aging","volume":"44","author":"Kriete","year":"2009","journal-title":"Exp. Gerontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-\u03baB p65 and Strategies for Therapeutic Manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1038\/jid.2008.122","article-title":"Reactive Oxygen Species in Tumor Necrosis Factor-\u03b1-Activated Primary Human Keratinocytes: Implications for Psoriasis and Inflammatory Skin Disease","volume":"128","author":"Young","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2174\/138920010791526051","article-title":"Protecting Skin Photoaging by NF-\u03baB Inhibitor","volume":"11","author":"Tanaka","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Garc\u00eda, V.A., Alameda, J.P., Page, A., and Casanova, M.L. (2021). Role of NF-\u03baB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models. Cells, 10.","DOI":"10.3390\/cells10081906"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Xue, N., Liu, Y., Jin, J., Ji, M., and Chen, X. (2022). Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136941"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.1039\/D1FO01383A","article-title":"A promising strategy for investigating the anti-aging effect of natural compounds: A case study of caffeoylquinic acids","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.2174\/0929867033456981","article-title":"Structure-Activity Relationships of HIV-1 Integrase Inhibitors-Enzyme-Ligand Interactions","volume":"10","author":"Maurin","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/tpj.15390","article-title":"Caffeoylquinic Acids: Chemistry, Biosynthesis, Occurrence, Analytical Challenges, and Bioactivity","volume":"107","author":"Kamimura","year":"2021","journal-title":"Plant J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11625","DOI":"10.1021\/jf303771s","article-title":"Antioxidant and DNA-Protective Activities of Chlorogenic Acid Isomers","volume":"60","author":"Xu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Indy Tamayose, C., dos Santos, E.A., Roque, N., Costa-Lotufo, L.V., and Pena Ferreira, M.J. (2019). Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity. Chem. Biodivers., 16.","DOI":"10.1002\/cbdv.201900093"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e5276130","DOI":"10.1155\/2016\/5276130","article-title":"Role of Antioxidants and Natural Products in Inflammation","volume":"2016","author":"Arulselvan","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"35374","DOI":"10.1039\/C8RA07549B","article-title":"Novel Caffeoylquinic Acid Derivatives from Lonicera japonica Thunb. Flower Buds Exert Pronounced Anti-HBV Activities","volume":"8","author":"Ge","year":"2018","journal-title":"RSC Adv."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1021\/acs.jafc.0c03804","article-title":"Current Advances in Naturally Occurring Caffeoylquinic Acids: Structure, Bioactivity, and Synthesis","volume":"68","author":"Liu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3233\/NUA-2012-0012","article-title":"Caffeoylquinic Acid Induces ATP Production and Energy Metabolism in Human Neurotypic SH-SY5Y Cells","volume":"1","author":"Sasaki","year":"2012","journal-title":"Nutr. Aging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1080\/13880209.2016.1190381","article-title":"In Vivo Anti-Inflammatory Activity of Caffeoylquinic Acid Derivatives from Solidago virgaurea in Rats","volume":"54","author":"Ezzat","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jphotobiol.2016.10.017","article-title":"Molecular Mechanism of the Binding of 3,4,5-Tri-O-caffeoylquinic Acid to Human Serum Albumin: Saturation Transfer Difference NMR, Multi-Spectroscopy, and Docking Studies","volume":"165","author":"Tang","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological Roles of MAPK Signaling Pathways in Human Diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-Activated Protein Kinases in Apoptosis Regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Long, Y., Wang, W., Zhang, Y., Du, F., Zhang, S., Li, Z., Deng, J., and Li, J. (2023). Photoprotective Effects of Dendrobium nobile Lindl. Polysaccharides against UVB-Induced Oxidative Stress and Apoptosis in HaCaT Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076120"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2005.12.032","article-title":"Grape Seed Proanthocyanidins Inhibit UV-Radiation-Induced Oxidative Stress and Activation of MAPK and NF-\u03baB Signaling in Human Epidermal Keratinocytes","volume":"40","author":"Mantena","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/aps.2017.26","article-title":"JNK\/AP-1 Activation Contributes to Tetrandrine Resistance in T-Cell Acute Lymphoblastic Leukaemia","volume":"38","author":"Liou","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e681","DOI":"10.1016\/j.wneu.2022.05.032","article-title":"Impinging Flow Induces Expression of Monocyte Chemoattractant Protein-1 in Endothelial Cells Through Activation of the c-Jun N-Terminal Kinase\/c-Jun\/p38\/c-Fos Pathway","volume":"164","author":"Zhu","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00403-009-0994-y","article-title":"The UV Response of the Skin: A Review of the MAPK, NF\u03baB and TNF\u03b1 Signal Transduction Pathways","volume":"302","author":"Muthusamy","year":"2010","journal-title":"Arch. Dermatol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.fsi.2019.08.013","article-title":"Insight into the Molecular Function and Transcriptional Regulation of Activator Protein 1 (AP-1) Components c-Jun\/c-Fos Ortholog in Red Lip Mullet (Liza haematocheila)","volume":"93","author":"Janson","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1468-3083.2003.00751.x","article-title":"Antioxidant Activity, Lipid Peroxidation and Skin Diseases. What\u2019s New","volume":"17","author":"Briganti","year":"2003","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104198","DOI":"10.1016\/j.jff.2020.104198","article-title":"Trehalose against UVB-Induced Skin Photoaging by Suppressing MMP Expression and Enhancing Procollagen I Synthesis in HaCaT Cells","volume":"74","author":"Xiao","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.4014\/jmb.1406.06038","article-title":"Oral Administration of Lactobacillus plantarum HY7714 Protects Hairless Mouse Against Ultraviolet B-Induced Photoaging","volume":"24","author":"Kim","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1011-1344(01)00201-9","article-title":"Solar UV Irradiation and Dermal Photoaging","volume":"63","author":"Wlaschek","year":"2001","journal-title":"J. Photochem. Photobiol. 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