{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:22:57Z","timestamp":1789507377362,"version":"build-2803163510"},"reference-count":108,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T00:00:00Z","timestamp":1707004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["DTS21\/00086"],"award-info":[{"award-number":["DTS21\/00086"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["FQM-7316"],"award-info":[{"award-number":["FQM-7316"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["P20_00013"],"award-info":[{"award-number":["P20_00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["DTS21\/00086"],"award-info":[{"award-number":["DTS21\/00086"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["FQM-7316"],"award-info":[{"award-number":["FQM-7316"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P20_00013"],"award-info":[{"award-number":["P20_00013"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Retinitis pigmentosa is a common cause of inherited blindness in adults, which in many cases is associated with an increase in the formation of reactive oxygen species (ROS) that induces DNA damage, triggering Poly-ADP-Ribose Polymerase 1 (PARP1) activation and leading to parthanatos-mediated cell death. Previous studies have shown that resveratrol (RSV) is a promising molecule that can mitigate PARP1 overactivity, but its low bioavailability is a limitation for medical use. This study examined the impact of a synthesized new acylated RSV prodrug, piceid octanoate (PIC-OCT), in the 661W cell line against H2O2 oxidative stress and in rd10 mice. PIC-OCT possesses a better ADME profile than RSV. In response to H2O2, 661W cells pretreated with PIC-OCT preserved cell viability in more than 38% of cells by significantly promoting SIRT1 nuclear translocation, preserving NAD+\/NADH ratio, and suppressing intracellular ROS formation. These effects result from expressing antioxidant genes, maintaining mitochondrial function, reducing PARP1 nuclear expression, and preventing AIF nuclear translocation. In rd10 mice, PIC-OCT inhibited PAR-polymer formation, increased SIRT1 expression, significantly reduced TUNEL-positive cells in the retinal outer nuclear layer, preserved ERGs, and enhanced light chamber activity (all p values &lt; 0.05). Our findings corroborate that PIC-OCT protects photoreceptors by modulating the SIRT1\/PARP1 axis in models of retinal degeneration.<\/jats:p>","DOI":"10.3390\/antiox13020201","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T05:22:44Z","timestamp":1707110564000},"page":"201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Piceid Octanoate Protects Retinal Cells against Oxidative Damage by Regulating the Sirtuin 1\/Poly-ADP-Ribose Polymerase 1 Axis In Vitro and in rd10 Mice"],"prefix":"10.3390","volume":"13","author":[{"given":"Seyed Mohamadmehdi","family":"Moshtaghion","sequence":"first","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Caballano-Infantes","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-6316","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Plaza Reyes","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-3915","authenticated-orcid":false,"given":"Lourdes","family":"Vald\u00e9s-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Gallego","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-6473","authenticated-orcid":false,"given":"Berta","family":"de la Cerda","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio S.","family":"Riga","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-8289","authenticated-orcid":false,"given":"Manuel","family":"\u00c1lvarez-Dolado","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-282X","authenticated-orcid":false,"given":"Pablo","family":"Pe\u00f1alver","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, Institute of Parasitology and Biomedicine L\u00f3pez-Neyra (IPBLN), PTS-Granada, Avda. del Conocimiento, 17, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-405X","authenticated-orcid":false,"given":"Juan C.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, Institute of Parasitology and Biomedicine L\u00f3pez-Neyra (IPBLN), PTS-Granada, Avda. del Conocimiento, 17, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-0205","authenticated-orcid":false,"given":"Francisco J.","family":"D\u00edaz-Corrales","sequence":"additional","affiliation":[{"name":"Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andaluc\u00eda, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Am\u00e9rico Vespucio 24, 41092 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, W., Liu, S., Li, P., and Yao, K. (2022). Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094883"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cge.12181","article-title":"Alternative Splicing and Retinal Degeneration","volume":"84","author":"Liu","year":"2013","journal-title":"Clin. 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