{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:16:47Z","timestamp":1791433007701,"version":"4.3.3"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Innovation 2030-Major Project","award":["2023ZD0406307"],"award-info":[{"award-number":["2023ZD0406307"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The natural edible characteristics of Chinese herbs have led more and more people to study them as an alternative product to antibiotics. In this study, crude extracts of Glycyrrhiza radix and Atractylodes macrocephala (abbreviated as GRAM) with glycyrrhizic acid content not less than 0.2 mg\/g were selected to evaluate the effects of GRAM on the immune and antioxidant capacity of model animals. Thirty 21-day-old male Leghorn chickens were weighed and randomly assigned to one of three groups of ten animals each. The treatments comprised a control group (CON), in which saline was injected at day 31, day 33, and day 35, an LPS-treated group (LPS), in which LPS (0.5 mg\/kg of BW) was injected at day 31, day 33, and day 35, and finally a GRAM and LPS-treated group, (G-L) in which a GRAM-treated diet (at GRAM 2 g\/kg) was fed from day 21 to day 35 with LPS injection (0.5 mg\/kg of BW) at day 31, day 33, and day 35. The results of diarrhea grade and serum antioxidant measurement showed that the LPS group had obvious diarrhea symptoms, serum ROS and MDA were significantly increased, and T-AOC was significantly decreased. The oxidative stress model of LPS was successfully established. The results of immune and antioxidant indexes showed that feeding GRAM significantly decreased levels of the pro-inflammatory factors TNF-\u03b1, IL-1\u03b2, and IL-6 (p &lt; 0.05) and significantly increased levels of the anti-inflammatory factors IL-4 and IL-10 and levels of the antioxidant enzymes GSH-Px and CAT (p &lt; 0.05). GRAM resisted the influence of LPS on ileum morphology, liver, and immune organs and maintained normal index values for ileum morphology, liver, and immune organs. In summary, this study confirmed the antidiarrheal effect of GRAM, which improved the immune and antioxidant capacity of model animals by regulating inflammatory cytokine levels and antioxidant enzyme activity in poultry.<\/jats:p>","DOI":"10.3390\/antiox13050578","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T12:27:11Z","timestamp":1715171231000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Crude Extract of Glycyrrhiza Radix and Atractylodes macrocephala on Immune and Antioxidant Capacity of SPF White Leghorn Chickens in an Oxidative Stress Model"],"prefix":"10.3390","volume":"13","author":[{"given":"Chaosheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-0977","authenticated-orcid":false,"given":"Guohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agriculture Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1017\/S1466252316000207","article-title":"Alternatives to Antibiotics for Maximizing Growth Performance and Feed Efficiency in Poultry: A Review","volume":"18","author":"Gadde","year":"2017","journal-title":"Anim. Health Res. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.aninu.2018.03.002","article-title":"Use of Antibiotics in Broiler Production: Global Impacts and Alternatives","volume":"4","author":"Mehdi","year":"2018","journal-title":"Anim. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.ijbiomac.2022.09.227","article-title":"Recent Advances in Medicinal and Edible Homologous Polysaccharides: Extraction, Purification, Structure, Modification, and Biological Activities","volume":"222","author":"Xue","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ma, A., Zou, F., Zhang, R., and Zhao, X. (2022). The Effects and Underlying Mechanisms of Medicine and Food Homologous Flowers on the Prevention and Treatment of Related Diseases. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14430"},{"key":"ref_5","first-page":"185","article-title":"A Molecular Docking Study of Rhizoma Atractylodis and Rhizoma Atractylodis Macrocephalae Herbal Pair with Respect to Type 2 Diabetes Mellitus","volume":"5","author":"Chen","year":"2018","journal-title":"J. Tradit. Chin. Med. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ijbiomac.2019.06.059","article-title":"Polysaccharide Extracted From Atractylodes Macrocephala Koidz (Pamk) Induce Apoptosis in Transplanted H22 Cells in Mice","volume":"137","author":"Feng","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_7","first-page":"3585","article-title":"Comparison of Volatile Oil of Atractylodis Rhizoma and Atractylodis Macrocephalae Rhizoma before and after Co-Decocting by Using GC-MS","volume":"25","author":"Song","year":"2023","journal-title":"Mod. Tradit. Chin. Med. Mater. Medica-World Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/ptr.6598","article-title":"Protective Effects of Glycycoumarin On Liver Diseases","volume":"34","author":"Zhang","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ijbiomac.2020.03.192","article-title":"Chemical Structure and Effects of Antioxidation and Against Alpha-Glucosidase of Natural Polysaccharide from Glycyrrhiza Inflata Batalin","volume":"155","author":"Pan","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115686","DOI":"10.1016\/j.jep.2022.115686","article-title":"Chemical Analysis of the Chinese Herbal Medicine Licorice (Gan-Cao): An Update Review","volume":"299","author":"Shang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3821248","DOI":"10.1155\/2020\/3821248","article-title":"Natural Chalcones in Chinese Materia Medica: Licorice","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid. Based Complement Altern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Leite, C., Bonafe, G.A., Carvalho, S.J., Martinez, C., Ortega, M.M., and Ribeiro, M.L. (2022). The Anti-Inflammatory Properties of Licorice (Glycyrrhiza Glabra)-Derived Compounds in Intestinal Disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084121"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/tox.23715","article-title":"Isoliquiritigenin Induces Oxidative Stress and Immune Response in Zebrafish Embryos","volume":"38","author":"Su","year":"2023","journal-title":"Environ. Toxicol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"722567","DOI":"10.3389\/fvets.2021.722567","article-title":"Methionine Deficiency Affects Liver and Kidney Health, Oxidative Stress, and Ileum Mucosal Immunity in Broilers","volume":"8","author":"Song","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"649785","DOI":"10.3389\/fcvm.2021.649785","article-title":"Systematic Understanding of Pathophysiological Mechanisms of Oxidative Stress-Related Conditions-Diabetes Mellitus, Cardiovascular Diseases, and Ischemia-Reperfusion Injury","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.aninu.2021.10.006","article-title":"Nutritional Strategies to Alleviate Oxidative Stress in Sows","volume":"9","author":"Li","year":"2022","journal-title":"Anim. Nutr."},{"key":"ref_17","first-page":"6137","article-title":"Biological Functions of Atractyodes lancea Extract and Its Application Prospect in Livestock and Poultry Production","volume":"35","author":"Gao","year":"2023","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1080\/21655979.2021.1937445","article-title":"Glycyrrhizic Acid Alleviates the Meconium-Induced Acute Lung Injury in Neonatal Rats by Inhibiting Oxidative Stress through Mediating the Keap1\/Nrf2\/Ho-1 Signal Pathway","volume":"12","author":"Zhu","year":"2021","journal-title":"Bioengineered"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhou, Q., Zhang, S., Geng, X., Jiang, H., Dai, Y., Wang, P., Hua, M., Gao, Q., Lang, S., and Hou, L. (2022). Antioxidant Effects of Roasted Licorice in a Zebrafish Model and its Mechanisms. Molecules, 27.","DOI":"10.3390\/molecules27227743"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tang, T., Wang, X., Wang, L., Chen, M., Cheng, J., Zuo, M., Gu, J., Ding, R., Zhou, P., and Huang, J. (2022). Liquiritin Inhibits H2O2-Induced Oxidative Stress Injury in H9C2 Cells via the Ampk\/Sirt1\/Nf-kb Signaling Pathway. J Food Biochem, 46.","DOI":"10.1111\/jfbc.14351"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Li, L., He, Y., Wang, N., Li, Y., Du, Y., He, N., Wang, B., and Zhang, T. (2023). Atractylone in the Atractylodes Macrocephala Rhizoma Essential Oil and its Anti-Inflammatory Activity. Molecules, 28.","DOI":"10.3390\/molecules28217340"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Shi, K., Xiao, Y., Dong, Y., Wang, D., Xie, Y., Tu, J., Xu, K., Zhou, Z., Cao, G., and Liu, Y. (2022). Protective Effects of Atractylodis Lancea Rhizoma On Lipopolysaccharide-Induced Acute Lung Injury Via Tlr4\/Nf-Kappab and Keap1\/Nrf2 Signaling Pathways In Vitro and In Vivo. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232416134"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.joca.2012.02.010","article-title":"Improving Bioscience Research Reporting: The Arrive Guidelines for Reporting Animal Research","volume":"20","author":"Kilkenny","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3945\/jn.112.164947","article-title":"Fish Oil Enhances Intestinal Integrity and Inhibits Tlr4 and Nod2 Signaling Pathways in Weaned Pigs After Lps Challenge","volume":"142","author":"Liu","year":"2012","journal-title":"J. Nutr."