{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:02:01Z","timestamp":1794312121356,"version":"4.9.0"},"reference-count":108,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Pregnancy is a complex and challenging process associated with physiological changes whose objective is to adapt the maternal organism to the increasing energetic requirements due to embryo and fetal development. A failed adaptation to these demands may lead to pregnancy complications that threaten the health of both mothers and their offspring. Since mitochondria are the main organelle responsible for energy generation in the form of ATP, the adequate state of these organelles seems crucial for proper pregnancy development and healthy pregnancy outcomes. The homeostasis of these organelles depends on several aspects, including their content, biogenesis, energy production, oxidative stress, dynamics, and signaling functions, such as apoptosis, which can be modified in relation to diseases during pregnancy. The etiology of pregnancy disorders like preeclampsia, fetal growth restriction, and gestational diabetes mellitus is not yet well understood. Nevertheless, insufficient placental perfusion and oxygen transfer are characteristic of many of them, being associated with alterations in the previously cited different aspects of mitochondrial homeostasis. Therefore, and due to the capacity of these multifactorial organelles to respond to physiological and pathophysiological stimuli, it is of great importance to gather the currently available scientific information regarding the relationship between main pregnancy complications and mitochondrial alterations. According to this, the present review is intended to show clear insight into the possible implications of mitochondria in these disorders, thus providing relevant information for further investigation in relation to the investigation and management of pregnancy diseases.<\/jats:p>","DOI":"10.3390\/antiox13080979","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:23:05Z","timestamp":1723616585000},"page":"979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pregnancy Disorders: A Potential Role for Mitochondrial Altered Homeostasis"],"prefix":"10.3390","volume":"13","author":[{"given":"Juan M.","family":"Toledano","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, 18071 Granada, Spain"},{"name":"Nutrition and Food Sciences Ph.D. Program, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Puche-Juarez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, 18071 Granada, Spain"},{"name":"Nutrition and Food Sciences Ph.D. Program, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9225-8225","authenticated-orcid":false,"given":"Jose Maria","family":"Galvez-Navas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"},{"name":"C\u00e1ncer Registry of Granada, Andalusian School of Public Health, Cuesta del Observatorio 4, Campus Universitario de Cartuja, 18011 Granada, Spain"},{"name":"Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS), 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-7851","authenticated-orcid":false,"given":"Jorge","family":"Moreno-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS), 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-1757","authenticated-orcid":false,"given":"Javier","family":"Diaz-Castro","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS), 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-6296","authenticated-orcid":false,"given":"Julio J.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS), 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2013.04.014","article-title":"Steroid hormone synthesis in mitochondria","volume":"379","author":"Miller","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.steroids.2015.09.006","article-title":"Multiple functions of syncytiotrophoblast mitochondria","volume":"103","author":"Martinez","year":"2015","journal-title":"Steroids"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00418-004-0677-x","article-title":"Oxidative stress in the placenta","volume":"122","author":"Myatt","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/01.ogx.0000193879.79268.59","article-title":"The role of placental oxidative stress and lipid peroxidation in preeclampsia","volume":"60","author":"Gupta","year":"2005","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mito.2018.06.007","article-title":"Effects of mitochondrial disease\/dysfunction on pregnancy: A retrospective study","volume":"46","author":"Karaa","year":"2019","journal-title":"Mitochondrion"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1469-7580.2008.00978.x","article-title":"Oxygen, the Janus gas; its effects on human placental development and function","volume":"215","author":"Burton","year":"2009","journal-title":"J. Anat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s10995-013-1307-9","article-title":"Descriptive epidemiology of chronic hypertension, gestational hypertension, and preeclampsia in New York State, 1995\u20132004","volume":"18","author":"Savitz","year":"2014","journal-title":"Matern. Child. Health J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine Growth Restriction: Antenatal and Postnatal Aspects","volume":"10","author":"Sharma","year":"2016","journal-title":"Clin. Med. Insights Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Colleoni, F., Padmanabhan, N., Yung, H.W., Watson, E.D., Cetin, I., Tissot van Patot, M.C., Burton, G.J., and Murray, A.J. (2013). Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: A role for miRNA-210 and protein synthesis inhibition. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055194"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.beem.2012.05.003","article-title":"Cellular and molecular mechanisms of mitochondrial function","volume":"26","author":"Osellame","year":"2012","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: Overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial Dynamics and Its Involvement in Disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11302-012-9305-8","article-title":"ATP synthesis and storage","volume":"8","author":"Bonora","year":"2012","journal-title":"Purinergic Signal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0161-5890(01)00108-0","article-title":"Calcium and oxidative stress: From cell signaling to cell death","volume":"38","author":"Ermak","year":"2002","journal-title":"Mol. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11751","DOI":"10.1021\/ja9018572","article-title":"The Molecular Mechanism of the Catalase Reaction","volume":"131","author":"Vidossich","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/ar.22553","article-title":"Mitochondrial swelling and incipient outer membrane rupture in preapoptotic and apoptotic cells","volume":"295","author":"Sesso","year":"2012","journal-title":"Anat. Rec."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/cdd.2008.57","article-title":"Mitochondrial fission and fusion dynamics: The long and short of it","volume":"15","author":"Berman","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1080\/15548627.2021.1975914","article-title":"The multifaceted regulation of mitophagy by endogenous metabolites","volume":"18","author":"Zhang","year":"2022","journal-title":"Autophagy"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bassi, G., Sidhu, S.K., and Mishra, S. (2021). The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis. Cells, 10.","DOI":"10.3390\/cells10081851"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: Pathophysiology, Challenges, and Perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Guerby, P., Tasta, O., Swiader, A., Pont, F., Bujold, E., Parant, O., Vayssiere, C., Salvayre, R., and Negre-Salvayre, A. (2021). Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia. Redox Biol., 40.","DOI":"10.1016\/j.redox.2021.101861"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e12653","DOI":"10.1111\/aji.12653","article-title":"Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes","volume":"77","author":"Sultana","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/0002-9378(91)90016-K","article-title":"Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy","volume":"165","author":"Wang","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12944-022-01663-5","article-title":"Foetal lipoprotein oxidation and preeclampsia","volume":"21","author":"Ceballos","year":"2022","journal-title":"Lipids Health Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11010-008-9739-z","article-title":"Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia","volume":"313","author":"Kaur","year":"2008","journal-title":"Mol. Cell Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijgo.2015.03.001","article-title":"Regional differences in the placental levels of oxidative stress markers in pre-eclampsia","volume":"129","author":"Sahay","year":"2015","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chiarello, D.I., Abad, C., Rojas, D., Toledo, F., V\u00e1zquez, C.M., Mate, A., Sobrevia, L., and Mar\u00edn, R. (2020). Oxidative stress: Normal pregnancy versus preeclampsia. Biochim. Biophys. Acta Mol. Basis Dis., 1866.","DOI":"10.1016\/j.bbadis.2018.12.005"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/HYPERTENSIONAHA.121.18298","article-title":"Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension","volume":"79","author":"Butts","year":"2022","journal-title":"Hypertension"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"McCarthy, C., and Kenny, L.C. (2016). Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia. Sci. Rep., 6.","DOI":"10.1038\/srep32683"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1089\/ars.2019.7891","article-title":"The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy","volume":"34","author":"Yang","year":"2021","journal-title":"Antioxid. Redox Signal"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Vishnyakova, P.A., Volodina, M.A., Tarasova, N.V., Marey, M.V., Tsvirkun, D.V., Vavina, O.V., Khodzhaeva, Z.S., Kan, N.E., Menon, R., and Vysokikh, M.Y. (2016). Mitochondrial role in adaptive response to stress conditions in preeclampsia. Sci. Rep., 6.","DOI":"10.1038\/srep32410"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shi, Z., Long, W., Zhao, C., Guo, X., Shen, R., and Ding, H. (2013). Comparative proteomics analysis suggests that placental mitochondria are involved in the development of pre-eclampsia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064351"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.placenta.2012.07.002","article-title":"MIR-210 modulates mitochondrial respiration in placenta with preeclampsia","volume":"33","author":"Muralimanoharan","year":"2012","journal-title":"Placenta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/s41419-018-1190-9","article-title":"Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery","volume":"9","author":"Holland","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4939-1031-1_12","article-title":"Effect of preeclampsia on placental function: Influence of sexual dimorphism, microRNA\u2019s and