{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:44:47Z","timestamp":1772135087165,"version":"3.50.1"},"reference-count":82,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAR 2020 (Fondo di Ateneo per la Ricerca 2020) of University of Sassari"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Goji berry (GB) shows beneficial effects on human health, although its effects on the male rabbit have been little investigated. This study examines the impact of GB dietary supplementation on the semen traits, antioxidant capacity of seminal plasma, and histological features of the reproductive tract of rabbit buck. Eighteen rabbits were distributed into two dietary groups: one receiving a commercial feed (Control), and the other a feed supplemented with 1% of GB (Goji). After a nutritional adaptation period of 60 days, the animals were subjected to semen collection every 15 days. The semen traits, libido, antioxidant, and inflammatory parameters were collected and analyzed. The rabbits were sacrificed after 60 days, and tissues of the genital tract were analyzed. Compared to the Control group, the Goji group showed higher spermatozoa concentration, motility, and vitality (p &lt; 0.05), as well as fewer abnormal spermatozoa and a higher libido (p &lt; 0.1). Histological features such as functional activity and hyperplasia were improved by GB and correlated with some semen traits (p &lt; 0.05). Conversely, antioxidant and anti-inflammatory parameters were unaffected by the diet. These findings suggest that GB acts on the tissues of the reproductive tract positively influencing semen quality, although further studies are needed to understand the effect on oxidative stress.<\/jats:p>","DOI":"10.3390\/antiox12111959","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:16:21Z","timestamp":1698916581000},"page":"1959","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Goji Berry in the Diet of the Rabbit Buck: Effects on Semen Quality, Oxidative Status and Histological Features of the Reproductive Tract"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-2801","authenticated-orcid":false,"given":"Gabriele","family":"Brecchia","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Mu\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Tirana, Kod\u00ebr Kam\u00ebz, 1029 Tirana, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albana","family":"Munga","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Tirana, Kod\u00ebr Kam\u00ebz, 1029 Tirana, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7970","authenticated-orcid":false,"given":"Laura","family":"Menchetti","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-8359","authenticated-orcid":false,"given":"Livio","family":"Galosi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-5984","authenticated-orcid":false,"given":"Giacomo","family":"Rossi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93\/95, 62024 Matelica, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-4610","authenticated-orcid":false,"given":"Olimpia","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, 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dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majlind","family":"Sul\u00e7e","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Tirana, Kod\u00ebr Kam\u00ebz, 1029 Tirana, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enkeleda","family":"Ozuni","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Tirana, Kod\u00ebr Kam\u00ebz, 1029 Tirana, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigj","family":"Turmalaj","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Agricultural University of Tirana, Kod\u00ebr Kam\u00ebz, 1029 Tirana, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-757X","authenticated-orcid":false,"given":"Marta","family":"Castrica","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedicine and Food Science, University of Padova, Agripolis, Viale dell\u2019Universit\u00e0 16, 35020 Legnaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-4890","authenticated-orcid":false,"given":"Maria Rachele","family":"Ceccarini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-1627","authenticated-orcid":false,"given":"Federica","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Fioretti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell\u2019Elce di Sotto 8, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alda","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell\u2019Universit\u00e0 6, 26900 Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-0514","authenticated-orcid":false,"given":"Maria Laura","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, 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Devel. