{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:26:09Z","timestamp":1789647969150,"version":"4.0.0"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Health Research Institute (NHRI), Taiwan","award":["BN-112-PP-01"],"award-info":[{"award-number":["BN-112-PP-01"]}]},{"name":"National Health Research Institute (NHRI), Taiwan","award":["111-2221-E-002-037-MY3"],"award-info":[{"award-number":["111-2221-E-002-037-MY3"]}]},{"name":"National Science and Technology Council (NSTC), Taiwan","award":["BN-112-PP-01"],"award-info":[{"award-number":["BN-112-PP-01"]}]},{"name":"National Science and Technology Council (NSTC), Taiwan","award":["111-2221-E-002-037-MY3"],"award-info":[{"award-number":["111-2221-E-002-037-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Oxidative stress resulting from reactive oxygen species (ROS) is often considered to be the leading cause of interstitial cystitis (IC), which is a chronic inflammatory disease. Antioxidants have been proven to have promising therapeutic effects on IC. In this study, we present an antioxidant intervention for IC by introducing curcumin-loaded cerium oxide nanoparticles (Cur-CONPs). Recognizing oxidative stress as the primary contributor to IC, our research builds on previous work utilizing cerium oxide nanoparticles (CONPs) for their outstanding antioxidant and anti-inflammatory properties. However, given the need to effectively relieve acute inflammation, we engineered Cur-CONPs to harness the short-term radical-scavenging antioxidant prowess of curcumin. Through in vitro studies, we demonstrate that the Cur-CONPs exhibit not only robust antioxidant capabilities but also superior anti-inflammatory properties over CONPs alone. Furthermore, in vivo studies validate the therapeutic effects of Cur-CONPs on IC. Mice with IC subjected to the Cur-CONP treatment exhibited improved micturition behaviors, relief from pelvic pain sensitivity, and reduced expression of inflammatory proteins (IL-6, IL-1\u03b2, TNF-\u03b1, Cox2). These findings suggest that the synergistic antioxidant properties of the Cur-CONPs that combine the sustained antioxidant properties of CONPs and acute anti-inflammatory capabilities of curcumin hold promise as a novel treatment strategy for IC.<\/jats:p>","DOI":"10.3390\/antiox13070826","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization and Therapeutic Potential of Curcumin-Loaded Cerium Oxide Nanoparticles for Interstitial Cystitis Management"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2343-560X","authenticated-orcid":false,"given":"Yang-Chen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jyun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-8140","authenticated-orcid":false,"given":"Chun-Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yantai Research Institute, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin 150009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Yantai Research Institute, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin 150009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-6671","authenticated-orcid":false,"given":"Feng-Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 10617, Taiwan"},{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","first-page":"1199","article-title":"Interstitial cystitis: Urgency and frequency syndrome","volume":"64","author":"Metts","year":"2001","journal-title":"Am. 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