{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:07:23Z","timestamp":1791547643022,"version":"4.3.4"},"reference-count":57,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project of Swine Innovation Team in Guangdong Modern Agricultural Research System","award":["2022KJ126"],"award-info":[{"award-number":["2022KJ126"]}]},{"name":"Project of Swine Innovation Team in Guangdong Modern Agricultural Research System","award":["2021YFD1300401-2"],"award-info":[{"award-number":["2021YFD1300401-2"]}]},{"name":"Project of Swine Innovation Team in Guangdong Modern Agricultural Research System","award":["2021A1515010440"],"award-info":[{"award-number":["2021A1515010440"]}]},{"name":"National Key Research and Development Program","award":["2022KJ126"],"award-info":[{"award-number":["2022KJ126"]}]},{"name":"National Key Research and Development Program","award":["2021YFD1300401-2"],"award-info":[{"award-number":["2021YFD1300401-2"]}]},{"name":"National Key Research and Development Program","award":["2021A1515010440"],"award-info":[{"award-number":["2021A1515010440"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2022KJ126"],"award-info":[{"award-number":["2022KJ126"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2021YFD1300401-2"],"award-info":[{"award-number":["2021YFD1300401-2"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2021A1515010440"],"award-info":[{"award-number":["2021A1515010440"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>This study evaluated the effects of maternal selenium-enriched yeast (SeY) supplementation during late gestation and lactation on sow performance, transfer of selenium (Se) and redox status, and gut microbiota community, as well as on the gut health of offspring. Seventy pregnant sows on day 85 of gestation were randomly allocated to the following two treatments: (1) sows who were fed a basal diet (basal diet contained 0.3 mg\/kg Se as Na2SeO3, n = 35); (2) and sows who were fed a SeY-supplemented diet (basal diet with 0.2 mg\/kg Se as SeY, n = 35). The offspring piglets were only cross-fostered within the group on day 3 of lactation (L3) according to the pig farm epidemic prevention policy. The plasma, milk, and feces samples from 10 sows, as well as plasma and intestinal samples per treatment, were collected on L1 and L21, respectively. Our results showed that maternal SeY supplementation increased the first week average weight and ADG of piglets (p &lt; 0.05). Compared with the CON group, the SeY supplementation increased the Se content in the plasma and milk of sows and the plasma of piglets on L1 and L21 (p &lt; 0.05). In addition, in sows, the levels of fat in the milk on L21, the level of IgA, T-AOC, and GSH-Px in the plasma on L21, and the level of T-AOC and GSH-Px in the colostrum were increased, while the MDA content was decreased in the plasma on L1 and in the colostrum and milk on L14 (p &lt; 0.05). In the piglet plasma, the levels of IgA on L1 and L21, GSH-Px on L1, and GSH on L21 were increased, while the MDA content was decreased on L1 (p &lt; 0.05). Maternal SeY supplementation up-regulated the small intestinal protein abundances of MUC1, E-cadherin, ZO-1, occludin, and claudin and activated the Nrf2\/Keap1 signaling pathway in weaned offspring piglets. The 16S rRNA sequencing results showed that fecal microbiota had distinct separations during lactation, and the relative abundances of unclassified_f_Lachnospiraceae, Prevotaceae_UCG-001, and Lachnospiraceae_NK4A136_group were increased on L1. Collectively, the current findings suggest that maternal SeY supplementation during late gestation and lactation could improve the piglet\u2019s growth performance, Se status, antioxidant capacity and immunoglobulins transfer at the first week of lactation, as well as alter the fecal microbiota composition by increasing antioxidative-related and SCFA-producing microbiota in sows. These changes contributed to enhancing the small intestinal barrier function and activating the Nrf2\/Keap1 pathway in offspring.<\/jats:p>","DOI":"10.3390\/antiox12122064","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T03:58:02Z","timestamp":1701403082000},"page":"2064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Maternal Selenium-Enriched Yeast Supplementation in Sows Enhances Offspring Growth and Antioxidant Status through the Nrf2\/Keap1 Pathway"],"prefix":"10.3390","volume":"12","author":[{"given":"Liang","family":"Xiong","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongbin","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhuai","family":"Yue","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-3354","authenticated-orcid":false,"given":"Shihai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"},{"name":"National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China"},{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wutai","family":"Guan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"},{"name":"National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China"},{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/jn\/134.9.2169","article-title":"Maternal nutrition and fetal development","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1017\/S1751731111000772","article-title":"Oxidative stress status of highly prolific sows during gestation and lactation","volume":"5","author":"Kim","year":"2011","journal-title":"Animal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3109\/10715762.2013.848277","article-title":"Birth oxidative stress and the development of an antioxidant system in newborn piglets","volume":"47","author":"Yin","year":"2013","journal-title":"Free Radic. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108520","DOI":"10.1016\/j.intimp.2022.108520","article-title":"Intestinal morphology and immune profiles are altered in piglets by early-weaning","volume":"105","author":"Cao","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"634283","DOI":"10.3389\/fphys.2021.634283","article-title":"D-Galactose induces chronic oxidative stress and alters gut microbiota in weaned piglets","volume":"12","author":"Han","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fvets.2019.00046","article-title":"Nutritional intervention for the intestinal development and health of weaned pigs","volume":"6","author":"Xiong","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.anifeedsci.2016.08.021","article-title":"Selenium and vitamin E in sow diets: II. Effect on selenium status and antioxidant status of the progeny","volume":"221","author":"Chen","year":"2016","journal-title":"Anim. Feed. Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cbpb.2008.08.009","article-title":"Selenoproteins and maternal nutrition","volume":"151","author":"Pappas","year":"2008","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9311","DOI":"10.1039\/D2FO00675H","article-title":"Maternal supplementation with Artemisia annua L. ameliorates intestinal inflammation via inhibiting the TLR4\/NF-\u03baB and MAPK pathways and improves the oxidative stability of offspring","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.aninu.2023.05.002","article-title":"Advances in selenium supplementation: From selenium-enriched yeast to potential selenium-enriched insects, and selenium nanoparticles","volume":"14","author":"Ferrari","year":"2023","journal-title":"Anim. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1011850","DOI":"10.3389\/fnut.2022.1011850","article-title":"Selenium supplementation and pregnancy outcomes","volume":"9","author":"Dahlen","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_12","first-page":"137","article-title":"Mammalian selenoproteins","volume":"6","author":"Zachara","year":"1992","journal-title":"J. Trace Elem. Electrolytes Health Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"skaa366","DOI":"10.1093\/jas\/skaa366","article-title":"Effect of maternal organic selenium supplementation during pregnancy on sow reproductive performance and long-term effect on their progeny","volume":"98","author":"Mou","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5490743","DOI":"10.1155\/2020\/5490743","article-title":"Selenium-enriched yeast alleviates oxidative stress-induced intestinal mucosa disruption in weaned pigs","volume":"2020","author":"Liu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2527\/2000.781100x","article-title":"Effect of organic and inorganic selenium sources and levels on sow colostrum and milk selenium content","volume":"78","author":"Mahan","year":"2000","journal-title":"J. Anim. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2527\/jas.2005-311","article-title":"Comparative effects of organic and inorganic selenium on selenium transfer from sows to nursing pigs","volume":"84","author":"Yoon","year":"2006","journal-title":"J. Anim. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2527\/2004.8251343x","article-title":"Long-term effects of dietary organic and inorganic selenium sources and levels on reproducing sows and their progeny","volume":"82","author":"Mahan","year":"2004","journal-title":"J. Anim. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anifeedsci.2016.08.022","article-title":"Selenium and vitamin E in sow diets: I. Effect on antioxidant status and reproductive performance in multiparous sows","volume":"221","author":"Chen","year":"2016","journal-title":"Anim. Feed. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.5713\/ab.22.0104","article-title":"Effects of selenium source and level on the physiological response, reproductive performance, serum Se level and milk composition in gestating sows","volume":"35","author":"Jin","year":"2022","journal-title":"Anim. Biosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.2527\/1996.74112711x","article-title":"Effect of inorganic or organic selenium at two dietary levels on reproductive performance and tissue selenium concentrations in first-parity gilts and their progeny","volume":"74","author":"Mahan","year":"1996","journal-title":"J. Anim. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jtemb.2018.11.010","article-title":"Increasing selenium supply for heat-stressed or actively cooled sows improves piglet preweaning survival, colostrum and milk composition, as well as maternal selenium, antioxidant status and immunoglobulin transfer","volume":"52","author":"Chen","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.anifeedsci.2015.11.006","article-title":"Selenium in sow nutrition","volume":"211","author":"Surai","year":"2016","journal-title":"Anim. Feed. Sci. Technol."},{"key":"ref_23","unstructured":"(2017). National Food Safety Standard Determination of Selenium in Food (Standard No. GB5009.93-2017)."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wang, H., Ji, Y., Yin, C., Deng, M., Tang, T., Deng, B., Ren, W., Deng, J., Yin, Y., and Tan, C. (2018). Differential analysis of gut microbiota correlated with oxidative stress in sows with high or low litter performance during lactation. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01665"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2527\/2005.834852x","article-title":"Comparison of dietary selenium fed to grower-finisher pigs from various regions of the United States on resulting tissue Se and loin mineral concentrations","volume":"83","author":"Mahan","year":"2005","journal-title":"J. Anim. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1096\/fj.13-231852","article-title":"Maternal-fetal transfer of selenium in the mouse","volume":"27","author":"Burk","year":"2013","journal-title":"FASEB J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2527\/jas1977.454738x","article-title":"Efficacy of inorganic selenium supplementation to sow diets on resulting carry-over to their progeny","volume":"45","author":"Mahan","year":"1977","journal-title":"J. Anim. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bortolozzo, F.P., Zanin, G.P., Ulguim, R.D.R., and Mellagi, A.P.G. (2023). Managing reproduction in hyperprolific sow herds. Animals, 13.","DOI":"10.3390\/ani13111842"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yang, X., Hu, R., Shi, M., Wang, L., Yan, J., Gong, J., Zhang, Q., He, J., and Wu, S. (2023). Placental malfunction, fetal survival and development caused by sow metabolic disorder: The impact of maternal oxidative stress. Antioxidants, 12.","DOI":"10.3390\/antiox12020360"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.2527\/jas.2014-7590","article-title":"Effect of inorganic or organic selenium supplementation on reproductive performance and tissue trace mineral concentrations in gravid first-parity gilts, fetuses, and nursing piglets","volume":"92","author":"Ma","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.aninu.2020.01.004","article-title":"Combined yeast culture and organic selenium supplementation during late gestation and lactation improve preweaning piglet performance by enhancing the antioxidant capacity and milk content in nutrient-restricted sows","volume":"6","author":"Zhang","year":"2020","journal-title":"Anim. