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China","award":["IZCOZ0_205415"],"award-info":[{"award-number":["IZCOZ0_205415"]}]},{"name":"dual-chain integration project by the administration of traditional Chinese medicine, Shaanxi Province, China","award":["IZCOZ0_177070"],"award-info":[{"award-number":["IZCOZ0_177070"]}]},{"name":"China Scholarship Council","award":["2022KXJ-019"],"award-info":[{"award-number":["2022KXJ-019"]}]},{"name":"China Scholarship Council","award":["2023-ZDLSF-56"],"award-info":[{"award-number":["2023-ZDLSF-56"]}]},{"name":"China Scholarship Council","award":["2022-SLRH-LG-005"],"award-info":[{"award-number":["2022-SLRH-LG-005"]}]},{"name":"China Scholarship Council","award":["202206550010"],"award-info":[{"award-number":["202206550010"]}]},{"name":"China Scholarship Council","award":["310030_212558"],"award-info":[{"award-number":["310030_212558"]}]},{"name":"China Scholarship Council","award":["IZCOZ0_205415"],"award-info":[{"award-number":["IZCOZ0_205415"]}]},{"name":"China Scholarship Council","award":["IZCOZ0_177070"],"award-info":[{"award-number":["IZCOZ0_177070"]}]},{"name":"Swiss National Science Foundation","award":["2022KXJ-019"],"award-info":[{"award-number":["2022KXJ-019"]}]},{"name":"Swiss National Science Foundation","award":["2023-ZDLSF-56"],"award-info":[{"award-number":["2023-ZDLSF-56"]}]},{"name":"Swiss National Science Foundation","award":["2022-SLRH-LG-005"],"award-info":[{"award-number":["2022-SLRH-LG-005"]}]},{"name":"Swiss National Science Foundation","award":["202206550010"],"award-info":[{"award-number":["202206550010"]}]},{"name":"Swiss National Science Foundation","award":["310030_212558"],"award-info":[{"award-number":["310030_212558"]}]},{"name":"Swiss National Science Foundation","award":["IZCOZ0_205415"],"award-info":[{"award-number":["IZCOZ0_205415"]}]},{"name":"Swiss National Science Foundation","award":["IZCOZ0_177070"],"award-info":[{"award-number":["IZCOZ0_177070"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Hashimoto\u2019s thyroiditis (HT) is not only the most frequent autoimmune thyroid disease (AITD), but it also has a significant impact on patients\u2019 health-related quality of life (HRQoL), and it has been variably associated with differentiated thyroid carcinoma. Even though its pathogenesis is still incompletely understood, oxidative stress is believed to play an important role. Hypothyroidism related to later stages of HT can be treated with levothyroxine substitution therapy; various approaches such as selenium supplementation and iodine-restricted diets have been proposed as disease-modifying treatments for earlier stages, and even thyroidectomy has been suggested for refractory cases of painful HT. Nevertheless, many patients still report suboptimal HRQoL, highlighting an unmet medical need in this area. The concepts and approaches of traditional Chinese medicine (TCM) in treating HT are not broadly known in the West. Here, we provide an overview of TCM for HT, including combinations of TCM with selenium. We encompass evidence from clinical trials and other studies related to complex TCM prescriptions, single herbs used in TCM, and phytochemicals; wherever possible, we delineate the probable underlying molecular mechanisms. The findings show that the main active components of TCM for HT have commonly known or presumed antioxidant and anti-inflammatory activities, which may account for their potential utility in HT. Further exploring the practices of TCM for HT and combining them with evidence- and mechanism-based approaches according to Western standards may help to identify new strategies to alter the clinical course of the disease and\/or to treat patients\u2019 symptoms better and improve their HRQoL.<\/jats:p>","DOI":"10.3390\/antiox13070868","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T13:12:57Z","timestamp":1721394777000},"page":"868","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Traditional Chinese Medicine for Hashimoto\u2019s Thyroiditis: Focus on Selenium and Antioxidant Phytochemicals"],"prefix":"10.3390","volume":"13","author":[{"given":"Sheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Thyropathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China"},{"name":"Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos G.","family":"Ziros","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-6067","authenticated-orcid":false,"given":"Dionysios V.","family":"Chartoumpekis","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Psarias","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-4089","authenticated-orcid":false,"given":"Leonidas","family":"Duntas","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Metabolism and Diabetes, Evgenideion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhe","family":"Zuo","sequence":"additional","affiliation":[{"name":"Thyroid Disease Diagnosis and Treatment Center, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine and Rehabilitation, Beijing Health Vocational College, Beijing 101101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Thyropathy, Sunsimiao Hospital, Beijing University of Chinese Medicine, Tongchuan 727100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-4941","authenticated-orcid":false,"given":"Gerasimos P.","family":"Sykiotis","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ITC1","DOI":"10.7326\/AITC202007070","article-title":"Hypothyroidism","volume":"173","author":"McDermott","year":"2020","journal-title":"Ann. 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