{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:13:24Z","timestamp":1788300804565,"version":"build-2803163510"},"reference-count":129,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Periodontal disease is an inflammatory condition characterized by an aberrant immune response against a dysbiotic dental biofilm, with oxidative stress performing an essential role in its pathogenesis. This paper presents a patent mining, performed in the Orbit Intelligence patent database, related to antioxidant phytochemicals in the technological developments that are working to prevent and treat periodontal disease. To access the documents, the descriptors \u201cPERIODONTAL\u201d and \u201cANTIOXIDANT\u201d were typed in the title, abstract, and claim search fields. A total of 322 patents demonstrate the growing interest in researching natural antioxidants for scientific and technological purposes. The top ten countries regarding the number of family patents produced were the United States, the European Office, Japan, South Korea, China, India, Mexico, Denmark, Canada, and Great Britain. The most cited compounds were vitamin C, green tea, quercetin, melatonin, lycopene, resveratrol, and curcumin. These compounds have been used for the technological development of gels, membranes, dentifrices, chewing gum, orally disintegrating film, mouthwash, mouth spray, and mouth massage cream and exhibit the ability to neutralize free radicals and reduce oxidative stress, a critical factor in the development and progression of periodontal diseases. The patent documents have shown that using antioxidant compounds in conjunction with traditional periodontal treatments is a promising area of interest in periodontal therapy.<\/jats:p>","DOI":"10.3390\/antiox13050566","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:52:02Z","timestamp":1714715522000},"page":"566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-4397","authenticated-orcid":false,"given":"Paulo Jos\u00e9 Lima","family":"Juiz","sequence":"first","affiliation":[{"name":"Center for Science and Technology in Energy and Sustainability, Federal University of Rec\u00f4ncavo da Bahia, Feira de Santana 44042-280, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Teles Barbalho","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Center for Science and Technology in Energy and Sustainability, Federal University of Rec\u00f4ncavo da Bahia, Feira de Santana 44042-280, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8258-1739","authenticated-orcid":false,"given":"Edilson Ara\u00fajo","family":"Pires","sequence":"additional","affiliation":[{"name":"Faculty of Education and Integrated Sciences of Sert\u00e3o de Canind\u00e9, State University of Cear\u00e1, Canind\u00e9 62700-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0113-7864","authenticated-orcid":false,"given":"Cristiane Flora","family":"Villarreal","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Federal University of Bahia, Salvador 40170-290, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abdulkareem, A.A., Firas, B.A., Ali, J.B., Al-Sharqia, S.S., Gulb, A.S., and Iain, L.C.C. (2023). Current concepts in the pathogenesis of periodontitis: From symbiosis to dysbiosis. J. Oral. Microbiol., 15.","DOI":"10.1080\/20002297.2023.2197779"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sedghi, L.M., Bacino, M., and Kapila, Y.L. (2021). Periodontal Disease: The Good, The Bad, and The Unknown. Frontiers in Cellular and Infection Microbiology. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.766944"},{"key":"ref_3","first-page":"9728172","article-title":"Identification of Key Genes and Pathways Associated with Oxidative Stress in Periodontitis","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Salvi, G.E., Roccuzzo, A., Imber, J.C., St\u00e4hli, A., Klinge, B., and Lang, N.P. (2023). Clinical periodontal diagnosis. Periodontol. 2000, online ahead of print.","DOI":"10.1111\/prd.12487"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jcpe.13506","article-title":"Global, regional, and national burden of severe periodontitis, 1990\u20132019: An analysis of the global burden of disease study 2019","volume":"48","author":"Chen","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_6","unstructured":"Gasner, N.S., and Schure, R.S. (2024, January 27). Periodontal Disease, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554590\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.47102\/annals-acadmedsg.2021503","article-title":"Periodontal disease and systemic health: An update for medical practitioners","volume":"51","author":"Kalhan","year":"2022","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current Concepts in the Management of Periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int. Dent. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e095","DOI":"10.1590\/1807-3107bor-2021.vol35.0095","article-title":"New tendencies in non-surgical periodontal therapy","volume":"35","author":"Haas","year":"2021","journal-title":"Braz. Oral. Res."