{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:02:47Z","timestamp":1792000967462,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HPLC-MS\/MS measurements","award":["EQM170023"],"award-info":[{"award-number":["EQM170023"]}]},{"name":"HPLC-MS\/MS measurements","award":["DST\/CON 0075\/2018"],"award-info":[{"award-number":["DST\/CON 0075\/2018"]}]},{"name":"HPLC-MS\/MS measurements","award":["1 047 M4602"],"award-info":[{"award-number":["1 047 M4602"]}]},{"name":"HPLC-MS\/MS measurements","award":["1210076"],"award-info":[{"award-number":["1210076"]}]},{"name":"Department of Science and Innovation (IK-based Technology Innovation (DSI)","award":["EQM170023"],"award-info":[{"award-number":["EQM170023"]}]},{"name":"Department of Science and Innovation (IK-based Technology Innovation (DSI)","award":["DST\/CON 0075\/2018"],"award-info":[{"award-number":["DST\/CON 0075\/2018"]}]},{"name":"Department of Science and Innovation (IK-based Technology Innovation (DSI)","award":["1 047 M4602"],"award-info":[{"award-number":["1 047 M4602"]}]},{"name":"Department of Science and Innovation (IK-based Technology Innovation (DSI)","award":["1210076"],"award-info":[{"award-number":["1210076"]}]},{"name":"Department of Agriculture Land Reform and Rural Development (DALRRD)","award":["EQM170023"],"award-info":[{"award-number":["EQM170023"]}]},{"name":"Department of Agriculture Land Reform and Rural Development (DALRRD)","award":["DST\/CON 0075\/2018"],"award-info":[{"award-number":["DST\/CON 0075\/2018"]}]},{"name":"Department of Agriculture Land Reform and Rural Development (DALRRD)","award":["1 047 M4602"],"award-info":[{"award-number":["1 047 M4602"]}]},{"name":"Department of Agriculture Land Reform and Rural Development (DALRRD)","award":["1210076"],"award-info":[{"award-number":["1210076"]}]},{"name":"FONDECYT Project","award":["EQM170023"],"award-info":[{"award-number":["EQM170023"]}]},{"name":"FONDECYT Project","award":["DST\/CON 0075\/2018"],"award-info":[{"award-number":["DST\/CON 0075\/2018"]}]},{"name":"FONDECYT Project","award":["1 047 M4602"],"award-info":[{"award-number":["1 047 M4602"]}]},{"name":"FONDECYT Project","award":["1210076"],"award-info":[{"award-number":["1210076"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antioxidants"],"abstract":"<jats:p>Herbal teas are used in South Africa as digestives to lower glycaemia and for other indications. However, the chemical composition of the infusions and their effect on enzymes related to metabolic syndrome is poorly known. The composition of infusions and methanol extracts of B. saligna (Scrophulariaceae), Lippia javanica, L. scaberrima, and Phyla dulcis (Verbenaceae) was assessed and the effect of the infusions and extract was determined towards \u03b1-glucosidase, \u03b1-amylase, and pancreatic lipase. The commercial herbal products were extracted separately with MeOH or hot water to obtain the extract\/infusion for comparative studies. Total phenolic, total flavonoid and antioxidant capacity were assessed. The fingerprints of the MeOH extracts and infusions were compared by HPLD-DAD. The extract constituents were tentatively identified by HPLC-MS\/MS and NMR analyses. From the extracts\/infusions, 57 compounds were identified, including iridoids, phenylpropanoid glycosides, flavonoids, and caffeic acid derivatives, among others. The MeOH extracts and infusions showed strong inhibition towards \u03b1-glucosidase with IC50 in the range of 0.13\u20130.84 \u00b5g\/mL for the phenolic-enriched infusion extract (PEI) and 0.47\u20130.50 \u00b5g\/mL for the MeOH extracts, respectively. The P. dulcis PEI showed higher inhibition towards \u03b1-glucosidase, and the MeOH extract of L. scaberrima was better than the PEI. At 100 \u00b5g\/mL, the PEI from the four herbal teas reduces the activity of \u03b1-amylase by 23.03\u201328.61%, with L. javanica as the most active tea. Three of the species are high in phenylpropanoid glycosides, while P. dulcis contains rosmarinic acid. Some 26 compounds were identified in the infusion from B. saligna, 28 from L. scaberrima, and 21 from P. dulcis. Four of them are common in all the teas, namely decaffeoylverbascoside, verbascoside, isoverbascoside, and tuberonic acid hexoside. Ten compounds occur in two of the teas and seventeen, fifteen, and eleven compounds were detected only in B. saligna, L. scaberrima, and P. dulcis, respectively. Most of the compounds are reported for the first time from the crude drug infusions. The results give some support for the traditional use of herbal teas as digestives and\/or indications for diabetes. The chemical fingerprints set the basis for quality control of the crude drugs, based on the main constituents and differential compounds occurring in the samples.<\/jats:p>","DOI":"10.3390\/antiox13101219","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:34:36Z","timestamp":1728560076000},"page":"1219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemical Profiling, Enzyme Inhibitory Activity and Antioxidant Capacity of South African Herbal Teas: Buddleja saligna, Lippia javanica, L. scaberrima and Phyla dulcis"],"prefix":"10.3390","volume":"13","author":[{"given":"N\u00e9lida","family":"Nina","sequence":"first","affiliation":[{"name":"Laboratorio de Qu\u00edmica de Productos Naturales, Instituto de Qu\u00edmica de Recursos Naturales, Campus Lircay, Universidad de Talca, Talca 3480094, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-8556","authenticated-orcid":false,"given":"Alberto","family":"Burgos-Edwards","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica de Productos Naturales, Instituto de Qu\u00edmica de Recursos Naturales, Campus Lircay, Universidad de Talca, Talca 3480094, Chile"},{"name":"Departamento de Fitoqu\u00edmica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de Asunci\u00f3n, Campus San Lorenzo P.O. Box 2169, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Theoduloz","sequence":"additional","affiliation":[{"name":"Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Campus Lircay, Universidad de Talca, Talca 3480094, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Physiology and Allied Sciences, Amity Institute of Health Allied Sciences, Amity University, Noida 201301, Uttar Pradesh, India"},{"name":"Department of Pharmacology, Faculty of Health Sciences, School of Clinical Medicines, University of Free State, Bloemfontein 9300, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2921-8882","authenticated-orcid":false,"given":"Motlalepula Gilbert","family":"Matsabisa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Health Sciences, School of Clinical Medicines, University of Free State, Bloemfontein 9300, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9228-5378","authenticated-orcid":false,"given":"Guillermo","family":"Schmeda-Hirschmann","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica de Productos Naturales, Instituto de Qu\u00edmica de Recursos Naturales, Campus Lircay, Universidad de Talca, Talca 3480094, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phymed.2012.09.010","article-title":"Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential","volume":"20","author":"Muller","year":"2012","journal-title":"Phytomedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.foodchem.2008.11.093","article-title":"Berry polyphenols inhibit pancreatic lipase activity in vitro","volume":"115","author":"McDougall","year":"2009","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11101-019-09610-6","article-title":"Flavonoids as alpha-glucosidase inhibitors: Mechanistic approaches merged with enzyme kinetics and molecular modelling","volume":"19","author":"Sari","year":"2020","journal-title":"Phytochem. 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