{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:08:46Z","timestamp":1767895726018,"version":"3.49.0"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council (NSTC)","award":["MOST 111-2320-B-034-001"],"award-info":[{"award-number":["MOST 111-2320-B-034-001"]}]},{"name":"National Science and Technology Council (NSTC)","award":["108-AS-14.2.3-AD-a3"],"award-info":[{"award-number":["108-AS-14.2.3-AD-a3"]}]},{"name":"National Science and Technology Council (NSTC)","award":["109-AS-12.2.3-AD-a3"],"award-info":[{"award-number":["109-AS-12.2.3-AD-a3"]}]},{"name":"National Science and Technology Council (NSTC)","award":["CMRPG2L0112"],"award-info":[{"award-number":["CMRPG2L0112"]}]},{"name":"Ministry of Agriculture","award":["MOST 111-2320-B-034-001"],"award-info":[{"award-number":["MOST 111-2320-B-034-001"]}]},{"name":"Ministry of Agriculture","award":["108-AS-14.2.3-AD-a3"],"award-info":[{"award-number":["108-AS-14.2.3-AD-a3"]}]},{"name":"Ministry of Agriculture","award":["109-AS-12.2.3-AD-a3"],"award-info":[{"award-number":["109-AS-12.2.3-AD-a3"]}]},{"name":"Ministry of Agriculture","award":["CMRPG2L0112"],"award-info":[{"award-number":["CMRPG2L0112"]}]},{"name":"Chang Gung Memorial Hospital","award":["MOST 111-2320-B-034-001"],"award-info":[{"award-number":["MOST 111-2320-B-034-001"]}]},{"name":"Chang Gung Memorial Hospital","award":["108-AS-14.2.3-AD-a3"],"award-info":[{"award-number":["108-AS-14.2.3-AD-a3"]}]},{"name":"Chang Gung Memorial Hospital","award":["109-AS-12.2.3-AD-a3"],"award-info":[{"award-number":["109-AS-12.2.3-AD-a3"]}]},{"name":"Chang Gung Memorial Hospital","award":["CMRPG2L0112"],"award-info":[{"award-number":["CMRPG2L0112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Osteoarthritis (OA) is a progressive disease that causes pain, stiffness, and inflammation in the affected joints. Currently, there are no effective treatments for preventing the worst outcomes, such as synovitis or cartilage degradation. Sarcodia montagneana and Corbicula fluminea are common species found in the ocean or in freshwater areas. Their extracts are demonstrated to possess both antioxidative and anti-inflammatory functions. This study aimed to investigate the synergistic effects of the extracts of Sarcodia montagneana (SME) and Corbicula fluminea (FCE) on reducing local and systemic inflammation, as well as their efficacy in OA symptom relief. An in vitro monocytic LPS-treated THP-1 cell model and in vivo MIA-induced mouse OA model were applied, and the results showed that the combinatory usage of SME and FCE effectively suppressed IFN-\u03b3 and TNF-\u03b1 production when THP-1 cells were treated with LPS. SME and FCE also significantly decreased the systemic TNF-\u03b1 level and joint swelling and prevented the loss of proteoglycan in the cartilage within the joints of OA mice. The data shown here provide a potential solution for the treatment of osteoarthritis.<\/jats:p>","DOI":"10.3390\/antiox12122068","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T08:36:59Z","timestamp":1701419819000},"page":"2068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Synergistic Effects of Corbicula fluminea and Sarcodia montagneana on Alleviating Systemic Inflammation and Osteoarthritis Progression"],"prefix":"10.3390","volume":"12","author":[{"given":"Tse-Hung","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan"},{"name":"School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 33303, Taiwan"},{"name":"Research Center for Food and Cosmetic Safety, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan"},{"name":"Department of Chemical Engineering and Graduate Institute of Biochemical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang-Hung","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1147-6359","authenticated-orcid":false,"given":"Chia-Hui","family":"Hsu","sequence":"additional","affiliation":[{"name":"Center for Animal Health and Food Safety, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Jer","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang-Wen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2254-8344","authenticated-orcid":false,"given":"Chen-Si","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Lin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Life Science, Chinese Culture University, Taipei 11114, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/BOR.0b013e32835a9428","article-title":"Aging processes and the development of osteoarthritis","volume":"25","author":"Loeser","year":"2013","journal-title":"Curr. 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