{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:53Z","timestamp":1791925673804,"version":"4.3.4"},"reference-count":410,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["AG059096"],"award-info":[{"award-number":["AG059096"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Dietary restriction (DR) protocols frequently employ intermittent fasting. Following a period of fasting, meal consumption increases lipogenic gene expression, including that of NADPH-generating enzymes that fuel lipogenesis in white adipose tissue (WAT) through the induction of transcriptional regulators SREBP-1c and CHREBP. SREBP-1c knockout mice, unlike controls, did not show an extended lifespan on the DR diet. WAT cytoplasmic NADPH is generated by both malic enzyme 1 (ME1) and the pentose phosphate pathway (PPP), while liver cytoplasmic NADPH is primarily synthesized by folate cycle enzymes provided one-carbon units through serine catabolism. During the daily fasting period of the DR diet, fatty acids are released from WAT and are transported to peripheral tissues, where they are used for beta-oxidation and for phospholipid and lipid droplet synthesis, where monounsaturated fatty acids (MUFAs) may activate Nrf1 and inhibit ferroptosis to promote longevity. Decreased WAT NADPH from PPP gene knockout stimulated the browning of WAT and protected from a high-fat diet, while high levels of NADPH-generating enzymes in WAT and macrophages are linked to obesity. But oscillations in WAT [NADPH]\/[NADP+] from feeding and fasting cycles may play an important role in maintaining metabolic plasticity to drive longevity. Studies measuring the WAT malate\/pyruvate as a proxy for the cytoplasmic [NADPH]\/[NADP+], as well as studies using fluorescent biosensors expressed in the WAT of animal models to monitor the changes in cytoplasmic [NADPH]\/[NADP+], are needed during ad libitum and DR diets to determine the changes that are associated with longevity.<\/jats:p>","DOI":"10.3390\/antiox13070820","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T14:40:50Z","timestamp":1720449650000},"page":"820","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity"],"prefix":"10.3390","volume":"13","author":[{"given":"Leah E.","family":"Jamerson","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-6798","authenticated-orcid":false,"given":"Patrick C.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1074\/jbc.TM117.000258","article-title":"Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism","volume":"293","author":"Goodman","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11064-017-2428-0","article-title":"Glutamate dehydrogenase, a complex enzyme at a crucial metabolic branch point","volume":"44","author":"Smith","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40170-017-0173-0","article-title":"Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase\/methenyltetrahydrofolate cyclohydrolase","volume":"5","author":"Shin","year":"2017","journal-title":"Cancer Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.redox.2015.03.004","article-title":"Redox theory of aging","volume":"5","author":"Jones","year":"2015","journal-title":"Redox Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10522-008-9191-1","article-title":"Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver","volume":"10","author":"Hagopian","year":"2009","journal-title":"Biogerontology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0891-5849(03)00388-5","article-title":"Effects of age and caloric restriction on glutathione redox state in mice","volume":"35","author":"Rebrin","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2020.02.008","article-title":"Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging","volume":"180","author":"Ma","year":"2020","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1038\/ncomms4837","article-title":"Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice","volume":"5","author":"Miwa","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1474-9726.2010.00613.x","article-title":"Modulation of white adipose tissue proteome by aging and calorie restriction","volume":"9","author":"Valle","year":"2010","journal-title":"Aging Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100362","DOI":"10.1016\/j.jlr.2023.100362","article-title":"Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6","volume":"64","author":"Qian","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00018-020-03490-2","article-title":"Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity","volume":"78","author":"Kim","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/acel.12576","article-title":"Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction","volume":"16","author":"Fujii","year":"2017","journal-title":"Aging Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11138","DOI":"10.1074\/jbc.R117.779678","article-title":"Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes","volume":"292","author":"Rossner","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E488","DOI":"10.1152\/ajpendo.00110.2012","article-title":"Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan","volume":"303","author":"Steinbaugh","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41467-023-36181-0","article-title":"FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans","volume":"14","author":"Choi","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tuckowski, A.M., Beydoun, S., Kitto, E.S., Bhat, A., Howington, M.B., Sridhar, A., Bhandari, M., Chambers, K., and Leiser, S.F. (2024). fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans. bioRxiv.","DOI":"10.1101\/2024.05.17.594584"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E108","DOI":"10.1152\/ajpendo.00524.2009","article-title":"Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates","volume":"298","author":"Bruss","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nchembio.2047","article-title":"Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage","volume":"12","author":"Liu","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/s42255-021-00487-4","article-title":"Serine catabolism generates liver NADPH and supports hepatic lipogenesis","volume":"3","author":"Zhang","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/s42255-020-00298-z","article-title":"CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels","volume":"2","author":"Chini","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Peluso, A., Damgaard, M.V., Mori, M.A.S., and Treebak, J.T. (2021). Age-Dependent Decline of NAD(+)-Universal Truth or Confounded Consensus?. Nutrients, 14.","DOI":"10.20944\/preprints202111.0458.v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41587-019-0377-7","article-title":"An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD(+) imbalance","volume":"38","author":"Patgiri","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1042\/bj1030514","article-title":"The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver","volume":"103","author":"Williamson","year":"1967","journal-title":"Biochem. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E636","DOI":"10.1152\/ajpendo.00094.2021","article-title":"Acute carbohydrate overfeeding: A redox model of insulin action and its impact on metabolic dysfunction in humans","volume":"321","author":"Istfan","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/BF00970599","article-title":"Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes","volume":"20","author":"McKenna","year":"1995","journal-title":"Neurochem. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s42255-019-0121-0","article-title":"A nutritional memory effect counteracts benefits of dietary restriction in old mice","volume":"1","author":"Hahn","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"109859","DOI":"10.1016\/j.neuropharm.2024.109859","article-title":"Impact of caloric restriction on oxidative stress and key glycolytic enzymes in the cerebral cortex, liver and kidney of old and middle-aged mice","volume":"247","author":"Vatashchuk","year":"2024","journal-title":"Neuropharmacology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0168-8278(97)80358-3","article-title":"Age-dependent modifications in rat hepatocyte antioxidant defense systems","volume":"27","author":"Sanz","year":"1997","journal-title":"J. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mce.2018.01.025","article-title":"Hepatic NAD(+) levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL\/6JBomTac mice","volume":"473","author":"Dall","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj1150609a","article-title":"The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver","volume":"115","author":"Veech","year":"1969","journal-title":"Biochem. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/iub.1997","article-title":"The \u201cgreat\u201d controlling nucleotide coenzymes","volume":"71","author":"Veech","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0047-6374(89)90049-3","article-title":"Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat","volume":"48","author":"Feuers","year":"1989","journal-title":"Mech. Ageing Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.4238\/2012.May.9.4","article-title":"Differential expression analysis of porcine MDH1, MDH2 and ME1 genes in adipose tissues","volume":"11","author":"Zhou","year":"2012","journal-title":"Genet. Mol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/21623945.2017.1288321","article-title":"The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity","volume":"6","author":"Park","year":"2017","journal-title":"Adipocyte"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1210\/en.2011-1023","article-title":"Circadian feeding drive of metabolic activity in adipose tissue and not hyperphagia triggers overweight in mice: Is there a role of the pentose-phosphate pathway?","volume":"153","author":"Stucchi","year":"2012","journal-title":"Endocrinology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.7150\/thno.82697","article-title":"Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis","volume":"13","author":"Chen","year":"2023","journal-title":"Theranostics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0026-0495(76)90001-9","article-title":"Enzymes related to lipogenesis in the adipose tissue of obese subjects","volume":"25","author":"Belfiore","year":"1976","journal-title":"Metabolism"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0026-0495(76)90143-8","article-title":"NADPH-forming dehydrogenases in the adipose tissue of obese and nonobese diabetics","volume":"25","author":"Belfiore","year":"1976","journal-title":"Metabolism"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12967-023-04431-w","article-title":"ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis","volume":"21","author":"Convertini","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/MCB.01260-12","article-title":"Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress","volume":"33","author":"Ham","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"39968","DOI":"10.1074\/jbc.M402260200","article-title":"Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism","volume":"279","author":"Koh","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng.325","article-title":"Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks","volume":"41","author":"Yang","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhong, H., Beaulaurier, J., Lum, P.Y., Molony, C., Yang, X., Macneil, D.J., Weingarth, D.T., Zhang, B., Greenawalt, D., and Dobrin, R. (2010). Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1000932"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.freeradbiomed.2023.11.019","article-title":"Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice","volume":"210","author":"Valverde","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e13275","DOI":"10.1111\/acel.13275","article-title":"G6PD overexpression protects from oxidative stress and age-related hearing loss","volume":"19","author":"Celaya","year":"2020","journal-title":"Aging Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10894","DOI":"10.1038\/ncomms10894","article-title":"G6PD protects from oxidative damage and improves healthspan in mice","volume":"7","author":"Brioche","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"E543","DOI":"10.1152\/ajpendo.00491.2013","article-title":"Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice","volume":"306","author":"Wang","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Huang, C., Luo, Y., Zeng, B., Chen, Y., Liu, Y., Chen, W., Liao, X., Liu, Y., Wang, Y., and Wang, X. (2023). Branched-chain amino acids prevent obesity by inhibiting the cell cycle in an NADPH-FTO-m(6)A coordinated manner. J. Nutr. Biochem., 122.","DOI":"10.1016\/j.jnutbio.2023.109437"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.bbalip.2018.08.008","article-title":"FTO regulates adipogenesis by controlling cell cycle progression via m(6)A-YTHDF2 dependent mechanism","volume":"1863","author":"Wu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1128\/MCB.25.12.5146-5157.2005","article-title":"Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity","volume":"25","author":"Park","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/db05-1570","article-title":"Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals","volume":"55","author":"Park","year":"2006","journal-title":"Diabetes"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.2337\/db16-0060","article-title":"Glucose-6-phosphate dehydrogenase deficiency improves insulin resistance with reduced adipose tissue inflammation in obesity","volume":"65","author":"Ham","year":"2016","journal-title":"Diabetes"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, B., Wang, C., Lu, P., Ji, Y., Wang, X., Liu, C., Lu, X., Xu, X., and Wang, X. (2022). IDH1 Promotes foam cell formation by aggravating macrophage ferroptosis. Biology, 11.","DOI":"10.3390\/biology11101392"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1164\/rccm.202203-0482OC","article-title":"NRF2 Activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease","volume":"207","author":"Ryan","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cmet.2016.07.023","article-title":"Caloric restriction leads to browning of white adipose tissue through Type 2 immune signaling","volume":"24","author":"Fabbiano","year":"2016","journal-title":"Cell Metab."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Al-Dwairi, A., Pabona, J.M., Simmen, R.C., and Simmen, F.A. (2012). Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046716"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.2337\/db21-0272","article-title":"Spatial regulation of reactive oxygen species via G6PD in brown adipocytes supports thermogenic function","volume":"70","author":"Sohn","year":"2021","journal-title":"Diabetes"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"113417","DOI":"10.1016\/j.celrep.2023.113417","article-title":"Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation","volume":"42","author":"Ge","year":"2023","journal-title":"Cell Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1016\/j.bmc.2008.02.030","article-title":"Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme","volume":"16","author":"Shin","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Fraga, C.G., Oteiza, P.I., Hid, E.J., and Galleano, M. (2023). (Poly)phenols and the regulation of NADPH oxidases. Redox Biol., 67.","DOI":"10.1016\/j.redox.2023.102927"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sofiullah, S.S.M., Murugan, D.D., Muid, S.A., Seng, W.Y., Kadir, S., Abas, R., Ridzuan, N.R.A., Zamakshshari, N.H., and Woon, C.K. (2023). Natural bioactive compounds targeting NADPH oxidase pathway in cardiovascular diseases. Molecules, 28.","DOI":"10.3390\/molecules28031047"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.atherosclerosis.2006.08.033","article-title":"A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit","volume":"193","author":"Bursill","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.hoc.2015.11.006","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"30","author":"Luzzatto","year":"2016","journal-title":"Hematol.\/Oncol. Clin. N. Am."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Loniewska, M.M., Gupta, A., Bhatia, S., MacKay-Clackett, I., Jia, Z., and Wells, P.G. (2020). DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice. Redox Biol., 28.","DOI":"10.1016\/j.redox.2019.101332"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5529256","DOI":"10.1155\/2021\/5529256","article-title":"The controversial role of glucose-6-phosphate dehydrogenase deficiency on cardiovascular disease: A narrative review","volume":"2021","author":"Dore","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0003-9861(77)90346-0","article-title":"Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats","volume":"184","author":"Tischler","year":"1977","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-5793(77)80129-4","article-title":"Effect of ammonia on mitochondrial and cytosolic NADH and NADPH systems in isolated rat liver cells","volume":"76","author":"Tischler","year":"1977","journal-title":"FEBS Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cels.2021.09.001","article-title":"NAD(+) flux is maintained in aged mice despite lower tissue concentrations","volume":"12","author":"McReynolds","year":"2021","journal-title":"Cell Syst."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.cell.2010.10.002","article-title":"Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction","volume":"143","author":"Someya","year":"2010","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1101\/gad.1650608","article-title":"Tissue-specific regulation of SIRT1 by calorie restriction","volume":"22","author":"Chen","year":"2008","journal-title":"Genes Dev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e32638","DOI":"10.7554\/eLife.32638","article-title":"Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides","volume":"7","author":"Sallin","year":"2018","journal-title":"eLife"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s42255-023-00912-w","article-title":"PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy","volume":"5","author":"Dou","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/acel.12264","article-title":"ATF4 activity: A common feature shared by many kinds of slow-aging mice","volume":"13","author":"Li","year":"2014","journal-title":"Aging Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0712162105","article-title":"Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction","volume":"105","author":"Pearson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev-nutr-062320-111849","article-title":"The origins, evolution, and future of dietary methionine restriction","volume":"42","author":"Fang","year":"2022","journal-title":"Annu. Rev. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/gerona\/glt160","article-title":"Lifelong caloric restriction reprograms hepatic fat metabolism in mice","volume":"69","author":"Kuhla","year":"2014","journal-title":"J. Gerontol. Ser. A Biomed. Sci. Med. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1126\/science.abk0297","article-title":"Circadian alignment of early onset caloric restriction promotes longevity in male C57BL\/6J mice","volume":"376","author":"Izumo","year":"2022","journal-title":"Science"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.116.022495","article-title":"Normalization of NAD+ redox balance as a therapy for heart failure","volume":"134","author":"Lee","year":"2016","journal-title":"Circulation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1002\/hbm.26329","article-title":"Age-associated change in pyruvate metabolism investigated with hyperpolarized (13) C-MRI of the human brain","volume":"44","author":"Uthayakumar","year":"2023","journal-title":"Hum. Brain Mapp."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10041","DOI":"10.18632\/aging.103373","article-title":"Lactate dehydrogenase expression modulates longevity and neurodegeneration in drosophila melanogaster","volume":"12","author":"Long","year":"2020","journal-title":"Aging"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"20087","DOI":"10.1073\/pnas.1008189107","article-title":"High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A\/B ratio","volume":"107","author":"Ross","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Chen, L., Huang, L., Gu, Y., Cang, W., Sun, P., and Xiang, Y. (2022). Lactate-lactylation hands between metabolic reprogramming and immunosuppression. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911943"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1385\/CBB:37:1:37","article-title":"Regulation of cytosolic malate dehydrogenase by juvenile hormone in Drosophila melanogaster","volume":"37","author":"Farkas","year":"2002","journal-title":"Cell Biochem. Biophys."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.bbrc.2014.12.020","article-title":"Overexpression of malic enzyme in the larval stage extends Drosophila lifespan","volume":"456","author":"Kim","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mad.2012.02.001","article-title":"Misexpression screen delineates novel genes controlling Drosophila lifespan","volume":"133","author":"Paik","year":"2012","journal-title":"Mech. Ageing Dev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10522-007-9112-8","article-title":"Late onset of dietary restriction reverses age-related decline of malate-aspartate shuttle enzymes in the liver and kidney of mice","volume":"9","author":"Goyary","year":"2008","journal-title":"Biogerontology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/iub.2367","article-title":"The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway","volume":"72","author":"Borst","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0003-9861(74)90337-3","article-title":"Evidence for electrogenic aspartate transport in rat liver mitochondria","volume":"161","author":"LaNoue","year":"1974","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1042\/CS20160897","article-title":"Redox theory of aging: Implications for health and disease","volume":"131","author":"Go","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/s41467-020-16423-1","article-title":"Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death","volume":"11","author":"Balsa","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.aad0489","article-title":"mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle","volume":"351","author":"Hoxhaj","year":"2016","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cell.2018.03.001","article-title":"Amino acid restriction triggers angiogenesis via GCN2\/ATF4 regulation of VEGF and H(2)S production","volume":"173","author":"Longchamp","year":"2018","journal-title":"Cell"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.molcel.2019.03.031","article-title":"ER and nutrient stress promote assembly of respiratory chain supercomplexes through the PERK-eIF2\u03b1 axis","volume":"74","author":"Balsa","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"113868","DOI":"10.1016\/j.celrep.2024.113868","article-title":"PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle","volume":"43","author":"Benzarti","year":"2024","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncb2738","article-title":"ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death","volume":"15","author":"Han","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/ng.3421","article-title":"NRF2 regulates serine biosynthesis in non-small cell lung cancer","volume":"47","author":"DeNicola","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.devcel.2024.01.024","article-title":"SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway","volume":"59","author":"Tan","year":"2024","journal-title":"Dev. Cell"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Moon, S.J., Dong, W., Stephanopoulos, G.N., and Sikes, H.D. (2020). Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress. Bioeng. Transl. Med., 5.","DOI":"10.1002\/btm2.10184"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41589-023-01283-9","article-title":"Cytosolic and mitochondrial NADPH fluxes are independently regulated","volume":"19","author":"Niu","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Guay, C., Joly, E., Pepin, E., Barbeau, A., Hentsch, L., Pineda, M., Madiraju, S.R., Brunengraber, H., and Prentki, M. (2013). A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic \u00df-cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0077097"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/iub.249","article-title":"The mitochondrial citrate carrier: Metabolic role and regulation of its activity and expression","volume":"61","author":"Gnoni","year":"2009","journal-title":"IUBMB Life"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1023\/A:1020501021222","article-title":"Human mitochondrial transmembrane metabolite carriers: Tissue distribution and its implication for mitochondrial disorders","volume":"30","author":"Huizing","year":"1998","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10863-012-9475-7","article-title":"The mitochondrial oxoglutarate carrier: From identification to mechanism","volume":"45","author":"Miniero","year":"2013","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_104","unstructured":"Moon, S.J. (2022). Toward Quantitative Understanding of Compartmentalized NADPH Metabolism in Cancer Cells. [Ph.D. Dissertation, Massachusetts Institute of Technology]."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Moon, S.J., Pepe, A.C., Dong, W., Kelleher, J.K., Vander Heiden, M.G., Stephanopoulos, G.N., and Sikes, H.D. (2024). NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells. bioRxiv.","DOI":"10.1101\/2024.04.27.591477"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cmet.2020.12.002","article-title":"Tumor reliance on cytosolic versus mitochondrial one-carbon flux depends on folate availability","volume":"33","author":"Lee","year":"2021","journal-title":"Cell Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.freeradbiomed.2013.05.049","article-title":"A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL\/6J mice results in mitochondrial redox abnormalities","volume":"63","author":"Ronchi","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Bradshaw, P.C. (2019). Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging. Nutrients, 11.","DOI":"10.3390\/nu11030504"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s42255-021-00374-y","article-title":"Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth","volume":"3","author":"Tran","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.abd5491","article-title":"Mitochondrial NADP(H) generation is essential for proline biosynthesis","volume":"372","author":"Zhu","year":"2021","journal-title":"Science"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2019.11.020","article-title":"A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells","volume":"31","author":"Yoo","year":"2020","journal-title":"Cell Metab."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"111861","DOI":"10.1016\/j.intimp.2024.111861","article-title":"A novel HDAC6 inhibitor attenuate APAP-induced liver injury by regulating MDH1-mediated oxidative stress","volume":"131","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/acel.12575","article-title":"Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids","volume":"16","author":"Miller","year":"2017","journal-title":"Aging Cell"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Ying, D., Zhang, G., Huang, H., Tan, W.S., and Cai, H. (2024). Optimizing glutamine concentration enhances ex vivo expansion of natural killer cells through improved redox status. Biotechnol. Prog.","DOI":"10.1002\/btpr.3464"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1038\/emboj.2013.186","article-title":"FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells","volume":"32","author":"Yeo","year":"2013","journal-title":"EMBO J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41589-020-0533-x","article-title":"A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway","volume":"16","author":"Ghergurovich","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/B978-0-12-152829-4.50008-2","article-title":"Function and regulation of the pentose phosphate pathway in brain","volume":"29","author":"Baquer","year":"1988","journal-title":"Curr. Top. Cell. Regul."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Meng, Q., Zhang, Y., Hao, S., Sun, H., Liu, B., Zhou, H., Wang, Y., and Xu, Z.X. (2022). Recent findings in the regulation of G6PD and its role in diseases. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.932154"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s42255-023-00832-9","article-title":"A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells","volume":"5","author":"Cheng","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/emboj.2010.330","article-title":"ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair","volume":"30","author":"Cosentino","year":"2011","journal-title":"EMBO J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/iub.1329","article-title":"The regulation of the oxidative phase of the pentose phosphate pathway: New answers to old problems","volume":"66","year":"2014","journal-title":"IUBMB Life"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"17113","DOI":"10.1074\/jbc.M117.810309","article-title":"Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions","volume":"292","author":"Yao","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"107541","DOI":"10.1016\/j.lungcan.2024.107541","article-title":"Malate, a natural inhibitor of 6PGD, improves the efficacy of chemotherapy in lung cancer","volume":"190","author":"Sun","year":"2024","journal-title":"Lung Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s42255-023-00863-2","article-title":"The pentose phosphate pathway in health and disease","volume":"5","author":"TeSlaa","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/diabetes.49.5.718","article-title":"Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: Possible implication of a pyruvate\/citrate shuttle in insulin secretion","volume":"49","author":"Farfari","year":"2000","journal-title":"Diabetes"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.molcel.2019.10.015","article-title":"Dynamic regulation of ME1 phosphorylation and acetylation affects lipid metabolism and colorectal tumorigenesis","volume":"77","author":"Zhu","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Alektiar, J.M., Shan, M., Radyk, M.D., Zhang, L., Halbrook, C.J., Lin, L., Espinoza, C., Mier, I.F., Lavoie, B.L., and Salvatore, L. (2024). Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0303577"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"14937","DOI":"10.1038\/s41598-019-51397-1","article-title":"Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver","volume":"9","author":"Krupenko","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cmet.2018.01.014","article-title":"Caloric restriction engages hepatic RNA processing mechanisms in rhesus monkeys","volume":"27","author":"Rhoads","year":"2018","journal-title":"Cell Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e14554","DOI":"10.14814\/phy2.14554","article-title":"Divergent effects of glutathione depletion on isocitrate dehydrogenase 1 and the pentose phosphate pathway in hamster liver","volume":"8","author":"Jin","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"111437","DOI":"10.1016\/j.mad.2021.111437","article-title":"Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice","volume":"194","author":"Fuentealba","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"113043","DOI":"10.1016\/j.celrep.2023.113043","article-title":"The malate-aspartate shuttle is important for de novo serine biosynthesis","volume":"42","author":"Broeks","year":"2023","journal-title":"Cell Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ajhg.2019.07.015","article-title":"Bi-allelic GOT2 mutations cause a treatable malate-aspartate shuttle-related encephalopathy","volume":"105","author":"Ramos","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"154000","DOI":"10.1016\/j.metabol.2019.154000","article-title":"Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease","volume":"102","author":"Sim","year":"2020","journal-title":"Metabolism"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Cueto, R., Shen, W., Liu, L., Wang, X., Wu, S., Mohsin, S., Yang, L., Khan, M., Hu, W., and Snyder, N. (2024). SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome. Redox Biol., 73.","DOI":"10.1016\/j.redox.2024.103139"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-nutr-071715-050738","article-title":"Formate: The neglected member of one-carbon metabolism","volume":"36","author":"Brosnan","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"16037","DOI":"10.1074\/jbc.RA120.015129","article-title":"Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism","volume":"295","author":"Bhatia","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"101922","DOI":"10.1016\/j.arr.2023.101922","article-title":"Glycine and aging: Evidence and mechanisms","volume":"87","author":"Johnson","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e12953","DOI":"10.1111\/acel.12953","article-title":"Glycine supplementation extends lifespan of male and female mice","volume":"18","author":"Miller","year":"2019","journal-title":"Aging Cell"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Edwards, C., Canfield, J., Copes, N., Brito, A., Rehan, M., Lipps, D., Brunquell, J., Westerheide, S.D., and Bradshaw, P.C. (2015). Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet., 16.","DOI":"10.1186\/s12863-015-0167-2"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Liu, Y.J., Janssens, G.E., McIntyre, R.L., Molenaars, M., Kamble, R., Gao, A.W., Jongejan, A., Weeghel, M.V., MacInnes, A.W., and Houtkooper, R.H. (2019). Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet., 15.","DOI":"10.1371\/journal.pgen.1007633"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"eadi8317","DOI":"10.1126\/sciadv.adi8317","article-title":"Apollo-NADP(+) reveals in vivo adaptation of NADPH\/NADP(+) metabolism in electrically activated pancreatic \u03b2 cells","volume":"9","author":"Bui","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"110010","DOI":"10.1016\/j.neuropharm.2024.110010","article-title":"FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction","volume":"255","author":"Kim","year":"2024","journal-title":"Neuropharmacology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.bpj.2012.10.028","article-title":"Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism","volume":"103","author":"Sun","year":"2012","journal-title":"Biophys. J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exger.2019.01.001","article-title":"Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue","volume":"118","author":"Fujii","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/jn\/112.12.2301","article-title":"Alterations of NADPH-generating and drug-metabolizing enzymes by feed restriction in male rats","volume":"112","author":"Sachan","year":"1982","journal-title":"J. Nutr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"805","DOI":"10.18388\/abp.2004_3563","article-title":"Tissue-specific effect of refeeding after short- and long-term caloric restriction on malic enzyme gene expression in rat tissues","volume":"51","author":"Stelmanska","year":"2004","journal-title":"Acta Biochim. Pol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1093\/gerona\/glad017","article-title":"The effects of graded levels of calorie restriction: XIX. impact of graded calorie restriction on protein expression in the liver","volume":"78","author":"Wang","year":"2023","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1096\/fasebj.8.15.8001743","article-title":"Methionine restriction increases blood glutathione and longevity in F344 rats","volume":"8","author":"Richie","year":"1994","journal-title":"FASEB J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1096\/fj.03-0678fje","article-title":"Adipose tissue energy metabolism: Altered gene expression profile of mice subjected to long-term caloric restriction","volume":"18","author":"Higami","year":"2004","journal-title":"FASEB J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbrc.2015.08.098","article-title":"Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species","volume":"465","author":"Yu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1038\/s41467-021-23856-9","article-title":"Regulation of the one carbon folate cycle as a shared metabolic signature of longevity","volume":"12","author":"Annibal","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.2337\/db13-0501","article-title":"Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats","volume":"62","author":"Hasek","year":"2013","journal-title":"Diabetes"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Abrosimov, R., Baeken, M.W., Hauf, S., Wittig, I., Hajieva, P., Perrone, C.E., and Moosmann, B. (2024). Mitochondrial complex I inhibition triggers NAD(+)-independent glucose oxidation via successive NADPH formation, \u201cfutile\u201d fatty acid cycling, and FADH(2) oxidation. GeroScience.","DOI":"10.1007\/s11357-023-01059-y"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/88850","article-title":"Regulation of the caenorhabditis elegans longevity protein DAF-16 by insulin\/IGF-1 and germline signaling","volume":"28","author":"Lin","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/physiolgenomics.00083.2020","article-title":"Transcriptomic signature of fasting in human adipose tissue","volume":"52","author":"Defour","year":"2020","journal-title":"Physiol. Genom."