{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:05:49Z","timestamp":1773965149219,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PICT-2020-03263"],"award-info":[{"award-number":["PICT-2020-03263"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Chronic hypertension is a major risk factor for preeclampsia (PE), associated with significant maternal and neonatal morbidity. We previously demonstrated that pregnant stroke-prone spontaneously hypertensive rats (SHRSP) display a spontaneous PE-like phenotype with distinct placental, fetal, and maternal features. Here, we hypothesized that supplementation with alpha lipoic acid (ALA), a potent antioxidant, during early pregnancy could ameliorate the PE phenotype in this model. To test this hypothesis, timed pregnancies were established using 10 to 12-week-old SHRSP females (n = 19\u201316\/group), which were assigned to two treatment groups: ALA (injected intraperitoneally with 25 mg\/kg body weight ALA on gestation day (GD1, GD8, and GD12) or control, receiving saline following the same protocol. Our analysis of maternal signs showed that ALA prevented the pregnancy-dependent maternal blood pressure rise (GD14 blood pressure control 169.3 \u00b1 19.4 mmHg vs. 146.1 \u00b1 13.4 mmHg, p = 0.0001) and ameliorated renal function, as noted by the increased creatinine clearance and improved glomerular histology in treated dams. Treatment also improved the fetal growth restriction (FGR) phenotype, leading to increased fetal weights (ALA 2.19 \u00b1 0.5 g vs. control 1.98 \u00b1 0.3 g, p = 0.0074) and decreased cephalization indexes, indicating a more symmetric fetal growth pattern. This was associated with improved placental efficiency, decreased oxidative stress marker expression on GD14, and serum soluble fms-like tyrosine kinase 1 (sFlt1) levels on GD20. In conclusion, ALA supplementation mitigated maternal signs and improved placental function and fetal growth in SHRSP pregnancies, emerging as a promising therapy in pregnancies at high risk for PE.<\/jats:p>","DOI":"10.3390\/antiox13060730","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:14:16Z","timestamp":1718622856000},"page":"730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic Effect of Alpha Lipoic Acid in a Rat Preclinical Model of Preeclampsia: Focus on Maternal Signs, Fetal Growth and Placental Function"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-023X","authenticated-orcid":false,"given":"Gabriela","family":"Barrientos","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina Experimental, Hospital Alem\u00e1n, Ciudad Aut\u00f3noma de Buenos Aires C1118AAT, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Ciudad Aut\u00f3noma de Buenos Aires C1118AAT, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano L.","family":"Schuman","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Instituto de Investigaciones M\u00e9dicas Alfredo Lanari, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires C1053ABH, Argentina"},{"name":"Departamento de Cardiolog\u00eda Molecular, Instituto de Investigaciones M\u00e9dicas (IDIM), UBA-CONICET, Ciudad Aut\u00f3noma de Buenos Aires C1427ARN, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Landa","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Instituto de Investigaciones M\u00e9dicas Alfredo Lanari, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires C1053ABH, Argentina"},{"name":"Departamento de Cardiolog\u00eda Molecular, Instituto de Investigaciones M\u00e9dicas (IDIM), UBA-CONICET, Ciudad Aut\u00f3noma de Buenos Aires C1427ARN, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Robello","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Fisicoqu\u00edmica, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires C1053ABH, Argentina"},{"name":"Instituto de Bioqu\u00edmica y Medicina Molecular-Dr. Alberto Boveris (IBIMOL), UBA-CONICET, Ciudad Aut\u00f3noma de Buenos Aires C1113AAD, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Incardona","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n GADOR, Ciudad Aut\u00f3noma de Buenos Aires C1414CUI, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie L.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Galleano","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Fisicoqu\u00edmica, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires C1053ABH, Argentina"},{"name":"Instituto de Bioqu\u00edmica y Medicina Molecular-Dr. Alberto Boveris (IBIMOL), UBA-CONICET, Ciudad Aut\u00f3noma de Buenos Aires C1113AAD, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia I.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Experimental, Hospital Alem\u00e1n, Ciudad Aut\u00f3noma de Buenos Aires C1118AAT, Argentina"},{"name":"Facultad de Medicina, Instituto de Investigaciones M\u00e9dicas Alfredo Lanari, Universidad de Buenos Aires (UBA), Ciudad Aut\u00f3noma de Buenos Aires C1053ABH, Argentina"},{"name":"Departamento de Cardiolog\u00eda Molecular, Instituto de Investigaciones M\u00e9dicas (IDIM), UBA-CONICET, Ciudad Aut\u00f3noma de Buenos Aires C1427ARN, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International 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