{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:52:31Z","timestamp":1787226751525,"version":"build-2736575974"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:00:00Z","timestamp":1698537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG), Research Unit FOR-2558 \u201cTraceAge\u201d","award":["Scho 849\/6\u20132"],"award-info":[{"award-number":["Scho 849\/6\u20132"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG), Research Unit FOR-2558 \u201cTraceAge\u201d","award":["LocoTact, P17"],"award-info":[{"award-number":["LocoTact, P17"]}]},{"name":"CRC\/TR 296 \u201cLocal control of TH action\u201d","award":["Scho 849\/6\u20132"],"award-info":[{"award-number":["Scho 849\/6\u20132"]}]},{"name":"CRC\/TR 296 \u201cLocal control of TH action\u201d","award":["LocoTact, P17"],"award-info":[{"award-number":["LocoTact, P17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress, systemic inflammation, and metabolic derangements are hallmarks of burn pathophysiology. Severely burned patients are highly susceptible to infectious complications. Selenium-binding protein 1 (SELENBP1) modulates intracellular redox homeostasis, and elevated serum concentrations have been associated with adverse clinical outcomes in trauma patients. We hypothesized that serum SELENBP1 at hospital admission and during hospitalization may constitute a meaningful biomarker of disease severity and the clinical course in burn injury, with pulmonary infection as primary endpoint. To this end, we conducted a prospective cohort study that included 90 adult patients admitted to the Burn Center of the University Hospital Zurich, Switzerland. Patients were treated according to the local standard of care, with high-dose selenium supplementation during the first week. Serum SELENBP1 was determined at nine time-points up to six months postburn and the data were correlated to clinical parameters. SELENBP1 was initially elevated and rapidly declined within the first day. Baseline SELENBP1 levels correlated positively with the Abbreviated Burn Severity Index (ABSI) (R = 0.408; p &lt; 0.0001). In multiple logistic regression, a higher ABSI was significantly associated with increased pulmonary infection risk (OR, 14.4; 95% CI, 3.2\u201388.8; p = 0.001). Similarly, baseline SELENBP1 levels constituted a novel but less accurate predictor of pulmonary infection risk (OR, 2.5; 95% CI, 0.7\u20138.9; p = 0.164). Further studies are needed to explore the additional value of serum SELENBP1 when stratifying patients with respect to the clinical course following major burns and, potentially, for monitoring therapeutic measures aimed at reducing tissue damage and oxidative stress.<\/jats:p>","DOI":"10.3390\/antiox12111927","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:01:08Z","timestamp":1698555668000},"page":"1927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum Selenium-Binding Protein 1 (SELENBP1) in Burn Injury: A Potential Biomarker of Disease Severity and Clinical Course"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5831-265X","authenticated-orcid":false,"given":"Tabael L.","family":"Turan","sequence":"first","affiliation":[{"name":"Institute for Experimental Endocrinology, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland"},{"name":"Department of Plastic Surgery and Hand Surgery, Cantonal Hospital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-1680","authenticated-orcid":false,"given":"Julian","family":"Hackler","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Hoerner","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-8545","authenticated-orcid":false,"given":"Eddy","family":"Rijntjes","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia Reding","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Transplantation, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Plock","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland"},{"name":"Department of Plastic Surgery and Hand Surgery, Cantonal Hospital Aarau, 5001 Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-1555","authenticated-orcid":false,"given":"Lutz","family":"Schomburg","sequence":"additional","affiliation":[{"name":"Institute for Experimental Endocrinology, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.nutr.21.1.453","article-title":"Mammalian selenium-containing proteins","volume":"21","author":"Behne","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/carcin\/10.3.541","article-title":"Evidence for two selenium-binding proteins distinct from glutathione peroxidase in mouse liver","volume":"10","author":"Bansal","year":"1989","journal-title":"Carcinogenesis"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Elhodaky, M., and Diamond, A.M. (2018). Selenium-Binding Protein 1 in Human Health and Disease. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113437"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/mnfr.200700331","article-title":"Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer","volume":"52","author":"Li","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.redox.2018.11.004","article-title":"Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes","volume":"20","author":"Steinbrenner","year":"2019","journal-title":"Redox Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bbrc.2008.12.110","article-title":"Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner","volume":"379","author":"Jeong","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14457","DOI":"10.1074\/jbc.275.19.14457","article-title":"A 56-kDa selenium-binding protein participates in intra-Golgi protein transport","volume":"275","author":"Porat","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41588-017-0006-7","article-title":"Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis","volume":"50","author":"Pol","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Philipp, T.M., Gernoth, L., Will, A., Schwarz, M., Ohse, V.A., Kipp, A.P., Steinbrenner, H., and Klotz, L.O. (2023). Selenium-binding protein 1 (SELENBP1) is a copper-dependent thiol oxidase. Redox Biol., 65.","DOI":"10.1016\/j.redox.2023.102807"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3181\/00379727-196-43171","article-title":"Levels and 75Se-labeling of specific proteins as a consequence of dietary selenium concentration in mice and rats","volume":"196","author":"Bansal","year":"1991","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.3390\/nu7053938","article-title":"The subcellular location of selenoproteins and the impact on their function","volume":"7","author":"Diamond","year":"2015","journal-title":"Nutrients"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/carcin\/bgq114","article-title":"Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein","volume":"31","author":"Fang","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1158\/1078-0432.CCR-12-0183","article-title":"Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1alpha to promote hepatocellular carcinoma invasiveness","volume":"18","author":"Huang","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e615","DOI":"10.1038\/tp.2015.108","article-title":"SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia","volume":"5","author":"Udawela","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2203711119","DOI":"10.1073\/pnas.2203711119","article-title":"SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia","volume":"119","author":"Kim","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"680240","DOI":"10.3389\/fnins.2021.680240","article-title":"Selenium-Binding Protein 1 (SELENBP1) as Biomarker for Adverse Clinical Outcome after Traumatic Spinal Cord Injury","volume":"15","author":"Seelig","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jtemb.2019.01.005","article-title":"Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death","volume":"52","author":"Kuhn","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kuhn-Heid, E.C.D., Kuhn, E.C., Ney, J., Wendt, S., Seelig, J., Schwiebert, C., Minich, W.B., Stoppe, C., and Schomburg, L. (2019). Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery. Nutrients, 11.","DOI":"10.3390\/nu11092005"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jeschke, M.G., Gauglitz, G.G., Kulp, G.A., Finnerty, C.C., Williams, F.N., Kraft, R., Suman, O.E., Mlcak, R.P., and Herndon, D.N. (2011). Long-term persistance of the pathophysiologic response to severe burn injury. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021245"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s001340051250","article-title":"Time course of oxidative stress after major burns","volume":"26","author":"Goudable","year":"2000","journal-title":"Intensive Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1097\/BCR.0000000000000355","article-title":"Burns: Pathophysiology of Systemic Complications and Current Management","volume":"38","author":"Nielson","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00075197-199811000-00006","article-title":"Trace elements in trauma and burns","volume":"1","author":"Berger","year":"1998","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1186\/cc5084","article-title":"Reduction of nosocomial pneumonia after major burns by trace element supplementation: Aggregation of two randomised trials","volume":"10","author":"Berger","year":"2006","journal-title":"Crit. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1128\/CMR.19.2.403-434.2006","article-title":"Burn wound infections","volume":"19","author":"Church","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1093\/cid\/cix682","article-title":"Bacterial Infections After Burn Injuries: Impact of Multidrug Resistance","volume":"65","author":"Lachiewicz","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.burns.2012.09.017","article-title":"Cause of death and correlation with autopsy findings in burns patients","volume":"39","author":"Krishnan","year":"2013","journal-title":"Burns"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1186\/cc8170","article-title":"The leading causes of death after burn injury in a single pediatric burn center","volume":"13","author":"Williams","year":"2009","journal-title":"Crit. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/01.TA.0000029382.26295.AB","article-title":"The risk factors and time course of sepsis and organ dysfunction after burn trauma","volume":"54","author":"Fitzwater","year":"2003","journal-title":"J. Trauma."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0196-0644(82)80096-6","article-title":"The abbreviated burn severity index","volume":"11","author":"Tobiasen","year":"1982","journal-title":"Ann. Emerg. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bengtsson, Y., Demircan, K., Vallon-Christersson, J., Malmberg, M., Saal, L.H., Ryden, L., Borg, A., Schomburg, L., Sandsveden, M., and Manjer, J. (2023). Serum copper, zinc and copper\/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study. Redox Biol., 63.","DOI":"10.1016\/j.redox.2023.102728"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.redox.2016.12.025","article-title":"Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P","volume":"11","author":"Hybsier","year":"2017","journal-title":"Redox Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Flohe","year":"1984","journal-title":"Methods Enzymol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"tkad007","DOI":"10.1093\/burnst\/tkad007","article-title":"Current understanding of the chronic stress response to burn injury from human studies","volume":"11","author":"Osborne","year":"2023","journal-title":"Burns Trauma"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ams2.17","article-title":"Immune response to traumatic injury: Harmony and discordance of immune system homeostasis","volume":"1","author":"Osuka","year":"2014","journal-title":"Acute Med. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1034420","DOI":"10.3389\/fimmu.2022.1034420","article-title":"Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines","volume":"13","author":"Mulder","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0140-6736(14)60687-5","article-title":"The systemic immune response to trauma: An overview of pathophysiology and treatment","volume":"384","author":"Lord","year":"2014","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.shk.0000223120.26394.7d","article-title":"Cytokine expression profile over time in severely burned pediatric patients","volume":"26","author":"Finnerty","year":"2006","journal-title":"Shock"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0305-4179(96)00052-6","article-title":"Plasma cytokine levels in patients with severe burn injury--with reference to the relationship between infection and prognosis","volume":"22","author":"Yamada","year":"1996","journal-title":"Burns"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/s41598-022-05768-w","article-title":"Severity of thermal burn injury is associated with systemic neutrophil activation","volume":"12","author":"Laggner","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9503","DOI":"10.1074\/jbc.271.16.9503","article-title":"STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6","volume":"271","author":"Zhang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0014-5793(73)80755-0","article-title":"Glutathione peroxidase: A selenoenzyme","volume":"32","author":"Flohe","year":"1973","journal-title":"FEBS Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione peroxidase-1 in health and disease: From molecular mechanisms to therapeutic opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.bbagen.2009.03.015","article-title":"Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium","volume":"1790","author":"Schomburg","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1089\/wound.2013.0520","article-title":"The Role of Hypoxia-Inducible Factor in Wound Healing","volume":"3","author":"Hong","year":"2014","journal-title":"Adv. Wound Care"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"637","DOI":"10.14348\/molcells.2014.0150","article-title":"Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1","volume":"37","author":"Ruthenborg","year":"2014","journal-title":"Mol. Cells"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"26839","DOI":"10.1074\/jbc.M401907200","article-title":"Determinants of human plasma glutathione peroxidase (GPx-3) expression","volume":"279","author":"Bierl","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1158\/0008-5472.CAN-08-3643","article-title":"Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition","volume":"69","author":"Scortegagna","year":"2009","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5483\/BMBRep.2014.47.7.104","article-title":"Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1alpha and suppresses the malignant characteristics of prostate cancer cells","volume":"47","author":"Jeong","year":"2014","journal-title":"BMB Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000239763","article-title":"Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes","volume":"43","author":"Forceville","year":"2009","journal-title":"Eur. Surg. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.burns.2007.04.009","article-title":"Oxidative stress and anti-oxidative mobilization in burn injury","volume":"34","author":"Parihar","year":"2008","journal-title":"Burns"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1179\/135100003125001378","article-title":"An imbalance in antioxidant defense affects cellular function: The pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse","volume":"8","author":"Crack","year":"2003","journal-title":"Redox Rep."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhao, C., Zeng, H., Wu, R.T., and Cheng, W.H. (2016). Loss of Selenium-Binding Protein 1 Decreases Sensitivity to Clastogens and Intracellular Selenium Content in HeLa Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158650"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/11\/1927\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:13:43Z","timestamp":1760130823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/11\/1927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,29]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["antiox12111927"],"URL":"https:\/\/doi.org\/10.3390\/antiox12111927","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,29]]}}}