},{"key":"ref_157","first-page":"469","article-title":"Fatty acid synthesis de novo in human adipose tissue","volume":"46","author":"Goldrick","year":"1974","journal-title":"Clin. Sci. Mol. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/bj1190221","article-title":"The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of altered dietary and hormonal conditions","volume":"119","author":"Saggerson","year":"1970","journal-title":"Biochem. J."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.exger.2009.02.008","article-title":"Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates","volume":"44","author":"Rezzi","year":"2009","journal-title":"Exp. Gerontol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Lee, M.H., Malloy, C.R., Corbin, I.R., Li, J., and Jin, E.S. (2019). Assessing the pentose phosphate pathway using [2, 3-(13) C(2) ]glucose. NMR Biomed., 32.","DOI":"10.1002\/nbm.4096"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41598-018-36674-9","article-title":"Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood","volume":"9","author":"Teruya","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cmet.2020.04.018","article-title":"Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice","volume":"32","author":"Aon","year":"2020","journal-title":"Cell Metab."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cmet.2018.08.011","article-title":"Daily fasting improves health and survival in male mice independent of diet composition and calories","volume":"29","author":"Mitchell","year":"2019","journal-title":"Cell Metab."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/1873-3468.14809","article-title":"Functional interplay of lipid droplets and mitochondria","volume":"598","author":"Enkler","year":"2024","journal-title":"FEBS Lett."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1016\/S0021-9258(19)44677-2","article-title":"Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate","volume":"247","author":"Goodridge","year":"1972","journal-title":"J. Biol. Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1016\/S0021-9258(19)43775-7","article-title":"Regulation of fatty acid synthesis in isolated hepatocytes. Evidence for a physiological role for long chain fatty acyl coenzyme A and citrate","volume":"248","author":"Goodridge","year":"1973","journal-title":"J. Biol. Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1126\/science.aau3903","article-title":"Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase","volume":"363","author":"Hoxhaj","year":"2019","journal-title":"Science"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semcdb.2021.07.008","article-title":"Circadian NAD(P)(H) cycles in cell metabolism","volume":"126","author":"Levine","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2017.06.007","article-title":"Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System","volume":"26","author":"Green","year":"2017","journal-title":"Cell Metab."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of ferroptosis by lipid metabolism","volume":"33","author":"Pope","year":"2023","journal-title":"Trends Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cmet.2019.07.016","article-title":"Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans","volume":"30","author":"Stekovic","year":"2019","journal-title":"Cell Metab."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/gerona\/61.8.781","article-title":"Calorie restriction in mice: Effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition","volume":"61","author":"Faulks","year":"2006","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Choudhary, R.C., Kuschner, C.E., Kazmi, J., McDevitt, L., Espin, B.B., Essaihi, M., Nishikimi, M., Becker, L.B., and Kim, J. (2024). The role of phospholipid alterations in mitochondrial and brain dysfunction after cardiac arrest. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094645"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e2100308","DOI":"10.1002\/pmic.202100308","article-title":"A tale of two lipids: Lipid unsaturation commands ferroptosis sensitivity","volume":"23","author":"Rodencal","year":"2023","journal-title":"Proteomics"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biochi.2004.09.018","article-title":"SREBP transcription factors: Master regulators of lipid homeostasis","volume":"86","author":"Hegarty","year":"2004","journal-title":"Biochimie"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1074\/jbc.M105711200","article-title":"Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements","volume":"277","author":"Yoshikawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Song, Z., Xiaoli, A.M., and Yang, F. (2018). Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues. Nutrients, 10.","DOI":"10.3390\/nu10101383"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1432-1033.1971.tb01347.x","article-title":"Intra- and extramitochondrial isozymes of (NADP) malate dehydrogenase","volume":"19","author":"Brdiczka","year":"1971","journal-title":"Eur. J. Biochem."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H., and Higami, Y. (2020). Srebp-1c\/Fgf21\/Pgc-1\u03b1 axis regulated by leptin signaling in adipocytes-possible mechanism of caloric restriction-Associated metabolic remodeling of white adipose tissue. Nutrients, 12.","DOI":"10.3390\/nu12072054"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.1132191","article-title":"Transgenic mice with a reduced core body temperature have an increased life span","volume":"314","author":"Conti","year":"2006","journal-title":"Science"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Benzi, A., Sturla, L., Heine, M., Fischer, A.W., Spinelli, S., Magnone, M., Sociali, G., Parodi, A., Fenoglio, D., and Emionite, L. (2021). CD38 downregulation modulates NAD(+) and NADP(H) levels in thermogenic adipose tissues. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1866.","DOI":"10.1016\/j.bbalip.2020.158819"},{"key":"ref_183","first-page":"290","article-title":"Age-dependent hepatic lipogenic enzyme activities in starved-refed rats","volume":"16","author":"Chanez","year":"1990","journal-title":"Diabete Metab."},{"key":"ref_184","first-page":"1057","article-title":"Organ specific regulation of malic enzyme and hexosemonophosphate shunt dehydrogenases activity by high carbohydrate diet","volume":"19","author":"Zelewski","year":"1989","journal-title":"Biochem. Int."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Sarjeant, K., and Stephens, J.M. (2012). Adipogenesis. Cold Spring Harb. Perspect. Biol., 4.","DOI":"10.1101\/cshperspect.a008417"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41419-023-05564-y","article-title":"Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"11687","DOI":"10.1074\/jbc.M611911200","article-title":"Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver","volume":"282","author":"Yamamoto","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1194\/jlr.M043422","article-title":"LXR\u03b1 fuels fatty acid-stimulated oxygen consumption in white adipocytes","volume":"55","author":"Dib","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1074\/jbc.M113.545699","article-title":"Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP)","volume":"289","author":"Shao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1042\/BCJ20210071","article-title":"SREBP-1c and lipogenesis in the liver: An update1","volume":"478","author":"Phan","year":"2021","journal-title":"Biochem. J."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1073\/pnas.95.11.5987","article-title":"Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice","volume":"95","author":"Horton","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1194\/jlr.M700033-JLR200","article-title":"SREBP-1-independent regulation of lipogenic gene expression in adipocytes","volume":"48","author":"Sekiya","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Hahn, O., Gr\u00f6nke, S., Stubbs, T.M., Ficz, G., Hendrich, O., Krueger, F., Andrews, S., Zhang, Q., Wakelam, M.J., and Beyer, A. (2017). Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol., 18.","DOI":"10.1186\/s13059-017-1187-1"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/s41419-018-0923-0","article-title":"JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism","volume":"9","author":"Wei","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/gerona\/glr124","article-title":"Aging is associated with a shift of fatty metabolism toward lipogenesis","volume":"66","author":"Kuhla","year":"2011","journal-title":"J. Gerontol. Ser. A Biomed. Sci. Med. Sci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cmet.2022.03.010","article-title":"SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity","volume":"34","author":"Lee","year":"2022","journal-title":"Cell Metab."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"e14038","DOI":"10.1111\/acel.14038","article-title":"Calorie restriction reduces biomarkers of cellular senescence in humans","volume":"23","author":"Aversa","year":"2024","journal-title":"Aging Cell"},{"key":"ref_198","first-page":"7535","article-title":"Caloric restriction mitigates age-associated senescence characteristics in subcutaneous adipose tissue-derived stem cells","volume":"16","author":"Chinnapaka","year":"2024","journal-title":"Aging"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"33959","DOI":"10.1074\/jbc.M110.122978","article-title":"SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism","volume":"285","author":"Ponugoti","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid\/cholesterol regulator SREBP","volume":"24","author":"Walker","year":"2010","journal-title":"Genes. Dev."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2007.07.003","article-title":"SIRT2 regulates adipocyte differentiation through FoxO1 acetylation\/deacetylation","volume":"6","author":"Jing","year":"2007","journal-title":"Cell Metab."