{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:26:25Z","timestamp":1791123985465,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Health, Instituto de Salud Carlos III (ISCIII)","award":["PI20\/00084"],"award-info":[{"award-number":["PI20\/00084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Malondialdehyde (MDA) is a naturally occurring organic compound produced as a byproduct of lipid peroxidation. It serves as one of the most widely recognized biomarkers for oxidative stress. Elevated levels of MDA have been observed in patients with inflammatory bowel disease (IBD), suggesting its involvement in the pathogenesis and progression of the disease. In this study, we analyzed MDA levels within a well-characterized and extensive cohort of IBD patients. Our objective was to investigate the association between MDA levels and disease characteristics in this population. This is a cross-sectional study that encompassed 197 patients with IBD. Multivariable linear regression analysis was performed to study the relationship between disease characteristics and circulating MDA. MDA was significantly associated with male sex in IBD patients but not with other demographic characteristics or classic cardiovascular risk factors. Regarding disease features such as phenotype or activity indices, their relationship with MDA was scarce. Several lipid profile molecules showed a significant association with MDA levels after multivariable analysis. Similarly, the liver fibrosis-4 index and hepatic elastography values were significantly related to higher MDA levels after adjusting for covariates. In conclusion, the sources of elevated MDA in IBD are primarily linked to lipid profile abnormalities and liver disease.<\/jats:p>","DOI":"10.3390\/antiox13101171","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T06:55:52Z","timestamp":1727333752000},"page":"1171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Nayra","family":"Merino de Paz","sequence":"first","affiliation":[{"name":"Division of Dermatology, Dermamedicin Cl\u00ednicas, 38004 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-8711","authenticated-orcid":false,"given":"Marta","family":"Carrillo-Palau","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-207X","authenticated-orcid":false,"given":"Alejandro","family":"Hern\u00e1ndez-Camba","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Nuestra Se\u00f1ora de la Candelaria, 38010 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Abreu-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unit of Physiology, Department of Basic Medical Sciences, University of La Laguna, 38200 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"de Vera-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Division of Central Laboratory, Hospital Universitario de Canarias, 38200 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-9231","authenticated-orcid":false,"given":"Alejandra","family":"Gonz\u00e1lez-Delgado","sequence":"additional","affiliation":[{"name":"Division of Central Laboratory, Hospital Universitario de Canarias, 38200 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-1840","authenticated-orcid":false,"given":"Candelaria","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1.","family":"Gonz\u00e1lez-Gay","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"},{"name":"Department of Medicine and Psychiatry, University of Cantabria, 39011 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-5267","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Ferraz-Amaro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, Spain"},{"name":"Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7247238","DOI":"10.1155\/2019\/7247238","article-title":"A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management","volume":"161","author":"Rogler","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.amjmed.2022.08.012","article-title":"Inflammatory Bowel Disease and Cardiovascular Diseases","volume":"135","author":"Chen","year":"2022","journal-title":"Am. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Camba, A., Carrillo-Palau, M., Ramos, L., Alvarez-Buylla, N.H., Alonso-Abreu, I., Hern\u00e1ndez-P\u00e9rez, A., Vela, M., Arranz, L., Hern\u00e1ndez-Guerra, M., and Gonz\u00e1lez-Gay, M.\u00c1. (2021). Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081671"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.3748\/wjg.v22.i34.7727","article-title":"Co-Existence of Non-Alcoholic Fatty Liver Disease and Inflammatory Bowel Disease: A Review Article","volume":"22","author":"Chao","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Merino de Paz, N., Garc\u00eda-Gonz\u00e1lez, M., G\u00f3mez-Bernal, F., Quevedo-Abeledo, J.C., de Vera-Gonz\u00e1lez, A., L\u00f3pez-Mejias, R., Abreu-Gonz\u00e1lez, P., Mart\u00edn-Gonz\u00e1lez, C., Gonz\u00e1lez-Gay, M.\u00c1., and Ferraz-Amaro, I. (2023). Relationship between Malondialdehyde Serum Levels and Disease Features in a Full Characterized Series of 284 Patients with Systemic Lupus Erythematosus. Antioxidants, 12.","DOI":"10.3390\/antiox12081535"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Merino de Paz, N., Quevedo-Abeledo, J.C., G\u00f3mez-Bernal, F., de Vera-Gonz\u00e1lez, A., Abreu-Gonz\u00e1lez, P., Mart\u00edn-Gonz\u00e1lez, C., Gonz\u00e1lez-Gay, M.\u00c1., and Ferraz-Amaro, I. (2024). Malondialdehyde Serum Levels in a Full Characterized Series of 430 Rheumatoid Arthritis Patients. J. Clin. Med., 13.","DOI":"10.3390\/jcm13030901"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., and Mao, Z. (2024). The Emerging Role of Oxidative Stress in Inflammatory Bowel Disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1390351"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(80)92767-1","article-title":"A SIMPLE INDEX OF CROHN\u2019S-DISEASE ACTIVITY","volume":"315","author":"Harvey","year":"1980","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis","volume":"317","author":"Schroeder","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_13","unstructured":"(2021). SCORE2 Risk Prediction Algorithms: New Models to Estimate 10-Year Risk of Cardiovascular Disease in Europe. Eur. Heart J., 42, 2439\u20132454."