{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:12:08Z","timestamp":1792181528494,"version":"4.4.0"},"reference-count":86,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008342","name":"Western Sydney University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Curcumin, as the main active component of turmeric (Curcuma longa), has been demonstrated with various bioactivities. However, its potential therapeutic applications are hindered by challenges such as poor solubility and bioavailability, rapid metabolism, and pan-assay interference properties. Recent advancements have aimed to overcome these limitations by developing novel curcumin analogues and modifications. This brief review critically assesses recent studies on synthesising different curcumin analogues, including metal complexes, nano particulates, and other curcumin derivatives, focused on the antioxidant, anti-inflammatory, and anticancer effects of curcumin and its modified analogues. Exploring innovative curcumin derivatives offers promising strategies to address the challenges associated with its bioavailability and efficacy and valuable insights for future research directions.<\/jats:p>","DOI":"10.3390\/antiox13091092","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:20:29Z","timestamp":1725614429000},"page":"1092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-Inflammatory, and Anticancer Activities"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-2777","authenticated-orcid":false,"given":"Kirandeep","family":"Kaur","sequence":"first","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-0426","authenticated-orcid":false,"given":"Ahmad K.","family":"Al-Khazaleh","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-0197","authenticated-orcid":false,"given":"Deep Jyoti","family":"Bhuyan","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-9678","authenticated-orcid":false,"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Science, Western Sydney University, Parramatta, NSW 2150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-2209","authenticated-orcid":false,"given":"Chun Guang","family":"Li","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"ref_1","first-page":"2047","article-title":"Perspectivtees on new synthetic curcumin analogs and their potential anticancer properties","volume":"19","author":"Vyas","year":"2013","journal-title":"Curr. 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