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/jcmm.13297","article-title":"CD38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating Sirt1\/PPAR\u03b3 signaling pathway","volume":"22","author":"Wang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s11357-023-00863-w","article-title":"SIRT1 safeguards adipogenic differentiation by orchestrating anti-oxidative responses and suppressing cellular senescence","volume":"46","author":"Yu","year":"2024","journal-title":"GeroScience"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Calubag, M.F., Ademi, I., Yeh, C.Y., Babygirija, R., Pak, H.H., Bhoopat, A.M., Kasza, I., Green, C.L., Sonsalla, M.M., and Lamming, D.W. (2022). FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice. Aging Biol., 1.","DOI":"10.1101\/2022.07.29.501882"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e88080","DOI":"10.7554\/eLife.88080","article-title":"The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent","volume":"12","author":"Suchacki","year":"2023","journal-title":"eLife"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1038\/s41467-022-29499-8","article-title":"FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice","volume":"13","author":"Hill","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e00065","DOI":"10.7554\/eLife.00065","article-title":"The starvation hormone, fibroblast growth factor-21, extends lifespan in mice","volume":"1","author":"Zhang","year":"2012","journal-title":"eLife"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.yfrne.2018.06.002","article-title":"Homeostatic sensing of dietary protein restriction: A case for FGF21","volume":"51","author":"Hill","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2008.06.014","article-title":"The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man","volume":"8","author":"Kharitonenkov","year":"2008","journal-title":"Cell Metab."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.mad.2008.12.004","article-title":"Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats","volume":"130","author":"Oita","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/14728222.2017.1279146","article-title":"The NR4A subfamily of nuclear receptors: Potential new therapeutic targets for the treatment of inflammatory diseases","volume":"21","author":"Tajes","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"e13812","DOI":"10.1111\/acel.13812","article-title":"Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging","volume":"22","author":"Yu","year":"2023","journal-title":"Aging Cell"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1194\/jlr.M029355","article-title":"Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization","volume":"53","author":"Chao","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/en.2013-1758","article-title":"Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expression","volume":"155","author":"Min","year":"2014","journal-title":"Endocrinology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/jb\/mvm018","article-title":"Orphan nuclear receptor Nur77 accelerates the initial phase of adipocyte differentiation in 3T3-L1 cells by promoting mitotic clonal expansion","volume":"141","author":"Fumoto","year":"2007","journal-title":"J. Biochem."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Perez-Sieira, S., Martinez, G., Porteiro, B., Lopez, M., Vidal, A., Nogueiras, R., and Dieguez, C. (2013). Female Nur77-deficient mice show increased susceptibility to diet-induced obesity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053836"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"31525","DOI":"10.1074\/jbc.M701132200","article-title":"NR4A orphan nuclear receptors modulate insulin action and the glucose transport system: Potential role in insulin resistance","volume":"282","author":"Fu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/me.2012-1248","article-title":"Nr4a1 is required for fasting-induced down-regulation of Ppar\u03b32 in white adipose tissue","volume":"27","author":"Duszka","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1152\/physiolgenomics.00204.2005","article-title":"Evidence for Nr4a1 as a cold-induced effector of brown fat thermogenesis","volume":"24","author":"Kanzleiter","year":"2005","journal-title":"Physiol. Genom."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bbrc.2007.12.039","article-title":"Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity","volume":"366","author":"Pols","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mehy.2014.12.003","article-title":"The NR4A nuclear receptors as potential targets for anti-aging interventions","volume":"84","author":"Paillasse","year":"2015","journal-title":"Med. Hypotheses"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Sarver, D.C., Saqib, M., Chen, F., and Wong, G.W. (2024). Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age. bioRxiv.","DOI":"10.7554\/eLife.96926"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature21686","article-title":"Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan","volume":"544","author":"Han","year":"2017","journal-title":"Nature"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1101\/gad.266304.115","article-title":"SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat","volume":"29","author":"Lee","year":"2015","journal-title":"Genes Dev."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature05837","article-title":"PHA-4\/Foxa mediates diet-restriction-induced longevity of C. elegans","volume":"447","author":"Panowski","year":"2007","journal-title":"Nature"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Nishimura, Y., Sasagawa, S., Ariyoshi, M., Ichikawa, S., Shimada, Y., Kawaguchi, K., Kawase, R., Yamamoto, R., Uehara, T., and Yanai, T. (2015). Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Front. Pharmacol., 6.","DOI":"10.3389\/fphar.2015.00199"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.celrep.2017.09.042","article-title":"Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity","volume":"21","author":"Bolukbasi","year":"2017","journal-title":"Cell Rep."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/CIRCGENETICS.113.000169","article-title":"Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study","volume":"7","author":"Cornes","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1042\/BJ20050334","article-title":"Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans","volume":"389","author":"Sharma","year":"2005","journal-title":"Biochem. J."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature04942","article-title":"An ARC\/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis","volume":"442","author":"Yang","year":"2006","journal-title":"Nature"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Mejia-Martinez, F., Franco-Juarez, B., Moreno-Arriola, E., Hern\u00e1ndez-V\u00e1zquez, A., Martinez-Avila, M., G\u00f3mez-Manzo, S., Marcial-Quino, J., Carvajal, K., Velazquez-Arellano, A., and Ortega-Cuellar, D. (2017). The MXL-3\/SBP-1 axis is responsible for glucose-dependent fat accumulation in C. elegans. Genes, 8.","DOI":"10.3390\/genes8110307"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.celrep.2016.05.086","article-title":"Cholesterol-independent SREBP-1 maturation Is linked to ARF1 inactivation","volume":"16","author":"Smulan","year":"2016","journal-title":"Cell Rep."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.cell.2011.09.045","article-title":"A conserved SREBP-1\/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans","volume":"147","author":"Walker","year":"2011","journal-title":"Cell"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.devcel.2018.09.001","article-title":"Drug synergy slows aging and improves healthspan through IGF and SREBP lipid signaling","volume":"47","author":"Admasu","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"eadc8917","DOI":"10.1126\/sciadv.adc8917","article-title":"An antisteatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement","volume":"9","author":"Steinbaugh","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"e56580","DOI":"10.7554\/eLife.56580","article-title":"Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans","volume":"9","author":"Jenkins","year":"2020","journal-title":"eLife"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chembiol.2023.10.012","article-title":"Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury","volume":"31","author":"Mann","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41556-023-01136-6","article-title":"Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids","volume":"25","author":"Papsdorf","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"106265","DOI":"10.1016\/j.isci.2023.106265","article-title":"Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1\/SBP-1 dependent manner","volume":"26","author":"Xiao","year":"2023","journal-title":"iScience"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Ke, H., Luan, Y., Wu, S., Zhu, Y., and Tong, X. (2021). The role of mondo family transcription factors in nutrient-sensing and obesity. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.653972"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0401516101","article-title":"Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis","volume":"101","author":"Iizuka","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Cricr\u00ed, D., Coppi, L., Pedretti, S., Mitro, N., Caruso, D., De Fabiani, E., and Crestani, M. (2021). Histone Deacetylase 3 Regulates Adipocyte Phenotype at Early Stages of Differentiation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179300"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.celrep.2017.09.091","article-title":"Absence of carbohydrate response element binding protein in adipocytes causes systemic insulin resistance and impairs glucose transport","volume":"21","author":"Vijayakumar","year":"2017","journal-title":"Cell Rep."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Johnson, D.W., Llop, J.R., Farrell, S.F., Yuan, J., Stolzenburg, L.R., and Samuelson, A.V. (2014). The Caenorhabditis elegans Myc-Mondo\/Mad complexes integrate diverse longevity signals. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004278"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"10944","DOI":"10.1038\/ncomms10944","article-title":"Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals","volume":"7","author":"Nakamura","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"e2221553120","DOI":"10.1073\/pnas.2221553120","article-title":"Neuronal MML-1\/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity","volume":"120","author":"Shioda","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Matty, M.A., Lau, H.E., Haley, J.A., Singh, A., Chakraborty, A., Kono, K., Reddy, K.C., Hansen, M., and Chalasani, S.H. (2022). Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans. PLoS Genet., 18.","DOI":"10.1371\/journal.pgen.1010178"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.celrep.2019.06.057","article-title":"XBP-1 remodels lipid metabolism to extend longevity","volume":"28","author":"Imanikia","year":"2019","journal-title":"Cell Rep."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"e19493","DOI":"10.7554\/eLife.19493","article-title":"NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans","volume":"6","author":"Ewald","year":"2017","journal-title":"eLife"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"e07836","DOI":"10.7554\/eLife.07836","article-title":"Lipid-mediated regulation of SKN-1\/Nrf in response to germ cell absence","volume":"4","author":"Steinbaugh","year":"2015","journal-title":"eLife"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1159\/000375235","article-title":"FOXO3: A major gene for human longevity\u2014A mini-review","volume":"61","author":"Morris","year":"2015","journal-title":"Gerontology"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12944-019-1132-2","article-title":"FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c","volume":"18","author":"Wang","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Feng, P., Pang, P., Sun, Z., Xie, Z., Chen, T., Wang, S., Cao, Q., Mi, R., Zeng, C., and Lu, Y. (2024). Enhancer-mediated FOXO3 expression promotes MSC adipogenic differentiation by activating autophagy. Biochim. Biophys. Acta Mol. Basis Dis., 1870.","DOI":"10.1016\/j.bbadis.2023.166975"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00011-021-01463-0","article-title":"FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy: Role of FOXO3a in obesity","volume":"70","author":"Zhang","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"456","DOI":"10.15252\/embr.201439096","article-title":"FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression","volume":"16","author":"Charitou","year":"2015","journal-title":"EMBO Rep."