mitochondria","volume":"814","author":"Myatt","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yexcr.2017.07.029","article-title":"Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia","volume":"359","author":"Zhou","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.cub.2014.08.060","article-title":"Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles","volume":"24","author":"Udagawa","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e021726","DOI":"10.1161\/JAHA.121.021726","article-title":"Reduced Maternal Circulating Cell-Free Mitochondrial DNA Is Associated With the Development of Preeclampsia","volume":"11","author":"Cushen","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_43","first-page":"237","article-title":"A case-control study of maternal blood mitochondrial DNA copy number and preeclampsia risk","volume":"3","author":"Qiu","year":"2012","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_44","first-page":"120","article-title":"Maternal blood mitochondrial DNA copy number and placental abruption risk: Results from a preliminary study","volume":"4","author":"Williams","year":"2013","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1007\/s43032-021-00464-y","article-title":"Placental Mitochondrial Abnormalities in Preeclampsia","volume":"28","author":"Vangrieken","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"gaac026","DOI":"10.1093\/molehr\/gaac026","article-title":"Transcriptional profiles of genes related to mitochondrial aging in placental pathologies","volume":"29","author":"Bartho","year":"2022","journal-title":"Mol. Hum. Reprod."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Yu, J., Guo, X., Chen, R., and Feng, L. (2016). Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia. Biomed. Res. Int., 2016.","DOI":"10.1155\/2016\/6323086"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41419-018-0360-0","article-title":"Ceramide-induced BOK promotes mitochondrial fission in preeclampsia","volume":"9","author":"Ausman","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhou, X., Zhao, X., Zhou, W., Qi, H., Zhang, H., Han, T.L., and Baker, P. (2021). Impaired placental mitophagy and oxidative stress are associated with dysregulated BNIP3 in preeclampsia. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-99837-1"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jcb.26221","article-title":"Transcriptomic Profiling in Human Decidua of Severe Preeclampsia Detected by RNA Sequencing","volume":"119","author":"Tong","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1080\/21655979.2021.1997132","article-title":"Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells","volume":"13","author":"Chen","year":"2022","journal-title":"Bioengineered"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.4103\/0366-6999.158322","article-title":"Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models","volume":"128","author":"Han","year":"2015","journal-title":"Chin. Med. J."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Erlandsson, L., Ducat, A., Castille, J., Zia, I., Kalapotharakos, G., Hedstr\u00f6m, E., Vilotte, J.L., Vaiman, D., and Hansson, S.R. (2019). Alpha-1 microglobulin as a potential therapeutic candidate for treatment of hypertension and oxidative stress in the STOX1 preeclampsia mouse model. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-44639-9"},{"key":"ref_55","first-page":"45","article-title":"Placental apoptosis in preeclampsia, intrauterine growth retardation, and HELLP syndrome: An immunohistochemical study with caspase-3 and bcl-2","volume":"40","author":"Cali","year":"2013","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1582-4934.2010.01039.x","article-title":"Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: Effect on calcium exchange in placenta","volume":"15","author":"Takser","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Formanowicz, D., Mali\u0144ska, A., Nowicki, M., Kowalska, K., Gruca-Stryjak, K., Br\u0119borowicz, G., and Korybalska, K. (2019). Preeclampsia with Intrauterine Growth Restriction Generates Morphological Changes in Endothelial Cells Associated with Mitochondrial Swelling-An In Vitro Study. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111994"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.placenta.2018.07.004","article-title":"Abnormal steroidogenesis and aromatase activity in preeclampsia","volume":"69","author":"Berkane","year":"2018","journal-title":"Placenta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s13224-011-0092-x","article-title":"Placental insufficiency and fetal growth restriction","volume":"61","author":"Krishna","year":"2011","journal-title":"J. Obstet. Gynaecol. India"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1037\/bul0000091","article-title":"Mental health of extremely low birth weight survivors: A systematic review and meta-analysis","volume":"143","author":"Mathewson","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: A meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E404","DOI":"10.1152\/ajpendo.00426.2013","article-title":"Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia","volume":"306","author":"Stampalija","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000106488","article-title":"Role of oxidative stress in intrauterine growth restriction","volume":"64","author":"Biri","year":"2007","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mito.2020.08.008","article-title":"Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy","volume":"55","author":"Naha","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_66","first-page":"15","article-title":"Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction","volume":"17","author":"Singh","year":"2023","journal-title":"Int. J. Health Sci."