{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:02:30Z","timestamp":1773964950015,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and ICT of Korea","award":["NRF-2022R1A2C1013106"],"award-info":[{"award-number":["NRF-2022R1A2C1013106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The oxidative balance score (OBS) is a novel composite of pro- and anti-oxidative markers for assessing the risk of cardiometabolic diseases and non-alcoholic fatty liver disease (NAFLD). However, it has not yet been established whether the OBS is related to type 2 diabetes mellitus (T2DM), especially in a population without NALFD. Therefore, we aimed to investigate the longitudinal effect of the OBS on T2DM in a large cohort of Korean adults without NALFD. Data were assessed from 9798 participants without NALFD from the Korean Genome and Epidemiology Study-Health Examinees (KoGES-HEXA) cohort. The participants were divided into three groups according to OBS tertiles, identified as T1\u2013T3. We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for new-onset T2DM using multivariable Cox proportional hazard regression models over 6 years following the baseline survey. During the mean 3.5 years of follow-up, 145 individuals (1.48%; 56 men and 89 women) developed T2DM. The HRs of T2DM for the OBS tertiles were 0.79 (95% CI, 0.53\u20131.18) and 0.60 (95% CI, 0.39\u20130.93) in the T2 and T3 groups after adjusting for metabolic parameters in subjects without NALFD, respectively; however, the T2 group did not show statistical significance toward a decrease in incident T2DM. A low OBS may be a useful predictive marker in new-onset T2DM for middle-aged and older subjects without NALFD. This implies that the OBS could be an additional valuable tool for assessing the incidence of T2DM among individuals without NAFLD.<\/jats:p>","DOI":"10.3390\/antiox13010107","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T08:12:37Z","timestamp":1705392757000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxidative Balance Score and New-Onset Type 2 Diabetes Mellitus in Korean Adults without Non-Alcoholic Fatty Liver Disease: Korean Genome and Epidemiology Study-Health Examinees (KoGES-HEXA) Cohort"],"prefix":"10.3390","volume":"13","author":[{"given":"Mid-Eum","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Department of Family Medicine, Gangnam Severance Hospital, Seoul 06273, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-0676","authenticated-orcid":false,"given":"Dong Hyuk","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Department of Family Medicine, Yongin Severance Hospital, Yongin 16995, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-7995","authenticated-orcid":false,"given":"Seok-Jae","family":"Heo","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1733-5301","authenticated-orcid":false,"given":"Byoungjin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Department of Family Medicine, Yongin Severance Hospital, Yongin 16995, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-476X","authenticated-orcid":false,"given":"Yong Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Department of Family Medicine, Gangnam Severance Hospital, Seoul 06273, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.4093\/dmj.2022.0364","article-title":"Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022","volume":"46","author":"Lee","year":"2022","journal-title":"Diabetes Metab. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S2213-8587(22)00186-3","article-title":"Burden of diabetes and hyperglycaemia in adults in the Americas, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"10","author":"Cousin","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1066159","DOI":"10.3389\/fnut.2022.1066159","article-title":"Association between oxidative balance score and new-onset hypertension in adults: A community-based prospective cohort study","volume":"9","author":"Lee","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1038\/s41598-023-33407-5","article-title":"Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: A case\u2013control study","volume":"13","author":"Sohouli","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Son, D.-H., Lee, H.S., Seol, S.-Y., Lee, Y.-J., and Lee, J.-H. (2023). Association between the oxidative balance score and incident chronic kidney disease in adults. Antioxidants, 12.","DOI":"10.3390\/antiox12020335"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kwon, Y.-J., Park, H.-M., and Lee, J.-H. (2023). Inverse Association between Oxidative Balance Score and Incident Type 2 Diabetes Mellitus. Nutrients, 15.","DOI":"10.3390\/nu15112497"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1024\/0300-9831\/a000596","article-title":"Higher oxidative balance score is associated with better glycemic control among Iranian adults with type-2 diabetes","volume":"91","author":"Golmohammadi","year":"2019","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1148417","DOI":"10.3389\/fendo.2023.1148417","article-title":"Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S2468-1253(21)00020-0","article-title":"Non-alcoholic fatty liver disease: A multisystem disease requiring a multidisciplinary and holistic approach","volume":"6","author":"Targher","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3349\/ymj.2023.0183","article-title":"Questionnaire-Based Survey of Diabetes Self-Care Activities and Barriers among Young Korean Adults with Early-Onset Diabetes","volume":"65","author":"Park","year":"2024","journal-title":"Yonsei Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ecl.2016.06.005","article-title":"Nonalcoholic fatty liver disease: The new complication of type 2 diabetes mellitus","volume":"45","author":"Bril","year":"2016","journal-title":"Endocrinol. Metab. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3920196","DOI":"10.1155\/2020\/3920196","article-title":"The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)","volume":"2020","author":"Tanase","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/liv.13185","article-title":"Nonalcoholic fatty liver disease: Cause or consequence of type 2 diabetes?","volume":"36","author":"Valenti","year":"2016","journal-title":"Liver Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1093\/ije\/dyv316","article-title":"Cohort profile: The Korean genome and epidemiology study (KoGES) consortium","volume":"46","author":"Kim","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease","volume":"42","author":"Lee","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3350\/cmh.2020.0163","article-title":"The effect of moderate alcohol drinking in nonalcoholic fatty liver disease","volume":"26","author":"Choi","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40885-019-0124-x","article-title":"2018 Korean Society of Hypertension Guidelines for the management of hypertension: Part II-diagnosis and treatment of hypertension","volume":"25","author":"Lee","year":"2019","journal-title":"Clin. Hypertens."