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.foodres.2013.10.007","article-title":"Super Food Lycium barbarum (Solanaceae) Traceability via an Internal Transcribed Spacer 2 Barcode","volume":"54","author":"Xin","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tian, X., Liang, T., Liu, Y., Ding, G., Zhang, F., and Ma, Z. (2019). Extraction, Structural Characterization, and Biological Functions of Lycium barbarum Polysaccharides: A Review. Biomolecules, 9.","DOI":"10.3390\/biom9090389"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.14336\/AD.2017.0725","article-title":"Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent","volume":"8","author":"Gao","year":"2017","journal-title":"Aging Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.jbiotec.2016.05.114","article-title":"Effect of Lycium barbarum Berries Cultivated in Umbria (Italy) on Human Hepatocellular Carcinoma Cells","volume":"231","author":"Ceccarini","year":"2016","journal-title":"J. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.2147\/IJN.S136820","article-title":"Simple Nanoliposomes Encapsulating Lycium barbarum Polysaccharides as Adjuvants Improve Humoral and Cellular Immunity in Mice","volume":"12","author":"Bo","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.ijbiomac.2020.10.037","article-title":"Gastroprotective Effect of Lycium barbarum Polysaccharides and C-Phyocyanin in Rats with Ethanol-Induced Gastric Ulcer","volume":"165","author":"Lian","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kwok, S.S., Bu, Y., Lo, A.C.Y., Chan, T.C.Y., So, K.F., Lai, J.S.M., and Shih, K.C. (2019). A Systematic Review of Potential Therapeutic Use of Lycium barbarum Polysaccharides in Disease. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/4615745"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2437397","DOI":"10.1155\/2019\/2437397","article-title":"Goji Berries as a Potential Natural Antioxidant Medicine: An Insight into Their Molecular Mechanisms of Action","volume":"2019","author":"Ma","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Vidovi\u0107, B.B., Milin\u010di\u0107, D.D., Mar\u010deti\u0107, M.D., Djuri\u0161, J.D., Ili\u0107, T.D., Kosti\u0107, A., and Pe\u0161i\u0107, M.B. (2022). Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review. Antioxidants, 11.","DOI":"10.3390\/antiox11020248"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.foodres.2011.03.027","article-title":"A Review of Botanical Characteristics, Phytochemistry, Clinical Relevance in Efficacy and Safety of Lycium barbarum Fruit (Goji)","volume":"44","author":"Amagase","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1080\/14786419.2018.1543686","article-title":"Antimicrobial and Antioxidant Activity of Proteins from Feijoa sellowiana Berg. Fruit before and after in Vitro Gastrointestinal Digestion","volume":"34","author":"Piscopo","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mannucci, A., Argento, F.R., Fini, E., Coccia, M.E., Taddei, N., Becatti, M., and Fiorillo, C. (2021). The Impact of Oxidative Stress in Male Infertility. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.799294"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1088727","DOI":"10.5534\/wjmh.2014.32.1.1","article-title":"Effect of Oxidative Stress on Male Reproduction","volume":"32","author":"Agarwal","year":"2014","journal-title":"World J. Mens. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0090-4295(82)90018-8","article-title":"Further Clinical Experience with Testis Hypothermia for Infertility Due to Poor Semen","volume":"19","author":"Zorgniotti","year":"1982","journal-title":"Urology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00004032-197509000-00002","article-title":"Gonadic Function in Workmen with Long-Term Exposure to Microwaves","volume":"29","author":"Lancranjan","year":"1975","journal-title":"Health Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/aja.2012.46","article-title":"The Roles of Omega-3 and Omega-6 Fatty Acids in Idiopathic Male Infertility","volume":"14","author":"Safarinejad","year":"2012","journal-title":"Asian J. Androl."