{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:50:02Z","timestamp":1791460202414,"version":"4.3.4"},"reference-count":136,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Al Jalila Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Air pollution, either from indoor (household) or outdoor (ambient) sources, occurs when there is presence of respirable particles in the form of chemical, physical, or biological agents that modify the natural features of the atmosphere or environment. Today, almost 2.4 billion people are exposed to hazardous levels of indoor pollution, while 99% of the global population breathes air pollutants that exceed the World Health Organization guideline limits. It is not surprising that air pollution is the world\u2019s leading environmental cause of diseases and contributes greatly to the global burden of diseases. Upon entry, air pollutants can cause an increase in reactive oxygen species (ROS) production by undergoing oxidation to generate quinones, which further act as oxidizing agents to yield more ROS. Excessive production of ROS can cause oxidative stress, induce lipid peroxidation, enhance the binding of polycyclic aromatic hydrocarbons (PAHs) to their receptors, or bind to PAH to cause DNA strand breaks. The continuous and prolonged exposure to air pollutants is associated with the development or exacerbation of pathologies such as acute or chronic respiratory and cardiovascular diseases, neurodegenerative and skin diseases, and even reduced fertility potential. Males and females contribute to infertility equally, and exposure to air pollutants can negatively affect reproduction. In this review, emphasis will be placed on the implications of exposure to air pollutants on male fertility potential, bringing to light its effects on semen parameters (basic and advanced) and male sexual health. This study will also touch on the clinical implications of air pollution on male reproduction while highlighting the role of oxidative stress.<\/jats:p>","DOI":"10.3390\/antiox13010064","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T13:02:58Z","timestamp":1704114178000},"page":"64","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7661-7718","authenticated-orcid":false,"given":"Temidayo S.","family":"Omolaoye","sequence":"first","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongekile T.","family":"Skosana","sequence":"additional","affiliation":[{"name":"Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Marie","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashthi","family":"Ramsunder","sequence":"additional","affiliation":[{"name":"Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir M.","family":"Ayad","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Misurata University, Misratah P.O. Box 2478, Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-4367","authenticated-orcid":false,"given":"Stefan S.","family":"Du Plessis","sequence":"additional","affiliation":[{"name":"College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates"},{"name":"Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7602, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","article-title":"Evidence for decreasing quality of semen during past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"Br. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1289\/ehp.00108961","article-title":"The question of declining sperm density revisited: An analysis of 101 studies published 1934\u20131996","volume":"108","author":"Swan","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/humupd\/dmx022","article-title":"Temporal trends in sperm count: A systematic review and meta-regression analysis","volume":"23","author":"Levine","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1210\/jc.2015-2873","article-title":"Female reproductive disorders, diseases, and costs of exposure to endocrine disrupting chemicals in the European Union","volume":"101","author":"Hunt","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility","volume":"96","author":"Skakkebaek","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/aje\/kwp168","article-title":"Good semen quality and life expectancy: A cohort study of 43,277 men","volume":"170","author":"Jensen","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.fertnstert.2008.12.018","article-title":"Semen quality in fertile men in relation to psychosocial stress","volume":"93","author":"Gollenberg","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.eururo.2016.04.010","article-title":"Cigarette Smoking and Semen Quality: A New Meta-analysis Examining the Effect of the 2010 World Health Organization Laboratory Methods for the Examination of Human Semen","volume":"70","author":"Sharma","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humupd\/dms050","article-title":"BMI in relation to sperm count: An updated systematic review and collaborative meta-analysis","volume":"19","author":"Sermondade","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aju.2017.12.004","article-title":"Lifestyle causes of male infertility","volume":"16","author":"Durairajanayagam","year":"2018","journal-title":"Arab. J. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/humrep\/dev219","article-title":"Associations between urinary phthalate concentrations and semen quality parameters in a general population","volume":"30","author":"Bloom","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: The Endocrine Society\u2019s Second Scientific Statement on Endocrine-Disrupting Chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3945\/jn.115.226563","article-title":"Intake of Fruits and Vegetables with Low-to-Moderate Pesticide Residues Is Positively Associated with Semen-Quality Parameters among Young Healthy Men","volume":"146","author":"Chiu","year":"2016","journal-title":"J. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, M.H., Zhang, A.D., Shi, Z.D., Wang, L.G., and Qiu, Y. (2015). Changes in levels of seminal nitric oxide synthase, macrophage migration inhibitory factor, sperm DNA integrity and caspase-3 in fertile men after scrotal heat stress. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141320"},{"key":"ref_15","first-page":"26930","article-title":"Air Pollution and Quality of Sperm: A Meta-Analysis","volume":"17","author":"Najafi","year":"2015","journal-title":"Iran. Red. Crescent Med. J."},{"key":"ref_16","unstructured":"(2023, July 11). World Health Organization Air Pollution. Available online: https:\/\/www.who.int\/health-topics\/air-pollution#tab=tab_1."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Soppelsa, M.E., Lozano-Gracia, N., and Xu, L.C. (2019). The Effects of Pollution and Business Environment on Firm Productivity in Africa, World Bank.","DOI":"10.1596\/1813-9450-8834"},{"key":"ref_18","unstructured":"World Bank Group, T. (2022). The Global Health Cost of PM2.5 Air Pollution: A Case for Action Beyond 2021, World Bank."},{"key":"ref_19","unstructured":"WHO (2021). Human Health Effects of Polycyclic Aromatic Hydrocarbons as Ambient Air Pollutants, WHO."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/10937400701873472","article-title":"Human exposure to endocrine disrupters and semen quality","volume":"11","author":"Phillips","year":"2008","journal-title":"J. Toxicol. Environ. Heal. Part. B Crit. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41586-021-04190-y","article-title":"Air pollution exposure disparities across US population and income groups","volume":"601","author":"Jbaily","year":"2022","journal-title":"Nature"},{"key":"ref_22","unstructured":"WHO (2010). WHO Guidelines for Indoor Air Quality: Selected Pollutants, WHO. Chapter 5. Nitrogen Dioxide."},{"key":"ref_23","first-page":"160","article-title":"Update of the WHO global air quality guidelines: Systematic reviews-An introduction","volume":"170","author":"Jarosi","year":"2022","journal-title":"Environ. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"106435","DOI":"10.1016\/j.envint.2021.106435","article-title":"Short-term exposure to ozone, nitrogen dioxide, and sulphur dioxide and emergency department visits and hospital admissions due to asthma: A systematic review and meta-analysis","volume":"150","author":"Zheng","year":"2021","journal-title":"Environ. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105876","DOI":"10.1016\/j.envint.2020.105876","article-title":"Short-term exposure to particulate matter (PM 10 and PM 2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis","volume":"142","author":"Orellano","year":"2020","journal-title":"Environ. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105998","DOI":"10.1016\/j.envint.2020.105998","article-title":"Long-term exposure to NO2 and O3 and all-cause and respiratory mortality: A systematic review and meta-analysis","volume":"144","author":"Huangfu","year":"2020","journal-title":"Environ. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"105901","DOI":"10.1016\/j.envint.2020.105901","article-title":"Short-term exposure to carbon monoxide and myocardial infarction: A systematic review and meta-analysis","volume":"143","author":"Lee","year":"2020","journal-title":"Environ. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"106434","DOI":"10.1016\/j.envint.2021.106434","article-title":"NC-ND license Short-term exposure to sulphur dioxide (SO2) and all-cause and respiratory mortality: A systematic review and meta-analysis","volume":"150","author":"Orellano","year":"2021","journal-title":"Environ. Int."},{"key":"ref_29","first-page":"109","article-title":"Air Pollution: From sources of emissions to health effects","volume":"1","year":"2004","journal-title":"Breathe"},{"key":"ref_30","unstructured":"IARC (2015). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Outdoor Air Pollution, IARC."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1440-1843.2012.02213.x","article-title":"Air pollution: Impact and prevention","volume":"17","author":"Teran","year":"2012","journal-title":"Respirology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.envint.2014.10.005","article-title":"A review on the human health impact of airborne particulate matter","volume":"74","author":"Kim","year":"2015","journal-title":"Environ. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"882569","DOI":"10.3389\/fpubh.2022.882569","article-title":"The Physiological Effects of Air Pollution: Particulate Matter, Physiology and Disease","volume":"10","author":"Pryor","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MAJ.0b013e31803b900f","article-title":"Outdoor air pollution: Nitrogen dioxide, sulfur dioxide, and carbon monoxide health effects","volume":"333","author":"Chen","year":"2007","journal-title":"Am. J. Med. Sci."},{"key":"ref_35","first-page":"1","article-title":"Fast sulfate formation from oxidation of SO2 by NO2 and HONO observed in Beijing haze","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/JOM.0000000000001277","article-title":"Airborne Particulate Matter: Human Exposure and Health Effects","volume":"60","author":"Thompson","year":"2018","journal-title":"J. Occup. Environ. Med."},{"key":"ref_37","unstructured":"WHO (2021). WHO Laboratory Manual for the Examination and Processing of Human Semen, WHO. [6th ed.]."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1177\/1557988317752608","article-title":"Air Pollution and Human Sperm Sex Ratio","volume":"12","author":"Radwan","year":"2018","journal-title":"Am. J. Mens. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2016.07.018","article-title":"Human semen as an early, sensitive biomarker of highly polluted living environment in healthy men: A pilot biomonitoring study on trace elements in blood and semen and their relationship with sperm quality and RedOx status","volume":"66","author":"Bergamo","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/UROS.UROS_6_19","article-title":"The impact of the fine ambient particle on infertile male\u2019s sperm quality","volume":"30","author":"Chen","year":"2019","journal-title":"Urol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1289\/ehp.0901022","article-title":"The effect of ambient air pollution on sperm quality","volume":"118","author":"Hansen","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1007\/s11356-020-11589-z","article-title":"Pollutants and sperm quality: A systematic review and meta-analysis","volume":"28","author":"Pizzol","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"107919","DOI":"10.1016\/j.envint.2023.107919","article-title":"Association between ambient PM1 and semen quality: A cross-sectional study of 27,854 men in China","volume":"175","author":"Zhang","year":"2023","journal-title":"Environ. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-021-00585-w","article-title":"Impact of environmental factors on human semen quality and male fertility: A narrative review","volume":"34","author":"Kumar","year":"2022","journal-title":"Environ. Sci. Eur."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jurewicz, J., Dziewirska, E., Radwan, M., and Hanke, W. (2018). Air pollution from natural and anthropic sources and male fertility. Reprod. Biol. Endocrinol., 16.","DOI":"10.1186\/s12958-018-0430-2"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"113835","DOI":"10.1016\/j.ijheh.2021.113835","article-title":"Semen quality and sperm DNA integrity in city policemen exposed to polluted air in an urban industrial agglomeration","volume":"237","author":"Rubes","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1093\/humrep\/dei122","article-title":"Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality","volume":"20","author":"Rubes","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Vecoli, C., Montano, L., Borghini, A., Notari, T., Guglielmino, A., Mercuri, A., Turchi, S., and Andreassi, M.G. (2017). Effects of highly polluted environment on sperm telomere length: A pilot study. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081703"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.envint.2019.04.064","article-title":"Effects of maternal exposure to ambient air pollution on newborn telomere length","volume":"128","author":"Song","year":"2019","journal-title":"Environ. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s40618-019-01152-0","article-title":"Perfluoro-octanoic acid impairs sperm motility through the alteration of plasma membrane","volume":"43","author":"Cosci","year":"2020","journal-title":"J. Endocrinol. Invest."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/mutage\/geq024","article-title":"In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay","volume":"25","author":"Sipinen","year":"2010","journal-title":"Mutagenesis"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2016.12.004","article-title":"Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity","volume":"266","author":"Yan","year":"2017","journal-title":"Toxicol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/toxsci\/kfx261","article-title":"Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis","volume":"162","author":"Qiu","year":"2018","journal-title":"Toxicol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.toxlet.2015.06.015","article-title":"Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)\/protein kinase B (Akt) signaling pathway","volume":"237","author":"Cao","year":"2015","journal-title":"Toxicol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/tox.22556","article-title":"Fine particle matter disrupts the blood\u2013testis barrier by activating TGF-\u03b23\/p38 MAPK pathway and decreasing testosterone secretion in rat","volume":"33","author":"Liu","year":"2018","journal-title":"Environ. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110881","DOI":"10.1016\/j.ecoenv.2020.110881","article-title":"Chronic exposure to diesel exhaust particulate matter impairs meiotic progression during spermatogenesis in a mouse model","volume":"202","author":"Yang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ecoenv.2018.10.108","article-title":"PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183\/96\/182 cluster targeting FOXO1 in mouse","volume":"169","author":"Zhou","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/15376516.2017.1410743","article-title":"Urban fine particulate matter (PM2.5) exposure destroys blood\u2013testis barrier (BTB) integrity through excessive ROS-mediated autophagy","volume":"28","author":"Wei","year":"2017","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.etap.2016.09.001","article-title":"Sulfur dioxide inhalation lowers sperm quality and alters testicular histology via increasing expression of CREM and ACT proteins in rat testes","volume":"47","author":"Zhang","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1289\/ehp.99107539","article-title":"Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats","volume":"107","author":"Watanabe","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"114042","DOI":"10.1016\/j.ecoenv.2022.114042","article-title":"PM2.5 exposure at different concentrations and modes induces reproductive toxicity in male rats mediated by oxidative and endoplasmic reticulum stress","volume":"244","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.chemosphere.2017.09.082","article-title":"The reproductive toxicology of male SD rats after PM2.5 exposure mediated by the stimulation of endoplasmic reticulum stress","volume":"189","author":"Liu","year":"2017","journal-title":"Chemosphere"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.envres.2004.04.008","article-title":"Oxidation damage of sulfur dioxide on testicles of mice","volume":"96","author":"Meng","year":"2004","journal-title":"Environ. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ecoenv.2018.08.109","article-title":"Sulphur dioxide and arsenic affect male reproduction via interfering with spermatogenesis in mice","volume":"165","author":"Li","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fct.2016.05.017","article-title":"Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice","volume":"94","author":"Zhang","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0892-0362(98)00003-8","article-title":"Prenatal sulfur dioxide exposure induces changes in the behavior of adult male mice during agonistic encounters","volume":"20","author":"Fiore","year":"1998","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"113760","DOI":"10.1016\/j.ecoenv.2022.113760","article-title":"Maternal exposure to PM2.5 disrupting offspring spermatogenesis through induced sertoli cells apoptosis via inhibin B hypermethylation in mice","volume":"241","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"155252","DOI":"10.1016\/j.scitotenv.2022.155252","article-title":"Inverse association between ambient particulate matter and semen quality in Central China: Evidence from a prospective cohort study of 15,112 participants","volume":"833","author":"Ma","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"114731","DOI":"10.1016\/j.envres.2022.114731","article-title":"Linear and non-linear relationships between sulfur dioxide and semen quality: A longitudinal study in Anhui, China","volume":"216","author":"Ma","year":"2023","journal-title":"Environ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"109756","DOI":"10.1016\/j.envres.2020.109756","article-title":"Sperm quality and ambient air pollution exposure: A retrospective, cohort study in a Southern province of China","volume":"188","author":"Huang","year":"2020","journal-title":"Environ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.envpol.2013.12.030","article-title":"Air pollution and decreased semen quality: A comparative study of Chongqing urban and rural areas","volume":"187","author":"Zhou","year":"2014","journal-title":"Environ. Pollut."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.fertnstert.2008.12.089","article-title":"Decreased sperm motility is associated with air pollution in Salt Lake City","volume":"93","author":"Hammoud","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/GCO.0000000000000868","article-title":"The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction","volume":"35","author":"Seli","year":"2023","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1515\/reveh-2020-0136","article-title":"Air pollutants and impairments of male reproductive health-an overview","volume":"36","author":"Kumar","year":"2021","journal-title":"Rev. Environ. Health"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/nyas.14624","article-title":"Maternal exposure to sulfur dioxide before and after conception and the risk of hypospadias in offspring","volume":"1502","author":"Zhang","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"109528","DOI":"10.1016\/j.envres.2020.109528","article-title":"Ambient air pollution and male fecundity: A retrospective analysis of longitudinal data from a Chinese human sperm bank (2013\u20132018)","volume":"186","author":"Qiu","year":"2020","journal-title":"Environ. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"163532","DOI":"10.1016\/j.scitotenv.2023.163532","article-title":"Semen damage contributed over 50% to air-pollutant-induced infertility: A prospective cohort study of 3940 men in China","volume":"885","author":"Guo","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/03014460.2015.1013986","article-title":"Exposure to ambient air pollution-does it affect semen quality and the level of reproductive hormones?","volume":"43","author":"Radwan","year":"2015","journal-title":"Ann. Hum. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.envres.2016.05.053","article-title":"Sperm quality and environment: A retrospective, cohort study in a Northern province of Italy","volume":"150","author":"Santi","year":"2016","journal-title":"Environ. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"12806","DOI":"10.1021\/acs.est.7b03289","article-title":"Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China","volume":"51","author":"Liu","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"113117","DOI":"10.1016\/j.envres.2022.113117","article-title":"Association between ambient air pollution and blood sex hormones levels in men","volume":"211","author":"Zheng","year":"2022","journal-title":"Environ. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1289\/ehp.00108647","article-title":"Fecundability and parental exposure to ambient sulfur dioxide","volume":"108","author":"Dejmek","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Chen, Y.A., Chang, Y.K., Su, Y.R., and Chang, H.C. (2020). Ambient sulfur dioxide could have an impact on testicular volume from a observational study on a population of infertile male. BMC Urol., 20.","DOI":"10.1186\/s12894-020-00710-6"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"161472","DOI":"10.1016\/j.scitotenv.2023.161472","article-title":"Sulfur dioxide may predominate in the adverse effects of ambient air pollutants on semen quality among the general population in Hefei, China","volume":"867","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"109894","DOI":"10.1016\/j.envres.2020.109894","article-title":"Identifying critical exposure windows for ambient air pollution and semen quality in Chinese men","volume":"189","author":"Sun","year":"2020","journal-title":"Environ. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1289\/ehp.8232","article-title":"Exposure to environmental ozone alters semen quality","volume":"114","author":"Sokol","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/andr.12655","article-title":"Gaseous pollutant exposure affects semen quality in central China: A cross-sectional study","volume":"8","author":"Wang","year":"2020","journal-title":"Andrology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s43043-021-00086-z","article-title":"Cementing the relationship between conventional and advanced semen parameters","volume":"26","author":"Ayad","year":"2021","journal-title":"Middle East. Fertil. Soc. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/em.22381","article-title":"DNA-Protein Crosslinks from Environmental Exposure: Mechanisms of Formation and Repair","volume":"61","author":"Kojima","year":"2020","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2012.05.009","article-title":"Self-formation of optic cups and storable stratified neural retina from human ESCs","volume":"10","author":"Nakano","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.etap.2018.02.001","article-title":"Sperm DNA fragmentation: An early and reliable marker of air pollution","volume":"58","author":"Bosco","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"822257","DOI":"10.3389\/frph.2022.822257","article-title":"Oxidative Stress and Male Infertility: Evidence From a Research Perspective","volume":"4","author":"Ayad","year":"2022","journal-title":"Front. Reprod. Health"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1289\/ehp.00108887","article-title":"Semen quality and reproductive health of young Czech men exposed to seasonal air pollution","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/em.21883","article-title":"The relationship between exposure to air pollution and sperm disomy","volume":"56","author":"Jurewicz","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_95","first-page":"249","article-title":"Chromosomal anomalies in human gametes and pre-implantation embryos, and their potential effect on reproduction","volume":"33","author":"Szczygiet","year":"2001","journal-title":"Andrologia"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-2280(1997)30:2<175::AID-EM10>3.0.CO;2-A","article-title":"Use of fluorescence in situ hybridization (FISH] to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men","volume":"30","author":"Robbins","year":"1997","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_97","unstructured":"Baumgartner, D.J. (2014). Water Pollution\u2014Water Pollution Offences. Valuat. Soc. Cost., 30\u201343."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/jat.1321","article-title":"Organophosphorus pesticide exposure decreases sperm quality: Association between sperm parameters and urinary pesticide levels","volume":"28","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrg3142","article-title":"Epigenetics and the environment: Emerging patterns and implications","volume":"13","author":"Feil","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Bind, M.A., Coull, B., Suh, H., Wright, R., Baccarelli, A., Vokonas, P., and Schwartz, J. (2014). A novel genetic score approach using instruments to investigate interactions between pathways and environment: Application to air pollution. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096000"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2217\/epi.09.45","article-title":"Effects of arsenic exposure on DNA methylation and epigenetic gene regulation","volume":"2","author":"Reichard","year":"2010","journal-title":"Epigenomics"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Manikkam, M., Guerrero-Bosagna, C., Tracey, R., Haque, M.M., and Skinner, M.K. (2012). Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031901"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/em.22085","article-title":"Mutagenicity and oxidative damage induced by an organic extract of the particulate emissions from a simulation of the deepwater horizon surface oil burns","volume":"58","author":"DeMarini","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.aab3389","article-title":"Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection","volume":"350","author":"Blackburn","year":"2015","journal-title":"Science"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s41467-019-10301-1","article-title":"Uncovering the structure of self-regulation through data-driven ontology discovery","volume":"10","author":"Eisenberg","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_109","first-page":"387","article-title":"Air pollution and semen parameters in men seeking fertility treatment for the first time","volume":"32","author":"Wdowiak","year":"2019","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/humrep\/dep381","article-title":"Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction","volume":"25","author":"Li","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsxm.2018.12.013","article-title":"Elucidating Mechanisms of Long-Term Gasoline Vehicle Exhaust Exposure-Induced Erectile Dysfunction in a Rat Model","volume":"16","author":"Zhao","year":"2019","journal-title":"J. Sex. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_113","unstructured":"Sooriyamoorthy, T., and Leslie, S.W. (2023). Erectile Dysfunction, StatPearls Publishing."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12940-017-0216-6","article-title":"Erectile dysfunction and exposure to ambient Air pollution in a nationally representative cohort of older Men","volume":"16","author":"Tallon","year":"2017","journal-title":"Environ. Health"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"265.e9","DOI":"10.1016\/j.urology.2016.08.034","article-title":"Effects of Fine Particulate Matter on Erectile Function and Its Potential Mechanism in Rats","volume":"102","author":"Wang","year":"2017","journal-title":"Urology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e01419","DOI":"10.1016\/j.heliyon.2019.e01419","article-title":"Atmospheric levels of BPA associated with particulate matter in an urban environment","volume":"5","author":"Graziani","year":"2019","journal-title":"Heliyon"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/jamapsychiatry.2022.4812","article-title":"Long-term Exposure to Multiple Ambient Air Pollutants and Association with Incident Depression and Anxiety","volume":"80","author":"Yang","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"106377","DOI":"10.1016\/j.envint.2021.106377","article-title":"Association between ambient air pollution and pregnancy outcomes in patients undergoing in vitro fertilization in Shanghai, China: A retrospective cohort study","volume":"148","author":"Shi","year":"2021","journal-title":"Environ. Int."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"115015","DOI":"10.1016\/j.ecoenv.2023.115015","article-title":"Interaction of air pollution and meteorological factors on IVF outcomes: A multicenter study in China","volume":"259","author":"Wu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12958-021-00838-6","article-title":"The effect of short term exposure to outdoor air pollution on fertility","volume":"19","author":"Jacquemin","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_121","first-page":"82","article-title":"Does air pollution play a role in infertility?: A systematic review","volume":"16","author":"Gatimel","year":"2017","journal-title":"Environ. Health A Glob. Access Sci. Source"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"021005","DOI":"10.1088\/2752-5309\/accd10","article-title":"Association between traffic-related air pollution exposure and fertility-assisted births","volume":"1","author":"Thampy","year":"2023","journal-title":"Environ. Res. Health ERH"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/humrep\/dez128","article-title":"Ambient air pollution and in vitro fertilization treatment outcomes","volume":"34","author":"Boulet","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/humrep\/dey076","article-title":"Association between ambient air pollution and pregnancy rate in women who underwent IVF","volume":"33","author":"Choe","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"128436","DOI":"10.1016\/j.chemosphere.2020.128436","article-title":"Effects of PM2.5 exposure on reproductive system and its mechanisms","volume":"264","author":"Wang","year":"2021","journal-title":"Chemosphere"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.freeradbiomed.2020.04.031","article-title":"Oxidative stress in air pollution research","volume":"151","author":"Mudway","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.freeradbiomed.2010.05.011","article-title":"Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles","volume":"49","author":"Weissenberg","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_128","unstructured":"Leisegang, K. (2019). Oxidants, Antioxidants, Impact Oxidative Status Male Reproduction, Academic Press."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.urology.2007.11.041","article-title":"Age-Related Increase of Reactive Oxygen Species in Neat Semen in Healthy Fertile Men","volume":"71","author":"Cocuzza","year":"2008","journal-title":"Urology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10815-015-0454-x","article-title":"Reactive Oxygen Species (ROS) in human semen: Determination of a reference range","volume":"32","author":"Homa","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10815-014-0425-7","article-title":"Contemporary evidence on the physiological role of reactive oxygen species in human sperm function","volume":"32","author":"Agarwal","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Mannucci, A., Argento, F.R., Fini, E., Coccia, M.E., Taddei, N., Becatti, M., and Fiorillo, C. (2022). The Impact of Oxidative Stress in Male Infertility. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.799294"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.aju.2017.11.001","article-title":"Role of reactive oxygen species in male infertility: An updated review of literature","volume":"16","author":"Wagner","year":"2018","journal-title":"Arab. J. Urol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ecoenv.2018.09.118","article-title":"Spermatogenesis dysfunction induced by PM2.5 from automobile exhaust via the ROS-mediated MAPK signaling pathway","volume":"167","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1021\/es500937x","article-title":"Global perspective on the oxidative potential of airborne particulate matter: A synthesis of research findings","volume":"48","author":"Saffari","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijwd.2020.11.001","article-title":"Air pollution and skin disorders","volume":"7","author":"Roberts","year":"2021","journal-title":"Int. J. 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