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/clinchem\/hvab278","article-title":"National Kidney Foundation Laboratory Engagement Working Group recommendations for implementing the CKD-EPI 2021 race-free equations for estimated glomerular filtration rate: Practical guidance for clinical laboratories","volume":"68","author":"Miller","year":"2022","journal-title":"Clin. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4093\/dmj.2023.0135","article-title":"Dyslipidemia Fact Sheet in South Korea, 2022","volume":"47","author":"Jin","year":"2023","journal-title":"Diabetes Metab. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/sj.ejcn.1602657","article-title":"Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study","volume":"61","author":"Ahn","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"2. Classification and diagnosis of diabetes: Standards of care in diabetes\u20142023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41574-021-00512-2","article-title":"Type 2 diabetes mellitus in older adults: Clinical considerations and management","volume":"17","author":"Bellary","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/gutjnl-2020-322572","article-title":"Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: An updated meta-analysis of 501 022 adult individuals","volume":"70","author":"Mantovani","year":"2021","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrendo.2017.56","article-title":"Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance","volume":"13","author":"Meex","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/jn\/132.4.756","article-title":"A dietary oxidative balance score of vitamin C, \u03b2-carotene and iron intakes and mortality risk in male smoking Belgians","volume":"132","author":"Temme","year":"2002","journal-title":"J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Ruiz, \u00c1., Garc\u00eda-Villanova, B., Guerra-Hern\u00e1ndez, E., Amiano, P., Ruiz-Canela, M., and Molina-Montes, E. (2019). A review of a priori defined oxidative balance scores relative to their components and impact on health outcomes. Nutrients, 11.","DOI":"10.3390\/nu11040774"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1158\/1055-9965.EPI-13-0619","article-title":"Oxidative balance score, colorectal adenoma, and markers of oxidative stress and inflammation","volume":"23","author":"Kong","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00394-017-1407-1","article-title":"Oxidative balance score and serum \u03b3-glutamyltransferase level among Korean adults: A nationwide population-based study","volume":"57","author":"Cho","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.clnu.2023.06.015","article-title":"Oxidative balance score is inversely associated with the incidence of non-alcoholic fatty liver disease","volume":"42","author":"Cho","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S2213-8587(15)00316-2","article-title":"Relation of active, passive, and quitting smoking with incident type 2 diabetes: A systematic review and meta-analysis","volume":"3","author":"Pan","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pcad.2019.08.004","article-title":"Obesity, risk of diabetes and role of physical activity, exercise training and cardiorespiratory fitness","volume":"62","author":"Carbone","year":"2019","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF00275265","article-title":"Role of zinc in insulin biosynthesis: Some possible zinc-insulin interactions in the pancreatic B-cell","volume":"19","author":"Emdin","year":"1980","journal-title":"Diabetologia"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Seo, J.-A., Song, S.-W., Han, K., Lee, K.-J., and Kim, H.-N. (2014). The associations between serum zinc levels and metabolic syndrome in the Korean population: Findings from the 2010 Korean National Health and Nutrition Examination Survey. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105990"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12011-018-1611-8","article-title":"Nutritional effects of zinc on metabolic syndrome and type 2 diabetes: Mechanisms and main findings in human studies","volume":"188","author":"Ruz","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_37","unstructured":"Institute of Medicine (US) Panel on Micronutrients (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.advnut.2022.10.002","article-title":"Healthy plant-based diets improve dyslipidemias, insulin resistance, and inflammation in metabolic syndrome. A narrative review","volume":"14","author":"Thomas","year":"2023","journal-title":"Adv. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease","volume":"18","author":"Chow","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3349\/ymj.2020.61.3.218","article-title":"Leisure time physical activity to reduce metabolic syndrome risk: A 10-year community-based prospective study in Korea","volume":"61","author":"Jo","year":"2020","journal-title":"Yonsei Med. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2337\/dc22-1024","article-title":"Combination of multiple low-risk lifestyle behaviors and incident type 2 diabetes: A systematic review and dose-response meta-analysis of prospective cohort studies","volume":"46","author":"Khan","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3349\/ymj.2022.63.9.825","article-title":"Effect of Dapagliflozin in Combination with Lobeglitazone and Metformin in Korean Patients with Type 2 Diabetes in Real-World Clinical Practice","volume":"63","author":"Seo","year":"2022","journal-title":"Yonsei Med. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/cld.1045","article-title":"Nonalcoholic fatty liver disease and recent guideline updates","volume":"17","author":"Ando","year":"2021","journal-title":"Clin. Liver Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.annepidem.2014.02.015","article-title":"Oxidative balance score and risk for incident prostate cancer in a prospective US cohort study","volume":"24","author":"Lakkur","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/aje\/kwt007","article-title":"Using pathway-specific comprehensive exposure scores in epidemiology: Application to oxidative balance in a pooled case-control study of incident, sporadic colorectal adenomas","volume":"178","author":"Dash","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3748\/wjg.v20.i2.475","article-title":"Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Sumida","year":"2014","journal-title":"World J. Gastroenterol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/1\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:48:00Z","timestamp":1760104080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/1\/107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["antiox13010107"],"URL":"https:\/\/doi.org\/10.3390\/antiox13010107","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}