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/humrep\/der132","article-title":"The Role of Sperm Oxidative Stress in Male Infertility and the Significance of Oral Antioxidant Therapy","volume":"26","author":"Gharagozloo","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3279670","DOI":"10.1155\/2019\/3279670","article-title":"Effect of Dietary N-3 Source on Rabbit Male Reproduction","volume":"2019","author":"Castellini","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/S0015-0282(03)00374-1","article-title":"Psychosocial Factors Discriminate Oligozoospermic from Normozoospermic Men","volume":"79","author":"Balistreri","year":"2003","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-0037-1603568","article-title":"Male Infertility and Risk of Nonmalignant Chronic Diseases: A Systematic Review of the Epidemiological Evidence","volume":"35","author":"Glazer","year":"2017","journal-title":"Semin. Reprod. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0140-6736(77)92665-4","article-title":"Infertility in Male Pesticide Workers","volume":"310","author":"Whorton","year":"1977","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1289\/ehp.00108887","article-title":"Semen Quality and Reproductive Health of Young Czech Men Exposed to Seasonal Air Pollution","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1530\/rep.0.1210881","article-title":"Studies on the Metabolism of Essential Fatty Acids in Isolated Human Testicular Cells","volume":"121","author":"Hauger","year":"2001","journal-title":"Reproduction"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mce.2016.03.013","article-title":"Targeted Inactivation of the Mouse Epididymal Beta-Defensin 41 Alters Sperm Flagellar Beat Pattern and Zona Pellucida Binding","volume":"427","author":"Alvarez","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_26","first-page":"425","article-title":"Free Radicals: Their Beneficial and Detrimental Effects on Sperm Function","volume":"48","author":"Kothari","year":"2010","journal-title":"Indian. J. Exp. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2005.12.026","article-title":"Oxidative Stress, Sperm Survival and Fertility Control","volume":"250","author":"Aitken","year":"2006","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative Stress and Male Infertility: Current Knowledge of Pathophysiology and Role of Antioxidant Therapy in Disease Management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Montano, L., Maugeri, A., Volpe, M.G., Micali, S., Mirone, V., Mantovani, A., Navarra, M., and Piscopo, M. (2022). Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031568"},{"key":"ref_30","first-page":"187","article-title":"Effects of Antioxidant Treatment on Seminal Parameters in Patients Undergoing in Vitro Fertilization","volume":"91","author":"Gambera","year":"2019","journal-title":"Arch. Ital. Urol. E Androl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aju.2017.11.013","article-title":"Systematic Review of Antioxidant Types and Doses in Male Infertility: Benefits on Semen Parameters, Advanced Sperm Function, Assisted Reproduction and Live-Birth Rate","volume":"16","author":"Majzoub","year":"2018","journal-title":"Arab. J. Urol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/2090598X.2019.1599624","article-title":"Oxidative Stress and Sperm Function: A Systematic Review on Evaluation and Management","volume":"17","author":"Dutta","year":"2019","journal-title":"Arab. J. Urol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Castrica, M., Menchetti, L., Agradi, S., Curone, G., Vigo, D., Pastorelli, G., Di Giancamillo, A., Modina, S.C., Riva, F., and Serra, V. (2022). Effect of Bovine Colostrum Dietary Supplementation on Rabbit Meat Quality. Foods, 11.","DOI":"10.3390\/foods11213433"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e13554","DOI":"10.1111\/and.13554","article-title":"Lycium Barbarum Polysaccharide Protects against Ethanol-Induced Spermiotoxicity and Testicular Degeneration in Immp2l+\/\u2212 Mice","volume":"52","author":"Liu","year":"2020","journal-title":"Andrologia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/13685538.2018.1498079","article-title":"Lycium chinense Mill Improves Hypogonadism via Anti-Oxidative Stress and Anti-Apoptotic Effect in Old Aged Rat Model","volume":"23","author":"Jeong","year":"2020","journal-title":"Aging Male"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yexmp.2017.06.003","article-title":"Investigation of the Effects of Lycium barbarum Polysaccharides against Cadmium Induced Damage in Testis","volume":"103","author":"Varoni","year":"2017","journal-title":"Exp. Mol. Pathol."