{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:21:04Z","timestamp":1792189264813,"version":"4.4.0"},"reference-count":54,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972373"],"award-info":[{"award-number":["81972373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["PM201809170001"],"award-info":[{"award-number":["PM201809170001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Scientific Research Foundation for Advanced Talents of Xiang\u2019an Hospital of Xiamen University","award":["81972373"],"award-info":[{"award-number":["81972373"]}]},{"name":"the Scientific Research Foundation for Advanced Talents of Xiang\u2019an Hospital of Xiamen University","award":["PM201809170001"],"award-info":[{"award-number":["PM201809170001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Ferroptosis, as a novel regulable cell death, is characterized by iron overload, glutathione depletion, and an accumulation of lipid peroxides. Recently, it has been discovered that ferroptosis is involved in ischemia\/reperfusion (I\/R)-induced acute kidney injury (AKI) and plays a crucial role in renal tubular cell death. In this study, we tried to investigate the effect and mechanism of liproxstatin-1 (Lip-1) in I\/R-induced AKI and seek the key regulator of ferroptosis in I\/R-induced AKI. Mice were administrated with clamping bilateral renal pedicles for 30 min. We found that early growth response 1 (EGR1) might be a key regulator of ferroptosis, and Lip-1 could suppress ferroptosis via EGR1. Meanwhile, Lip-1 could reduce macrophage recruitment and the release of inflammatory cytokines. These findings indicated that Lip-1 alleviated I\/R-induced AKI via regulating EGR1, and it might pave the theoretical basis of a new therapeutic strategy for I\/R-induced AKI.<\/jats:p>","DOI":"10.3390\/antiox13020182","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T10:44:24Z","timestamp":1706697864000},"page":"182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Liproxstatin-1 Alleviated Ischemia\/Reperfusion-Induced Acute Kidney Injury via Inhibiting Ferroptosis"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhiyuan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, Xiamen Key Laboratory of Regeneration Medicine, Organ Transplantation Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Sun","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, Xiamen Key Laboratory of Regeneration Medicine, Organ Transplantation Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.athoracsur.2016.04.020","article-title":"Acute Kidney Injury Severity and Long-Term Readmission and Mortality after Cardiac Surgery","volume":"102","author":"Brown","year":"2016","journal-title":"Ann. 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