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The aim of the present study is to identify potential associations between RRD targets\u2019 perturbation and the risk of psychoses; to achieve this, Mendelian randomization analyses were conducted. The expression quantitative trait loci (eQTL) and protein QTL data were used to derive the genetic instrumental variables. We obtained the latest summary data of genome-wide association studies on seven psychoses as outcomes, including schizophrenia (SCZ), bipolar disorder (BD), major depressive disorder (MDD), attention-deficit\/hyperactivity disorder, autism, obsessive\u2013compulsive disorder and anorexia nervosa. In total, 95 unique targets were included in the eQTL panel, and 48 targets in the pQTL one. Genetic variations in the vitamin C target (OGFOD2, OR = 0.784, p = 2.14 \u00d7 10\u22127) and melatonin target (RORB, OR = 1.263, p = 8.80 \u00d7 10\u22129) were significantly related to the risk of SCZ. Genetic variation in the vitamin E (PRKCB, OR = 0.248, p = 1.24 \u00d7 10\u22125) target was related to an increased risk of BD. Genetic variation in the vitamin C target (P4HTM: cerebellum, OR = 1.071, p = 4.64 \u00d7 10\u22127; cerebellar hemisphere, OR = 1.092, p = 1.98 \u00d7 10\u22126) was related to an increased risk of MDD. Cognitive function mediated the effects on causal associations. In conclusion, this study provides supportive evidence for a causal association between RRD targets and risk of SCZ, BD or MDD, which were partially mediated by cognition.<\/jats:p>","DOI":"10.3390\/antiox13040398","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:45:01Z","timestamp":1711547101000},"page":"398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Association of Redox Regulatory Drug Target Genes with Psychiatric Disorders: A Mendelian Randomization Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-6686","authenticated-orcid":false,"given":"Zhe","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Mental Health, Peking University Sixth Hospital, No. 51 Hua Yuan Bei Road, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health, Peking University, Beijing 100191, 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Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41386-023-01690-5","article-title":"Finding new and better treatments for psychiatric disorders","volume":"49","author":"Paul","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sutkowy, P., Wo\u017aniak, A., Mila-Kierzenkowska, C., Szewczyk-Golec, K., Weso\u0142owski, R., Paw\u0142owska, M., and Nuszkiewicz, J. (2021). Physical Activity vs. Redox Balance in the Brain: Brain Health, Aging and Diseases. Antioxidants, 11.","DOI":"10.3390\/antiox11010095"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archpsyc.1991.01810360061009","article-title":"Oxygen radicals and neuropsychiatric illness: Some speculations","volume":"48","author":"Lohr","year":"1991","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: A review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-3956(02)00048-1","article-title":"Differential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain","volume":"37","author":"Parikh","year":"2003","journal-title":"J. Psychiatr. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11427-010-0013-8","article-title":"A meta-analysis of oxidative stress markers in schizophrenia","volume":"53","author":"Zhang","year":"2010","journal-title":"Sci. China Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/schbul\/sby125","article-title":"Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis","volume":"45","author":"Fraguas","year":"2019","journal-title":"Schizophr. Bull."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/bdi.12980","article-title":"Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls","volume":"23","author":"Gurpegui","year":"2021","journal-title":"Bipolar Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.4088\/JCP.14r09179","article-title":"Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: Results from a meta-analysis","volume":"76","author":"Gurpegui","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/acps.13026","article-title":"Oxidative and nitrosative stress markers in obsessive-compulsive disorder: A systematic review and meta-analysis","volume":"139","author":"Maia","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/erv.2420","article-title":"Oxidative Stress and Antioxidant Levels in Patients with Anorexia Nervosa after Oral Re-alimentation: A Systematic Review and Exploratory Meta-analysis","volume":"24","author":"Solmi","year":"2016","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8881770","DOI":"10.1155\/2021\/8881770","article-title":"Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives","volume":"2021","author":"Ermakov","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_16","first-page":"Cd008919","article-title":"Antioxidant treatments for schizophrenia","volume":"2","author":"Dean","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107520","DOI":"10.1016\/j.pharmthera.2020.107520","article-title":"Oxidation-reduction mechanisms in psychiatric disorders: A novel target for pharmacological intervention","volume":"210","author":"Rossetti","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lee, A.R.Y.B., Tariq, A., Lau, G., Tok, N.W.K., Tam, W.W.S., and Ho, C.S.H. (2022). Vitamin E, Alpha-Tocopherol, and Its Effects on Depression and Anxiety: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14030656"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Liu, Y., Yang, Z., Du, Y., Shi, S., and Cheng, Y. (2022). Antioxidant interventions in autism spectrum disorders: A meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry, 113.","DOI":"10.1016\/j.pnpbp.2021.110476"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lu, Z., Pu, C., Zhang, Y., Sun, Y., Liao, Y., Kang, Z., Feng, X., and Yue, W. (2022). Oxidative Stress and Psychiatric Disorders: Evidence from the Bidirectional Mendelian Randomization Study. Antioxidants, 11.","DOI":"10.3390\/antiox11071386"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gil Mart\u00ednez, V., Avedillo Salas, A., and Santander Ballest\u00edn, S. (2022). Vitamin Supplementation and Dementia: A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14051033"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41386-022-01456-5","article-title":"Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders","volume":"48","author":"Liu","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"ref_24","first-page":"1961","article-title":"Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: The role of the I2 statistic","volume":"45","author":"Bowden","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41588-021-00857-4","article-title":"Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology","volume":"53","author":"Mullins","year":"2021","journal-title":"Nat. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41593-018-0326-7","article-title":"Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions","volume":"22","author":"Howard","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41588-018-0269-7","article-title":"Discovery of the first genome-wide significant risk loci for attention deficit\/hyperactivity disorder","volume":"51","author":"Demontis","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41588-019-0344-8","article-title":"Identification of common genetic risk variants for autism spectrum disorder","volume":"51","author":"Grove","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"(OCGAS) IOCDFGCI-GaOCGAS (2018). Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis. Mol. Psychiatry, 23, 1181\u20131188.","DOI":"10.1038\/mp.2017.154"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-019-0439-2","article-title":"Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa","volume":"51","author":"Watson","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1126\/science.aav8130","article-title":"Single-cell genomics identifies cell type-specific molecular changes in autism","volume":"364","author":"Velmeshev","year":"2019","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41588-019-0404-0","article-title":"Abundant associations with gene expression complicate GWAS follow-up","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"113491","DOI":"10.1016\/j.psychres.2020.113491","article-title":"Identification of a functional SNP rs7304782 at schizophrenia risk locus 12q24.31 and validation of its association with schiz ophrenia in Chinese populations","volume":"294","author":"Ma","year":"2020","journal-title":"Psychiatry Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"R2357","DOI":"10.1152\/ajpregu.00687.2006","article-title":"Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H\/HeN mice homozygous for the RORbeta knockout","volume":"292","author":"Masana","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1399-5618.2009.00756.x","article-title":"Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia","volume":"11","author":"Mansour","year":"2009","journal-title":"Bipolar Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/jnnp-2013-305245","article-title":"Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis","volume":"85","author":"Lin","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.4049\/jimmunol.161.8.3912","article-title":"B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice","volume":"161","author":"Serreze","year":"1998","journal-title":"J. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jpsychires.2020.07.019","article-title":"Protein and mRNA expression of protein kinase C (PKC) in the postmortem brain of bipolar and schizophrenic subjects","volume":"130","author":"Pandey","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2019.04.023","article-title":"Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice","volume":"153","author":"Leinonen","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s44220-023-00110-3","article-title":"Neuroimaging and multiomics reveal cross-scale circuit abnormalities in schizophrenia","volume":"1","author":"Wang","year":"2023","journal-title":"Nat. Ment. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.neuron.2023.08.004","article-title":"Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice","volume":"111","author":"Farsi","year":"2023","journal-title":"Neuron"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.biopsych.2020.07.014","article-title":"Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome","volume":"89","author":"Hwang","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1080\/1028415X.2021.1956848","article-title":"Functional role of ascorbic acid in the central nervous system: A focus on neurogenic and synaptogenic processes","volume":"25","author":"Moretti","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00310622","article-title":"Some behavioural and EEG effects of ascorbic acid in rats","volume":"89","author":"Wambebe","year":"1986","journal-title":"Psychopharmacology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pnpbp.2009.02.003","article-title":"Ascorbic acid administration produces an antidepressant-like effect: Evidence for the involvement of monoaminergic neurotransmission","volume":"33","author":"Rosa","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.brainres.2006.09.098","article-title":"Effect of drug-induced ascorbic acid release in the striatum and the nucleus accumbens in hippocampus-lesioned rats","volume":"1125","author":"Dai","year":"2006","journal-title":"Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2006.01.022","article-title":"Differential effects of drug-induced ascorbic acid release in the striatum and nucleus accumbens of freely moving rats","volume":"399","author":"Gu","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"La Torre, M.E., Villano, I., Monda, M., Messina, A., Cibelli, G., Valenzano, A., Pisanelli, D., Panaro, M.A., Tartaglia, N., and Ambrosi, A. (2021). Role of Vitamin E and the Orexin System in Neuroprotection. Brain Sci., 11.","DOI":"10.3390\/brainsci11081098"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s007020070082","article-title":"Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB","volume":"107","author":"Behl","year":"2000","journal-title":"J. Neural Transm."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chauhan, S., Barbanta, A., Ettinger, U., and Kumari, V. (2023). Pineal Abnormalities in Psychosis and Mood Disorders: A Systematic Review. Brain Sci., 13.","DOI":"10.3390\/brainsci13050827"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.tjnut.2023.05.014","article-title":"Association of the Oxidative Balance Score and Cognitive Function and the Mediating Role of Oxidative Stress: Evidence from the National Health and Nutrition Examination Survey (NHANES) 2011\u20132014","volume":"153","author":"Song","year":"2023","journal-title":"J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/11633190-000000000-00000","article-title":"Antioxidants as antidepressants: Fact or fiction?","volume":"26","author":"Scapagnini","year":"2012","journal-title":"CNS Drugs"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/pcn.13502","article-title":"N-acetylcysteine for schizophrenia: A systematic review and meta-analysis","volume":"77","author":"Kishi","year":"2023","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"n2233","DOI":"10.1136\/bmj.n2233","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomisation (STROBE-MR): Explanation and Elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/4\/398\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:19:21Z","timestamp":1760105961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/4\/398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["antiox13040398"],"URL":"https:\/\/doi.org\/10.3390\/antiox13040398","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]}}}