},{"key":"ref_10","unstructured":"Poppolo, D.F., and Ouanounou, A. (2021). Mouthwashes and their use in dentistry: A review. Oral Health, 22\u201334. Available online: www.oralhealthgroup.com."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Haydari, M., Bardakci, A.G., Koldsland, O.C., Aass, A.M., Sandvik, L., and Preus, H.R. (2017). Comparing the effect of 0.06%, 0.12% and 0.2% chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: A parallel group, double masked randomized clinical trial. BMC Oral. Health, 17.","DOI":"10.1186\/s12903-017-0400-7"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103497","DOI":"10.1016\/j.jdent.2020.103497","article-title":"Current uses of chlorhexidine for management of oral disease: A narrative review","volume":"103","author":"Brookes","year":"2020","journal-title":"J. Dent."},{"key":"ref_13","first-page":"CD008676","article-title":"Chlorhexidine mouthrinse as an adjunctive treatment for gingival health","volume":"3","author":"James","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S310","DOI":"10.1093\/clinids\/16.Supplement_4.S310","article-title":"Tetracycline resistance in periodontal pathogens","volume":"16","author":"Olsvik","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1399-302X.1993.tb00583.x","article-title":"In vitro antimicrobial susceptibility of Porphyromonas gingivalis to azithromycin, a novel macrolide","volume":"8","author":"Pajukanta","year":"1993","journal-title":"Oral. Microbiol. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1034\/j.1600-0765.2002.00004.x","article-title":"Selection of antimicrobial agents in periodontal therapy","volume":"37","author":"Slots","year":"2002","journal-title":"J. Periodontal. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S1517-83822000000400003","article-title":"Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria","volume":"31","author":"Nascimento","year":"2000","journal-title":"Braz. J. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1902\/jop.2015.140378","article-title":"Periodontal regeneration\u2014Intrabony defects: A consensus report from the AAP Regeneration Workshop","volume":"86","author":"Reynolds","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1034\/j.1600-0757.2000.2220106.x","article-title":"Osseous resective surgery","volume":"22","author":"Carnevale","year":"2000","journal-title":"Periodontol. 2000"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/idj.12247","article-title":"Non-surgical management of tooth hypersensitivity","volume":"66","author":"Clark","year":"2016","journal-title":"Int. Dent. J."},{"key":"ref_21","first-page":"303","article-title":"A modified papilla preservation technique, 22 years later","volume":"40","author":"Checchi","year":"2009","journal-title":"Quintessence Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/2319-5932.144784","article-title":"Dentistry meets nature-role of herbs in periodontal care: A systematic review","volume":"12","author":"Pandita","year":"2014","journal-title":"J. Indian. Assoc. Public Health Dent."},{"key":"ref_23","first-page":"35","article-title":"Phytodentistry\u2014A boon","volume":"2","author":"Kaur","year":"2016","journal-title":"Arch. Dent. Med. Res."},{"key":"ref_24","first-page":"1","article-title":"Herbal therapy in periodontics: A review","volume":"3","author":"Anand","year":"2017","journal-title":"J. Res. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13756-019-0559-6","article-title":"Review on plant antimicrobials: A mechanistic viewpoint","volume":"8","author":"Khameneh","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Valverde, N., L\u00f3pez-Valverde, A., Montero, J., Rodr\u00edguez, C., Macedo de Sousa, B., and Aragoneses, J.M. (2023). Antioxidant, anti-inflammatory and antimicrobial activity of natural products in periodontal disease: A comprehensive review. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1226907"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Vo, T.T.T., Pei-Ming, C., Vo, P.T., Joyce, S.L.T., and I-Ta, L. (2020). The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights. Antioxidants, 9.","DOI":"10.3390\/antiox9121211"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral Microbiome: Unveiling the Fundamentals","volume":"23","author":"Deo","year":"2019","journal-title":"J. Oral. Maxillofac. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12275-020-9556-y","article-title":"Instruction of Microbiome Taxonomic Profiling Based on 16S rRNA Sequencing","volume":"58","author":"Kim","year":"2020","journal-title":"J. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1128\/aem.56.12.3890-3894.1990","article-title":"Intrageneric coaggregation among strains of human oral bacteria: Potential role in primary colonization of the tooth surface","volume":"56","author":"Kolenbrander","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4161\/viru.2.5.16140","article-title":"Bacterial interactions in dental biofilm","volume":"2","author":"Huang","year":"2011","journal-title":"Virulence"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/prd.12361","article-title":"The dental plaque biofilm matrix","volume":"86","author":"Jakubovics","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1128\/AEM.70.7.4340-4348.2004","article-title":"Development of a multispecies oral bacterial community in a saliva-conditioned flow cell","volume":"70","author":"Foster","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12331","article-title":"Current Understanding of Periodontal Disease Pathogenesis and Targets for Host-Modulation Therapy","volume":"84","author":"Hajishengallis","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_35","first-page":"530286","article-title":"The Nexus Between Periodontal Inflammation and Dysbiosis","volume":"11","author":"Bartold","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0952-7915(01)00304-1","article-title":"Toll-likereceptors:keymedi- ators of microbe detection","volume":"14","author":"Underhill","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/prd.12005","article-title":"Periodontal disease immunology: \u201cdouble indemnity\u201d in protecting the host","volume":"62","author":"Ebersole","year":"2013","journal-title":"Periodontol. 2000"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jcpe.12194","article-title":"Crevicular fluid biomark- ers and periodontal disease progression","volume":"41","author":"Kinney","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.archoralbio.2015.05.007","article-title":"The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review","volume":"60","author":"Muniz","year":"2015","journal-title":"Arch. Oral. Biol."},{"key":"ref_40","unstructured":"Newman, M.G., Takei, H., Klokkevold, H.P.R., and Carranza, F.A. (2012). Carranza\u2019s Clinical Periodontology, Elsevier Saunders. [11th ed.]."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1902\/jop.2005.76.11-S.2033","article-title":"Immune response: The key to bone resorption in periodontal disease","volume":"76","author":"Taubman","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"116500","DOI":"10.1016\/j.bone.2022.116500","article-title":"Osteoimmunology in periodontitis; a paradigm for Th17\/IL-17 inflammatory bone loss","volume":"163","author":"Ikeuchi","year":"2022","journal-title":"Bone"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"64","author":"Cekici","year":"2014","journal-title":"Periodontol. 2000"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-051X.2006.01029.x","article-title":"Compromised GCF total antioxidant capacity in periodontitis: Cause or effect?","volume":"34","author":"Chapple","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00784-016-2029-3","article-title":"Salivary oxidative stress biomarkers in chronic periodontitis and acute coronary syndrome","volume":"21","author":"Nguyen","year":"2017","journal-title":"Clin. Oral. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Chu, X., Sun, Z., Baek, D.S., Li, W., Mellors, J.W., Shapiro, S.D., and Dimitrov, D.S. (2021). Human antibody domains and fragments targeting neutrophil elastase as candidate therapeutics for cancer and inflammation-related diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011136"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-051X.2010.01678.x","article-title":"How has neutrophil research improved our understanding of periodontal pathogenesis?","volume":"38","author":"Nussbaum","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.actbio.2021.08.009","article-title":"Remodeling the periodontitis microenvironment for osteogenesis by using a reactive oxygen species-cleavable nanoplatform","volume":"135","author":"Qiu","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 6.","DOI":"10.3390\/ijms20133328"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/prd.12269","article-title":"Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics","volume":"82","author":"Marchesan","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fphys.2017.00351","article-title":"Pathways that Regulate ROS Scavenging Enzymes, and Their Role in Defense Against Tissue Destruction in Periodontitis","volume":"8","author":"Kanzaki","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tiv.2012.01.022","article-title":"Continuous presence of H2O2 induces mitochondrial-mediated, MAPK- and caspase-independent growth inhibition and cytotoxicity in human gingival fibroblasts","volume":"26","author":"Yu","year":"2012","journal-title":"Toxicol. In Vitro"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41368-022-00177-1","article-title":"Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system","volume":"14","author":"Xin","year":"2022","journal-title":"Int. J. Oral. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/187152011795677544","article-title":"Superoxide dismutase in redox biology: The roles of superoxide and hydrogen peroxide","volume":"11","author":"Buettner","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1089\/ars.2011.4123","article-title":"Redox Regulation of Mitochondrial Function","volume":"16","author":"Handy","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"419","DOI":"10.17219\/dmp\/112151","article-title":"Activity of enzymatic antioxidants in periodontitis: A systematic overview of the literature","volume":"56","author":"Toczewska","year":"2019","journal-title":"Dent. Med. Probl."},{"key":"ref_57","first-page":"25","article-title":"Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis","volume":"24","author":"Zhang","year":"2022","journal-title":"Medicine"},{"key":"ref_58","first-page":"185","article-title":"Responsible use of antimicrobials in periodontics","volume":"28","author":"Jorgensen","year":"2000","journal-title":"J. Calif. Dent. Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Taalab, M.R., Mahmoud, S.A., Moslemany, R.M.E., and Abdelaziz, D.M. (2021). Intrapocket application of tea tree oil gel in the treatment of stage 2 periodontitis. BMC Oral. Health, 5.","DOI":"10.1186\/s12903-021-01588-y"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1007\/s00784-021-03929-1","article-title":"Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of stage-III periodontitis patients: A randomized controlled clinical trial","volume":"25","author":"Elbehwashy","year":"2021","journal-title":"Clin. Oral. Investig."},{"key":"ref_61","unstructured":"Socialstyrelsen (2011). Nationella Riktlinjer f\u00f6r Vuxentandv\u00e5rd 2011-St\u00f6d f\u00f6r Styrning Och Ledning, Socialstyrelsen. Available online: https:\/\/www.socialstyrelsen.se\/en\/clinical-practise-guidelines-and-regulations\/regulations-and-guidelines\/national-guidelines\/."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s13063-022-06298-6","article-title":"The effect of (-)-epigallocatechin gallate as an adjunct to nonsurgical periodontal treatment: A randomized clinical trial","volume":"3","author":"Zeng","year":"2022","journal-title":"Trials"},{"key":"ref_63","unstructured":"EPO-European Patent Office (2024, March 09). Available online: www.epo.org."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Dosed\u011bl, M., Jirkovsk\u00fd, E., Mac\u00e1kov\u00e1, K., Kr\u010dmov\u00e1, L.K., Javorsk\u00e1, L., Pourov\u00e1, J., Mercolini, L., Remi\u00e3o, F., Nov\u00e1kov\u00e1, L., and Mlad\u011bnka, P. (2021). Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients, 13.","DOI":"10.3390\/nu13020615"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbrc.2012.11.110","article-title":"Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts","volume":"430","author":"Kishimoto","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bechara, N., Flood, V.M., and Gunton, J.E. (2022). A Systematic Review on the Role of Vitamin C in Tissue Healing. Antioxidants, 19.","DOI":"10.3390\/antiox11081605"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/00016357.2020.1734656","article-title":"Immune modulatory and antioxidant effects of locally administrated vitamin C in experimental periodontitis in rats","volume":"78","author":"Aytekin","year":"2020","journal-title":"Acta Odontol. Scand."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s13054-014-0460-x","article-title":"Vitamin C revisited","volume":"18","year":"2014","journal-title":"Crit. Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6679708","DOI":"10.1155\/2021\/6679708","article-title":"Ascorbic Acid: A New Player of Epigenetic Regulation in LPS-gingivalis Treated Human Periodontal Ligament Stem Cells","volume":"19","author":"Marconi","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pizzicannella, J., Diomede, F., Gugliandolo, A., Chiricosta, L., Bramanti, P., Merciaro, I., Orsini, T., Mazzon, E., and Trubiani, O. (2019). 3D printing PLA\/gingival stem cells\/ EVs upregulate miR-2861 and -210 during osteoangiogenesis commitment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133256"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e20200444","DOI":"10.1590\/1678-7757-2020-0444","article-title":"Effects of vitamin C local application on ligature-induced periodontitis in diabetic rats","volume":"28","author":"Toraman","year":"2020","journal-title":"J. Appl. Oral. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jobcr.2023.05.003","article-title":"Effect of non surgical periodontal therapy and vitamin C supplementation on total antioxidant capacity in patients with chronic generalised periodontitis\u2014A randomised controlled trial","volume":"13","author":"Nisha","year":"2023","journal-title":"J. Oral. Biol. Craniofac. Res."