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It triggers metabolic disorders such as insulin resistance, hyperlipemia, non-alcoholic fatty liver disease, chronic inflammation, oxidative stress, and gut microbiota dysbiosis. The aim of this study was to evaluate the beneficial effects of a combined intervention with caloric restriction, nutraceutical intake, and a mixed training protocol on oxidative stress, inflammation, and gut dysbiosis derived from the development of obesity in a C57BL6\/J mouse experimental model of diet-induced obesity (4.6 Kcal\/g diet, 45% Kcal as fat, and 20% fructose in the drinking fluid). The nutraceutical was formulated with ethanolic extracts of Argania spinosa pulp (10%) and Camelina sativa seeds (10%) and with protein hydrolysates from Psoralea corylifolia seeds (40%) and Spirodela polyrhiza whole plants (40%). The combination of nutraceutical and exercise decreased the animals\u2019 body weights and inflammatory markers (TNF\u03b1, IL-6, and resistin) in plasma, while increasing gene expression of cat, sod2, gsta2, and nqo1 in the liver. Obese animals showed lower \u03b2-diversity of microbiota and a higher Firmicutes\/Bacteroidetes ratio vs. normocaloric controls that were reversed by all interventions implemented. Dietary inclusion of a nutraceutical with high antioxidant potential combined with an exercise protocol can be beneficial for bodyweight control and improvement of metabolic status in patients undergoing obesity treatment.<\/jats:p>","DOI":"10.3390\/antiox13030274","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T10:47:30Z","timestamp":1708685250000},"page":"274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-8793","authenticated-orcid":false,"given":"Ana","family":"Guzm\u00e1n-Carrasco","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Sport and Health University Research Institute (IMUDS), Universidad de Granada, 18016 Granada, Spain"},{"name":"Cellbitec S.L., N.I.F. B04847216, Scientific Headquarters of the Almer\u00eda Technology Park, Universidad de Almer\u00eda, 04128 Almer\u00eda, Spain"},{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research (CIBM), Instituto Biosanitario de Granada (ibs.GRANADA), University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-9723","authenticated-orcid":false,"given":"Garyfallia","family":"Kapravelou","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Sport and Health University Research Institute (IMUDS), Universidad de Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"L\u00f3pez-Jurado","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Sport and Health University Research Institute (IMUDS), Universidad de Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Cellbitec S.L., N.I.F. B04847216, Scientific Headquarters of the Almer\u00eda Technology Park, Universidad de Almer\u00eda, 04128 Almer\u00eda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-9914","authenticated-orcid":false,"given":"Eduardo","family":"Andr\u00e9s-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Institute of Parasitology and Biomedicine \u201cL\u00f3pez-Neyra\u201d (IPBLN), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-8800","authenticated-orcid":false,"given":"Laura C.","family":"Terr\u00f3n-Camero","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Institute of Parasitology and Biomedicine \u201cL\u00f3pez-Neyra\u201d (IPBLN), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-7746","authenticated-orcid":false,"given":"Jos\u00e9","family":"Prados","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research (CIBM), Instituto Biosanitario de Granada (ibs.GRANADA), University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-806X","authenticated-orcid":false,"given":"Consolaci\u00f3n","family":"Melguizo","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research (CIBM), Instituto Biosanitario de Granada (ibs.GRANADA), University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-0764","authenticated-orcid":false,"given":"Jesus M.","family":"Porres","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Sport and Health University Research Institute (IMUDS), Universidad de Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-1621","authenticated-orcid":false,"given":"Rosario","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Center (CIBM), Sport and Health University Research Institute (IMUDS), Universidad de Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, January 24). 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