{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:45:05Z","timestamp":1788993905089,"version":"build-2803163510"},"reference-count":80,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca","award":["PRIN 2022 D.D. 104 del 02\/02\/2022"],"award-info":[{"award-number":["PRIN 2022 D.D. 104 del 02\/02\/2022"]}]},{"name":"Finanziato dall\u2019Unione Europea\u2014NextGenerationEU\u2014OBERON, 2022FYBMEX, Italy","award":["PRIN 2022 D.D. 104 del 02\/02\/2022"],"award-info":[{"award-number":["PRIN 2022 D.D. 104 del 02\/02\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Organogenesis occurs in the uterus under low oxygen levels (4%). Preterm birth exposes immature newborns to a hyperoxic environment, which can induce a massive production of reactive oxygen species and potentially affect organ development, leading to diseases such as necrotizing enterocolitis. The \u03b23-adrenoreceptor (\u03b23-AR) has an oxygen-dependent regulatory mechanism, and its activation exerts an antioxidant effect. To test the hypothesis that \u03b23-AR could protect postnatal ileal development from the negative impact of high oxygen levels, Sprague\u2013Dawley rat pups were raised under normoxia (21%) or hyperoxia (85%) for the first 2 weeks after birth and treated or not with BRL37344, a selective \u03b23-AR agonist, at 1, 3, or 6 mg\/kg. Hyperoxia alters ileal mucosal morphology, leading to increased cell lipid oxidation byproducts, reduced presence of \u03b23-AR-positive resident cells, decreased junctional protein expression, disrupted brush border, mucin over-production, and impaired vascularization. Treatment with 3 mg\/kg of BRL37344 prevented these alterations, although not completely, while the lower 1 mg\/kg dose was ineffective, and the higher 6 mg\/kg dose was toxic. Our findings indicate the potential of \u03b23-AR agonism as a new therapeutic approach to counteract the hyperoxia-induced ileal alterations and, more generally, the disorders of prematurity related to supra-physiologic oxygen exposure.<\/jats:p>","DOI":"10.3390\/antiox13070863","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T16:51:12Z","timestamp":1721321472000},"page":"863","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective Effects of Beta-3 Adrenoceptor Agonism on Mucosal Integrity in Hyperoxia-Induced Ileal Alterations"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2374-5147","authenticated-orcid":false,"given":"Patrizia","family":"Nardini","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy"},{"name":"Imaging Platform, Department 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