{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:06:22Z","timestamp":1792818382331,"version":"4.5.0"},"reference-count":115,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>The limited supply and rising demand for kidney transplantation has led to the use of allografts more susceptible to ischemic reperfusion injury (IRI) and oxidative stress to expand the donor pool. Organ preservation and procurement techniques, such as machine perfusion (MP) and normothermic regional perfusion (NRP), have been developed to preserve allograft function, though their long-term outcomes have been more challenging to investigate. We performed a systematic review and meta-analysis to examine the benefits of MP and NRP compared to traditional preservation techniques. PubMed (MEDLINE), Embase, Cochrane, and Scopus databases were queried, and of 13,794 articles identified, 54 manuscripts were included (n = 41 MP; n = 13 NRP). MP decreased the rates of 12-month graft failure (OR 0.67; 95%CI 0.55, 0.80) and other perioperative outcomes such as delayed graft function (OR 0.65; 95%CI 0.54, 0.79), primary nonfunction (OR 0.63; 95%CI 0.44, 0.90), and hospital length of stay (15.5 days vs. 18.4 days) compared to static cold storage. NRP reduced the rates of acute rejection (OR 0.48; 95%CI 0.35, 0.67) compared to in situ perfusion. Overall, MP and NRP are effective techniques to mitigate IRI and play an important role in safely expanding the donor pool to satisfy the increasing demands of kidney transplantation.<\/jats:p>","DOI":"10.3390\/antiox13060642","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:17:52Z","timestamp":1716549472000},"page":"642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Perfusion Techniques in Kidney Allograft Preservation to Reduce Ischemic Reperfusion Injury: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-9011","authenticated-orcid":false,"given":"Bima J.","family":"Hasjim","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California\u2013Irvine, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes M.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation, Northwestern Memorial Hospital, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-394X","authenticated-orcid":false,"given":"Michael","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California\u2013Irvine, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert R.","family":"Redfield","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California\u2013Irvine, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Ichii","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepatobiliary and Pancreas Surgery and Islet Cell Transplantation, University of California\u2013Irvine, Orange, CA 92868, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1093\/ndt\/gfz174","article-title":"A Single Number for Advocacy and Communication\u2014Worldwide More than 850 Million Individuals Have Kidney Diseases","volume":"34","author":"Jager","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hill, N.R., Fatoba, S.T., Oke, J.L., Hirst, J.A., O\u2019Callaghan, C.A., Lasserson, D.S., and Hobbs, F.D.R. (2016). Global Prevalence of Chronic Kidney Disease\u2014A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158765"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, Regional, and National Burden of Chronic Kidney Disease, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of Chronic Kidney Disease: An Update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.ajt.2023.02.004","article-title":"OPTN\/SRTR 2021 Annual Data Report: Kidney","volume":"23","author":"Lentine","year":"2023","journal-title":"Am. J. Transpl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and Reperfusion\u2014From Mechanism to Translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Granata, S., Votrico, V., Spadaccino, F., Catalano, V., Netti, G.S., Ranieri, E., Stallone, G., and Zaza, G. (2022). Oxidative Stress and Ischemia\/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants. Antioxidants, 11.","DOI":"10.3390\/antiox11040769"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Chapter Six\u2014Cell Biology of Ischemia\/Reperfusion Injury","volume":"Volume 298","author":"Jeon","year":"2012","journal-title":"International Review of Cell and Molecular Biology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1016\/S1743-9191(13)60029-1","article-title":"Impact of Static Cold Storage VS Hypothermic Machine Preservation on Ischemic Kidney Graft: Inflammatory Cytokines and Adhesion Molecules as Markers of Ischemia\/Reperfusion Tissue Damage. Our Preliminary Results","volume":"11","author":"Tozzi","year":"2013","journal-title":"Int. J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e13814","DOI":"10.1111\/ctr.13814","article-title":"Hypothermic Machine Perfusion Is Superior to Static Cold Storage in Deceased Donor Kidney Transplantation: A Meta-Analysis","volume":"34","author":"Tingle","year":"2020","journal-title":"Clin. Transplant."