},{"key":"ref_73","unstructured":"(2024, February 15). Reportlinker.com. Vitamin in United States Market Overview 2023\u20132027. Market Overview Report\u2014August 2023. Available online: https:\/\/www.reportlinker.com\/market-report\/DietarySupplement\/491893\/Vitamin?term=vitamin%20market&matchtype=b&loc_interest=&loc_physical=1001521&utm_group=standard&utm_term=vitamin%20market&utm_campaign=ppc&utm_source=google_ads&utm_medium=paid_ads&utm_content=transactionnel-1&gad_source=1&gclid=Cj0KCQiAoeGuBhCBARIsAGfKY7zhBzXJNBNIrZsLN_yl_ToqZVUE3tEej-k2cbQ0Xe5pfewZ6qKEhykaAhuzEALw_wcB."},{"key":"ref_74","unstructured":"(2024, February 15). Spoke Sciences. Available online: https:\/\/www.spokesciences.com."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Gandhi, M., Elfeky, O., Ertugrul, H., Chela, H.K., and Daglilar, E. (2023). Scurvy: Rediscovering a Forgotten Disease. Diseases, 26.","DOI":"10.3390\/diseases11020078"},{"key":"ref_76","unstructured":"Lateef, A., Darwesh, O.M., and Matter, I.A. (2021). Microbial Nanobiotechnology, Springer."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2174\/1567201816666190828153017","article-title":"Crossing the blood-brain barrier: A review on drug delivery strategies for treatment of the central nervous system diseases","volume":"16","author":"Mansor","year":"2019","journal-title":"Curr. Drug Deliv."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Mughal, T.A., Ali, S., Hassan, A., Kazmi, S.A.R., Saleem, M.Z., Shakir, H.A., Nazer, S., Farooq, M.A., Awan, M.Z., and Khan, M.A. (2021). Phytochemical screening, antimicrobial activity, in vitro and in vivo antioxidant activity of Berberis lycium Royle root bark extract. Braz. J. Biol., 84.","DOI":"10.1590\/1519-6984.249742"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Sionov, R.V., and Steinberg, D. (2022). Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria. Microorganisms, 16.","DOI":"10.3390\/microorganisms10061239"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1503\/cmaj.060228","article-title":"High-dose vitamin C therapy","volume":"174","author":"Assouline","year":"2006","journal-title":"Can. Med. Assoc. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.jnutbio.2015.07.001","article-title":"Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues","volume":"26","author":"Chu","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"114","DOI":"10.20473\/j.djmkg.v55.i2.p114-119","article-title":"A mucoadhesive gingival patch with Epigallocatechin-3-gallate green tea (Camellia sinensis) as an alternative adjunct therapy for periodontal disease: A narrative review","volume":"55","author":"Ramadhani","year":"2022","journal-title":"Dent. J."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Lin, S.Y., Kang, L., Wang, C.Z., Huang, H.H., Cheng, T.L., Huang, H.T., Lee, M.J., Lin, Y.S., Ho, M.L., and Wang, G.J. (2018). (-)-Epigallocatechin-3-gallate (EGCG) enhances osteogenic differentiation of human bone marrow mesenchymal stem cells. Molecules, 23.","DOI":"10.3390\/molecules23123221"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jobcr.2022.08.007","article-title":"The ability of mucoadhesive gingival patch loaded with EGCG on IL-6 and IL-10 expression in periodontitis","volume":"12","author":"Lashari","year":"2022","journal-title":"J. Oral. Biol. Craniofac. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Xu, D., Hu, M.J., Wang, Y.Q., and Cui, Y.L. (2019). Antioxidant activities of quercetin and its complexes for medicinal application. Molecules, 24.","DOI":"10.3390\/molecules24061123"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e2101505","DOI":"10.1002\/smll.202101505","article-title":"Quercetin-Loaded Ceria Nanocomposite Potentiate Dual-Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation","volume":"17","author":"Wang","year":"2021","journal-title":"Small"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Saha, S., Buttari, B., Panieri, E., Profumo, E., and Saso, L. (2020). An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules, 23.","DOI":"10.3390\/molecules25225474"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.2147\/DDDT.S315249","article-title":"Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis","volume":"15","author":"Wei","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.exger.2005.08.009","article-title":"Melatonin and sleep in aging population","volume":"40","author":"Zisapel","year":"2005","journal-title":"Exp. Gerontol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/S0021-9258(18)69351-2","article-title":"Isolation of Melatonin and 5-Methoxyindole-3-acetic Acid from Bovine Pineal Glands","volume":"235","author":"Lerner","year":"1960","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3389\/fpls.2021.683047","article-title":"A Systematic Review of Melatonin in Plants: An Example of Evolution of Literature","volume":"12","author":"Murch","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mce.2012.01.004","article-title":"Melatonin membrane receptors in peripheral tissues: Distribution and functions","volume":"351","author":"Slominski","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Purpura, S., Fernandes, G.V.O., Oliveira, F.P., and de Castro, F.C. (2022). Effects of Melatonin in the Non-Surgical Treatment of Periodontitis: A Systematic Review. Appl. Sci., 12.","DOI":"10.3390\/app122211698"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.3390\/ma8095273","article-title":"Biodegradable Materials for Bone Repair and Tissue Engineering Applications","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Kone\u010dn\u00e1, B., Chobodov\u00e1, P., Janko, J., Ba\u0148asov\u00e1, L., B\u00e1b\u00ed\u010dkov\u00e1, J., Celec, P., and T\u00f3thov\u00e1, \u013d. (2021). The Effect of Melatonin on Periodontitis. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms22052390"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Laurindo, L.F., de Carvalho, G.M., de Oliveira, Z.B., Figueira, M.E., Direito, R., de Alvares Goulart, R., Buglio, D.S., and Barbalho, S.M. (2023). Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics15010229"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1080\/10408398.2020.1850417","article-title":"Curcumin, autoimmune and inflammatory diseases: Going beyond conventional therapy\u2014A systematic review","volume":"62","author":"Marton","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"119125","DOI":"10.1016\/j.lfs.2021.119125","article-title":"Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo","volume":"270","author":"Tan","year":"2021","journal-title":"Life Sci."},{"key":"ref_100","first-page":"90","article-title":"Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to Scaling and Root Planing: A Clinical Study","volume":"7","author":"Anuradha","year":"2015","journal-title":"J. Int. Oral. Health"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Iova, G.M., Calniceanu, H., Popa, A., Szuhanek, C.A., Marcu, O., Ciavoi, G., and Scrobota, I. (2021). The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats. Molecules, 26.","DOI":"10.3390\/molecules26051332"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0165-1110(90)90014-3","article-title":"Possible Mutagens Derived from Lipids and Lipid Precursors","volume":"238","author":"Esterbauer","year":"1990","journal-title":"Mutat. Res.\/Rev. Genet. Toxicol."},{"key":"ref_103","first-page":"398","article-title":"Malondialdehyde Epitopes as Mediators of Sterile Inflammation","volume":"1862","author":"Busch","year":"2017","journal-title":"Biochim. Et Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_104","first-page":"501","article-title":"Properties and molecular mechanisms of resveratrol: A review","volume":"70","author":"Yang","year":"2015","journal-title":"Pharmazie"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1073\/pnas.1118462109","article-title":"Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance","volume":"109","author":"Gao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1172\/JCI11914","article-title":"Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer","volume":"107","author":"Yamamoto","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/JPER.17-0352","article-title":"Resveratrol derivative-rich melinjo seed extract induces healing in a murine model of established periodontitis","volume":"89","author":"Ikeda","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_108","unstructured":"Hevkalyuk, N.O. (2018). Clinical effectiveness of phytopreparatum \u201cRESVERAZIN\u201d in the complex treatment of generalized parodontitis. DOAJ."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.addr.2020.07.002","article-title":"Liposomes: Advancements and innovation in the manufacturing process","volume":"154\u2013155","author":"Shah","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/ijdr.IJDR_227_20","article-title":"Efficacy of antioxidants therapy on progression of periodontal disease\u2014A randomized control trial","volume":"32","author":"Wasti","year":"2021","journal-title":"Indian J. Dent. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00784-022-04789-z","article-title":"Effect of antioxidant lycopene on human osteoblasts","volume":"27","author":"Bengi","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"ref_112","first-page":"32","article-title":"The effect of Zingiber, Alpinia officinarum with periodontal therapy on clinical outcome and oxidative stress","volume":"49","author":"Muhammed","year":"2022","journal-title":"J. Hunan Univ. (Nat. Sci.)"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"103","DOI":"10.26682\/sjuod.2021.24.2.11","article-title":"The effect of Pepper Nigrum, Olea Europaea mouthwash with non surgical periodontal therapy on clinical outcome and oxidative stress in chronic periodontitis patients","volume":"24","author":"Salih","year":"2021","journal-title":"J. Duhok Univ."