},{"key":"ref_25","first-page":"136","article-title":"Effects of Live Yeast on Immune Responses and Intestinal Morphological Structure in Lipopolysaccharide-Challenged Broilers","volume":"97","author":"Wang","year":"2017","journal-title":"Can. J. Anim. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.anifeedsci.2015.07.001","article-title":"Bacillus Amyloliquefaciens Supplementation Alleviates Immunological Stress and Intestinal Damage in Lipopolysaccharide-Challenged Broilers","volume":"208","author":"Li","year":"2015","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.it.2012.09.004","article-title":"The Inflammatory Response in Sepsis","volume":"34","author":"Bosmann","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejphar.2016.04.006","article-title":"Glycyrrhizic Acid Pretreatment Prevents Sepsis-Induced Acute Kidney Injury via Suppressing Inflammation, Apoptosis and Oxidative Stress","volume":"781","author":"Zhao","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1159\/000493874","article-title":"N-Acetylcysteine Suppresses Lps-Induced Pathological Angiogenesis","volume":"49","author":"Zhang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1753425918769372","article-title":"Lps Challenge Increased Intestinal Permeability, Disrupted Mitochondrial Function and Triggered Mitophagy of Piglets","volume":"24","author":"Cao","year":"2018","journal-title":"Innate. Immun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3382\/ps.2010-00889","article-title":"Effects of Dietary Polyphenol-Rich Grape Products on Intestinal Microflora and Gut Morphology in Broiler Chicks","volume":"90","author":"Viveros","year":"2011","journal-title":"Poult. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wen, X., Zhong, R., Dang, G., Xia, B., Wu, W., Tang, S., Tang, L., Liu, L., Liu, Z., and Chen, L. (2022). Pectin Supplementation Ameliorates Intestinal Epithelial Barrier Function Damage by Modulating Intestinal Microbiota in Lipopolysaccharide-Challenged Piglets. J. Nutr. Biochem., 109.","DOI":"10.1016\/j.jnutbio.2022.109107"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/jpn.13694","article-title":"Effect of Dietary Licorice Flavonoids Powder On Performance, Intestinal Immunity and Health of Weaned Piglets","volume":"107","author":"You","year":"2023","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liu, B., Ma, R., Yang, Q., Yang, Y., Fang, Y., Sun, Z., and Song, D. (2023). Effects of Traditional Chinese Herbal Feed Additive on Production Performance, Egg Quality, Antioxidant Capacity, Immunity and Intestinal Health of Laying Hens. Animals, 13.","DOI":"10.3390\/ani13152510"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tang, X., Liu, B., Wang, X., Yu, Q., and Fang, R. (2018). Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect Ipec-J2 Cells from Lipopolysaccharides-Induced Apoptosis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030848"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10787-017-0412-6","article-title":"Potential Usefulness of Methyl Gallate in the Treatment of Experimental Colitis","volume":"26","author":"Anzoise","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1177\/1040638719863088","article-title":"Heinz Body-Related Interference with Leukocyte and Erythrocyte Variables Obtained by an Automated Hematology Analyzer in Cats","volume":"31","author":"Dondi","year":"2019","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s11517-020-02163-3","article-title":"Combining Dc-Gan with Resnet for Blood Cell Image Classification","volume":"58","author":"Ma","year":"2020","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"102040","DOI":"10.1016\/j.psj.2022.102040","article-title":"Rubber (Hevea Brasiliensis) Seed Oil Supplementation Attenuates Immunological Stress and Inflammatory Response in Lipopolysaccharide-Challenged Laying","volume":"101","author":"Liu","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100696","DOI":"10.1016\/j.animal.2022.100696","article-title":"Efficacy of Licorice Extract on the Growth Performance, Carcass Characteristics, Blood Indices and Antioxidants Capacity in Broilers","volume":"17","author":"Toson","year":"2023","journal-title":"Animal"},{"key":"ref_41","first-page":"44","article-title":"Effect of Ginkgo biloba extract on serum biochemical index and liver function of Cichlasoma managuense","volume":"47","author":"Lu","year":"2024","journal-title":"Feed. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/ps\/84.4.553","article-title":"An Acute Inflammatory Response Alters Bone Homeostasis, Body Composition, and the Humoral Immune Response of Broiler Chickens","volume":"84","author":"Mireles","year":"2005","journal-title":"Poult. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1080\/14786419.2020.1824223","article-title":"Hepatoprotective Effect of Total Flavonoids From Glycyrrhiza Uralensis Fisch in Liver Injury Mice","volume":"35","author":"Gou","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.psj.2020.11.036","article-title":"Protective Effect of the New Prepared Atractylodes Macrocephala Koidz Polysaccharide on Fatty Liver Hemorrhagic Syndrome in Laying Hens","volume":"100","author":"Miao","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_45","first-page":"951","article-title":"Chitooligosaccharide Promotes Immune Organ Development in Broiler Chickens and Reduces Serum Lipid Levels","volume":"32","author":"Li","year":"2017","journal-title":"Histol. Histopathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1139\/cjas-2018-0055","article-title":"Effects of Oral Administration of Essential Oils On Anti-Immune Stress, Antimicrobial Properties, and Repairing the Intestinal Damage in Broilers Challenged by Lipopolysaccharide","volume":"99","author":"Liu","year":"2019","journal-title":"Can. J. Anim. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.3382\/ps\/pev124","article-title":"Bacillus Amyloliquefaciens Supplementation Alleviates Immunological Stress in Lipopolysaccharide-Challenged Broilers at Early Age","volume":"94","author":"Li","year":"2015","journal-title":"Poult. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101302","DOI":"10.1016\/j.psj.2021.101302","article-title":"Chai Hu Oral Liquid Enhances the Immune Functions of Both Spleen and Bursa of Fabricius in Heat-Stressed Broilers through Strengthening Tlr4-Tbk1 Signaling Pathway","volume":"100","author":"Tang","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.3382\/ps\/pey575","article-title":"Effect of Carvacrol Essential Oils on Immune Response and Inflammation-Related Genes Expression in Broilers Challenged by Lipopolysaccharide","volume":"98","author":"Liu","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101725","DOI":"10.1016\/j.psj.2022.101725","article-title":"Lipopolysaccharide-Induced Splenic Ferroptosis in Goslings was Alleviated by Polysaccharide of Atractylodes Macrocephala Koidz Associated with Proinflammatory Factors","volume":"101","author":"Li","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"891429","DOI":"10.3389\/fvets.2022.891429","article-title":"Effects of Glycyrrhiza Polysaccharides On Chickens\u2019 Intestinal Health and Homeostasis","volume":"9","author":"Wu","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"942253","DOI":"10.3389\/fvets.2022.942253","article-title":"Dietary Licorice Flavonoids Powder Improves Serum Antioxidant Capacity and Immune Organ Inflammatory Responses in Weaned Piglets","volume":"9","author":"Yin","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, L., Lu, M., Peng, Y., Huang, J., Tang, X., Chen, J., Li, J., Hong, X., He, M., and Fu, H. (2023). Oxidatively Stressed Extracellular Microenvironment Drives Fibroblast Activation and Kidney Fibrosis. Redox. Biol., 67.","DOI":"10.1016\/j.redox.2023.102868"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Li, Y.F., Xu, B.Y., An, R., Du, X.F., Yu, K., Sun, J.H., Zhang, G.H., Wang, W., An, L.P., and Wu, G.L. (2019). Protective Effect of Anisodamine in Rats with Glycerol-Induced Acute Kidney Injury. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1394-y"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"153657","DOI":"10.1016\/j.tox.2023.153657","article-title":"Recombinant Klotho Alleviates Vancomycin-Induced Acute Kidney Injury by Upregulating Anti-Oxidative Capacity via Jak2\/Stat3\/Gpx3 Axis","volume":"499","author":"Wang","year":"2023","journal-title":"Toxicology"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/5\/578\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:41:48Z","timestamp":1760107308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/5\/578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["antiox13050578"],"URL":"https:\/\/doi.org\/10.3390\/antiox13050578","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,8]]}}}