},{"key":"ref_11","first-page":"32","article-title":"Normothermic Machine Perfusion of Kidney and Ischemia-Free Kidney Transplantation","volume":"13","author":"Wu","year":"2022","journal-title":"Organ Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1016\/j.transproceed.2021.09.011","article-title":"Hypothermic Machine Perfusion of Kidney Transplant: A Mini-Review","volume":"53","author":"Tatsis","year":"2021","journal-title":"Transplant. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ghoneima, A.S., Sousa Da Silva, R.X., Gosteli, M.A., Barlow, A.D., and Kron, P. (2023). Outcomes of Kidney Perfusion Techniques in Transplantation from Deceased Donors: A Systematic Review and Meta-Analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12123871"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/bjs.5909","article-title":"Experimental Renal Preservation by Normothermic Resuscitation Perfusion with Autologous Blood","volume":"95","author":"Bagul","year":"2008","journal-title":"Br. J. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s41591-023-02376-7","article-title":"Normothermic Machine Perfusion versus Static Cold Storage in Donation after Circulatory Death Kidney Transplantation: A Randomized Controlled Trial","volume":"29","author":"Hosgood","year":"2023","journal-title":"Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.5301\/IJAO.2011.8458","article-title":"Pulsatile Perfusion Preservation for Expanded-Criteria Donors Kidneys: Impact on Delayed Graft Function Rate","volume":"34","author":"Abboud","year":"2011","journal-title":"Int. J. Artif. Organs."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jrsm.1429","article-title":"Optimally Estimating the Sample Standard Deviation from the Five-Number Summary","volume":"11","author":"Shi","year":"2020","journal-title":"Res. Synth. Methods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally Estimating the Sample Mean from the Sample Size, Median, Mid-Range, and\/or Mid-Quartile Range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat. Methods Med. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00007890-198512000-00017","article-title":"Single-Donor Cold Storage versus Machine Perfusion in Cadaver Kidney Preservation","volume":"40","author":"Alijani","year":"1985","journal-title":"Transplantation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00007890-199008000-00011","article-title":"A Prospective Controlled Trial of Cold-Storage versus Machine-Perfusion Preservation in Cadaveric Renal Transplantation","volume":"50","author":"Merion","year":"1990","journal-title":"Transplantation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00007890-199401001-00027","article-title":"The Effect of Machine Perfusion Preservation versus Cold Storage on the Function of Kidneys from Non-Heart-Beating Donors","volume":"57","author":"Matsuno","year":"1994","journal-title":"Transplantation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1016\/S0041-1345(97)00991-3","article-title":"The Effect of Machine Perfusion Preservation on Early Function of Non-Heart-Beating Donor Kidneys","volume":"29","author":"Daemen","year":"1997","journal-title":"Transplant. Proc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0041-1345(98)01626-1","article-title":"Rejection Rate and Incidence of Acute Tubular Necrosis after Pulsatile Perfusion Preservation","volume":"31","author":"Kosieradzki","year":"1999","journal-title":"Transplant. Proc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1034\/j.1399-0012.2000.140605.x","article-title":"Improved Outcomes in Cadaveric Renal Allografts with Pulsatile Preservation","volume":"14","author":"Sellers","year":"2000","journal-title":"Clin. Transplant."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1111\/j.1600-6143.2007.01877.x","article-title":"Machine Perfusion Preservation Improves Renal Allograft Survival","volume":"7","author":"Kwiatkowski","year":"2007","journal-title":"Am. J. Transplant."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1432-2277.2008.00685.x","article-title":"Impact of Pulsatile Perfusion on Postoperative Outcome of Kidneys from Controlled Donors after Cardiac Death","volume":"21","author":"Muthusamy","year":"2008","journal-title":"Transpl. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.transproceed.2008.03.052","article-title":"Machine Perfusion as a Tool to Select Kidneys Recovered From Uncontrolled Donors after Cardiac Death","volume":"40","author":"Reznik","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/TP.0b013e318187b978","article-title":"Comparison of Pulsatile Perfusion and Cold Storage for Paired Kidney Allografts","volume":"86","author":"Shah","year":"2008","journal-title":"Transplantation"},{"key":"ref_30","first-page":"14","article-title":"The Early and Long Term Function and Survival of Kidney Alografts Stored before Transplantation by Hypothermic Pulsatile Perfusion. A Prospective Randomized Study","volume":"14","author":"Kwiatkowski","year":"2009","journal-title":"Ann. Transpl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/SLA.0b013e3181ffc256","article-title":"Machine Perfusion Versus Cold Storage for the Preservation of Kidneys Donated after Cardiac Death: A Multicenter, Randomized, Controlled Trial","volume":"252","author":"Jochmans","year":"2010","journal-title":"Ann. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1111\/j.1600-6143.2010.03165.x","article-title":"Cold Machine Perfusion Versus Static Cold Storage of Kidneys Donated after Cardiac Death: A UK Multicenter Randomized Controlled Trial","volume":"10","author":"Watson","year":"2010","journal-title":"Am. J. Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1432-2277.2011.01232.x","article-title":"Machine Perfusion versus Cold Storage for Preservation of Kidneys from Expanded Criteria Donors after Brain Death: Machine Perfusion for ECD Kidneys","volume":"24","author":"Treckmann","year":"2011","journal-title":"Transpl. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1093\/ndt\/gfs321","article-title":"Machine Perfusion versus Cold Storage for the Preservation of Kidneys from Donors \u226565 Years Allocated in the Eurotransplant Senior Programme","volume":"27","author":"Gallinat","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1600-6143.2011.03983.x","article-title":"Kidney Graft Outcome and Quality (after Transplantation) From Uncontrolled Deceased Donors after Cardiac Arrest","volume":"12","author":"Hanf","year":"2012","journal-title":"Am. J. Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMc1111038","article-title":"Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation","volume":"366","author":"Moers","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jamcollsurg.2012.12.025","article-title":"To Pump or Not to Pump: A Comparison of Machine Perfusion vs Cold Storage for Deceased Donor Kidney Transplantation","volume":"216","author":"Cannon","year":"2013","journal-title":"J. Am. Coll. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.transproceed.2012.10.017","article-title":"Initial Experience with Hypothermic Machine Perfusion of Kidneys from Deceased Donors in the Uppsala Region in Sweden","volume":"45","author":"Sedigh","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/bju.12960","article-title":"Hypothermic Machine Perfusion Improves D Oppler Ultrasonography Resistive Indices and Long-term Allograft Function after Renal Transplantation: A Single-centre Analysis","volume":"116","author":"Dion","year":"2015","journal-title":"BJU Int."},{"key":"ref_40","first-page":"130","article-title":"Hypothermic Machine Perfusion Permits Extended Cold Ischemia Times with Improved Early Graft Function","volume":"13","author":"Guy","year":"2015","journal-title":"Exp. Clin. Transpl."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000431025","article-title":"Hypothermic Machine Perfusion in DCD Kidney Transplantation: A Single Center Experience","volume":"96","author":"Yao","year":"2015","journal-title":"Urol. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11845-014-1235-8","article-title":"Single Centre Experience of Hypothermic Machine Perfusion of Kidneys from Extended Criteria Deceased Heart-Beating Donors: A Comparative Study","volume":"185","author":"Forde","year":"2016","journal-title":"Ir. J. Med. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/tri.12964","article-title":"Early Experience with Hypothermic Machine Perfusion of Living Donor Kidneys\u2014A Retrospective Study","volume":"30","author":"Moser","year":"2017","journal-title":"Transpl. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1097\/TXD.0000000000000672","article-title":"Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants with High Incidence of Delayed Graft Function","volume":"3","author":"Neto","year":"2017","journal-title":"Transplant. Direct"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/aor.12836","article-title":"Effect of Hypothermic Machine Perfusion on the Preservation of Kidneys Donated after Cardiac Death: A Single-Center, Randomized, Controlled Trial","volume":"41","author":"Wang","year":"2017","journal-title":"Artif. Organs"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/aor.12828","article-title":"Outcome Improvement for Hypothermic Machine Perfusion Versus Cold Storage for Kidneys From Cardiac Death Donors","volume":"41","author":"Zhong","year":"2017","journal-title":"Artif. Organs"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1097\/TP.0000000000002188","article-title":"The Benefits of Hypothermic Machine Preservation and Short Cold Ischemia Times in Deceased Donor Kidneys","volume":"102","author":"Kox","year":"2018","journal-title":"Transplantation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.transproceed.2018.12.010","article-title":"Static Cold Storage vs Ex Vivo Machine Perfusion: Results From a Comparative Study on Renal Transplant Outcome in a Controlled Donation after Circulatory Death Program","volume":"51","author":"Arlaban","year":"2019","journal-title":"Transplant. Proc."