{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:37:52Z","timestamp":1783525072061,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2023YFE0124400"],"award-info":[{"award-number":["2023YFE0124400"]}]},{"name":"National Key Research and Development Program of China","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"National Key Research and Development Program of China","award":["2024B03J1267"],"award-info":[{"award-number":["2024B03J1267"]}]},{"name":"Key Project of Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China","award":["2023YFE0124400"],"award-info":[{"award-number":["2023YFE0124400"]}]},{"name":"Key Project of Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"Key Project of Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China","award":["2024B03J1267"],"award-info":[{"award-number":["2024B03J1267"]}]},{"name":"Guangzhou Key Research and Development Plan Project","award":["2023YFE0124400"],"award-info":[{"award-number":["2023YFE0124400"]}]},{"name":"Guangzhou Key Research and Development Plan Project","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"Guangzhou Key Research and Development Plan Project","award":["2024B03J1267"],"award-info":[{"award-number":["2024B03J1267"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>There are different stress resistance among different breeds of pigs. Changes in intestinal stem cells (ISCs) are still unclear among various breeds of piglets after early weaning. In the current study, Taoyuan Black and Duroc piglets were slaughtered at 21 days of age (early weaning day) and 24 days of age (3 days after early weaning) for 10 piglets in each group. The results showed that the rate of ISC-driven epithelial renewal in local Taoyuan Black pigs hardly changed after weaning for 3 days. However, weaning stress significantly reduced the weight of the duodenum and jejunum in Duroc piglets. Meanwhile, the jejunal villus height, tight junction-related proteins (ZO-1, Occludin, and Claudin1), as well as the trans-epithelial electrical resistance (TEER) values, were down-regulated after weaning for 3 days in Duroc piglets. Moreover, compared with Unweaned Duroc piglets, the numbers of Olfm4+ ISC cells, PCNA+ mitotic cells, SOX9+ secretory progenitor cells, and Villin+ absorptive cells in the jejunum were reduced significantly 3 days after weaning. And ex vivo jejunal crypt-derived organoids exhibited growth disadvantages in weaned Duroc piglets. Notably, the Keap1\/Nrf2 signaling activities and the expression of HO-1 were significantly depressed in weaned Duroc piglets compared to Unweaned Duroc piglets. Thus, we can conclude that ISCs of Duroc piglets were more sensitive to weaning stress injury than Taoyuan Black piglets, and Keap1\/Nrf2 signaling is involved in this process.<\/jats:p>","DOI":"10.3390\/antiox13101188","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:39:35Z","timestamp":1727678375000},"page":"1188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Weaning Inhibits Intestinal Stem Cell Expansion to Disrupt the Intestinal Integrity of Duroc Piglets via Regulating the Keap1\/Nrf2 Signaling"],"prefix":"10.3390","volume":"13","author":[{"given":"Ying-Chao","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-4595","authenticated-orcid":false,"given":"Cheng-Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science in South China, State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Cai","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-9485","authenticated-orcid":false,"given":"Xiu-Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-6682","authenticated-orcid":false,"given":"Xiang-Feng","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chao","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, Z., Tan, C., Duan, C., Wu, J., Zhou, D., Hou, L., Qian, W., Han, C., and Hou, X. (2023). FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response. Redox Biol., 60.","DOI":"10.1016\/j.redox.2023.102618"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.1038\/s41467-020-20222-z","article-title":"The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness","volume":"11","author":"Grinat","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.stem.2017.05.001","article-title":"Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells","volume":"21","author":"Jadhav","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0168-1591(89)90006-3","article-title":"When to wean\u2014Observations from free-ranging domestic pigs","volume":"23","author":"Per","year":"1989","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gresse, R., Chaucheyras, D.F., Denis, S., Beaumont, M., Van, W.T., Forano, E., and Blanquet, D.S. (2021). Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon (MPigut-IVM). J. Anim. Sci. Biotechnol., 12.","DOI":"10.3389\/fmicb.2021.703421"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hussain, T., Wang, J., Murtaza, G., Metwally, E., Yang, H., Kalhoro, M.S., Kalhoro, D.H., Rahu, B.A., Tan, B., and Sahito, R.A. (2021). The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress. Oxid. Med. Cell. Longev., 6676444.","DOI":"10.1155\/2021\/6676444"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/gutjnl-2020-321339","article-title":"SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation","volume":"70","author":"Peuker","year":"2021","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2017.10.009","article-title":"Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195","volume":"154","author":"Xiao","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wang, P., Luo, Y., Huang, J., Gao, S., Zhu, G., Dang, Z., Gai, J., Yang, M., Zhu, M., and Zhang, H. (2020). The genome evolution and domestication of tropical fruit mango. Genome Biol., 21.","DOI":"10.1186\/s13059-020-01959-8"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.chom.2018.11.006","article-title":"A Microbiota-Derived Bacteriocin Targets the Host to Confer Diarrhea Resistance in Early-Weaned Piglets","volume":"24","author":"Hu","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jiang, Z.P., Su, W.F., Yang, M.Z., Li, W.T., Gong, T., Zhang, Y., Wen, C.Y., Wang, X.X., Wang, Y.Z., and Jin, M.L. (2022). Screening of Bacteria Inhibiting Clostridium perfringens and Assessment of Their Beneficial Effects In Vitro and In Vivo with Whole Genome Sequencing Analysis. Microorganisms, 10.","DOI":"10.3390\/microorganisms10102056"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"You, X., Liu, M., Liu, Q., Li, H., Qu, Y., Gao, X., Huang, C., Luo, G., Cao, G., and Xu, D. (2022). miRNA let-7 family regulated by NEAT1 and ARID3A\/NF-\u03baB inhibits PRRSV-2 replication in vitro and in vivo. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010820"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yang, Y., Zhou, R., Mu, Y., Hou, X., Tang, Z., and Li, K. (2016). Genome-wide analysis of DNA methylation in obese, lean, and miniature pig breeds. Sci. Rep., 6.","DOI":"10.1038\/srep30160"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ding, S., Cheng, Y., Azad, M.K., Dong, H., He, J., Huang, P., and Kong, X. (2023). Dietary fiber alters immunity and intestinal barrier function of different breeds of growing pigs. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1104837"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Campbell, J.M., Crenshaw, J.D., and Polo, J. (2013). The biological stress of early weaned piglets. J. Anim. Sci. Biotechnol., 4.","DOI":"10.1186\/2049-1891-4-19"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Degroote, J., Vergauwen, H., Wang, W., Van Ginneken, C., De, S.S., and Michiels, J. (2020). Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function. J. Anim. Sci. Biotechnol., 11.","DOI":"10.1186\/s40104-020-00440-7"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dowley, A., Sweeney, T., Conway, E., Vigors, S., Ryan, M.T., Yadav, S., Wilson, J., and O\u2019Doherty, J.V. (2023). The effects of dietary supplementation with mushroom or selenium enriched mushroom powders on the growth performance and intestinal health of post-weaned pigs. J. Anim. Sci. Biotechnol., 14.","DOI":"10.1186\/s40104-022-00808-x"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Liu, S., Xiong, Y., Cao, S., Wen, X., Xiao, H., Li, Y., Chi, L., He, D., Jiang, Z., and Wang, L. (2022). Dietary Stevia Residue Extract Supplementation Improves Antioxidant Capacity and Intestinal Microbial Composition of Weaned Piglets. Antioxidants, 11.","DOI":"10.3390\/antiox11102016"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lovatt, M., Kocaba, V., Hui, N.J., Soh, Y.Q., and Mehta, J.S. (2020). Nrf2: A unifying transcription factor in the pathogenesis of Fuchs\u2019 endothelial corneal dystrophy. Redox Biol., 37.","DOI":"10.1016\/j.redox.2020.101763"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pomatto, L.D., Sun, P.Y., Yu, K., Gullapalli, S., Bwiza, C.P., Sisliyan, C., Wong, S., Zhang, H., Forman, H.J., and Oliver, P.L. (2019). Limitations to adaptive homeostasis in a hyperoxia-induced model of accelerated ageing. Redox Biol., 24.","DOI":"10.1016\/j.redox.2019.101194"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.15252\/embj.201490686","article-title":"Generating human intestinal tissues from pluripotent stem cells to study devel opment and disease","volume":"34","author":"Sinagoga","year":"2015","journal-title":"Embo. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jare.2020.04.020","article-title":"Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of mesenteric lymph nodes","volume":"24","author":"Streich","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/ng.2811","article-title":"Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars","volume":"45","author":"Li","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.scitotenv.2017.08.078","article-title":"Climate and drought risk regionalisation in China based on probabilistic aridity and drought index","volume":"612","author":"Wu","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wang, X.Y., Ran, X.Q., Niu, X., Huang, S.H., Li, S., and Wang, J.F. (2017). Whole-genome sequence analysis reveals selection signatures for important economic traits in Xiang pigs. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-14686-w"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ding, S., Cheng, Y., Azad, M.K., Zhu, Q., Huang, P., and Kong, X. (2022). Developmental Changes of Immunity and Different Responses to Weaning Stress of Chinese Indigenous Piglets and Duroc Piglets during Suckling and Weaning Periods. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415781"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gao, Y., Ma, X., Zhou, Y., and Li, Y. (2022). Dietary supplementation of squalene increases the growth performance of early-weaned piglets by improving gut microbiota, intestinal barrier, and blood antioxidant capacity. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.995548"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.aninu.2020.07.011","article-title":"Dietary chenodeoxycholic acid improves growth performance and intestinal health by altering serum metabolic profiles and gut bacteria in weaned piglets","volume":"7","author":"Song","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Farr\u00e9, R., Fiorani, M., Abdu, R.S., and Matteoli, G. (2020). Intestinal Permeability, Inflammation and the Role of Nutrients. Nutrients, 12.","DOI":"10.3390\/nu12041185"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrgastro.2016.169","article-title":"The intestinal epithelial barrier: A therapeutic target","volume":"14","author":"Odenwald","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2009.03.003","article-title":"The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression","volume":"237","author":"Pinton","year":"2009","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ecco-jcc\/jjz188","article-title":"Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease","volume":"14","author":"Sharma","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1021\/acs.jafc.3c08044","article-title":"Lithocholic Acid Alleviates Deoxynivalenol-Induced Inflammation and Oxidative Stress via PPAR\u03b3-Mediated Epigenetically Transcriptional Reprogramming in Porcine Intestinal Epithelial Cells","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1956281","DOI":"10.1080\/19490976.2021.1956281","article-title":"A bovine lactoferricin-lactoferrampin-encoding Lactobacillus reuteri CO21 regulates the intestinal mucosal immunity and enhances the protection of piglets against enterotoxigenic Escherichia coli K88 challenge","volume":"13","author":"Xie","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gu, H., Liu, Y., Zhao, Y., Qu, H., Li, Y., Ahmed, A.A., Liu, H.Y., Hu, P., and Cai, D. (2023). Hepatic Anti-Oxidative Genes CAT and GPX4 Are Epigenetically Modulated by ROR\u03b3\/NRF2 in Alphacoronavirus-Exposed Piglets. Antioxidants, 12.","DOI":"10.3390\/antiox12061305"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.aninu.2021.05.002","article-title":"Dietary high protein-induced diarrhea and intestinal inflammation by activation of NF-\u03baB signaling in piglets","volume":"7","author":"Yin","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.stem.2020.01.008","article-title":"Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient","volume":"26","author":"McCarthy","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.devcel.2020.07.009","article-title":"Intestinal Regeneration: Regulation by the Microenvironment","volume":"54","author":"Hageman","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_39","first-page":"159","article-title":"The interaction among gut microbes, the intestinal barrier and short chain fatty acids","volume":"11","author":"Ma","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"19","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"109670","DOI":"10.1016\/j.cellsig.2020.109670","article-title":"Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms","volume":"72","author":"Priya","year":"2020","journal-title":"Cell Signal."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bardel\u010d\u00edkov\u00e1, A., \u0160oltys, J., and Moj\u017ei\u0161, J. (2023). Oxidative Stress, Inflammation and Colorectal Cancer: An Overview. Antioxidants, 12.","DOI":"10.3390\/antiox12040901"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chen, Q., Gao, L., Li, J., Yuan, Y., Wang, R., Tian, Y., and Lei, A. (2022). \u03b1-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway. Oxid. Med. Cell. Longev., 7113793.","DOI":"10.1155\/2022\/7113793"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"23","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.devcel.2021.03.034","article-title":"Duffy J and Wang MC, Lipid metabolism and lipid signals in aging and longevity","volume":"56","author":"Mutlu","year":"2021","journal-title":"Dev. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6998","DOI":"10.1126\/sciadv.ade6998","article-title":"Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget\u2019s disease of bone","volume":"9","author":"Hu","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tifs.2017.02.002","article-title":"KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane","volume":"69","author":"Fahey","year":"2017","journal-title":"Trends Food Sci. Tech."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: From basic science to therapeutic applications","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/cvr\/cvn350","article-title":"Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits","volume":"81","author":"Ding","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamaneurol.2013.593","article-title":"SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy","volume":"70","author":"Winer","year":"2013","journal-title":"JAMA Neurol."}],"container-title":["Antioxidants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/10\/1188\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:07:35Z","timestamp":1760112455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3921\/13\/10\/1188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["antiox13101188"],"URL":"https:\/\/doi.org\/10.3390\/antiox13101188","relation":{},"ISSN":["2076-3921"],"issn-type":[{"value":"2076-3921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}