},{"key":"ref_67","first-page":"1336","article-title":"Mitochondrial and glycolysis-regulatory gene expression profiles are associated with intrauterine growth restriction","volume":"33","author":"Jones","year":"2020","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1111\/jcmm.14282","article-title":"Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling","volume":"23","author":"Youssef","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.placenta.2009.03.005","article-title":"Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta","volume":"30","author":"Davy","year":"2009","journal-title":"Placenta"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"381.e1","DOI":"10.1016\/j.ajog.2010.01.036","article-title":"Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction","volume":"202","author":"Sharon","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/bj3480425","article-title":"Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells","volume":"348","author":"Lee","year":"2000","journal-title":"Biochem. J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1523\/JNEUROSCI.5654-07.2008","article-title":"Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism","volume":"28","author":"Gutsaeva","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.fertnstert.2015.05.005","article-title":"Involvement of estrogen-related receptor-\u03b3 and mitochondrial content in intrauterine growth restriction and preeclampsia","volume":"104","author":"Poidatz","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.placenta.2008.09.012","article-title":"Higher mitochondrial DNA content in human IUGR placenta","volume":"29","author":"Lattuada","year":"2008","journal-title":"Placenta"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2018.08.001","article-title":"Increased mitochondrial DNA copy number in maternal peripheral blood is associated with low birth weight in Lombok, Indonesia","volume":"70","author":"Priliani","year":"2018","journal-title":"Placenta"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"E1258","DOI":"10.1152\/ajpendo.00437.2002","article-title":"Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats","volume":"285","author":"Peterside","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.placenta.2021.07.303","article-title":"Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies","volume":"112","author":"Bartho","year":"2021","journal-title":"Placenta"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhu, H.L., Shi, X.T., Xu, X.F., Zhou, G.X., Xiong, Y.W., Yi, S.J., Liu, W.B., Dai, L.M., Cao, X.L., and Xu, D.X. (2021). Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2\/ATF4\/BNIP3-dependent mitophagy in placental trophoblasts. Redox Biol., 40.","DOI":"10.1016\/j.redox.2021.101854"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"106319","DOI":"10.1016\/j.envint.2020.106319","article-title":"Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts","volume":"147","author":"Zhu","year":"2021","journal-title":"Environ. Int."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Parsons, A.M., and Bouma, G.J. (2021). A Potential Role and Contribution of Androgens in Placental Development and Pregnancy. Life, 11.","DOI":"10.3390\/life11070644"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Shi, D., Zhou, X., Cai, L., Wei, X., Zhang, L., Sun, Q., Zhou, F., and Sun, L. (2023). Placental DNA methylation analysis of selective fetal growth restriction in monochorionic twins reveals aberrant methylated CYP11A1 gene for fetal growth restriction. FASEB J., 37.","DOI":"10.1096\/fj.202300742R"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12967-018-1666-5","article-title":"Heterogeneity of insulin resistance and beta cell dysfunction in gestational diabetes mellitus: A prospective cohort study of perinatal outcomes","volume":"16","author":"Liu","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Fantone, S., Gesuita, R., Di Renzo, G.C., Meyyazhagan, A., Tersigni, C., Scambia, G., Di Simone, N., and Marzioni, D. (2022). HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?. Diagnostics, 12.","DOI":"10.3390\/diagnostics12112705"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"399","DOI":"10.15537\/smj.2015.4.10307","article-title":"Gestational diabetes mellitus","volume":"36","author":"Alfadhli","year":"2015","journal-title":"Saudi Med. J."},{"key":"ref_85","first-page":"45","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links","volume":"11","author":"Oguntibeju","year":"2019","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.placenta.2005.01.002","article-title":"Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes","volume":"27","author":"Biri","year":"2006","journal-title":"Placenta"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Emiliano, J., Fajardo-Araujo, M.E., Z\u00fa\u00f1iga-Trujillo, I., P\u00e9rez-V\u00e1zquez, V., Sandoval-Salazar, C., and \u00d3rnelas-V\u00e1zquez, J.K. (2017). Mitochondrial content, oxidative, and nitrosative stress in human full-term placentas with gestational diabetes mellitus. Reprod. Biol. Endocrinol., 15.","DOI":"10.1186\/s12958-017-0244-7"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1089\/ars.2010.3765","article-title":"The role of oxidative stress in the pathophysiology of gestational diabetes mellitus","volume":"15","author":"Lappas","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Sarina, and