},{"key":"ref_49","first-page":"e5091","article-title":"Outcomes of Deceased Donor Kidney Transplantation Using Expanded Criteria Donor Kidneys Following Pulsatile Preservation","volume":"11","author":"Basu","year":"2019","journal-title":"Cureus"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/ndt\/gfz175","article-title":"Comparison of Machine Perfusion versus Cold Storage in Kidney Transplant Recipients from Expanded Criteria Donors: A Cohort-Based Study","volume":"35","author":"Foucher","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"17726","DOI":"10.1038\/s41598-020-74839-7","article-title":"Decrease of Renal Resistance during Hypothermic Oxygenated Machine Perfusion Is Associated with Early Allograft Function in Extended Criteria Donation Kidney Transplantation","volume":"10","author":"Meister","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/TP.0000000000002907","article-title":"Cold Pulsatile Machine Perfusion Versus Static Cold Storage for Kidneys Donated after Circulatory Death: A Multicenter Randomized Controlled Trial","volume":"104","author":"Summers","year":"2020","journal-title":"Transplantation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/jamasurg.2021.0949","article-title":"Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant: A Randomized Clinical Trial","volume":"156","author":"Husen","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.transproceed.2021.01.022","article-title":"Hypothermic Machine Perfusion of Kidneys Compensates for Extended Storage Time: A Single Intervention with a Significant Impact","volume":"53","author":"Kruszyna","year":"2021","journal-title":"Transplant. Proc."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Weberskirch, S., Katou, S., Reuter, S., Kneifel, F., Morgul, M., Becker, F., Houben, P., Pascher, A., Vogel, T., and Radunz, S. (2022). Dynamic Parameters of Hypothermic Machine Perfusion\u2014An Image of Initial Graft Function in Adult Kidney Transplantation?. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195698"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJMoa2118265","article-title":"Hypothermia or Machine Perfusion in Kidney Donors","volume":"388","author":"Malinoski","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e1391","DOI":"10.1097\/TXD.0000000000001391","article-title":"Application of Ex Vivo Normothermic Machine Perfusion in Deceased Donors with Acute Kidney Injury with Successful Renal Transplantation: A Preliminary Experience","volume":"8","author":"Choudhary","year":"2022","journal-title":"Transplant. Direct"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1432-2277.2000.tb01086.x","article-title":"Normothermic Recirculation Reduces Primary Graft Dysfunction of Kidneys Obtained from Non-Heart-Beating Donors","volume":"13","author":"Valero","year":"2000","journal-title":"Transpl. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jamcollsurg.2010.12.033","article-title":"Lessons Learned from a Single Center\u2019s Experience with 134 Donation after Cardiac Death Donor Kidney Transplants","volume":"212","author":"Farney","year":"2011","journal-title":"J. Am. Coll. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.acuroe.2015.06.007","article-title":"Uncontrolled Non-Heartbeating Donors (Types I\u2013II) with Normothermic Recirculation vs. Heartbeating Donors: Evaluation of Functional Results and Survival","volume":"39","year":"2015","journal-title":"Actas Urol\u00f3gicas Espa\u00f1olas"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1111\/ajt.14214","article-title":"Improving the Outcomes of Organs Obtained From Controlled Donation after Circulatory Death Donors Using Abdominal Normothermic Regional Perfusion","volume":"17","author":"Suberviola","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e366","DOI":"10.1097\/TXD.0000000000000802","article-title":"First Scandinavian Protocol for Controlled Donation after Circulatory Death Using Normothermic Regional Perfusion","volume":"4","author":"Foss","year":"2018","journal-title":"Transplant. Direct"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/tri.12722","article-title":"Transplantation of Kidneys from Uncontrolled Donation after Circulatory Determination of Death: Comparison with Brain Death Donors with or without Extended Criteria and Impact of Normothermic Regional Perfusion","volume":"29","author":"Demiselle","year":"2016","journal-title":"Transpl. Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/ajt.14991","article-title":"Kidney Transplant from Uncontrolled Donation after Circulatory Death Donors Maintained by nECMO Has Long-Term Outcomes Comparable to Standard Criteria Donation after Brain Death","volume":"19","author":"Molina","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/TP.0000000000002753","article-title":"Kidney Transplant From Uncontrolled Donation after Circulatory Death: Contribution of Normothermic Regional Perfusion","volume":"104","author":"Antoine","year":"2020","journal-title":"Transplantation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.transproceed.2020.02.043","article-title":"Comparison Between Kidney Transplantation after Circulatory Death and after Brain Death: A Monocentric Retrospective Study after 1 Year of Follow-Up","volume":"52","author":"Mori","year":"2020","journal-title":"Transplant. Proc."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Delsuc, C., Faure, A., Berthiller, J., Dorez, D., Matillon, X., Meas-Yedid, V., Floccard, B., Marcotte, G., Labeye, V., and Rabeyrin, M. (2018). Uncontrolled Donation after Circulatory Death: Comparison of Two Kidney Preservation Protocols on Graft Outcomes. BMC Nephrol., 19.","DOI":"10.1186\/s12882-017-0805-1"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1111\/ajt.16622","article-title":"Improved Short-Term Outcomes of Kidney Transplants in Controlled Donation after the Circulatory Determination of Death with the Use of Normothermic Regional Perfusion","volume":"21","author":"Padilla","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e14431","DOI":"10.1111\/ctr.14431","article-title":"Transplantation of Kidneys after Normothermic Perfusion: A Single Center Experience","volume":"35","author":"Pearson","year":"2021","journal-title":"Clin. Transplant."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.kint.2018.09.014","article-title":"Kidney Transplantation from Donors after Uncontrolled Circulatory Death: The Spanish Experience","volume":"95","author":"Padilla","year":"2019","journal-title":"Kidney Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e13716","DOI":"10.1111\/ctr.13716","article-title":"Machine Perfusion of Donor Kidneys May Reduce Graft Rejection","volume":"33","author":"Samoylova","year":"2019","journal-title":"Clin. Transplant."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1158\/1078-0432.CCR-18-0088","article-title":"Multimodal Meta-Analysis of 1,494 Hepatocellular Carcinoma Samples Reveals Significant Impact of Consensus Driver Genes on Phenotypes","volume":"25","author":"Chaudhary","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Tingle, S.J., Figueiredo, R.S., Moir, J.A., Goodfellow, M., Talbot, D., and Wilson, C.H. (2019). Machine Perfusion Preservation versus Static Cold Storage for Deceased Donor Kidney Transplantation. Cochrane Database Syst. Rev., 3.","DOI":"10.1002\/14651858.CD011671.pub2"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chen, R., Wang, H., Song, L., Hou, J., Peng, J., Dai, H., and Peng, L. (2020). Predictors and One-Year Outcomes of Patients with Delayed Graft Function after Deceased Donor Kidney Transplantation. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-02181-1"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1111\/ajt.16574","article-title":"Effect of Delayed Graft Function on Longer-Term Outcomes after Kidney Transplantation from Donation after Circulatory Death Donors in the United Kingdom: A National Cohort Study","volume":"21","author":"Phillips","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/ndt\/gfn667","article-title":"Association between Delayed Graft Function and Allograft and Patient Survival: A Systematic Review and Meta-Analysis","volume":"24","author":"Yarlagadda","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e14022","DOI":"10.1111\/ctr.14022","article-title":"Financial Impact of Delayed Graft Function in Kidney Transplantation","volume":"34","author":"Kim","year":"2020","journal-title":"Clin. Transplant."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/j.1600-6143.2012.04030.x","article-title":"Cost-Effectiveness of Hypothermic Machine Preservation Versus Static Cold Storage in Renal Transplantation","volume":"12","author":"Groen","year":"2012","journal-title":"Am. J. Transplant."