{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:56:21Z","timestamp":1792018581831,"version":"4.4.0"},"reference-count":51,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"earmarked fund for CARS","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"earmarked fund for CARS","award":["2022ZD003"],"award-info":[{"award-number":["2022ZD003"]}]},{"name":"Key Projects of Maoming Laboratory","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"Key Projects of Maoming Laboratory","award":["2022ZD003"],"award-info":[{"award-number":["2022ZD003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Piglet weaning is an important stage in production where changes in the environment and diet can cause problems such as intestinal inflammation and diarrhea. Vitamin A is an essential nutrient for human and animal growth and has immunomodulatory and inflammatory effects. A large body of literature has previously reported on the use of vitamin A in piglet production, so our experiment added different concentrations of vitamin A (0, 1100, 2200, 4400, 8800, and 17,600 IU\/kg) to weaned piglet diets to study the effects of different doses on growth performance, intestinal barrier, inflammation, and flora in weaned piglets. We selected 4400 IU\/kg as the optimum concentration of vitamin A in relation to average daily weight gain, feed intake, feed-to-weight ratio, and diarrhea rate, and subsequently tested the inflammatory factors, immunoglobulin content, antioxidant levels, and intestinal flora of weaned piglets. Results: We observed that the diarrhea rate of weaned piglets was significantly lower after the addition of 4400 IU\/kg of vitamin A to the diet (p &lt; 0.05). A control group and a 4400 IU\/kg VA group were selected for subsequent experiments. We found that after the addition of vitamin A, the serum CAT level of weaned piglets increased significantly, the expression of Claudin-1 in the jejunum and ileum increased significantly, the expression of Occludin gene in the jejunum increased significantly, the expression of IL-5 and IL-10 in the ileum increased significantly (p &lt; 0.05), and the expression of IL-4, IL-5, and IL-10 in the ileum increased significantly (p &lt; 0.05). Meanwhile, in the colonic flora of vitamin A-added weaned piglets, the relative abundance of Actinobacteria and Erysipelotrichales decreased significantly, while the relative abundance of Bacteroidales increased significantly (p &lt; 0.05). The results of this study indicated that vitamin A at 4400 IU\/kg reduces diarrhea in weaned piglets by increasing antioxidant levels, increasing intestinal tight junction protein gene expression, and regulating colonic gut microbiota.<\/jats:p>","DOI":"10.3390\/antiox12122049","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T11:54:48Z","timestamp":1701086088000},"page":"2049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Vitamin A on Growth Performance, Antioxidants, Gut Inflammation, and Microbes in Weaned Piglets"],"prefix":"10.3390","volume":"12","author":[{"given":"Shengnan","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory Maoming Branch, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory Maoming Branch, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailei","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory Maoming Branch, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Wen","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory Maoming Branch, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory Maoming Branch, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510640, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"},{"name":"Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China"},{"name":"Lingnan Modern Agricultural Science and Technology Guangdong Provincial Laboratory Maoming Branch, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0031-9384(00)00404-2","article-title":"Neuroendocrine consequences of very early weaning in swine","volume":"72","author":"Hay","year":"2001","journal-title":"Physiol. 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