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The objective is to investigate the main intracellular pathways activated after exposure to ozone, considering the dosage of antioxidant enzymes and markers of oxidative stress. (2) Methods: This systematic review was performed based on the PRISMA guidelines and using a structured search in MEDLINE (PubMed), Scopus, and Web of Science. Bias analysis and methodological quality assessments were examined using the SYRCLE Risk of Bias tool. (3) Results: Nineteen studies were selected. The results showed that the exposure to ozone has a protective effect on liver tissue, promoting a decrease in inflammatory markers and a reduction in oxidative stress in liver tissue. In addition, ozone exposure also promoted an increase in antioxidant enzymes. The morphological consequences of controlling these intracellular pathways were reducing the tissue inflammatory process and reducing areas of degeneration and necrosis. (4) Conclusions: Ozone exposure has a beneficial effect on models of liver injury through the decrease in oxidative stress in tissue and inflammatory markers. In addition, it regulates the Nrf2\/ARE antioxidant pathway and blocks the NF-\u03baB inflammatory pathway.<\/jats:p>","DOI":"10.3390\/antiox13020212","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T03:36:17Z","timestamp":1707363377000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models"],"prefix":"10.3390","volume":"13","author":[{"given":"Silvania Mol","family":"Pelinsari","sequence":"first","affiliation":[{"name":"Departament of General Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e1urea Matias","family":"Sarandy","sequence":"additional","affiliation":[{"name":"Departament of General Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"},{"name":"Plants for Human Health Institute, North Carolina Research Campus, North Carolina State University, Kannapolis, NC 28081, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Ferreira","family":"Vilela","sequence":"additional","affiliation":[{"name":"Agriculture and Livestock Research Enterprise of Minas Gerais (EPAMIG-Sudeste), Vi\u00e7osa 36570-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[{"name":"Departament of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil"},{"name":"Departament of Animal Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Schlamb","sequence":"additional","affiliation":[{"name":"Plants for Human Health Institute, North Carolina Research Campus, North Carolina State University, Kannapolis, NC 28081, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reggiani Vilela","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departament of General Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"},{"name":"Departament of Animal Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-981-16-5689-7_14","article-title":"Early-stage detection of liver disease through machine learning algorithms BT-advances indata and information sciences","volume":"Volume 318","author":"Tiwari","year":"2022","journal-title":"Advances in Data and Information Sciences"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. 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