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.transproceed.2012.09.065","article-title":"Economic Impact of the Introduction of Machine Perfusion Preservation in a Kidney Transplantation Program in the Expanded Donor Era: Cost-Effectiveness Assessment","volume":"44","author":"Galeano","year":"2012","journal-title":"Transplant. Proc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1016\/j.transproceed.2009.10.004","article-title":"The Cost-Effectiveness of Organ Preservation Methods in Renal Transplantation: US Projections Based on the Machine Preservation Trial","volume":"41","author":"Garfield","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000334245","article-title":"Dendritic Cells and Damage-Associated Molecular Patterns: Endogenous Danger Signals Linking Innate and Adaptive Immunity","volume":"4","author":"Nace","year":"2011","journal-title":"J. Innate Immun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/CIRCULATIONAHA.119.042501","article-title":"Endothelial Cell\u2013Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production","volume":"141","author":"Liu","year":"2020","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/TP.0000000000001323","article-title":"Association Between Delayed Graft Function and Graft Loss in Donation after Cardiac Death Kidney Transplants\u2014A Paired Kidney Registry Analysis","volume":"101","author":"Lim","year":"2017","journal-title":"Transplantation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/SLA.0000000000003515","article-title":"The Neglectable Impact of Delayed Graft Function on Long-Term Graft Survival in Kidneys Donated after Circulatory Death Associates with Superior Organ Resilience","volume":"270","author":"McGuinness","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"106021","DOI":"10.1016\/j.ijsu.2021.106021","article-title":"Implementation of Donation after Circulatory Death Kidney Transplantation Can Safely Enlarge the Donor Pool: A Systematic Review and Meta-Analysis","volume":"92","author":"Rijkse","year":"2021","journal-title":"Int. J. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/TP.0000000000000070","article-title":"Donation after Circulatory Determination of Death: The University of Michigan Experience with Extracorporeal Support","volume":"98","author":"Sall","year":"2014","journal-title":"Transplantation"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/TP.0000000000004281","article-title":"In Situ Normothermic Regional Perfusion in Controlled Donation after Circulatory Determination Death: Organ Utilization, Outcomes, and Elusiveness of a Randomized Clinical Trial","volume":"107","author":"Hessheimer","year":"2023","journal-title":"Transplantation"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1177\/0963689719872699","article-title":"Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms","volume":"28","author":"Chen","year":"2019","journal-title":"Cell Transpl."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/ajt.16929","article-title":"MicroRNA Antagonist Therapy during Normothermic Machine Perfusion of Donor Kidneys","volume":"22","author":"Thompson","year":"2022","journal-title":"Am. J. Transplant."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Panisello Rosello, A., Teixeira Da Silva, R., Castro, C., Bardallo, R.G., Calvo, M., Folch-Puy, E., Carbonell, T., Palmeira, C., Rosell\u00f3 Catafau, J., and Adam, R. (2020). Polyethylene Glycol 35 as a Perfusate Additive for Mitochondrial and Glycocalyx Protection in HOPE Liver Preservation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165703"},{"key":"ref_91","unstructured":"Guarrera, J., Polyak, M., O\u2019Mar Arrington, B., Boykin, J., Brown, T., Jean-Jacques, M., Kapur, S., Stubenbord, W., and Kinkhabwala, M. (2004). Transplantation Proceedings, Elsevier."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e1250","DOI":"10.1097\/TXD.0000000000001250","article-title":"Intraoperative Verapamil Fails to Reduce Delayed Graft Function in Donation after Circulatory Death Renal Allografts","volume":"8","author":"Lovett","year":"2022","journal-title":"Transpl. Direct"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/ctr.12647","article-title":"Enhancing Kidney Function with Thrombolytic Therapy Following Donation after Cardiac Death: A Multicenter Quasi-Blinded Prospective Randomized Trial","volume":"29","author":"Woodside","year":"2015","journal-title":"Clin. Transplant."},{"key":"ref_94","first-page":"S1","article-title":"Machine Pulsatile Perfusion Parameters and Histological Findings from a Multicenter Randomized Controlled Trial of Thrombolytic Therapy Following Dcd Kidney Donation","volume":"99","author":"Woodside","year":"2015","journal-title":"Transplantation"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/TP.0000000000004269","article-title":"Abdominal Organ Preservation Solutions in the Age of Machine Perfusion","volume":"107","author":"Ramos","year":"2023","journal-title":"Transplantation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/ajt.15798","article-title":"First-in-Human Use of a Marine Oxygen Carrier (M101) for Organ Preservation: A Safety and Proof-of-Principle Study","volume":"20","author":"Badet","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_97","first-page":"S614","article-title":"Addition of an Oxygen Carrier (Hemo2life) in Preservation Solution for Preventing Ischemia Reperfusion Injuries","volume":"23","author":"Jaishankar","year":"2023","journal-title":"Am. J. Transplant."