{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:37:59Z","timestamp":1790656679059,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This aberrant protein affects several signaling pathways connected to both apoptosis and cell proliferation. It has been demonstrated that tyrosine kinase inhibitor treatment in chronic myeloid leukemia acts by inducing oxidative stress and, depending on its level, can activate signaling pathways responsible for either apoptosis or survival in leukemic cells. Additionally, oxidative stress and reactive oxygen species generation also mediate apoptosis through genomic activation. Furthermore, it was shown that oxidative stress has a role in both BCR-ABL-independent and BCR-ABL-dependent resistance pathways to tyrosine kinases, while patients with chronic myeloid leukemia were found to have a significantly reduced antioxidant level. The ideal environment for tyrosine kinase inhibitor therapy is produced by a favorable oxidative status. We discuss the latest studies that aim to manipulate the redox system to alter the apoptosis of cancerous cells.<\/jats:p>","DOI":"10.3390\/antiox13040461","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T11:53:53Z","timestamp":1713182033000},"page":"461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-8239","authenticated-orcid":false,"given":"Alessandro","family":"Allegra","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u2018Gaetano Barresi\u2019, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mirabile","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u2018Gaetano Barresi\u2019, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-1781","authenticated-orcid":false,"given":"Santino","family":"Caserta","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u2018Gaetano Barresi\u2019, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7947-158X","authenticated-orcid":false,"given":"Fabio","family":"Stagno","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u2018Gaetano Barresi\u2019, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Russo","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u2018Gaetano Barresi\u2019, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-7449","authenticated-orcid":false,"given":"Giovanni","family":"Pioggia","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), 98164 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liongue, C., and Ward, A.C. (2024). Myeloproliferative Neoplasms: Diseases Mediated by Chronic Activation of Signal Transducer and Activator of Transcription (STAT) Proteins. Cancers, 16.","DOI":"10.3390\/cancers16020313"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/annonc\/mdn091","article-title":"ESMO guidelines working group chronic myelogenous leukemia: ESMO clinical recommendations for the diagnosis, treatment and follow-up","volume":"19","author":"Hochhaus","year":"2008","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrc1567","article-title":"Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia","volume":"5","author":"Ren","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: Mechanisms of blastic transformation","volume":"120","author":"Perrotti","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood-2012-03-380147","article-title":"How I treat CML blast crisis","volume":"120","author":"Hehlmann","year":"2012","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_7","first-page":"w13659","article-title":"Reactive oxygen species: From health to disease","volume":"142","author":"Brieger","year":"2012","journal-title":"Swiss. Med. Wkly."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-pathol-012513-104651","article-title":"Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited","volume":"9","author":"Lambeth","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/acs.chemrev.7b00698","article-title":"Redox signaling by reactive electrophiles and oxidants","volume":"118","author":"Parvez","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/cdd.2013.186","article-title":"ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis","volume":"21","author":"Shi","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.25083\/rbl\/25.1\/1267.1274","article-title":"The involvement of oxidative stress in chronic myeloid leukemia","volume":"25","author":"Pascu","year":"2020","journal-title":"Rom. Biotechnol. Lett."},{"key":"ref_12","first-page":"70","article-title":"The role of oxidative stress in essential thrombocythemia","volume":"53","author":"Pascu","year":"2018","journal-title":"Arch. Balk. Med. Union"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.37358\/RC.19.10.3486","article-title":"Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia","volume":"70","author":"Diaconu","year":"2019","journal-title":"Rev. Chim."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.37358\/RC.19.8.7435","article-title":"Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential Thrombocythemia","volume":"70","author":"Diaconu","year":"2019","journal-title":"Rev. Chim."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cancemi, G., Cicero, N., Allegra, A., and Gangemi, S. (2023). Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders. Antioxidants, 12.","DOI":"10.3390\/antiox12091674"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Allegra, A., Caserta, S., Genovese, S., Pioggia, G., and Gangemi, S. (2023). Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival. Antioxidants, 12.","DOI":"10.20944\/preprints202305.0677.v1"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.clinbiochem.2012.07.100","article-title":"Changes in advanced oxidation protein products, advanced glycation end products, and s-nitrosylated proteins, in patients affected by polycythemia vera and essential thrombocythemia","volume":"45","author":"Musolino","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00011-012-0498-7","article-title":"Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions","volume":"61","author":"Gangemi","year":"2012","journal-title":"Inflamm. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/07357907.2011.629383","article-title":"Relationship between advanced oxidation protein products, advanced glycation end products, and S-nitrosylated proteins with biological risk and MDR-1 polymorphisms in patients affected by B-chronic lymphocytic leukemia","volume":"30","author":"Gangemi","year":"2012","journal-title":"Cancer Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.2217\/pgs.12.103","article-title":"Advances in treatment of chronic myeloid leukemia with tyrosine kinase inhibitors: The evolving role of Bcr-Abl mutations and mutational analysis","volume":"13","author":"Soverini","year":"2012","journal-title":"Pharmacogenomics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1038\/leu.2015.196","article-title":"\u03b2-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia","volume":"29","author":"Eiring","year":"2015","journal-title":"Leukemia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/leu.2014.245","article-title":"Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapyresistant chronic myeloid leukemia","volume":"29","author":"Eiring","year":"2015","journal-title":"Leukemia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/03093640701859089","article-title":"BCR\/ABL, DNA damage and DNA repair: Implications for new treatment concepts","volume":"49","author":"Skorski","year":"2008","journal-title":"Leuk. Lymphoma"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/leu.2008.78","article-title":"BCR\/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress","volume":"22","author":"Koptyra","year":"2008","journal-title":"Leukemia"},{"key":"ref_25","first-page":"2791","article-title":"Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70\/86 heterodimer","volume":"62","author":"Gaymes","year":"2002","journal-title":"Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mrgentox.2005.10.010","article-title":"Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR\/ABL kinase-mediated DNA repair","volume":"603","author":"Majsterek","year":"2006","journal-title":"Mutat. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.mrgentox.2008.06.002","article-title":"STI571 reduces NER activity in BCR\/ABL-expressing cells","volume":"654","author":"Sliwinski","year":"2008","journal-title":"Mutat. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1158\/0008-5472.CAN-07-6858","article-title":"BCR\/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations","volume":"68","author":"Stoklosa","year":"2008","journal-title":"Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s11033-009-9730-0","article-title":"BCR\/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells","volume":"37","author":"Poplawski","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/leu.2012.294","article-title":"BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability","volume":"27","author":"Slupianek","year":"2013","journal-title":"Leukemia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood-2005-07-2815","article-title":"BCR\/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance","volume":"108","author":"Koptyra","year":"2006","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/leu.2014.249","article-title":"AKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells","volume":"28","author":"Flis","year":"2014","journal-title":"Leukemia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1038\/leu.2013.123","article-title":"Anti-oxidant vitamin E prevents accumulation of imatinib-resistant BCR-ABL1 kinase mutations in CML-CP xenografts in NSG mice","volume":"27","author":"Hoser","year":"2013","journal-title":"Leukemia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/jnci\/djx236","article-title":"Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition","volume":"110","author":"Mitchell","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hou, G., Wang, X., Wang, A., Yuan, L., Zheng, Q., Xiao, H., and Wang, H. (2024). The role of secreted proteins in efferocytosis. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1332482"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Dehkordi, M.H., Munn, R.G.K., and Fearnhead, H.O. (2022). Non-canonical roles of apoptotic caspases in the nervous system. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.840023"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Petushkova, A.I., and Zamyatnin, A.A. (2020). Redox-Mediated Post-Translational Modifications of Proteolytic Enzymes and Their Role in Protease Functioning. Biomolecules, 10.","DOI":"10.3390\/biom10040650"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Li, K., Deng, Z., Lei, C., Ding, X., Li, J., and Wang, C. (2024). The Role of Oxidative Stress in Tumorigenesis and Progression. Cells, 13.","DOI":"10.3390\/cells13050441"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2012.04.026","article-title":"Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence","volume":"149","author":"Li","year":"2012","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/excr.2000.4839","article-title":"TheBcl-2 protein family","volume":"256","author":"Antonsson","year":"2000","journal-title":"Exp. Cell Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.lungcan.2010.06.002","article-title":"Anticancer activity of Noscapine, an opioid alkaloid in combination with cisplatin in human non-small cell lung cancer","volume":"71","author":"Chougule","year":"2011","journal-title":"Lung Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2010.05608.x","article-title":"Role of oxidative\/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation","volume":"1203","author":"Azad","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3240820","DOI":"10.1155\/2020\/3240820","article-title":"Oxidative Stress Induces Chondrocyte Apoptosis through Caspase-Dependent and Caspase-Independent Mitochondrial Pathways and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide","volume":"2020","author":"Zhuang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_45","first-page":"420","article-title":"Involvement of Oxidative Stress in Resistance to Tyrosine-Kinase Inhibitors Therapy in Chronic Myeloid Leukemia","volume":"46","author":"Pascu","year":"2020","journal-title":"Curr. Health Sci. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1038\/sj.onc.1204840","article-title":"Activation of the RacGTPase inhibits apoptosis in human tumor cells","volume":"20","author":"Pervaiz","year":"2001","journal-title":"Oncogene"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-5793(98)01410-0","article-title":"Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu","volume":"440","author":"Clement","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.179.1.21","article-title":"Cutting edge: Antioxidative properties of myeloid dendritic cells: Protection of T cells and NK cells from oxygen radical-induced inactivation and apoptosis","volume":"179","author":"Thoren","year":"2007","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/cdd.2008.3","article-title":"Redox regulation of anoikis: Reactive oxygen species as essential mediators of cell survival","volume":"15","author":"Giannoni","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0027-5107(01)00091-4","article-title":"The contribution of endogenous sources of DNA damage to the multiple mutations in cancer","volume":"477","author":"Jackson","year":"2001","journal-title":"Mutat. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0006-2952(02)01172-3","article-title":"Cellular glutathione and thiols metabolism","volume":"64","author":"Dickinson","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cbi.2011.06.007","article-title":"Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways","volume":"193","author":"Ho","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3892\/ijmm.2012.895","article-title":"Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells","volume":"29","author":"Gao","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1158\/0008-5472.CAN-06-0409","article-title":"Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphomacells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors","volume":"66","author":"Chen","year":"2006","journal-title":"Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0167-5699(94)90018-3","article-title":"Oxidative stress as a mediator of apoptosis","volume":"15","author":"Buttke","year":"1994","journal-title":"Immunol. Today"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1349-7006.2011.02107.x","article-title":"Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance","volume":"103","author":"Chakraborty","year":"2012","journal-title":"Cancer Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.4161\/cc.25920","article-title":"Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells","volume":"12","author":"Ciarcia","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jsps.2019.10.005","article-title":"Evaluation of oxidative stress responses in human circulating blood cells after imatinib mesylate treatment-Implications to its mechanism of action","volume":"27","author":"Gajski","year":"2019","journal-title":"Saudi Pharm. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41419-024-06515-x","article-title":"Endoplasmic reticulum stress and the unfolded protein response: Emerging regulators in progression of traumatic brain injury","volume":"15","author":"Yang","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1701096","DOI":"10.1183\/13993003.01096-2017","article-title":"Dasatinib increases endothelial permeability leading to pleural effusion","volume":"51","author":"Phan","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.taap.2012.04.010","article-title":"Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes","volume":"261","author":"Xue","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_62","first-page":"7","article-title":"Dasatinib treatment based on BCR- ABL mutation detection in imatinib- resistant patients with chronic myeloid leukemia","volume":"37","author":"Jiang","year":"2016","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"ref_63","first-page":"469","article-title":"Variables associated with BCR-ABL kinase domain mutation in TKI-resistant patients with chronic myeloid leukemia","volume":"41","author":"Shi","year":"2020","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4161\/cc.10.2.14537","article-title":"Impact of BCR-ABL mutations on patients with chronic myeloid leukemia","volume":"10","author":"Hochhaus","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1002\/jcb.26686","article-title":"Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells","volume":"119","author":"Damiano","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_66","first-page":"63","article-title":"Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line","volume":"20","author":"Bazi","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/jcp.25118","article-title":"Comparison of Dasatinib, Nilotinib, and Imatinib in the Treatment of Chronic Myeloid Leukemia","volume":"231","author":"Ciarcia","year":"2016","journal-title":"J. Cell Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5581\/1516-8484.20120091","article-title":"Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors","volume":"34","author":"Petrola","year":"2012","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e23050","DOI":"10.1002\/jcla.23050","article-title":"Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study","volume":"34","author":"Ammar","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_70","first-page":"455","article-title":"Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib","volume":"41","author":"Cheng","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1089\/ars.2016.6750","article-title":"Heterogeneity