{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:01Z","timestamp":1777902001788,"version":"3.51.4"},"reference-count":73,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004803","name":"Universidad Michoacana de San Nicol\u00e1s de Hidalgo","doi-asserted-by":"publisher","award":["CIC-UMSNH-2023,2024"],"award-info":[{"award-number":["CIC-UMSNH-2023,2024"]}],"id":[{"id":"10.13039\/501100004803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004881","name":"Mexican Social Security Institute","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/PRIO\/19\/109, Register number R-2019-1602-015"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/19\/109, Register number R-2019-1602-015"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Early life stress (ELS) is a risk factor for the development of chronic diseases resulting from functional alterations of organs in the cardiorespiratory and renal systems. This work studied the changes in oxidative stress enzyme activities (EAs) of SOD, CAT, GPX, GR, GST, NOS, MDA, and FRAP in different organs (heart, liver, kidney, adrenal glands (AGs), and pancreas) of male and female Sprague\u2013Dawley rat pups on postnatal day (PN) 15, immediately after basal and acute or chronic stress conditions were accomplished, as follows: basal control (BC; undisturbed maternal pups care), stress control (SC; 3 h maternal separation on PN15), basal maternal separation (BMS; daily 3 h maternal separation on PN 1-14), and stress maternal separation (SMS; daily 3 h maternal separation on PN 1-14 and 3 h maternal separation on PN15). Acute or long-term stress resulted in overall oxidative stress, increase in EA, and reduced antioxidant capacity in these organs. Some different response patterns, due to precedent SMS, were observed in specific organs, especially in the AGs. Acute stress exposure increases the EA, but chronic stress generates a response in the antioxidant system in some of the organs studied and is damped in response to a further challenge.<\/jats:p>","DOI":"10.3390\/antiox13070802","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:23:43Z","timestamp":1719980623000},"page":"802","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early Life Stress Influences Oxidative Stress Enzyme Activities in Liver, Heart, Kidney, Suprarenal Glands, and Pancreas in Male and Female Rat Pups"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7273-5458","authenticated-orcid":false,"given":"Bertha","family":"Fenton Navarro","sequence":"first","affiliation":[{"name":"Laboratorio de Glicobiolog\u00eda y Farmacognosia, Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \u201cDr. Ignacio Ch\u00e1vez\u201d, Universidad Michoacana de San Nicol\u00e1s de Hidalgo. Av. Dr. Rafael Carrillo S\/N, Esq. Dr. Salvador Gonz\u00e1lez Herrej\u00f3n Bosque, Cuauht\u00e9moc, Morelia 58020, Michoac\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis Abraham","family":"Casimiro Aguayo","sequence":"additional","affiliation":[{"name":"Laboratorio de Glicobiolog\u00eda y Farmacognosia, Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \u201cDr. Ignacio Ch\u00e1vez\u201d, Universidad Michoacana de San Nicol\u00e1s de Hidalgo. Av. Dr. Rafael Carrillo S\/N, Esq. Dr. Salvador Gonz\u00e1lez Herrej\u00f3n Bosque, Cuauht\u00e9moc, Morelia 58020, Michoac\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayr Luis","family":"Torres G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratorio de Glicobiolog\u00eda y Farmacognosia, Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \u201cDr. Ignacio Ch\u00e1vez\u201d, Universidad Michoacana de San Nicol\u00e1s de Hidalgo. Av. Dr. Rafael Carrillo S\/N, Esq. Dr. Salvador Gonz\u00e1lez Herrej\u00f3n Bosque, Cuauht\u00e9moc, Morelia 58020, Michoac\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Cervantes Alfaro","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias, Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \u201cDr. Ignacio Ch\u00e1vez\u201d, Universidad Michoacana de San Nicol\u00e1s de Hidalgo, Morelia 58000, Michoac\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-6188","authenticated-orcid":false,"given":"Luz","family":"Torner","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Centro de Investigaci\u00f3n Biom\u00e9dica de Michoac\u00e1n, Instituto Mexicano del Seguro Social; Cam. de La Arboleda # 300, La Huerta, Morelia 58341, Michoac\u00e1n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neubiorev.2016.07.018","article-title":"Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents","volume":"74","author":"Murphy","year":"2017","journal-title":"Neurosci. 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