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s13063-023-07302-3","article-title":"Evaluation of the Efficacy of HEMO2life\u00ae, a Marine OXYgen Carrier for Organ Preservation (OxyOp2) in Renal Transplantation: Study Protocol for a Multicenter Randomized Trial","volume":"24","author":"Nowak","year":"2023","journal-title":"Trials"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.etap.2009.12.006","article-title":"Quercetin Protects Rat Liver against Lead-Induced Oxidative Stress and Apoptosis","volume":"29","author":"Liu","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e624","DOI":"10.1097\/TXD.0000000000001077","article-title":"A Novel Preservation Solution Containing Quercetin and Sucrose for Porcine Kidney Transplantation","volume":"6","author":"Gochi","year":"2020","journal-title":"Transplant. Direct"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.juro.2015.07.096","article-title":"Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation","volume":"194","author":"Lobb","year":"2015","journal-title":"J. Urol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.niox.2018.10.004","article-title":"H2S Supplementation: A Novel Method for Successful Organ Preservation at Subnormothermic Temperatures","volume":"81","author":"Juriasingani","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.redox.2015.04.008","article-title":"Protection against Renal Ischemia\u2013Reperfusion Injury in Vivo by the Mitochondria Targeted Antioxidant MitoQ","volume":"5","author":"Dare","year":"2015","journal-title":"Redox Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1046\/j.1523-1755.2000.00212.x","article-title":"Tempol, a Membrane-Permeable Radical Scavenger, Reduces Oxidant Stress-Mediated Renal Dysfunction and Injury in the Rat","volume":"58","author":"Chatterjee","year":"2000","journal-title":"Kidney Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS Promote Mitochondrial Dysfunction and Inflammation in Ischemic Acute Kidney Injury by Disrupting TFAM-Mediated mtDNA Maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41419-020-02871-6","article-title":"XJB-5-131 Inhibited Ferroptosis in Tubular Epithelial Cells after Ischemia\u2212reperfusion Injury","volume":"11","author":"Zhao","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13287-016-0283-6","article-title":"Mesenchymal Stem Cell-Based Therapy in Kidney Transplantation","volume":"7","author":"Chen","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13287-021-02289-7","article-title":"Mesenchymal Stem Cells and Extracellular Vesicles in Therapy against Kidney Diseases","volume":"12","author":"Huang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2016.7","article-title":"Mesenchymal Stromal Cells in Renal Transplantation: Opportunities and Challenges","volume":"12","author":"Casiraghi","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1111\/jcmm.13249","article-title":"Perfusion of Isolated Rat Kidney with Mesenchymal Stromal Cells\/Extracellular Vesicles Prevents Ischaemic Injury","volume":"21","author":"Gregorini","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e486141","DOI":"10.1155\/2015\/486141","article-title":"Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model","volume":"2015","author":"Koch","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/jama.2012.316","article-title":"Induction Therapy with Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants: A Randomized Controlled Trial","volume":"307","author":"Tan","year":"2012","journal-title":"JAMA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12967-018-1422-x","article-title":"Allogeneic Mesenchymal Stem Cells as Induction Therapy Are Safe and Feasible in Renal Allografts: Pilot Results of a Multicenter Randomized Controlled Trial","volume":"16","author":"Sun","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1097\/TP.0000000000004107","article-title":"Shifting Clinical Trial Endpoints in Kidney Transplantation: The Rise of Composite Endpoints and Machine Learning to Refine Prognostication","volume":"106","author":"Anwar","year":"2022","journal-title":"Transplantation"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"100629","DOI":"10.1016\/j.trre.2021.100629","article-title":"Emerging Biomarkers of Delayed Graft Function in Kidney Transplantation","volume":"35","author":"Mezzolla","year":"2021","journal-title":"Transplant. Rev."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/6\/642\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:48:19Z","timestamp":1760107699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/6\/642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":115,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["antiox13060642"],"URL":"https:\/\/doi.org\/10.3390\/antiox13060642","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]}}}