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1039\/D0FO02274H","article-title":"Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-\u03baB and ERK\/Beclin-1 pathways","volume":"12","author":"Mou","year":"2021","journal-title":"Food Funct."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Avery, J.C., and Hoffmann, P.R. (2018). Selenium, selenoproteins, and immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gelderman, A., and Clapper, J. (2013). Effects of inorganic or organic selenium on immunoglobulins in swine. J. Anim. Sci. Biotechnol., 4.","DOI":"10.1186\/2049-1891-4-47"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, Z., Dong, Y., Chen, S., Jia, X., Jiang, X., Che, L., Lin, Y., Li, J., Feng, B., and Fang, Z. (2021). Organic selenium increased gilts antioxidant capacity, immune function, and changed intestinal microbiota. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.723190"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.2527\/jas1989.6751299x","article-title":"Porcine immunoglobulin transfer after prepartum treatment with selenium or vitamin E","volume":"67","author":"Hayek","year":"1989","journal-title":"J. Anim. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.3168\/jds.2007-0348","article-title":"Selenium addition to colostrum increases immunoglobulin G absorption by newborn calves","volume":"90","author":"Kamada","year":"2007","journal-title":"J. Dairy Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2018.05.066","article-title":"Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease","volume":"127","author":"Short","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e13357","DOI":"10.1111\/asj.13357","article-title":"Regulation of the intestinal barrier by nutrients: The role of tight junctions","volume":"91","author":"Suzuki","year":"2020","journal-title":"Anim. Sci. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.emboj.7600605","article-title":"E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions","volume":"24","author":"Tunggal","year":"2005","journal-title":"EMBO J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1039\/C5TX00214A","article-title":"Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK\/STAT and Nrf2 pathways","volume":"5","author":"Nunes","year":"2016","journal-title":"Toxicol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-018-07859-7","article-title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","volume":"10","author":"Singh","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2174\/1568009617666171002144228","article-title":"Oxidative stress and cancer: The role of Nrf2","volume":"18","author":"Sajadimajd","year":"2018","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/gutjnl-2012-303731","article-title":"Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium","volume":"63","author":"Chen","year":"2014","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"105243","DOI":"10.1016\/j.phrs.2020.105243","article-title":"The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases","volume":"163","author":"Piotrowska","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, P., Li, K., Zou, C., Tong, C., Sun, L., Cao, Z., Yang, S., and Lyu, Q. (2020). Selenium Yeast Alleviates Ochratoxin A-induced hepatotoxicity via modulation of the PI3K\/AKT and Nrf2\/Keap1 signaling pathways in chickens. Toxins, 12.","DOI":"10.1155\/2020\/4048706"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sun, H., Zhang, M., Li, J., and Shan, A. (2021). DL-selenomethionine alleviates oxidative stress induced by zearalenone via Nrf2\/Keap1 signaling pathway in IPEC-J2 cells. Toxins, 13.","DOI":"10.3390\/toxins13080557"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Beam, A., Clinger, E., and Hao, L. (2021). Effect of diet and dietary components on the composition of the gut microbiota. Nutrients, 13.","DOI":"10.3390\/nu13082795"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1111\/1462-2920.13006","article-title":"Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults","volume":"17","author":"Tap","year":"2015","journal-title":"Environ. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2018.02.044","article-title":"The human gut microbiome: From association to modulation","volume":"172","author":"Schmidt","year":"2018","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jgh.14536","article-title":"Beneficial effect of butyrate-producing Lachnospiraceae on stress-induced visceral hypersensitivity in rats","volume":"34","author":"Zhang","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"121312","DOI":"10.1016\/j.lfs.2022.121312","article-title":"Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota","volume":"314","author":"Wu","year":"2023","journal-title":"Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1039\/D1FO03396D","article-title":"Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model by modulating the gut microbiota","volume":"13","author":"Sheng","year":"2022","journal-title":"Food Funct."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrmicro1817","article-title":"Polysaccharide utilization by gut bacteria: Potential for new insights from genomic analysis","volume":"6","author":"Flint","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/cphy.c170050","article-title":"Role of short chain fatty acid receptors in intestinal physiology and pathophysiology","volume":"8","author":"Priyadarshini","year":"2018","journal-title":"Compr. Physiol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/12\/2064\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:35:45Z","timestamp":1760132145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/12\/12\/2064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["antiox12122064"],"URL":"https:\/\/doi.org\/10.3390\/antiox12122064","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]}}}