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","article-title":"Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004\u20132006\u20132011). An Update on Behalf of the Advisory Board of the 3rd, 4th and 5th Watching the Risk Symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0003-2697(92)90102-D","article-title":"Interpretation of the Thiobarbituric Acid Reactivity of Rat Liver and Brain Homogenates in the Presence of Ferric Ion and Ethylenediaminetetraacetic Acid","volume":"202","author":"Kikugawa","year":"1992","journal-title":"Anal. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s004250050524","article-title":"Improving the Thiobarbituric Acid-Reactive-Substances Assay for Estimating Lipid Peroxidation in Plant Tissues Containing Anthocyanin and Other Interfering Compounds","volume":"207","author":"Hodges","year":"1999","journal-title":"Planta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0024-3205(91)90550-U","article-title":"The Biological Significance of Malondialdehyde Determination in the Assessment of Tissue Oxidative Stress","volume":"48","author":"Valenzuela","year":"1991","journal-title":"Life Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and Abuse of HOMA Modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1111\/j.1572-0241.2007.01520.x","article-title":"Abdominal Ultrasound for Diagnosis of Nonalcoholic Fatty Liver Disease (NAFLD)","volume":"102","author":"Mishra","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1111\/j.1572-0241.2007.01526.x","article-title":"The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation","volume":"102","author":"Hamaguchi","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/hep.21420","article-title":"Accuracy of Liver Stiffness Measurement for the Diagnosis of Cirrhosis in Patients with Chronic Liver Diseases","volume":"44","author":"Ziol","year":"2006","journal-title":"Hepatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.dld.2007.10.019","article-title":"Noninvasive Assessment of Liver Fibrosis by Measurement of Stiffness in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)","volume":"40","author":"Yoneda","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.21669","article-title":"FIB-4: An Inexpensive and Accurate Marker of Fibrosis in HCV Infection. Comparison with Liver Biopsy and Fibrotest","volume":"46","author":"Mallet","year":"2007","journal-title":"Hepatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/1319-3767.36750","article-title":"Lipid Peroxides in Patients with Inflammatory Bowel Disease","volume":"13","author":"Alzoghaibi","year":"2007","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cbf.1224","article-title":"Serum Paraoxonase 1 Activity and Malondialdehyde Levels in Patients with Ulcerative Colitis","volume":"24","author":"Baskol","year":"2006","journal-title":"Cell Biochem. Funct."},{"key":"ref_26","first-page":"368","article-title":"The Relationship between Neutrophil\/Lymphocyte and Platelet\/Lymphocyte Ratios with Oxidative Stress in Active Crohn\u2019s Disease Patients","volume":"20","author":"Eraldemir","year":"2016","journal-title":"Hippokratia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/1319-3767.111956","article-title":"Oxidative Stress Markers in Intestinal Mucosa of Tunisian Inflammatory Bowel Disease Patients","volume":"19","author":"Bouzid","year":"2013","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.2174\/092986712803530458","article-title":"The Role of Oxidative Stress in Anti-Tumor Necrosis Factor Antibody Treatment in Crohn\u2019s Disease","volume":"19","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/01.CIR.98.15.1487","article-title":"Oxidized LDL and Malondialdehyde-Modified LDL in Patients with Acute Coronary Syndromes and Stable Coronary Artery Disease","volume":"98","author":"Holvoet","year":"1998","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11789-017-0084-1","article-title":"Lipoprotein(a) and Its Role in Inflammation, Atherosclerosis and Malignancies","volume":"12","author":"Schmitz","year":"2017","journal-title":"Clin. Res. Cardiol. Suppl."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Carrillo-Palau, M., Hern\u00e1ndez-Camba, A., Alvarez-Buylla, N.H., Ramos, L., Alonso-Abreu, I., Hern\u00e1ndez-P\u00e9rez, A., Vela, M., Arranz, L., Hern\u00e1ndez-Guerra, M., and Gonz\u00e1lez-Gay, M. (2021). Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease. J. Clin. Med., 10.","DOI":"10.3390\/jcm10143062"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ijcard.2003.10.035","article-title":"Insulin Resistance Increases Circulating Malondialdehyde-Modified LDL and Impairs Endothelial Function in Healthy Young Men","volume":"97","author":"Mizuno","year":"2004","journal-title":"Int. J. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.4254\/wjh.v13.i11.1534","article-title":"Liver Involvement in Inflammatory Bowel Disease: What Should the Clinician Know?","volume":"13","author":"Losurdo","year":"2021","journal-title":"World J. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.14740\/gr990w","article-title":"Hepatobiliary Manifestations and Complications in Inflammatory Bowel Disease: A Review","volume":"11","author":"Fousekis","year":"2018","journal-title":"Gastroenterol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zelber-Sagi, S., Ivancovsky-Wajcman, D., Fliss-Isakov, N., Hahn, M., Webb, M., Shibolet, O., Kariv, R., and Tirosh, O. (2020). Serum Malondialdehyde Is Associated with Non-Alcoholic Fatty Liver and Related Liver Damage Differentially in Men and Women. Antioxidants, 9.","DOI":"10.3390\/antiox9070578"}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/10\/1171\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:03:36Z","timestamp":1760112216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/10\/1171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["antiox13101171"],"URL":"https:\/\/doi.org\/10.3390\/antiox13101171","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]}}}