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"20132","DOI":"10.1074\/jbc.M112.347211","article-title":"FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c","volume":"287","author":"Deng","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1074\/jbc.M600272200","article-title":"FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"5190","DOI":"10.1038\/ncomms6190","article-title":"Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors","volume":"5","author":"Haeusler","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/acel.12340","article-title":"The life-extending effect of dietary restriction requires Foxo3 in mice","volume":"14","author":"Shimokawa","year":"2015","journal-title":"Aging Cell"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1474-9726.2010.00563.x","article-title":"FoxO1 is involved in the antineoplastic effect of calorie restriction","volume":"9","author":"Yamaza","year":"2010","journal-title":"Aging Cell"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1078223","article-title":"Extended longevity in mice lacking the insulin receptor in adipose tissue","volume":"299","author":"Kahn","year":"2003","journal-title":"Science"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10522-007-9099-1","article-title":"Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver","volume":"8","author":"Caro","year":"2007","journal-title":"Biogerontology"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1474-9726.2009.00538.x","article-title":"Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long-lived pigeon, Columba livia","volume":"9","author":"Lambert","year":"2010","journal-title":"Aging Cell"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/gerona\/62.4.352","article-title":"Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver","volume":"62","author":"Ayala","year":"2007","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1096\/fj.05-5568com","article-title":"Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins","volume":"20","author":"Sanz","year":"2006","journal-title":"FASEB J"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1111\/febs.15714","article-title":"Is the NDUFV2 subunit of the hydrophilic complex I domain a key determinant of animal longevity?","volume":"288","author":"Pamplona","year":"2021","journal-title":"FEBS J."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s42255-024-01038-3","article-title":"Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity","volume":"6","author":"Jiang","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s13105-019-00676-6","article-title":"Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression","volume":"75","author":"Koc","year":"2019","journal-title":"J. Physiol. Biochem."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cmet.2016.03.009","article-title":"Mitochondrial ROS produced via reverse electron transport extend animal lifespan","volume":"23","author":"Sriram","year":"2016","journal-title":"Cell Metab."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/10715762.2024.2342962","article-title":"Calorie restriction anti-hypertrophic effects are associated with improved mitochondrial content, blockage of Ca(2+)-induced mitochondrial damage, and lower reverse electron transport-mediated oxidative stress","volume":"58","year":"2024","journal-title":"Free Radic. Res."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2337\/db19-1087","article-title":"Transketolase deficiency in adipose tissues protects mice from diet-induced obesity by promoting lipolysis","volume":"69","author":"Tian","year":"2020","journal-title":"Diabetes"},{"key":"ref_272","unstructured":"Nakao, K., Minato, N., and Uemoto, S. (2015). Diverting Glycolysis to Combat Oxidative Stress. Innovative Medicine: Basic Research and Development, Springer."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"e220047","DOI":"10.1530\/JOE-22-0047","article-title":"Loss of transketolase promotes the anti-diabetic role of brown adipose tissues","volume":"256","author":"Ji","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2337\/db16-0283","article-title":"Adipocyte-specific deletion of manganese superoxide dismutase protects from diet-induced obesity through increased mitochondrial uncoupling and biogenesis","volume":"65","author":"Han","year":"2016","journal-title":"Diabetes"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/21623945.2016.1273298","article-title":"Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes","volume":"6","author":"Ortega","year":"2017","journal-title":"Adipocyte"},{"key":"ref_276","first-page":"81","article-title":"Mitochondrial electron transport chain-derived superoxide exits macrophages: Implications for mononuclear cell-mediated pathophysiological processes","volume":"1","author":"Li","year":"2016","journal-title":"React. Oxyg. Species"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1038\/s41467-022-34468-2","article-title":"Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes","volume":"13","author":"Moore","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"112488","DOI":"10.1016\/j.celrep.2023.112488","article-title":"Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program","volume":"42","author":"Guilherme","year":"2023","journal-title":"Cell Rep."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s42255-020-00330-2","article-title":"NADPH levels affect cellular epigenetic state by inhibiting HDAC3-Ncor complex","volume":"3","author":"Li","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41467-017-00182-7","article-title":"HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning","volume":"8","author":"Ferrari","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2337\/db12-0548","article-title":"Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue","volume":"62","author":"Galmozzi","year":"2013","journal-title":"Diabetes"},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Paluvai, H., Shanmukha, K.D., Tyedmers, J., and Backs, J. (2023). Insights into the function of HDAC3 and NCoR1\/NCoR2 co-repressor complex in metabolic diseases. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1190094"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"32006","DOI":"10.1074\/jbc.M112.362467","article-title":"Stimulation of histone deacetylase activity by metabolites of intermediary metabolism","volume":"287","author":"Vogelauer","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"E150","DOI":"10.1152\/ajpendo.00465.2017","article-title":"HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection","volume":"315","author":"Zhang","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.exger.2016.02.015","article-title":"The effects of Rpd3 on fly metabolism, health, and longevity","volume":"86","author":"Woods","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Kobayashi, M., Deguchi, Y., Nozaki, Y., and Higami, Y. (2021). Contribution of PGC-1\u03b1 to obesity- and caloric restriction-related physiological changes in white adipose tissue. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116025"},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Yuliana, A., Jheng, H.F., Kawarasaki, S., Nomura, W., Takahashi, H., Ara, T., Kawada, T., and Goto, T. (2018). \u03b2-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082436"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"PRDM16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cmet.2007.06.001","article-title":"Transcriptional control of brown fat determination by PRDM16","volume":"6","author":"Seale","year":"2007","journal-title":"Cell Metab."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"17489","DOI":"10.18632\/aging.203238","article-title":"HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes","volume":"13","author":"Lv","year":"2021","journal-title":"Aging"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nature22819","article-title":"Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge","volume":"546","author":"Emmett","year":"2017","journal-title":"Nature"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"e111239","DOI":"10.15252\/embj.2022111239","article-title":"Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial-nuclear communication","volume":"41","author":"Pouikli","year":"2022","journal-title":"EMBO J."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41419-022-04752-6","article-title":"Adipose tissue aging: Mechanisms and therapeutic implications","volume":"13","author":"Ou","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Wang, X., Xu, M., and Li, Y. (2022). Adipose tissue aging and metabolic disorder, and the impact of nutritional interventions. Nutrients, 14.","DOI":"10.3390\/nu14153134"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cmet.2016.10.012","article-title":"physiological suppression of lipotoxic liver damage by complementary actions of HDAC3 and SCAP\/SREBP","volume":"24","author":"Papazyan","year":"2016","journal-title":"Cell Metab."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.freeradbiomed.2019.08.006","article-title":"Opposing action of NCoR1 and PGC-1\u03b1 in mitochondrial redox homeostasis","volume":"143","author":"Lima","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cell.2011.10.017","article-title":"NCoR1 is a conserved physiological modulator of muscle mass and oxidative function","volume":"147","author":"Yamamoto","year":"2011","journal-title":"Cell"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.18632\/aging.100856","article-title":"RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity","volume":"7","author":"Frankel","year":"2015","journal-title":"Aging"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1126\/science.1078986","article-title":"Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction","volume":"298","author":"Rogina","year":"2002","journal-title":"Science"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0531-5565(02)00064-5","article-title":"Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast","volume":"37","author":"Jiang","year":"2002","journal-title":"Exp. Gerontol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"43014","DOI":"10.1074\/jbc.M305905200","article-title":"Deacetylase activity is required for cAMP activation of a subset of CREB target genes","volume":"278","author":"Fass","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.bbagrm.2012.09.005","article-title":"The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter","volume":"1819","author":"Yokoyama","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"eabe2771","DOI":"10.1126\/sciadv.abe2771","article-title":"The regulatory enzymes and protein substrates for the lysine \u03b2-hydroxybutyrylation pathway","volume":"7","author":"Huang","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_304","doi-asserted-by":"crossref","unstructured":"Ito, M., Nishida, Y., Iwamoto, T., Kanai, A., Aoyama, S., Ueki, K., Uzawa, H., Iida, H., and Watada, H. (2024). Protein acylations induced by a ketogenic diet demonstrate diverse patterns depending on organs and differ between histones and global proteins. Biochem. Biophys. Res. Commun., 712\u2013713.","DOI":"10.1016\/j.bbrc.2024.149960"},{"key":"ref_305","doi-asserted-by":"crossref","unstructured":"Tsusaka, T., Najar, M.A., Schwarz, B., Bohrnsen, E., Oses-Prieto, J.A., Lee, C., Burlingame, A.L., Bosio, C.M., Burslem, G.M., and Goldberg, E.L. (2023). Reversible histone deacetylase activity catalyzes lysine acylation. bioRxiv.","DOI":"10.1101\/2023.11.17.567549"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/j.atherosclerosis.2018.06.924","article-title":"Epigenetic regulation of white adipose tissue physiology: Histone deacetylase 3 as a key molecular switch of white adipose tissue metabolism and browning","volume":"275","author":"Longo","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.1198125","article-title":"A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism","volume":"331","author":"Feng","year":"2011","journal-title":"Science"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nm.2744","article-title":"Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration","volume":"18","author":"Sun","year":"2012","journal-title":"Nat. Med."