Li, D (2019). F.; Feng, Z.Q.; Du, J.; Zhao, W.H.; Huang, N.; Jia, J.C.; Wu, Z.Y.; Alamusi; Wang, Y.Y.; et al. Mechanism of Placenta Damage in Gestational Diabetes Mellitus by Investigating TXNIP of Patient Samples and Gene Functional Research in Cell Line. Diabetes Ther., 10, 2265\u20132288.","DOI":"10.1007\/s13300-019-00713-z"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"655","DOI":"10.7754\/Clin.Lab.2012.120227","article-title":"Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A pilot study","volume":"59","author":"Qiu","year":"2013","journal-title":"Clin. Lab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/10715760500188796","article-title":"Oxidative stress promotes the increase of matrix metalloproteinases-2 and -9 activities in the feto-placental unit of diabetic rats","volume":"39","author":"Pustovrh","year":"2005","journal-title":"Free Radic. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1071\/RD01032","article-title":"Oxidative stress and altered prostanoid production in the placenta of streptozotocin-induced diabetic rats","volume":"14","author":"White","year":"2002","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.placenta.2017.06.001","article-title":"Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis","volume":"57","author":"Jiang","year":"2017","journal-title":"Placenta"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s11033-019-05221-8","article-title":"Thioredoxin, thioredoxin interacting protein and transducer and activator of transcription 3 in gestational diabetes","volume":"47","author":"Pasternak","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbrc.2018.12.021","article-title":"The association of plasma peroxiredoxin 3 with insulin in pregnant women","volume":"508","author":"Wang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1042\/CS20160076","article-title":"Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: Role of miR-143","volume":"130","author":"Muralimanoharan","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.placenta.2021.09.015","article-title":"The effect of gestational diabetes on the expression of mitochondrial fusion proteins in placental tissue","volume":"115","author":"Kolac","year":"2021","journal-title":"Placenta"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"283124","DOI":"10.1155\/2015\/283124","article-title":"Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus","volume":"2015","author":"Meng","year":"2015","journal-title":"Obstet. Gynecol. Int."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0888-7543(95)80058-T","article-title":"Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis","volume":"25","author":"Tiranti","year":"1995","journal-title":"Genomics"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1113\/JP280593","article-title":"Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus","volume":"599","author":"Fisher","year":"2021","journal-title":"J. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2378189","DOI":"10.1155\/2018\/2378189","article-title":"Impact of Obesity and Hyperglycemia on Placental Mitochondria","volume":"2018","author":"Anelli","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.orcp.2017.01.002","article-title":"Prepregnancy maternal diabetes combined with obesity impairs placental mitochondrial function involving Nrf2\/ARE pathway and detrimentally alters metabolism of offspring","volume":"12","author":"Duan","year":"2018","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.placenta.2014.06.368","article-title":"The effect of pre-existing maternal obesity and diabetes on placental mitochondrial content and electron transport chain activity","volume":"35","author":"Hastie","year":"2014","journal-title":"Placenta"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1016\/j.placenta.2010.12.011","article-title":"Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes","volume":"32","author":"Sobrevia","year":"2011","journal-title":"Placenta"},{"key":"ref_105","first-page":"C039","article-title":"Intracellular pH modulation in human umbilical vein endothelial cells requires sodium\/proton exchangers activity in gestational diabesity but sodium\/proton exchanger-1 activity in gestational diabetes with maternal pre-gestational normal weight or overweight","volume":"43","author":"Fuentes","year":"2019","journal-title":"Physiol. Soc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/jcp.24993","article-title":"The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction","volume":"230","author":"Sultan","year":"2015","journal-title":"J. Cell Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e000923","DOI":"10.1136\/bmjdrc-2019-000923","article-title":"Increased placental mitochondrial fusion in gestational diabetes mellitus: An adaptive mechanism to optimize feto-placental metabolic homeostasis?","volume":"8","author":"Abbade","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"S617","DOI":"10.33549\/physiolres.934794","article-title":"Steroids, steroid associated substances and gestational diabetes mellitus","volume":"70","author":"Hill","year":"2021","journal-title":"Physiol. Res."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/8\/979\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:35:39Z","timestamp":1760110539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/8\/979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":108,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["antiox13080979"],"URL":"https:\/\/doi.org\/10.3390\/antiox13080979","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}