},{"key":"ref_37","first-page":"599","article-title":"Study on Protective Action of Lycium barbarum Polysaccharides on DNA Imparments of Testicle Cells in Mice","volume":"32","author":"Huang","year":"2003","journal-title":"Wei Sheng Yan Jiu"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1080\/13880209.2021.1961822","article-title":"SIRT 3 Was Involved in Lycium barbarum Seed Oil Protection Testis from Oxidative Stress: In Vitro and in Vivo Analyses","volume":"59","author":"Yang","year":"2021","journal-title":"Pharm. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-8741(02)00169-1","article-title":"Protective Effect of Fructus lycii Polysaccharides against Time and Hyperthermia-Induced Damage in Cultured Seminiferous epithelium","volume":"82","author":"Wang","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1507\/endocrj.EJ16-0430","article-title":"Protective Effects of Lycium barbarum Polysaccharide on Male Sexual Dysfunction and Fertility Impairments by Activating Hypothalamic Pituitary Gonadal Axis in Streptozotocin-Induced Type-1 Diabetic Male Mice","volume":"64","author":"Shi","year":"2017","journal-title":"Endocr. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/ptr.3314","article-title":"Antagonistic Effects of Lycium barbarum Polysaccharides on the Impaired Reproductive System of Male Rats Induced by Local Subchronic Exposure to 60Co-\u03b3 Irradiation","volume":"25","author":"Luo","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fphar.2020.00742","article-title":"Effects of Lycium barbarum Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/ptr.3633","article-title":"Protective Effect of Lycium barbarum Polysaccharides against Doxorubicin-Induced Testicular Toxicity in Rats","volume":"26","author":"Xin","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1039\/C6FO01583B","article-title":"Protective Effect of Lycium barbarum Polysaccharides against Cadmium-Induced Testicular Toxicity in Male Mice","volume":"8","author":"Zhang","year":"2017","journal-title":"Food Funct."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1677\/joe.1.05983","article-title":"Leptin Receptor Expression and in Vitro Leptin Actions on Prostaglandin Release and Nitric Oxide Synthase Activity in the Rabbit Oviduct","volume":"185","author":"Zerani","year":"2005","journal-title":"J. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1530\/rep.1.00083","article-title":"Expression Patterns of Cytokines, P53 and Nitric Oxide Synthase Isoenzymes in Corpora lutea of Pseudopregnant Rabbits during Spontaneous luteolysis","volume":"127","author":"Boiti","year":"2004","journal-title":"Reproduction"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Cremonesi, P., Curone, G., Biscarini, F., Cotozzolo, E., Menchetti, L., Riva, F., Marongiu, M.L., Castiglioni, B., Barbato, O., and Munga, A. (2022). Dietary Supplementation with Goji Berries (Lycium barbarum) Modulates the Microbiota of Digestive Tract and Caecal Metabolites in Rabbits. Animals, 12.","DOI":"10.3390\/ani12010121"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1530\/rep.0.1250807","article-title":"Regulation of Nitric Oxide Synthase Isoforms and Role of Nitric Oxide during Prostaglandin F2alpha-Induced Luteolysis in Rabbits","volume":"125","author":"Boiti","year":"2003","journal-title":"Reproduction"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1677\/JOE-10-0109","article-title":"Expression of Type I GNRH Receptor and in Vivo and in Vitro GNRH-I Effects in Corpora lutea of Pseudopregnant Rabbits","volume":"207","author":"Zerani","year":"2010","journal-title":"J. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Andoni, E., Curone, G., Agradi, S., Barbato, O., Menchetti, L., Vigo, D., Zelli, R., Cotozzolo, E., Ceccarini, M.R., and Faustini, M. (2021). Effect of Goji Berry (Lycium barbarum) Supplementation on Reproductive Performance of Rabbit Does. Animals, 11.","DOI":"10.3390\/ani11061672"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Brecchia, G., Sulce, M., Curone, G., Barbato, O., Canali, C., Troisi, A., Munga, A., Polisca, A., Agradi, S., and Ceccarini, M.R. (2022). Goji Berry (Lycium barbarum) Supplementation during Pregnancy Influences Insulin Sensitivity in Rabbit Does but Not in Their Offspring. Animals, 12.","DOI":"10.3390\/ani12010039"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Menchetti, L., Curone, G., Andoni, E., Barbato, O., Troisi, A., Fioretti, B., Polisca, A., Codini, M., Canali, C., and Vigo, D. (2020). Impact of Goji Berries (Lycium barbarum) Supplementation on the Energy Homeostasis of Rabbit Does: Uni- and Multivariate Approach. Animals, 10.","DOI":"10.3390\/ani10112000"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Castrica, M., Menchetti, L., Balzaretti, C.M., Branciari, R., Ranucci, D., Cotozzolo, E., Vigo, D., Curone, G., Brecchia, G., and Miraglia, D. (2020). Impact of Dietary Supplementation with Goji Berries (Lycium barbarum) on Microbiological Quality, Physico-Chemical, and Sensory Characteristics of Rabbit Meat. Foods, 9.","DOI":"10.3390\/foods9101480"},{"key":"ref_54","first-page":"320","article-title":"Semen Quality Improvement in a Man with Idiopathic Infertility Treated with Traditional Korean Medicine: A Case Report","volume":"11","author":"Jo","year":"2015","journal-title":"Explor. J. Sci. Health"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.lfs.2006.02.012","article-title":"Lycium barbarum Polysaccharides: Protective Effects against Heat-Induced Damage of Rat Testes and H2O2-Induced DNA Damage in Mouse Testicular Cells and Beneficial Effect on Sexual Behavior and Reproductive Function of Hemicastrated Rats","volume":"79","author":"Luo","year":"2006","journal-title":"Life Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1039\/C6FO01575A","article-title":"Beneficial Effects of Lycium barbarum Polysaccharide on Spermatogenesis by Improving Antioxidant Activity and Inhibiting Apoptosis in Streptozotocin-Induced Diabetic Male Mice","volume":"8","author":"Shi","year":"2017","journal-title":"Food Funct."},{"key":"ref_57","first-page":"387","article-title":"Lycium Barbarum Polysaccharide Reduces Testicular Spermatogenic Injury in Immp2l\u2212\/\u2212 mice through GPX4 and AIF Pathways","volume":"27","author":"Liu","year":"2021","journal-title":"Zhonghua Nan Ke Xue"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/asj.13295","article-title":"Semen Quality Improvement in Boars Fed with Supplemental Wolfberry (Lycium barbarum)","volume":"90","author":"Yang","year":"2019","journal-title":"Anim. Sci. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.theriogenology.2019.02.011","article-title":"Lycium Barbarum and Laminaria Japonica Polysaccharides Improve Cashmere Goat Sperm Quality and Fertility Rate after Cryopreservation","volume":"129","author":"Ren","year":"2019","journal-title":"Theriogenology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/19396368.2014.891163","article-title":"Long-Term Effects of Silver Nanoparticles on Reproductive Activity of Rabbit Buck","volume":"60","author":"Castellini","year":"2014","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108018","DOI":"10.1016\/j.meatsci.2019.108018","article-title":"The Effect of Goji Berries (Lycium barbarum) Dietary Supplementation on Rabbit Meat Quality","volume":"161","author":"Menchetti","year":"2020","journal-title":"Meat Sci."},{"key":"ref_62","first-page":"60","article-title":"Prediction of the Apparent Digestible Energy Content of Commercial Pelleted Feeds for Rabbits","volume":"11","author":"Maertens","year":"1988","journal-title":"J. Appl. Rabbit. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.anireprosci.2011.12.009","article-title":"Rabbit Sexual Behavior, Semen and Sperm Characteristics When Supplemented with Sprouted Wheat","volume":"129","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"ref_64","unstructured":"Garson, G.D. (2012). Measures of Association (Statistical Associates \u201cBlue Book\u201d Series 8) (English Edition), Statistical Associates Publishers. [1st ed.]."},{"key":"ref_65","unstructured":"Field, A., Miles, J., and Field, Z. (2009). SAGE Publications. [3rd ed.]."},{"key":"ref_66","unstructured":"Field, A. (2013). Discovering Statistics Using IBM SPSS Statistics, SAGE Publications."