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41420-023-01399-w","article-title":"The role of HDAC3 and its inhibitors in regulation of oxidative stress and chronic diseases","volume":"9","author":"He","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1101\/sqb.2011.76.011494","article-title":"Circadian epigenomic remodeling and hepatic lipogenesis: Lessons from HDAC3","volume":"76","author":"Sun","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_311","doi-asserted-by":"crossref","unstructured":"Xu, Y.C., Zheng, H., Hogstrand, C., Tan, X.Y., Zhao, T., Song, Y.F., Wei, X.L., Wu, L.X., and Luo, Z. (2023). Novel mechanism for zinc inducing hepatic lipolysis via the HDAC3-mediated deacetylation of \u03b2-catenin at lysine 311. J. Nutr. Biochem., 121.","DOI":"10.1016\/j.jnutbio.2023.109429"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"e2318935121","DOI":"10.1073\/pnas.2318935121","article-title":"Glucose regulation of adipose tissue browning by CBP\/p300- and HDAC3-mediated reversible acetylation of CREBZF","volume":"121","author":"Cui","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.1117728","article-title":"Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS","volume":"310","author":"Nisoli","year":"2005","journal-title":"Science"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1096\/fj.10-170415","article-title":"Does calorie restriction induce mitochondrial biogenesis? A reevaluation","volume":"25","author":"Hancock","year":"2011","journal-title":"FASEB J."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cell.2018.06.031","article-title":"Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes","volume":"174","author":"Guan","year":"2018","journal-title":"Cell"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"18691","DOI":"10.1073\/pnas.1909883116","article-title":"Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold","volume":"116","author":"Adlanmerini","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Hughes, M.E., DiTacchio, L., Hayes, K.R., Vollmers, C., Pulivarthy, S., Baggs, J.E., Panda, S., and Hogenesch, J.B. (2009). Harmonics of circadian gene transcription in mammals. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000442"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1242\/bio.20134259","article-title":"MNADK, a novel liver-enriched mitochondrion-localized NAD kinase","volume":"2","author":"Zhang","year":"2013","journal-title":"Biol. Open"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1159\/000489058","article-title":"Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells","volume":"46","author":"Sandbichler","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"10508","DOI":"10.1073\/pnas.1000788107","article-title":"A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation","volume":"107","author":"Kawai","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1073\/pnas.1913712117","article-title":"Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response","volume":"117","author":"Laothamatas","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1073\/pnas.0702448104","article-title":"Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity","volume":"104","author":"Green","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_323","doi-asserted-by":"crossref","unstructured":"Duszka, K., Gregor, A., Guillou, H., K\u00f6nig, J., and Wahli, W. (2020). Peroxisome Proliferator-Activated Receptors and Caloric Restriction-Common Pathways Affecting Metabolism, Health, and Longevity. Cells, 9.","DOI":"10.3390\/cells9071708"},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Argmann, C., Dobrin, R., Heikkinen, S., Auburtin, A., Pouilly, L., Cock, T.A., Koutnikova, H., Zhu, J., Schadt, E.E., and Auwerx, J. (2009). Ppargamma2 is a key driver of longevity in the mouse. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000752"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"e13267","DOI":"10.1111\/acel.13267","article-title":"PPAR\u03b3 agonists delay age-associated metabolic disease and extend longevity","volume":"19","author":"Xu","year":"2020","journal-title":"Aging Cell"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature02583","article-title":"Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma","volume":"429","author":"Picard","year":"2004","journal-title":"Nature"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/gerona\/60.11.1394","article-title":"Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor\/binding protein knockout mice","volume":"60","author":"Masternak","year":"2005","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"26933","DOI":"10.1038\/srep26933","article-title":"Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice","volume":"6","author":"Trammell","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_330","doi-asserted-by":"crossref","unstructured":"Pogson, J.H., Ivatt, R.M., Sanchez-Martinez, A., Tufi, R., Wilson, E., Mortiboys, H., and Whitworth, A.J. (2014). The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004815"},{"key":"ref_331","doi-asserted-by":"crossref","unstructured":"Latha Laxmi, I.P., Job, A.T., Manickam, V., and Tamizhselvi, R. (2024). Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm. Mol. Biol. Rep., 51.","DOI":"10.1007\/s11033-024-09430-8"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41556-024-01400-3","article-title":"Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51","volume":"26","author":"Liu","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"e111901","DOI":"10.15252\/embj.2022111901","article-title":"Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA","volume":"42","author":"Ngo","year":"2023","journal-title":"EMBO J."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cac2.12247","article-title":"Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1","volume":"42","author":"Wu","year":"2022","journal-title":"Cancer Commun."},{"key":"ref_335","doi-asserted-by":"crossref","unstructured":"Liu, N., Wu, W.L., Wan, X.R., Wang, J., Huang, J.N., Jiang, Y.Y., Sheng, Y.C., Wu, J.C., Liang, Z.Q., and Qin, Z.H. (2024). Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition. Redox Biol., 73.","DOI":"10.1016\/j.redox.2024.103176"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/s41422-023-00879-z","article-title":"FSP1 oxidizes NADPH to suppress ferroptosis","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell Res."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s42255-020-0181-1","article-title":"MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis","volume":"2","author":"Ding","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41419-021-04018-7","article-title":"The regulation of ferroptosis by MESH1 through the activation of the integrative stress response","volume":"12","author":"Lin","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"16362","DOI":"10.1038\/s41598-017-16587-9","article-title":"ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish","volume":"7","author":"Yeh","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"eabf2017","DOI":"10.1126\/sciadv.abf2017","article-title":"ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity","volume":"8","author":"Xiao","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_341","doi-asserted-by":"crossref","unstructured":"Mak, K.H., Zhao, Q., Hu, P.-W., Au-Yeung, C.-L., Yang, J., Duraine, L., Yu, Y., Abu-Remaileh, M., Sabatini, D., and Wang, J.D. (2020). Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling. bioRxiv.","DOI":"10.1101\/2020.04.18.048561"},{"key":"ref_342","doi-asserted-by":"crossref","unstructured":"Wang, M.C., Oakley, H.D., Carr, C.E., Sowa, J.N., and Ruvkun, G. (2014). Gene pathways that delay Caenorhabditis elegans reproductive senescence. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004752"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"111669","DOI":"10.1016\/j.exger.2021.111669","article-title":"Mild calorie restriction, but not 17\u03b1-estradiol, extends ovarian reserve and fertility in female mice","volume":"159","author":"Isola","year":"2022","journal-title":"Exp. Gerontol."},{"key":"ref_344","doi-asserted-by":"crossref","unstructured":"Cheng, C.F., Ku, H.C., Cheng, J.J., Chao, S.W., Li, H.F., Lai, P.F., Chang, C.C., Don, M.J., Chen, H.H., and Lin, H. (2019). Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3. Commun. Biol., 2.","DOI":"10.1038\/s42003-019-0624-y"},{"key":"ref_345","doi-asserted-by":"crossref","unstructured":"Ku, H.C., Chan, T.Y., Chung, J.F., Kao, Y.H., and Cheng, C.F. (2022). The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning. Biomed. Pharmacother., 145.","DOI":"10.1016\/j.biopha.2021.112440"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/cr.2010.4","article-title":"ATF4 regulates lipid metabolism and thermogenesis","volume":"20","author":"Wang","year":"2010","journal-title":"Cell Res."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"109742","DOI":"10.1016\/j.celrep.2021.109742","article-title":"Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism","volume":"36","author":"Paulo","year":"2021","journal-title":"Cell Rep."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41586-021-03221-y","article-title":"Creatine kinase B controls futile creatine cycling in thermogenic fat","volume":"590","author":"Rahbani","year":"2021","journal-title":"Nature"},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1126\/science.abl8007","article-title":"Time-restricted feeding mitigates obesity through adipocyte thermogenesis","volume":"378","author":"Hepler","year":"2022","journal-title":"Science"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00109-016-1480-6","article-title":"Adipose HIF-1\u03b1 causes obesity by suppressing brown adipose tissue thermogenesis","volume":"95","author":"Jun","year":"2017","journal-title":"J. Mol. Med."},{"key":"ref_351","doi-asserted-by":"crossref","unstructured":"Ryoo, H.D. (2024). The integrated stress response in metabolic adaptation. J. Biol. Chem., 300.","DOI":"10.1016\/j.jbc.2024.107151"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s10565-021-09608-x","article-title":"Cooperation of ATF4 and CTCF promotes adipogenesis through transcriptional regulation","volume":"38","author":"Chen","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/pin.13371","article-title":"Effect of mitochondrial quantity and quality controls in white adipose tissue on healthy lifespan: Essential roles of GH\/IGF-1-independent pathways in caloric restriction-mediated metabolic remodeling","volume":"73","author":"Otani","year":"2023","journal-title":"Pathol. Int."},{"key":"ref_354","doi-asserted-by":"crossref","unstructured":"Vasconcelos, A.R., Dos Santos, N.B., Scavone, C., and Munhoz, C.D. (2019). Nrf2\/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00033"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1038\/s41388-018-0360-7","article-title":"Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism","volume":"37","author":"Bai","year":"2018","journal-title":"Oncogene"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3164\/jcbn.23-106","article-title":"Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation","volume":"74","author":"Sekine","year":"2024","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1093\/emboj\/17.6.1779","article-title":"Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice","volume":"17","author":"Chan","year":"1998","journal-title":"EMBO J."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"e13444","DOI":"10.1111\/acel.13444","article-title":"Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction","volume":"20","author":"Cano","year":"2021","journal-title":"Aging Cell"},{"key":"ref_359","doi-asserted-by":"crossref","unstructured":"Hu, S., Feng, J., Wang, M., Wufuer, R., Liu, K., Zhang, Z., and Zhang, Y. (2022). Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks. Redox Biol., 57.","DOI":"10.1016\/j.redox.2022.102470"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.freeradbiomed.2020.01.005","article-title":"Deletion of Nrf2 shortens lifespan in C57BL6\/J male mice but does not alter the health and survival benefits of caloric restriction","volume":"152","author":"Pomatto","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"33554","DOI":"10.1074\/jbc.M804597200","article-title":"Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes","volume":"283","author":"Ohtsuji","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1042\/BJ20151182","article-title":"Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity","volume":"473","author":"Zhang","year":"2016","journal-title":"Biochem. J."