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"302","DOI":"10.12688\/f1000research.129891.3","article-title":"Efficacy of Lycium barbarum (Goji berry) mouthwash for managing periodontitis: A randomized clinical trial [version 2; peer review: 2 approved with reservations]","volume":"12","author":"Sanghavi","year":"2023","journal-title":"F1000Research"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"287","DOI":"10.9734\/jpri\/2021\/v33i61A35588","article-title":"Preparation of Mouthwash Using Red Tea and Its Antimicrobial and Antioxidant Activity","volume":"33","author":"Ramamoorthy","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Muddathir, A.M., Mohieldin, E.A.M., and Mitsunaga, T. (2020). In vitro activities of Acacia nilotica (L.) Delile bark fractions against Oral Bacteria, Glucosyltransferase and as antioxidant. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-020-03147-4"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1055\/s-0041-1741374","article-title":"Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study","volume":"17","author":"Nugraha","year":"2023","journal-title":"Eur. J. Dent."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"27211","DOI":"10.34117\/bjdv8n4-296","article-title":"(Antimicrobial and antioxidant activity of hydroalcoholic extracts of bee propolis (Tetragonisca angustula) and\/or Calendula officinalis and potential use in mouthwash formulation\/Atividade antimicrobiana e antioxidante de extratos hidroalco\u00f3licos de propolis de abelha (Tetragonisca angustula) e\/ou Calendula officinalis e potencial uso na formula\u00e7\u00e3o de enxaguantes bucais","volume":"8","author":"Ansiliero","year":"2022","journal-title":"Braz. J. Dev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e122155","DOI":"10.5812\/jjnpp-122155","article-title":"Evaluation of Aloe vera as a Natural Pharmaceutic in Mouthwashes: A Narrative Review","volume":"17","author":"Poorkazemi","year":"2022","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"798","DOI":"10.5005\/jp-journals-10024-3573","article-title":"Comparative Evaluation of the Effectiveness of Triphala and Chlorhexidine in Full-mouth Disinfection Treatment of Periodontitis in Type 2 Diabetes Patients","volume":"24","author":"Rathod","year":"2023","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_121","first-page":"63","article-title":"Comprehensive Review on Ficus deltoidea Effervescent Mouthwash Formulation in Treating Oral Pathogens","volume":"7","author":"Mehul","year":"2021","journal-title":"Int. J. Health Med. Sci. Acad. Res. Publ. Group"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Tahmasebi, E., Maskani, P., Farimani, M.M., Mosaddad, S.A., Hosseini, Z.S., Ranjbar, R., Salesi, M., and Yazdanian, M. (2023). Investigation of cytotoxicity and oral antibacterial effects of four biomaterials\/herbal formulations. Biomass Conv. Bioref., 1\u201319.","DOI":"10.1007\/s13399-023-04897-0"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Milia, E.P., Sardellitti, L., and Eick, S. (2023). Antimicrobial Efficiency of Pistacia lentiscus L. Derivates against Oral Biofilm-Associated Diseases\u2014A Narrative Review. Microorganisms, 11.","DOI":"10.3390\/microorganisms11061378"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3329\/bjms.v22i20.66312","article-title":"The Medicinal Chemistry of Curcuma longa: A Narrative Review","volume":"22","author":"Bhandary","year":"2023","journal-title":"Bangladesh J. Med. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"354","DOI":"10.9734\/jpri\/2021\/v33i61A35595","article-title":"Evaluation of Efficacy of 20% Nigella sativa on Gingival Health","volume":"33","author":"Ilangovan","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"ref_126","first-page":"3193","article-title":"Evaluation of cytotoxic activity of Chrysopogon zizanioides mouthwash\u2014An in vitro study","volume":"12","author":"Saravanan","year":"2020","journal-title":"Int. J. Pharm. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1287\/mnsc.48.1.90.14271","article-title":"Who is selling the ivory tower? Sources of growth in university licensing","volume":"48","author":"Thursby","year":"2002","journal-title":"Manag. Sci."},{"key":"ref_128","unstructured":"(2023, December 12). FMI\u2014Future Market Insights. Available online: https:\/\/www.futuremarketinsights.com\/reports\/antioxidants-market."},{"key":"ref_129","unstructured":"(2023, December 12). Markets and Markets. Available online: https:\/\/www.marketsandmarkets.com\/Market-Reports\/oral-care-market-80546246.html?gad_source=1&gclid=Cj0KCQiAm4WsBhCiARIsAEJIEzWCLkrJBi16B6RKjulGAzeW6sbXugBldOsYi8RPH3uEPX-kStvTdSwaAvUIEALw_wcB."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/5\/566\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:39:08Z","timestamp":1760107148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/5\/566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":129,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["antiox13050566"],"URL":"https:\/\/doi.org\/10.3390\/antiox13050566","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]}}}