{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:06:06Z","timestamp":1790859966993,"version":"4.1.0"},"reference-count":164,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The article presents a review of the relationships between melatonin and neurodevelopmental disorders. First, the antioxidant properties of melatonin and its physiological effects are considered to understand better the role of melatonin in typical and atypical neurodevelopment. Then, several neurodevelopmental disorders occurring during infancy, such as autism spectrum disorder or neurogenetic disorders associated with autism (including Smith\u2013Magenis syndrome, Angelman syndrome, Rett\u2019s syndrome, Tuberous sclerosis, or Williams\u2013Beuren syndrome) and neurodevelopmental disorders occurring later in adulthood like bipolar disorder and schizophrenia, are discussed with regard to impaired melatonin production and circadian rhythms, in particular, sleep\u2013wake rhythms. This article addresses the issue of overlapping symptoms that are commonly observed within these different mental conditions and debates the role of abnormal melatonin production and altered circadian rhythms in the pathophysiology and behavioral expression of these neurodevelopmental disorders.<\/jats:p>","DOI":"10.3390\/antiox12112017","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:32:32Z","timestamp":1700476352000},"page":"2017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Melatonin in Neurodevelopmental Disorders: A Critical Literature Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Cyrille","family":"Feybesse","sequence":"first","affiliation":[{"name":"P\u00f4le Hospitalo-Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent (PHUPEA), Centre Hospitalier Guillaume Regnier, 154 rue de Ch\u00e2tillon, 35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chokron","sequence":"additional","affiliation":[{"name":"Integrative Neuroscience and Cognition Center (INCC), CNRS UMR 8002, Universit\u00e9 Paris Cit\u00e9, 45 rue des Saints-P\u00e8res, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Tordjman","sequence":"additional","affiliation":[{"name":"P\u00f4le Hospitalo-Universitaire de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent (PHUPEA), Centre Hospitalier Guillaume Regnier, 154 rue de Ch\u00e2tillon, 35000 Rennes, France"},{"name":"Integrative Neuroscience and Cognition Center (INCC), CNRS UMR 8002, Universit\u00e9 Paris Cit\u00e9, 45 rue des Saints-P\u00e8res, 75006 Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Rennes, 2 Avenue du Professeur L\u00e9on Bernard, 35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jad.2015.07.017","article-title":"The bipolarity of light and dark: A review on bipolar disorder and circadian cycles","volume":"185","author":"Abreu","year":"2015","journal-title":"J. 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