},{"key":"ref_363","doi-asserted-by":"crossref","unstructured":"Xue, P., Hou, Y., Zuo, Z., Wang, Z., Ren, S., Dong, J., Fu, J., Wang, H., Andersen, M.E., and Zhang, Q. (2020). Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPAR\u03b3 expression. Redox Biol., 30.","DOI":"10.1016\/j.redox.2019.101414"},{"key":"ref_364","doi-asserted-by":"crossref","unstructured":"Ren, S., Bian, Y., Hou, Y., Wang, Z., Zuo, Z., Liu, Z., Teng, Y., Fu, J., Wang, H., and Xu, Y. (2021). The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models. Redox Biol., 44.","DOI":"10.1016\/j.redox.2021.102015"},{"key":"ref_365","doi-asserted-by":"crossref","unstructured":"Shen, W., Ren, S., Hou, Y., Zuo, Z., Liu, S., Liu, Z., Fu, J., Wang, H., Yang, B., and Zhao, R. (2023). Single-nucleus RNA-sequencing reveals NRF1\/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice. Redox Biol., 67.","DOI":"10.1016\/j.redox.2023.102879"},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MCO.0b013e32834136f2","article-title":"The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation","volume":"14","author":"Sykiotis","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_367","doi-asserted-by":"crossref","unstructured":"Bauz\u00e1-Thorbr\u00fcgge, M., Peris, E., Zamani, S., Micallef, P., Paul, A., Bartesaghi, S., Benrick, A., and Wernstedt Asterholm, I. (2023). NRF2 is essential for adaptative browning of white adipocytes. Redox Biol., 68.","DOI":"10.1016\/j.redox.2023.102951"},{"key":"ref_368","doi-asserted-by":"crossref","unstructured":"Shi, Y., Huang, X., Zeng, Y., Zhai, M., Yao, H., Liu, C., Li, B., Gong, S., Yu, Q., and Zhuang, J. (2024). Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity. Redox Biol., 69.","DOI":"10.1016\/j.redox.2023.103013"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/path.5504","article-title":"A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue","volume":"252","author":"Bowman","year":"2020","journal-title":"J. Pathol."},{"key":"ref_370","doi-asserted-by":"crossref","unstructured":"Braud, L., Pini, M., Stec, D.F., Manin, S., Derumeaux, G., Stec, D.E., Foresti, R., and Motterlini, R. (2021). Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice. Redox Biol., 38.","DOI":"10.1016\/j.redox.2020.101805"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1089\/ars.2019.7769","article-title":"Nuclear factor E2-related Factor 2 mediates oxidative stress-induced lipid accumulation in adipocytes by increasing adipogenesis and decreasing lipolysis","volume":"32","author":"Sun","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"9292","DOI":"10.1074\/jbc.M109.093955","article-title":"Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity","volume":"285","author":"Pi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"E180","DOI":"10.1152\/ajpendo.00311.2017","article-title":"Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice","volume":"315","author":"Chartoumpekis","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1074\/jbc.M115.673756","article-title":"Increased energy expenditure, Ucp1 expression, and resistance to diet-induced obesity in mice lacking nuclear factor-Erythroid-2-related transcription Factor-2 (Nrf2)","volume":"291","author":"Schneider","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng1248","article-title":"Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation","volume":"35","author":"Wakabayashi","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_376","doi-asserted-by":"crossref","unstructured":"Xu, J., Donepudi, A.C., Moscovitz, J.E., and Slitt, A.L. (2013). Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079841"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"101638","DOI":"10.1016\/j.isci.2020.101638","article-title":"Downregulation of keap1 confers features of a fasted metabolic state","volume":"23","author":"Knatko","year":"2020","journal-title":"iScience"},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.abb.2015.11.040","article-title":"Keap1\/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet","volume":"591","author":"Slocum","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbrc.2022.06.073","article-title":"The splicing factor 9G8 regulates the expression of NADPH-producing enzyme genes in Drosophila","volume":"620","author":"Weidman","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1203\/00006450-199107000-00022","article-title":"Postnatal changes in pyridine nucleotides in rat hepatocytes: Composition and O2 dependence","volume":"30","author":"Aw","year":"1991","journal-title":"Pediatr. Res."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"100929","DOI":"10.1016\/j.isci.2020.100929","article-title":"Srsf7 establishes the juvenile transcriptome through age-dependent alternative splicing in mice","volume":"23","author":"Kadota","year":"2020","journal-title":"iScience"},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"e2022120118","DOI":"10.1073\/pnas.2022120118","article-title":"Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction","volume":"118","author":"Condon","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_383","doi-asserted-by":"crossref","unstructured":"Bruch, J., Xu, H., De Andrade, A., and H\u00f6glinger, G. (2014). Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113070"},{"key":"ref_384","doi-asserted-by":"crossref","unstructured":"Liu, X., Devadiga, S.A., Stanley, R.F., Morrow, R., Janssen, K., Quesnel-Valli\u00e8res, M., Pomp, O., Moverley, A.A., Li, C., and Skuli, N. (2024). A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. bioRxiv.","DOI":"10.1101\/2023.06.25.546449"},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"e2306871","DOI":"10.1002\/advs.202306871","article-title":"SRSF1 Is required for mitochondrial homeostasis and thermogenic function in brown adipocytes through its control of Ndufs3 splicing","volume":"11","author":"Yuan","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41467-023-35932-3","article-title":"Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death","volume":"14","author":"Arif","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2011.06.007","article-title":"Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis","volume":"14","author":"Lerin","year":"2011","journal-title":"Cell Metab."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"14078","DOI":"10.1074\/jbc.M112.355206","article-title":"SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status","volume":"287","author":"Yu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"e13721","DOI":"10.1111\/acel.13721","article-title":"SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction","volume":"21","author":"Dhillon","year":"2022","journal-title":"Aging Cell"},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/ars.2018.7703","article-title":"Sirt3 deficiency shortens life span and impairs cardiac mitochondrial function rescued by opa1 gene transfer","volume":"31","author":"Benigni","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"155275","DOI":"10.1016\/j.metabol.2022.155275","article-title":"The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions","volume":"135","author":"Fu","year":"2022","journal-title":"Metabolism"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1016\/j.molcel.2022.06.026","article-title":"Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation","volume":"82","author":"Mary","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"33562","DOI":"10.1074\/jbc.M704442200","article-title":"NAD kinase levels control the NADPH concentration in human cells","volume":"282","author":"Pollak","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cmet.2015.03.007","article-title":"SIRT3 mediates multi-tissue coupling for metabolic fuel switching","volume":"21","author":"Richards","year":"2015","journal-title":"Cell Metab."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"e121758","DOI":"10.1172\/jci.insight.121758","article-title":"Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL\/6J","volume":"3","author":"Timmermans","year":"2018","journal-title":"JCI insight"},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.2337\/db06-0358","article-title":"Deletion of nicotinamide nucleotide transhydrogenase: A new quantitive trait locus accounting for glucose intolerance in C57BL\/6J mice","volume":"55","author":"Freeman","year":"2006","journal-title":"Diabetes"},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1474-9726.2007.00304.x","article-title":"SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction","volume":"6","author":"Wang","year":"2007","journal-title":"Aging Cell"},{"key":"ref_399","doi-asserted-by":"crossref","unstructured":"Garcia, A.A., Mathews, I.I., Horikoshi, N., Matsui, T., Kaur, M., Wakatsuki, S., and Mochly-Rosen, D. (2022). Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2022.101610"},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1038\/s41467-023-41895-2","article-title":"Acetylation-dependent coupling between G6PD activity and apoptotic signaling","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_401","first-page":"1304","article-title":"Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.molcel.2012.10.024","article-title":"Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome","volume":"49","author":"Hebert","year":"2013","journal-title":"Mol. Cell."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.molcel.2014.01.016","article-title":"Regulation of autophagy by cytosolic acetyl-coenzyme a","volume":"53","author":"Marino","year":"2014","journal-title":"Mol. Cell."},{"key":"ref_404","doi-asserted-by":"crossref","unstructured":"Weeks, J., Strom, A.I., Widjaja, V., Alexander, S., Pucher, D.K., and Sohl, C.D. (2021). Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics. Biomolecules, 11.","DOI":"10.3390\/biom11050740"},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0300-595X(76)80028-X","article-title":"Starvation in man","volume":"5","author":"Cahill","year":"1976","journal-title":"Clin. Endocrinol. Metab."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.nutr.26.061505.111258","article-title":"Fuel metabolism in starvation","volume":"26","author":"Cahill","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"109487","DOI":"10.1016\/j.celrep.2021.109487","article-title":"Ketogenesis impact on liver metabolism revealed by proteomics of lysine \u03b2-hydroxybutyrylation","volume":"36","author":"Koronowski","year":"2021","journal-title":"Cell Rep."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2016.03.036","article-title":"Metabolic Regulation of Gene Expression by Histone Lysine \u03b2-Hydroxybutyrylation","volume":"62","author":"Xie","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_409","doi-asserted-by":"crossref","unstructured":"Scherschel, M., Niemeier, J.-O., Jacobs, L., Hoffmann, M., Diederich, A., Bell, C., H\u00f6hne, P., Raetz, S., Kroll, J., and Steinbeck, J. (2024). The NAPstar family of NADP redox state sensors highlights glutathione as the primary mediator of anti-oxidative electron flux. BioRxiv.","DOI":"10.1101\/2024.02.14.580349"},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nchembio.2454","article-title":"A genetically encoded tool for manipulation of NADP(+)\/NADPH in living cells","volume":"13","author":"Cracan","year":"2017","journal-title":"Nat. Chem. Biol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/7\/820\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:11:53Z","timestamp":1760109113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/7\/820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":410,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["antiox13070820"],"URL":"https:\/\/doi.org\/10.3390\/antiox13070820","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]}}}