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.foodchem.2012.10.005","article-title":"Recently Introduced Foods as New Allergenic Sources: Sensitisation to Goji Berries (Lycium barbarum)","volume":"137","author":"Ferrer","year":"2013","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fendo.2020.00164","article-title":"Lycium Barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats","volume":"11","author":"Lei","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_69","first-page":"2727","article-title":"The Protective Effect of Goji Berry Extract in Ischemic Reperfusion in Testis Torsion","volume":"8","author":"Dursun","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"690808","DOI":"10.1155\/2013\/690808","article-title":"Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol a in Mice","volume":"2013","author":"Zhang","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jep.2014.04.013","article-title":"The Effect of Lycium Barbarum Polysaccharides on the Male Rats\u2019 Reproductive System and Spermatogenic Cell Apoptosis Exposed to Low-Dose Ionizing Irradiation","volume":"154","author":"Luo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.anireprosci.2009.03.012","article-title":"Effects of Chronic Heat Stress on Testicular Structures, Serum Testosterone and Cortisol Concentrations in Developing Lambs","volume":"117","author":"Rasooli","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/aji.12558","article-title":"Protective Effect of Polysaccharides from Lycium Barbarum on Spermatogenesis of Mice with Impaired Reproduction System Induced by Cyclophosphamide","volume":"76","author":"Qian","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_74","unstructured":"Dalton, J.C. (October, January 30). Semen Quality Factors Associated with Fertility. Proceedings of the Applied Reproductive Strategies in Beef Cattle\u2014Northwest, Boise, ID, USA."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/advances\/nmy057","article-title":"The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review Andmeta-Analysis of Randomized Clinical Trials","volume":"9","author":"Vizmanos","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Duracka, M., Lukac, N., Kacaniova, M., Kantor, A., Hleba, L., Ondruska, L., and Tvrda, E. (2019). Antibiotics Versus Natural Biomolecules: The Case of In Vitro Induced Bacteriospermia by Enterococcus Faecalis in Rabbit Semen. Molecules, 24.","DOI":"10.3390\/molecules24234329"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Tuttolomondo, A., Simonetta, I., Daidone, M., Mogavero, A., Ortello, A., and Pinto, A. (2019). Metabolic and Vascular Effect of the Mediterranean Diet. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194716"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1745-7262.2008.00306.x","article-title":"Stimulating Effects of Quercetin on Sperm Quality and Reproductive Organs in Adult Male Rats","volume":"10","author":"Taepongsorat","year":"2008","journal-title":"Asian J. Androl."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e13155","DOI":"10.1111\/aji.13155","article-title":"In Vitro Antioxidation Effect of Quercetin on Sperm Function from the Infertile Patients with Leukocytospermia","volume":"82","author":"Diao","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Tvrd\u00e1, E., Benko, F., Slanina, T., and du Plessis, S.S. (2021). The Role of Selected Natural Biomolecules in Sperm Production and Functionality. Molecules, 26.","DOI":"10.3390\/molecules26175196"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2605.2006.00690.x","article-title":"Can Lycopene Be Delivered into Semen via Prostasomes? In Vitro Incorporation and Retention Studies","volume":"29","author":"Goyal","year":"2006","journal-title":"Int. J. Androl."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Tvrd\u00e1, E., Kov\u00e1\u010dik, A., Tu\u0161imov\u00e1, E., Pa\u00e1l, D., Mackovich, A., Alimov, J., and Luk\u00e1\u010d, N. (2016). Antioxidant Efficiency of Lycopene on Oxidative Stress\u2014Induced Damage in Bovine Spermatozoa. J. Anim. Sci. Biotechnol., 7.","DOI":"10.1186\/s40104-016-0113-9"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/11\/1959\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:16:06Z","timestamp":1760130966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/11\/1959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":82,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["antiox12111959"],"URL":"https:\/\/doi.org\/10.3390\/antiox12111959","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,2]]}}}