in Cancer Metabolism: New Concepts in an Old Field","volume":"26","author":"Gentric","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrc3803","article-title":"Mitochondrial ROS in cancer: Initiators, amplifiers or an Achilles\u2019heel?","volume":"14","author":"Sabharwal","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"172486","DOI":"10.1016\/j.ejphar.2019.172486","article-title":"Combined effects of quercetin and curcumin on anti-inflammatory and antimicrobial parameters in vitro","volume":"859","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"162750","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: An overview","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.2174\/0929867324666171006144208","article-title":"Polyphenols in food: Cancer prevention and apoptosis induction","volume":"25","author":"Sharma","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1042\/CS20160935","article-title":"Curcumin mediates anticancer effects by modulating multiple cell signaling pathways","volume":"131","author":"Kunnumakkara","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tiv.2017.12.001","article-title":"Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-\u03baB pathways","volume":"47","author":"Allegra","year":"2018","journal-title":"Toxicol. Vitro"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07357907.2016.1247166","article-title":"Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies","volume":"35","author":"Allegra","year":"2017","journal-title":"Cancer Investig."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: Problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/01635581.2018.1380208","article-title":"Synergistic induction of apoptosis by quercetin and curcumin in chronic myeloid leukemia (K562) cells","volume":"70","author":"Kocturk","year":"2018","journal-title":"Nutr. Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/01635581.2020.1767167","article-title":"Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved","volume":"73","author":"Serdar","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/np020241f","article-title":"Brosimacutins AI, Nine New Flavonoids from Brosimum acutifolium","volume":"65","author":"Takashima","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1055\/s-2005-871272","article-title":"Four New Flavonoids from Brosimum acutifolium and their Cytotoxic Activity","volume":"71","author":"Takashima","year":"2005","journal-title":"Planta Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ardp.201000011","article-title":"Synthesis and Anticancer Activity of Novel Betulinic acid and Betulin Derivatives","volume":"343","author":"Kommera","year":"2010","journal-title":"Arch. Pharm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.bmcl.2012.02.009","article-title":"Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents","volume":"22","author":"Bai","year":"2012","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_86","first-page":"1777","article-title":"Design, Synthesis and Biological Evaluation of Betulinic Acid Derivatives as New Antitumor Agents for Leukemia","volume":"17","author":"Waechter","year":"2017","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/mnfr.200700491","article-title":"Betulinic acid: A natural product with anticancer activity","volume":"53","author":"Fulda","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2174\/1871520620666200124111634","article-title":"Betulinic Acid and Brosimine B Hybrid Derivatives as Potential Agents against Female Cancers","volume":"20","author":"Willig","year":"2020","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Willig, J.B., de Couto, N.M.G., Vianna, D.R.B., Mariot, C.D.S., Gnoatto, S.C.B., Buffon, A., and Pilger, D.A. (2023). Betulinic Acid-Brosimine B Hybrid Compound Has a Synergistic Effect with Imatinib in Chronic Myeloid Leukemia Cell Line, Modulating Apoptosis and Autophagy. Pharmaceuticals, 16.","DOI":"10.3390\/ph16040586"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ejmech.2018.10.062","article-title":"Natural products hybrids: 3,5,40-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells","volume":"161","author":"Hassan","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"61457","DOI":"10.18632\/oncotarget.18390","article-title":"Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas","volume":"8","author":"Ackermann","year":"2017","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.bmcl.2011.02.029","article-title":"Hybrid compounds as new Bcr\/Abl inhibitors","volume":"21","author":"Wang","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/sj.bjc.6603672","article-title":"Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57","volume":"96","author":"Corazzari","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s10495-006-9289-3","article-title":"Mechanisms of fenretinide-induced apoptosis","volume":"11","author":"Hail","year":"2006","journal-title":"Apoptosis"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.1302352110","article-title":"Preferential eradication of acute myelogenous leukemia stem cells by fenretinide","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wang, K., Fang, H., Xiao, D., Zhu, X., He, M., Pan, X., Shi, J., Zhang, H., Jia, X., and Du, Y. (2009). Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007538"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbrc.2011.01.036","article-title":"Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells","volume":"405","author":"Jiang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3892\/or.2013.2499","article-title":"A novel imidazopyridine PI3K inhibitor with anticancer activity in non-small cell lung cancer cells","volume":"30","author":"Lee","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ml300282t","article-title":"Synthesis and anti-inflammatory evaluation of novel benzimidazole and imidazopyridine derivatives","volume":"4","author":"Chen","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_100","first-page":"299","article-title":"Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)","volume":"5","author":"Jeong","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/ml500244m","article-title":"Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages","volume":"5","author":"Zou","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1021\/acs.jmedchem.9b01736","article-title":"Design, synthesis, and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3K\/mTOR dual inhibitors","volume":"63","author":"Yu","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5417024","DOI":"10.1155\/2020\/5417024","article-title":"Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress","volume":"2020","author":"Frizon","year":"2020","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Radomska, D., Czarnomysy, R., Radomski, D., and Bielawski, K. (2021). Selenium Compounds as Novel Potential Anticancer Agents. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031009"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Burkner, G.T., Dias, D.A., Souza, K.F.S., Ara\u00fajo, A.J.P., Basilio, D.C.L.S., Jacobsen, F.T., Moraes, A.C.R., Silva-Filho, S.E., Cavalcante, M.F.O., and Moraes, C.A.O. (2023). Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells. Molecules, 28.","DOI":"10.3390\/molecules28020893"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bbrc.2018.07.039","article-title":"Novel selenylated imidazo[1,2-a ]pyridines for breast cancer chemotherapy: Inhibition of cell proliferation by Akt-mediated regulation, DNA cleavage and apoptosis","volume":"503","author":"Almeida","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Dos Santos, D.C., Rafique, J., Saba, S., Almeida, G.M., Siminski, T., P\u00e1dua, C., and Ourique, F. (2021). Apoptosis oxidative damage-mediated and antiproliferative effect of selenylated imidazo[1,2-a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo. J. Biochem. Mol. Toxicol., 35.","DOI":"10.1002\/jbt.22663"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jpp\/rgaa070","article-title":"A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat\/high-fructose diet in mice","volume":"73","author":"Veloso","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dnarep.2015.10.004","article-title":"Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung cancer cells","volume":"37","author":"Semreen","year":"2016","journal-title":"DNA Repair"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s13071-015-1159-9","article-title":"Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: A comparative modelling analysis","volume":"8","author":"Stolk","year":"2015","journal-title":"Parasit. Vectors."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1080\/15548627.2016.1231494","article-title":"Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer","volume":"12","author":"Wang","year":"2016","journal-title":"Autophagy"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1158\/0008-5472.CAN-15-2887","article-title":"Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1\/Akt Axis in Breast Cancer","volume":"76","author":"Dou","year":"2016","journal-title":"Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.15252\/emmm.201404084","article-title":"The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer","volume":"6","author":"Melotti","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"16222","DOI":"10.1038\/srep16222","article-title":"Modulation of P2X4\/P2X7\/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death","volume":"5","author":"Draganov","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1182\/blood-2010-01-262675","article-title":"The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells","volume":"116","author":"Sharmeen","year":"2010","journal-title":"Blood"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbrc.2018.02.063","article-title":"Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress","volume":"497","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Gees, M., Colsoul, B., and Nilius, B. (2010). The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb. Perspect. Biol., 2.","DOI":"10.1101\/cshperspect.a003962"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00281-015-0525-1","article-title":"Role of TRP ion channels in cancer and tumorigenesis","volume":"38","author":"Shapovalov","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/carcin\/bgp138","article-title":"Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas\/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner","volume":"30","author":"Amantini","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1471-4159.2007.04582.x","article-title":"Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation","volume":"102","author":"Amantini","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Liu, L., Sun, X., Guo, Y., and Ge, K. (2022). Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1\/Ca2+ pathway. Chem. Biol. Interact., 351.","DOI":"10.1016\/j.cbi.2021.109756"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"21244","DOI":"10.18632\/oncotarget.25052","article-title":"Effects of CB2 and TRPV1 receptors\u2019 stimulation in pediatric acute T-lymphoblastic leukemia","volume":"9","author":"Punzo","year":"2018","journal-title":"Oncotarget"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Maggi, F., Morelli, M.B., Aguzzi, C., Zeppa, L., Nabissi, M., Polidori, C., Santoni, G., and Amantini, C. (2023). Calcium influx, oxidative stress, and apoptosis induced by TRPV1 in chronic myeloid leukemia cells: Synergistic effects with imatinib. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1129202"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Allegra, A., Gioacchino, M.D., Tonacci, A., Petrarca, C., and Gangemi, S. (2021). Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective. Nanomaterials, 11.","DOI":"10.3390\/nano11112792"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"140713","DOI":"10.1016\/j.chemosphere.2023.140713","article-title":"Exploring the cytotoxicity mechanisms of copper ions and copper oxide nanoparticles in cells from the excretory system","volume":"347","year":"2024","journal-title":"Chemosphere"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.nano.2010.10.001","article-title":"Selective toxicity of ZnO nanoparticles toward Gram positive bacteria and cancer cells by apoptosis through lipid peroxidation","volume":"7","author":"Premanathan","year":"2011","journal-title":"Nanomedicine"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.colsurfb.2014.06.064","article-title":"Synthesis, characterization and toxicological evaluation of iron oxide nanoparticles in human lung alveolar epithelial cells","volume":"122","author":"Dwivedi","year":"2014","journal-title":"Colloids Surf. B Biointerfaces."},{"key":"ref_128","first-page":"993","article-title":"CuO nanoparticles induce cytotoxicity and apoptosis in human K562 cancer cell line via mitochondrial pathway, through reactive oxygen species and P53","volume":"18","author":"Shafagh","year":"2015","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_129","first-page":"208","article-title":"Ultraviolet damage, DNA repair and vitamin D in nonmelanoma skin cancer and in malignant melanoma: An update","volume":"810","author":"Reichrath","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1038\/sj.onc.1205743","article-title":"DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way","volume":"21","author":"Kulms","year":"2002","journal-title":"Oncogene"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Allegra, A., Pioggia, G., Tonacci, A., Musolino, C., and Gangemi, S. (2020). Oxidative Stress and Photodynamic Therapy of Skin Cancers: Mechanisms, Challenges and Promising Developments. Antioxidants, 9.","DOI":"10.3390\/antiox9050448"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2013.12.021","article-title":"Induction of bystander effects by UVA, UVB, and UVC radiation in human fibroblasts and the implication of reactive oxygen species","volume":"68","author":"Widel","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"18111","DOI":"10.3390\/ijms160818111","article-title":"UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib","volume":"16","author":"Synowiec","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ymthe.2024.01.005","article-title":"The landscape of nanoparticle-based siRNA delivery and therapeutic development","volume":"32","author":"Moazzam","year":"2024","journal-title":"Mol. Ther."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1158\/0008-5472.CAN-12-3955","article-title":"Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem\/progenitor cells","volume":"73","author":"Casetti","year":"2013","journal-title":"Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41418-018-0195-3","article-title":"Crashing the computer: Apoptosis vs. necroptosis in neuroinflammation","volume":"26","author":"Heckmann","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","article-title":"Immunogenic cell death in cancer therapy","volume":"31","author":"Kroemer","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1387\/ijdb.150061pa","article-title":"Immunogenic cell death","volume":"59","author":"Garg","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2018.02.006","article-title":"Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy","volume":"153","author":"Radogna","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature12639","article-title":"Functional interaction between autophagy and ciliogenesis","volume":"502","author":"Pampliega","year":"2013","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4161\/auto.7.5.14226","article-title":"Autophagic cell death: Loch Ness monster or endangered species?","volume":"7","author":"Shen","year":"2011","journal-title":"Autophagy"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/15548627.2016.1162359","article-title":"ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells","volume":"12","author":"Karvela","year":"2016","journal-title":"Autophagy"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.critrevonc.2017.02.004","article-title":"The roles of reactive oxygen species (ROS) and autophagy in the survival and death of leukemia cells","volume":"112","author":"Chen","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Ianniciello, A., Rattigan, K.M., and Helgason, G.V. (2018). The ins and outs of autophagy and metabolism in hematopoietic and leukemic stem cells: Food for thought. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00120"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"ra81","DOI":"10.1126\/scisignal.2001017","article-title":"Akt and autophagy cooperate to promote survival of drug-resistant glioma","volume":"3","author":"Fan","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12967-017-1223-7","article-title":"Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells","volume":"15","author":"Kim","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41419-020-2304-8","article-title":"Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia","volume":"11","author":"Song","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/4\/461\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:27:43Z","timestamp":1760106463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/4\/461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,13]]},"references-count":148,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["antiox13040461"],"URL":"https:\/\/doi.org\/10.3390\/antiox13040461","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,13]]}}}