{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:42Z","timestamp":1760145582244,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott Nutrition"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Brain alpha-tocopherol (\u03b1T) concentration was previously reported to be inversely associated with neurofibrillary tangle (NFT) counts in specific brain structures from centenarians. However, the contribution of natural or synthetic \u03b1T stereoisomers to this relationship is unknown. In this study, \u03b1T stereoisomers were quantified in the temporal cortex (TC) of 47 centenarians in the Georgia Centenarian Study (age: 102.2 \u00b1 2.5 years, BMI: 22.1 \u00b1 3.9 kg\/m2) and then correlated with amyloid plaques (diffuse and neuritic plaques; DPs, NPs) and NFTs in seven brain regions. The natural stereoisomer, RRR-\u03b1T, was the primary stereoisomer in all subjects, accounting for &gt;50% of total \u03b1T in all but five subjects. %RRR was inversely correlated with DPs in the frontal cortex (FC) (\u03c1 = \u22120.35, p = 0.032) and TC (\u03c1 = \u22120.34, p = 0.038). %RSS (a synthetic \u03b1T stereoisomer) was positively correlated with DPs in the TC (\u03c1 = 0.39, p = 0.017) and with NFTs in the FC (\u03c1 = 0.37, p = 0.024), TC (\u03c1 = 0.42, p = 0.009), and amygdala (\u03c1 = 0.43, p = 0.008) after controlling for covariates. Neither RRR- nor RSS-\u03b1T were associated with premortem global cognition. Even with the narrow and normal range of BMIs, BMI was correlated with %RRR-\u03b1T (\u03c1 = 0.34, p = 0.021) and %RSS-\u03b1T (\u03c1 = \u22120.45, p = 0.002). These results providing the first characterization of TC \u03b1T stereoisomer profiles in centenarians suggest that DP and NFT counts, but not premortem global cognition, are influenced by the brain accumulation of specific \u03b1T stereoisomers. Further study is needed to confirm these findings and to determine the potential role of BMI in mediating this relationship.<\/jats:p>","DOI":"10.3390\/antiox13080997","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:11:28Z","timestamp":1724062288000},"page":"997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians"],"prefix":"10.3390","volume":"13","author":[{"given":"Jia Pei","family":"Chan","sequence":"first","affiliation":[{"name":"Abbott Nutrition, Columbus, OH 43219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-3797","authenticated-orcid":false,"given":"Jirayu","family":"Tanprasertsuk","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-0032","authenticated-orcid":false,"given":"Elizabeth J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-425X","authenticated-orcid":false,"given":"Priyankar","family":"Dey","sequence":"additional","affiliation":[{"name":"College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA"},{"name":"Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala 147004, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-2038","authenticated-orcid":false,"given":"Richard S.","family":"Bruno","sequence":"additional","affiliation":[{"name":"College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard W.","family":"Poon","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, University of Georgia-Athens, Athens, GA 30602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-2283","authenticated-orcid":false,"given":"Adam","family":"Davey","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Nutrition Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Woodard","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-3823","authenticated-orcid":false,"given":"Matthew J.","family":"Kuchan","sequence":"additional","affiliation":[{"name":"Abbott Nutrition, Columbus, OH 43219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1056\/NEJM198707303170502","article-title":"Lack of Tocopherol in Peripheral Nerves of Vitamin E-Deficient Patients with Peripheral Neuropathy","volume":"317","author":"Traber","year":"1987","journal-title":"N. 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